Increased 24-h energy expenditure in type 2 diabetes.


OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND METHODS:Data from 31 subjects with type 2 diabetes and 61 nondiabetic control subjects were analyzed. The 24-h energy expenditure, basal metabolic rate (BMR), and sleeping energy expenditure (EEsleep) between 1:00 a.m. and 6:00 a.m. were measured in whole-body respiratory chambers. Body composition was assessed by dual-energy X-ray absorptiometry (DXA). RESULTS:No significant differences in unadjusted EEsleep, BMR, and 24-h energy expenditure were observed between the type 2 diabetic group and the control group. After adjustment for fat-free mass (FFM), fat mass, SPA, sex, and age, EEsleep and BMR were, respectively, 7.7 and 6.9% higher in the type 2 diabetic group compared with the control group. This was equivalent to 144 +/- 40 kcal/day (P = 0.001) and 139 +/- 61 kcal/day (P = 0.026), respectively. Adjusted 24-h energy expenditure was 6.5% higher in the type 2 diabetic group compared with the nondiabetic control subjects (2,679 +/- 37 vs. 2,515 +/- 23 kcal/day, P = 0.002). In multiple regression analyses, FFM, fat mass, SPA, and diabetes status were all significant determinants of EEsleep and 24-h energy expenditure, explaining 83 and 81% of the variation, respectively. CONCLUSIONS:This study confirms reports in Pima Indians that basal and 24-h energy expenditure adjusted for body composition, SPA, sex, and age are higher in individuals with type 2 diabetes compared with nondiabetic control subjects and may be even more pronounced in Caucasians.


Diabetes Care


Diabetes care


Bitz C,Toubro S,Larsen TM,Harder H,Rennie KL,Jebb SA,Astrup A




Has Abstract


2004-10-01 00:00:00














  • Low-dose bedtime NPH insulin in treatment of secondary failure to glyburide.

    abstract::Secondary failure to oral hypoglycemic agents (OHAs) is a possible outcome for non-insulin-dependent diabetes mellitus (NIDDM) patients and poses a serious therapeutic problem. In this study, we evaluated the effect of adding a single bedtime low-dose NPH insulin injection to the previous ineffective sulfonylurea ther...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Trischitta V,Italia S,Borzi V,Tribulato A,Mazzarino S,Squatrito S,Vigneri R

    更新日期:1989-09-01 00:00:00

  • Temporal variation in incidence of IDDM in Canterbury, New Zealand.

    abstract:OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

    更新日期:1992-07-01 00:00:00

  • Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men.

    abstract:OBJECTIVE:To investigate the effect of normal aging on the protective responses against hypoglycemia, in view of the fact that type II diabetes is primarily a disease of aging, and its treatment is associated with risk of hypoglycemia with cognitive impairment. RESEARCH DESIGN AND METHODS:Plasma glucose was lowered st...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Matyka K,Evans M,Lomas J,Cranston I,Macdonald I,Amiel SA

    更新日期:1997-02-01 00:00:00

  • Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes.

    abstract:OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: White NH,Chase HP,Arslanian S,Tamborlane WV,4030 Study Group.

    更新日期:2009-03-01 00:00:00

  • Faster Compared With Standard Insulin Aspart During Day-and-Night Fully Closed-Loop Insulin Therapy in Type 1 Diabetes: A Double-Blind Randomized Crossover Trial.

    abstract:OBJECTIVE:We evaluated the safety and efficacy of day-and-night fully closed-loop insulin therapy using faster (Faster-CL) compared with standard insulin aspart (Standard-CL) in young adults with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a double-blind, randomized, crossover trial, 20 participants with type 1 di...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Dovc K,Piona C,Yeşiltepe Mutlu G,Bratina N,Jenko Bizjan B,Lepej D,Nimri R,Atlas E,Muller I,Kordonouri O,Biester T,Danne T,Phillip M,Battelino T

    更新日期:2020-01-01 00:00:00

  • Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study.

    abstract:OBJECTIVE:To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Nachum Z,Zafran N,Salim R,Hissin N,Hasanein J,Gam Ze Letova Y,Suleiman A,Yefet E

    更新日期:2017-03-01 00:00:00

  • Incomplete elimination of the ABBOS epitope of bovine serum albumin under simulated gastrointestinal conditions of infants.

    abstract:OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Alting AC,Meijer RJ,van Beresteijn EC

    更新日期:1997-05-01 00:00:00

  • Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

    abstract::Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Hardt PD,Brendel MD,Kloer HU,Bretzel RG

    更新日期:2008-02-01 00:00:00

  • Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial.

    abstract:OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

    更新日期:2016-11-01 00:00:00

  • Longitudinal development of left ventricular diastolic function in patients with type 2 diabetes.

    abstract:OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Venskutonyte L,Jarnert C,Rydén L,Kjellström B

    更新日期:2014-11-01 00:00:00

  • A health economic model to assess the long-term effects and cost-effectiveness of orlistat in obese type 2 diabetic patients.

    abstract:OBJECTIVES:Obesity is a common condition in type 2 diabetic patients. Treating obesity may enhance hypoglycemic treatment and contribute to the reduction of long-term microvascular and macrovascular complications. Orlistat reduces cardiovascular risk factors in obese type 2 diabetic patients. The objectives of this stu...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lamotte M,Annemans L,Lefever A,Nechelput M,Masure J

    更新日期:2002-02-01 00:00:00

  • Specific relation between abdominal obesity and early-phase hyperglycemia is modulated by hepatic insulin resistance in healthy older women.

    abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: DiPietro L,Dziura J,Yeckel CW

    更新日期:2010-01-01 00:00:00

  • Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study.

    abstract:OBJECTIVE:To evaluate the effectiveness of systemic hyperbaric oxygen therapy (s HBOT) in addition to a comprehensive protocol in decreasing major amputation rate in diabetic patients hospitalized for severe foot ulcer. RESEARCH DESIGN AND METHODS:From August 1993 to August 1995, 70 diabetic subjects were consecutivel...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Faglia E,Favales F,Aldeghi A,Calia P,Quarantiello A,Oriani G,Michael M,Campagnoli P,Morabito A

    更新日期:1996-12-01 00:00:00

  • Life years lost and lifetime health care expenditures associated with diabetes in the U.S., National Health Interview Survey, 1997-2000.

    abstract:OBJECTIVE:This study analyzed the lifetime health care expenditures and life years lost associated with diabetes in the U.S. RESEARCH DESIGN AND METHODS:Data from the National Health Interview Survey (NHIS), the Medical Expenditure Panel Survey from 1997 to 2000, and the NHIS Linked Mortality Public-use Files with a m...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Leung MY,Pollack LM,Colditz GA,Chang SH

    更新日期:2015-03-01 00:00:00

  • Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome.

    abstract:OBJECTIVE:Conjugated linoleic acid (CLA) is a group of dietary fatty acids with antiobesity and antidiabetic effects in some animals. The trans10cis12 (t10c12) CLA isomer seems to cause these effects, including improved insulin sensitivity. Whether such isomer-specific effects occur in humans is unknown. The aim of thi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Risérus U,Arner P,Brismar K,Vessby B

    更新日期:2002-09-01 00:00:00

  • Increased plasma levels of endothelin 1 and von Willebrand factor in patients with type 2 diabetes and dyslipidemia.

    abstract:OBJECTIVE:Endothelial markers endothelin 1 (ET-1) and von Willebrand factor (vWF) were assessed in patients with type 2 diabetes and dyslipidemia and in patients with hypercholesterolemia. RESEARCH DESIGN AND METHODS:In this case-control study, plasma ET-and vWF levels were measured by enzyme-linked immunosorbent assa...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Seligman BG,Biolo A,Polanczyk CA,Gross JL,Clausell N

    更新日期:2000-09-01 00:00:00

  • Combination insulin-sulfonylurea therapy.

    abstract::Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Lebovitz HE,Pasmantier R

    更新日期:1990-06-01 00:00:00

  • Differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people with metabolic syndrome.

    abstract:OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Bakris G,Molitch M,Hewkin A,Kipnes M,Sarafidis P,Fakouhi K,Bacher P,Sowers J,STAR Investigators.

    更新日期:2006-12-01 00:00:00

  • Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

    abstract:OBJECTIVE:To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS:We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Shen GQ,Ikegami H,Kawaguchi Y,Fujisawa T,Hamada Y,Ueda H,Shintani M,Nojima K,Kawabata Y,Yamada K,Babaya N,Ogihara T

    更新日期:1998-07-01 00:00:00

  • Erythrocyte sodium-lithium countertransport activity in non-nephropathic diabetic twins.

    abstract:OBJECTIVE:It has proved difficult to separate the role of the diabetic state as distinct from its complications in causing the elevation in erythrocyte sodium-lithium (Na-Li) countertransport activity that has been observed in diabetes. The present study sought to isolate the impact of diabetes on the countertransporte...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hardman TC,Dubrey SW,Leslie RD,Lant AF

    更新日期:1996-01-01 00:00:00

  • Interaction between plastic catheter tubings and regular insulin preparations used for continuous subcutaneous insulin-infusion therapy.

    abstract::In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

    更新日期:1987-05-01 00:00:00

  • Vital signs, QT prolongation, and newly diagnosed cardiovascular disease during severe hypoglycemia in type 1 and type 2 diabetic patients.

    abstract::OBJECTIVE To assess vital signs, QT intervals, and newly diagnosed cardiovascular disease during severe hypoglycemia in diabetic patients. RESEARCH DESIGN AND METHODS From January 2006 to March 2012, we conducted a retrospective cohort study to assess type 1 and type 2 diabetic patients with severe hypoglycemia at a n...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Tsujimoto T,Yamamoto-Honda R,Kajio H,Kishimoto M,Noto H,Hachiya R,Kimura A,Kakei M,Noda M

    更新日期:2014-01-01 00:00:00

  • Validation of the WHO-5 Well-Being Index in adolescents with type 1 diabetes.

    abstract:OBJECTIVE:It is recommended that the psychological status of adolescents with diabetes be assessed periodically as part of ongoing care. The World Health Organization-Five Well-Being Index (WHO-5) is a short self-report instrument that appears suitable for this purpose. This study is the first to assess the reliability...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: de Wit M,Pouwer F,Gemke RJ,Delemarre-van de Waal HA,Snoek FJ

    更新日期:2007-08-01 00:00:00

  • Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes.

    abstract:OBJECTIVE:Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknown. Increased demand due to obesity and/or insuli...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Røder ME,Dinesen B,Hartling SG,Houssa P,Vestergaard H,Sodoyez-Goffaux F,Binder C

    更新日期:1999-04-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

  • Mortality trends in subjects with and without diabetes during 33 years of follow-up.

    abstract::OBJECTIVE Mortality rates have declined substantially over the past decades in the general population, but the situation among diabetic subjects is less clear. The aim of this study was to analyze mortality trends in diabetic and nondiabetic subjects during 1972-2004. RESEARCH DESIGN AND METHODS Since 1972, all patien...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Jansson SP,Andersson DK,Svärdsudd K

    更新日期:2010-03-01 00:00:00

  • C-Peptide responses to glucose load in maturity-onset diabetes of the young (MODY).

    abstract::Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obe...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Mohan V,Snehalatha C,Ramachandran A,Jayashree R,Viswanathan M

    更新日期:1985-01-01 00:00:00

  • Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study.

    abstract:OBJECTIVE:There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ibsen DB,Steur M,Imamura F,Overvad K,Schulze MB,Bendinelli B,Guevara M,Agudo A,Amiano P,Aune D,Barricarte A,Ericson U,Fagherazzi G,Franks PW,Freisling H,Quiros JR,Grioni S,Heath AK,Huybrechts I,Katze V,Laouali N,

    更新日期:2020-11-01 00:00:00

  • The epidemiology of diabetes in pregnant Native Canadians. A risk profile.

    abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of diabetes in pregnancy (gestational diabetes mellitus [GDM] and NIDDM) and to identify risk factors in the development of GDM in a native population in northwestern Ontario, Canada. RESEARCH DESIGN AND METHODS:A retrospective analysis of 1,305 singl...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Harris SB,Caulfield LE,Sugamori ME,Whalen EA,Henning B

    更新日期:1997-09-01 00:00:00

  • Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes.

    abstract:OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Roguin A,Koch W,Kastrati A,Aronson D,Schomig A,Levy AP

    更新日期:2003-09-01 00:00:00