Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics.

abstract：OBJECTIVE:To investigate the effect of flexible intensive insulin therapy (FIIT) and an automated bolus calculator (ABC) in a Danish type 1 diabetes population treated with multiple daily injections. Furthermore, to test the feasibility of teaching FIIT in a 3-h structured course. RESEARCH DESIGN AND METHODS:The Bolus...

journal_title：Diabetes care

authors： Schmidt S,Meldgaard M,Serifovski N,Storm C,Christensen TM,Gade-Rasmussen B,Nørgaard K

更新日期：2012-05-01 00:00:00

abstract：:This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...

journal_title：Diabetes care

authors： Schwartz R,Teramo KA

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of day and night closed-loop insulin delivery in adults with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:Seventeen adults with type 1 diabetes on insulin pump therapy (means ± SD age 34 ± 9 years, HbA1c 7.6 ± 0.8%, and duration of diabetes 19 ± 9 year...

journal_title：Diabetes care

authors： Leelarathna L,Dellweg S,Mader JK,Allen JM,Benesch C,Doll W,Ellmerer M,Hartnell S,Heinemann L,Kojzar H,Michalewski L,Nodale M,Thabit H,Wilinska ME,Pieber TR,Arnolds S,Evans ML,Hovorka R,AP@home Consortium.

更新日期：2014-07-01 00:00:00

abstract：:It is now possible to virtually normalize ambient blood glucose levels in insulin-dependent diabetic women during pregnancy. Successful programs have been developed that utilize home blood glucose monitoring, physiologic delivery of insulin, and quantitation of caloric intake carefully matched to insulin dosage. The r...

journal_title：Diabetes care

authors： Jovanovic L,Peterson CM

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Women with diabetes have a high incidence and complication rate of urinary tract infections (UTIs). Our aims were to compare current treatment strategies with respect to recurrence rates in women with diabetes with those without diabetes. RESEARCH DESIGN AND METHODS:We used a Dutch registration database cont...

journal_title：Diabetes care

authors： Schneeberger C,Stolk RP,Devries JH,Schneeberger PM,Herings RM,Geerlings SE

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...

journal_title：Diabetes care

authors： Chaturvedi N,Stevens LK,Fuller JH

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...

journal_title：Diabetes care

authors： Alting AC,Meijer RJ,van Beresteijn EC

更新日期：1997-05-01 00:00:00

abstract：:Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (greater than 0.5 g/day) due to diabetic nephropathy. Mean ag...

journal_title：Diabetes care

authors： Parving HH,Andersen AR,Smidt UM,Friisberg B,Svendsen PA

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:To explore the hypothesis that a relationship exists between free radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND METHODS:The use of the total radical-trapping antioxidant parameter (TRAP) has very recently been proposed to explore the antioxidant property of a plasma and their...

journal_title：Diabetes care

authors： Ceriello A,Bortolotti N,Pirisi M,Crescentini A,Tonutti L,Motz E,Russo A,Giacomello R,Stel G,Taboga C

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:After a 6-week placebo baseline period, 102 hypertensive NIDDM patients were ...

journal_title：Diabetes care

authors： Chan JC,Nicholls MG,Cheung CK,Law LK,Swaminathan R,Cockram CS

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To establish quantitative characteristics of lifestyle counseling documentation associated with improved glycemic control in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied 10,870 hyperglycemic (HbA1c ≥7.0% [53 mmol/mol]) adults with diabetes followed at primary care practices ...

journal_title：Diabetes care

authors： Hosomura N,Goldberg SI,Shubina M,Zhang M,Turchin A

更新日期：2015-07-01 00:00:00

abstract：:OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated trends in diabetes prevalence across cohorts born 1910-1989 and provide the first estimates of age-specific diabetes incidence using nationally representative, measured data. RESEARCH DESIGN AND METHOD...

journal_title：Diabetes care

authors： Fishman EI,Stokes A,Preston SH

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for p...

journal_title：Diabetes care

authors： Sinha A,Rajan M,Hoerger T,Pogach L

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that residential environment may influence health behaviors and outcomes. We assessed whether perception of neighborhood problems was associated with diabetes behaviors and outcomes. RESEARCH DESIGN AND METHODS:This cross-sectional analysis included 7,830 diabetic adults enrolled in Trans...

journal_title：Diabetes care

authors： Gary TL,Safford MM,Gerzoff RB,Ettner SL,Karter AJ,Beckles GL,Brown AF

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Low plasma testosterone levels are associated with hyperinsulinemia and glucose intolerance in men. However, it is unclear whether these abnormalities are related to the concomitant alteration in regional adipose tissue (AT) accumulation associated with reduced androgen levels. RESEARCH DESIGN AND METHODS:We...

journal_title：Diabetes care

authors： Tchernof A,Després JP,Dupont A,Bélanger A,Nadeau A,Prud'homme D,Moorjani S,Lupien PJ,Labrie F

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...

journal_title：Diabetes care

authors： Bradley C,Eschwège E,de Pablos-Velasco P,Parhofer KG,Simon D,Vandenberghe H,Gönder-Frederick L

更新日期：2018-02-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of visual impairment and preventable blindness, and represents a significant socioeconomic cost for health care systems worldwide. Therefore, new approaches beyond current standards of diabetes care are needed. Based on the crucial pathogenic role of vascular endothelial growt...

journal_title：Diabetes care

authors： Simó R,Sundstrom JM,Antonetti DA

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:C242T polymorphi...

journal_title：Diabetes care

authors： Hayaishi-Okano R,Yamasaki Y,Kajimoto Y,Sakamoto K,Ohtoshi K,Katakami N,Kawamori D,Miyatsuka T,Hatazaki M,Hazama Y,Hori M

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Previous reviews of the effect of oral antidiabetic (OAD) agents on A1C levels summarized studies with varying designs and methodological approaches. Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels. RESEARCH DESIGN AND METHODS:The Excerpta Medica (EMBASE), the...

journal_title：Diabetes care

authors： Sherifali D,Nerenberg K,Pullenayegum E,Cheng JE,Gerstein HC

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Left ventricular remodeling occurs immediately after MI, involving structural changes in noninfarcted segment. However, the residual left ventricular pump function in NIDDM patients after acute MI has not been clarified. The purpose of this study was to evaluate the difference in the process of left ventricul...

journal_title：Diabetes care

authors： Iwasaka T,Takahashi N,Nakamura S,Sugiura T,Tarumi N,Kimura Y,Okubo N,Taniguchi H,Matsui Y,Inada M

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:Severe hyperglycemia and hypoglycemia ("severe dysglycemia") are serious complications of type 1 diabetes (T1D). Depression has been associated with severe dysglycemia in type 2 diabetes but has not been thoroughly examined specifically in T1D. We evaluated bidirectional associations between depression and se...

journal_title：Diabetes care

authors： Gilsanz P,Karter AJ,Beeri MS,Quesenberry CP Jr,Whitmer RA

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To determine whether an educational intervention for medical house staff improves blood glucose (BG) in hospitalized patients. RESEARCH DESIGN AND METHODS:All 116 medicine residents at an academic medical center were assigned to online or classroom training on inpatient dysglycemia in fall 2008. Both groups ...

journal_title：Diabetes care

authors： Tamler R,Green DE,Skamagas M,Breen TL,Looker HC,Babyatsky M,Leroith D

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Insulin resistance (IR) and the metabolic syndrome (MS) are associated with type 2 diabetes and adverse cardiovascular disease (CVD) risk factor profiles. Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are i...

journal_title：Diabetes care

authors： Resnick HE,Jones K,Ruotolo G,Jain AK,Henderson J,Lu W,Howard BV,Strong Heart Study.

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To study the association between selected risk factors and the subsequent incidence of type II diabetes over a 5-yr period. RESEARCH DESIGN AND METHODS:Between 1973 and 1976, a cohort of men from 22 clinical centers throughout the U.S. enrolled in the Usual Care group of the Multiple Risk Factor Intervention...

journal_title：Diabetes care

authors： Shaten BJ,Smith GD,Kuller LH,Neaton JD

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...

journal_title：Diabetes care

authors： Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

journal_title：Diabetes care

authors： Ozieh MN,Bishu KG,Dismuke CE,Egede LE

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...

journal_title：Diabetes care

authors： Bodmer M,Meier C,Krähenbühl S,Jick SS,Meier CR

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...

journal_title：Diabetes care

authors： Dubois-Laforgue D,Cornu E,Saint-Martin C,Coste J,Bellanné-Chantelot C,Timsit J,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To study the effect of birth weight on risk of type 2 diabetes in the schoolchildren in Taiwan. RESEARCH DESIGN AND METHODS:From 1992 to 1997, all schoolchildren aged 6-18 years were screened for diabetes in Taiwan Province. This cohort consisted of 1,966 patients with diabetes and 1,780 randomly selected su...

journal_title：Diabetes care

authors： Wei JN,Sung FC,Li CY,Chang CH,Lin RS,Lin CC,Chiang CC,Chuang LM

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may i...

journal_title：Diabetes care

authors： Teufel F,Geldsetzer P,Manne-Goehler J,Karlsson O,Koncz V,Deckert A,Theilmann M,Marcus ME,Ebert C,Seiglie JA,Agoudavi K,Andall-Brereton G,Gathecha G,Gurung MS,Guwatudde D,Houehanou C,Hwalla N,Kagaruki GB,Karki KB,Lab

更新日期：2020-10-01 00:00:00