Abstract:
OBJECTIVE:Depression is common in patients with type 2 diabetes and adversely affects quality of life and diabetes outcomes. We assessed whether light therapy, an antidepressant, improves mood and insulin sensitivity in patients with depression and type 2 diabetes. RESEARCH DESIGN AND METHODS:This randomized, double-blind, placebo-controlled trial included 83 patients with depression and type 2 diabetes. The intervention comprised 4 weeks of light therapy (10,000 lux) or placebo light therapy daily at home. Primary outcomes included depressive symptoms (Inventory of Depressive Symptomatology [IDS]) and insulin sensitivity (M-value derived from the results of a hyperinsulinemic-euglycemic clamp). Secondary outcomes were related psychological and glucometabolic measures. RESULTS:Intention-to-treat analysis showed that light therapy was not superior to placebo in reducing depressive symptoms (-3.9 IDS points [95% CI -9.0 to 1.2]; P = 0.248) and had no effect on insulin sensitivity (0.15 mg/kg*min [95% CI -0.41 to 0.70]; P = 0.608). Analyses incorporating only those participants who accurately adhered to the light therapy protocol (n = 51) provided similar results, but did suggest positive effects of light therapy on depression response rates (≥50% reduction in IDS points) (26% more response; P = 0.031). Prespecified analysis showed effect moderation by baseline insulin sensitivity (P = 0.009) and use of glucose-lowering medication (P = 0.023). Light therapy did not affect depressive symptoms in participants with higher insulin sensitivity or those who use only oral glucose-lowering medication or none at all, but it did produce a relevant effect in participants with lower insulin sensitivity (-12.9 IDS points [95% CI -21.6 to -4.2]; P = 0.017) and a trend toward effectiveness in those using insulin (-12.2 IDS points [95% CI -21.3 to -3.1]; P = 0.094). Light therapy was well tolerated. CONCLUSIONS:Although this trial is essentially inconclusive, secondary analyses indicate that light therapy might be a promising treatment for depression among a subgroup of highly insulin-resistant individuals with type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Brouwer A,van Raalte DH,Nguyen HT,Rutters F,van de Ven PM,Elders PJM,Moll AC,Van Someren EJW,Snoek FJ,Beekman ATF,Bremmer MAdoi
10.2337/dc18-1732subject
Has Abstractpub_date
2019-04-01 00:00:00pages
529-538issue
4eissn
0149-5992issn
1935-5548pii
dc18-1732journal_volume
42pub_type
杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap. RESEARCH DESIGN AND METHODS:GBD 2016 data, including prevalence and years lived with dis...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1614
更新日期:2020-05-01 00:00:00
abstract::It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.4.427
更新日期:1982-07-01 00:00:00
abstract:OBJECTIVE:To examine the association of renal function in diabetic patients with apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:Apo E genotypes, lipid and lipoprotein serum levels, creatinine clearance (CCr), and excretion of marker proteins were determined in German type 1 (IDDM; n = 162) and type 2...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.6.994
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Our objective was to analyze the prevalence, incidence, and mortality of diabetes in a population of 280,539 inhabitants. RESEARCH DESIGN AND METHODS:The incidence, prevalence, and deaths from diabetes at all ages of a population have been prospectively followed in the county of Skaraborg, Sweden, since 1991...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.773
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc16-2655
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:This study was performed to determine the net effects of euglycemia, resolution of renal failure, immunosuppressant drugs, and hyperinsulinemia on fasting lipid profiles of patients with renal failure and insulin-dependent diabetes mellitus (IDDM) after combined pancreas-kidney transplantation (PKT). RESEARC...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.1.35
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS:In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.1.95
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To explore patients' and health professionals' experiences of initiating insulin as part of the Treating To Target in Type 2 Diabetes (4-T) randomized controlled trial. RESEARCH DESIGN AND METHODS:Interviews were conducted with 45 trial participants and 21 health professionals and thematically analyzed. RES...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-0494
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1888
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.704
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS:A total of 3,475 nondiabetic subjects aged 3-18 years were sampled i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1040
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Determine the serum levels of endogenous secretory receptor for advanced glycation end products (esRAGEs) in patients with type 2 diabetes and mild cognitive impairment (MCI) and in control patients with type 2 diabetes but no MCI, and examine the relationship of esRAGE and MCI with other clinical factors. R...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0958
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To validate fasting indices of insulin sensitivity and secretion in a diverse pediatric population against gold standard estimates from euglycemic and hyperglycemic clamps. RESEARCH DESIGN AND METHODS:A total of 31 children (mean BMI 25.1 +/- 4.9 kg/m(2), mean age 8.7 +/- 1.4 years, 15 girls and 16 boys, 12 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.11.2081
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To test the utility of homeostasis model assessment (HOMA) in predicting insulin sensitivity [x10(- 4) min(-1)/(microIU/ml)] in children and to develop and compare two new prediction equations for insulin sensitivity in children using demographic and anthropometric measures in the presence or absence of fasti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.7.1203
更新日期:2002-07-01 00:00:00
abstract::Biosynthetic human insulin (BHI) and purified pork insulin (PPI) were compared for binding properties and stimulatory effect on 2-deoxyglucose transport in isolated rat fat cells. No difference between these types of insulin could be demonstrated. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.2.254
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2105
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of NIDDM and IGT in the urban and rural areas in southern India. RESEARCH DESIGN AND METHODS:Two populations of the same ethnic background, but different socioeconomic background were chosen for this study. Nine-hundred urban people and 1038 rural subjects were studied. Fasting and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.10.1348
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0630
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.12.3315
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To improve prognosis, it is important to predict the incidence of renal failure and cardiovascular disease in type 2 diabetic patients before the progression to advanced nephropathy. We investigated the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP), which is associated with rena...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1298
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-2222
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.5.386
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:Many of the metabolic benefits of Roux-en-Y gastric bypass (RYGB) occur before weight loss. In this study we investigated the influence of caloric restriction on the improvements in the metabolic responses that occur within the 1st week after RYGB. RESEARCH METHODS AND DESIGN: A mixed meal was administered to...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2107
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:This study describes changes in the distribution of cigarette smoking and in physicians' advice to quit smoking among the U.S. population with and without diabetes from the mid-1970s to 1990. RESEARCH DESIGN AND METHODS:Data on self-reported smoking status, physicians' advice to quit smoking, history of diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.5.694
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:This was a prospective follow-up study as a part of the nationwide Finnish Diabetic Nephropathy Study; 1,330 type 1 diabetic pat...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2306
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic properties of a nonmydriatic 200° ultra-widefield scanning laser ophthalmoscope (SLO) versus mydriatic Early Treatment of Diabetic Retinopathy Study (ETDRS) 7-field photography for diabetic retinopathy (DR) screening. RESEARCH DESIGN AND METHODS:A consecutive series of 212 eyes of 1...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0346
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-1385
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare clinical and biomechanical characteristics of balance in diabetic polyneuropathic elderly patients and normal age-matched subjects. RESEARCH DESIGN AND METHODS:Fifteen elderly with distal neuropathy (DNP) and 15 healthy age-matched subjects were evaluated with the b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.8.1187
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late-gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age). RESEARCH DESIGN AND METHODS:The relationships between morning nonfasting TG measured early ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.12.1550
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:Successful disease management is heavily influenced by access to care issues and patient behavior. Screening tests to detect chronic complications are part of diabetes management and may be influenced by access to care or patient decisions. The objective of this research was to examine how strongly access to ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1279
更新日期:2007-04-01 00:00:00