Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study.

Abstract:

OBJECTIVE:Age, diabetes, and elevated inflammatory markers independently increase the risk of functional decline. We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes. RESEARCH DESIGN AND METHODS:We analyzed data from a cohort of 2,895 well-functioning adults aged 70-79 years, followed for development of persistent functional limitation over 3.5 years. Participants were assessed for the presence of diabetes according to fasting glucose and/or hypoglycemic medication use and were divided into three equal groups (tertiles) according to level of CRP or IL-6. Persistent functional limitation was defined as difficulty climbing 10 steps or walking one-quarter mile on two consecutive semiannual assessments. RESULTS:At baseline, 702 participants (24%) had diabetes. CRP values were (median +/- SD) 2.8 +/- 4.4 versus 3.7 +/- 5.4 for those with normal glucose and diabetes, respectively (P < 0.001). The unadjusted incidence of functional limitation associated with increased levels of CRP and IL-6 was greater among participants with diabetes. After adjusting for clinical and demographic covariates, persistent functional limitation for the highest tertile was greater compared with that for the lowest tertile of CRP or IL-6 for those with and without diabetes. CRP hazard ratios (HRs) were 1.7 (95% CI 1.2-2.3) versus 1.4 (1.1-1.6), respectively. IL-6 HRs were 1.8 (1.3-2.5) versus 1.6 (1.4-2.0), respectively. CONCLUSIONS:In initially high-functioning older adults, those with diabetes and higher inflammatory burden had an increased risk of functional decline. Interventions at early stages to reduce inflammation may preserve function in these individuals.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Figaro MK,Kritchevsky SB,Resnick HE,Shorr RI,Butler J,Shintani A,Penninx BW,Simonsick EM,Goodpaster BH,Newman AB,Schwartz AV,Harris TB

doi

10.2337/dc06-0245

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

2039-45

issue

9

eissn

0149-5992

issn

1935-5548

pii

29/9/2039

journal_volume

29

pub_type

杂志文章
  • Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:OBJECTIVE:Prediabetes and type 2 diabetes mellitus (T2DM) are believed to be common and associated with a worse metabolic profile in patients with nonalcoholic fatty liver disease (NAFLD). However, no previous study has systematically screened this population. RESEARCH DESIGN AND METHODS:We studied the prevalence and ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1849

    authors: Ortiz-Lopez C,Lomonaco R,Orsak B,Finch J,Chang Z,Kochunov VG,Hardies J,Cusi K

    更新日期:2012-04-01 00:00:00

  • Cognitive function in younger type II diabetes.

    abstract:OBJECTIVE:To examine central nervous system involvement as a possible complication of diabetes by performing a comprehensive neuropsychological evaluation of relatively young (age < 55 years) NIDDM patients and a group of control subjects. RESEARCH DESIGN AND METHODS:A cross-sectional comparative study of 28 patients,...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.1.32

    authors: Dey J,Misra A,Desai NG,Mahapatra AK,Padma MV

    更新日期:1997-01-01 00:00:00

  • Increased foot pressures after great toe amputation in diabetes.

    abstract:OBJECTIVE:To compare peak pressures on the sole of the foot in non-insulin-dependent diabetic patients with isolated, unilateral amputations of the great toe and first metatarsal with the patients' contralateral, intact foot. RESEARCH DESIGN AND METHODS:Eleven patients with a unilateral great toe and partial first met...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.11.1460

    authors: Lavery LA,Lavery DC,Quebedeax-Farnham TL

    更新日期:1995-11-01 00:00:00

  • Decreased release of lipoprotein lipase is associated with vascular endothelial damage in NIDDM patients with microalbuminuria.

    abstract:OBJECTIVE:To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.11.2016

    authors: Kashiwazaki K,Hirano T,Yoshino G,Kurokawa M,Tajima H,Adachi M

    更新日期:1998-11-01 00:00:00

  • Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial.

    abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1711

    authors: Ell K,Katon W,Xie B,Lee PJ,Kapetanovic S,Guterman J,Chou CP

    更新日期:2010-04-01 00:00:00

  • Glycated hemoglobin and risk of hypertension in the atherosclerosis risk in communities study.

    abstract:OBJECTIVE:Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2248

    authors: Bower JK,Appel LJ,Matsushita K,Young JH,Alonso A,Brancati FL,Selvin E

    更新日期:2012-05-01 00:00:00

  • High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury.

    abstract:OBJECTIVE:The aim of this study was to compare the prevalence of both impaired fasting glucose (IFG) and diabetes between hepatitis C virus (HCV)-infected patients and patients with other liver diseases but anti-HCV-, taking into account the degree of liver damage. RESEARCH DESIGN AND METHODS:A total of 642 consecutiv...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1171

    authors: Lecube A,Hernández C,Genescà J,Esteban JI,Jardí R,Simó R

    更新日期:2004-05-01 00:00:00

  • Dietary fat intake and cognitive decline in women with type 2 diabetes.

    abstract:OBJECTIVE:Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. We investigated whether dietary fat, which modula...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1741

    authors: Devore EE,Stampfer MJ,Breteler MM,Rosner B,Kang JH,Okereke O,Hu FB,Grodstein F

    更新日期:2009-04-01 00:00:00

  • Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

    abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-0078

    authors: Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

    更新日期:2017-11-01 00:00:00

  • The impact of diabetes on survival among patients with first myocardial infarction.

    abstract:OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.5.704

    authors: Chun BY,Dobson AJ,Heller RF

    更新日期:1997-05-01 00:00:00

  • Fatty acid composition of serum lipid fractions in type 2 diabetic patients with microalbuminuria.

    abstract:OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.3.613

    authors: Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

    更新日期:2003-03-01 00:00:00

  • Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID).

    abstract:OBJECTIVE:In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated with poorer cognition, but the association of SH with cognitive function in late life is unknown. Given the increasing life expectancy in people with T1D, understanding the role of SH in brain health is crucial. RESEARCH DESIGN AN...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0906

    authors: Lacy ME,Gilsanz P,Eng C,Beeri MS,Karter AJ,Whitmer RA

    更新日期:2020-03-01 00:00:00

  • Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a french prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

    abstract:OBJECTIVE:In the French Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, cross-sectional analyses have shown that a higher consumption of dairy products and calcium are associated with a lower prevalence of the metabolic syndrome (MetS). We assess the influence of dairy products on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1772

    authors: Fumeron F,Lamri A,Abi Khalil C,Jaziri R,Porchay-Baldérelli I,Lantieri O,Vol S,Balkau B,Marre M,Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study Group.

    更新日期:2011-04-01 00:00:00

  • Frailty and Risk of Fractures in Patients With Type 2 Diabetes.

    abstract:OBJECTIVE:We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures. RESEARCH DESIGN AND METHODS:Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1965

    authors: Li G,Prior JC,Leslie WD,Thabane L,Papaioannou A,Josse RG,Kaiser SM,Kovacs CS,Anastassiades T,Towheed T,Davison KS,Levine M,Goltzman D,Adachi JD,CaMos Research Group.

    更新日期:2019-04-01 00:00:00

  • Impaired glucose tolerance and diabetes mellitus in elderly subjects.

    abstract::In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.6.600

    authors: Agner E,Thorsteinsson B,Eriksen M

    更新日期:1982-11-01 00:00:00

  • Racial variation in the control of diabetes among elderly medicare managed care beneficiaries.

    abstract:OBJECTIVE:To examine racial variation in the poor control of GHb, a GHb value >9.5%, or GHb not tested in 1999 among Medicare beneficiaries aged 65-75 years enrolled in managed care plans. RESEARCH DESIGN AND METHODS:The National Committee on Quality Assurance provides person-level data regarding diabetes care service...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.12.3250

    authors: McBean AM,Huang Z,Virnig BA,Lurie N,Musgrave D

    更新日期:2003-12-01 00:00:00

  • The use of metformin and the incidence of lung cancer in patients with type 2 diabetes.

    abstract:OBJECTIVE:Observational studies have associated metformin use with a decreased risk of lung cancer incidence in patients with type 2 diabetes, but the studies had important methodological shortcomings. The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0740

    authors: Smiechowski BB,Azoulay L,Yin H,Pollak MN,Suissa S

    更新日期:2013-01-01 00:00:00

  • Development of stable film test for rapid estimation of blood or plasma 3-hydroxybutyrate.

    abstract::A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.5.522

    authors: Harano Y,Aoki T,Nakajima Y,Kojima H,Kosugi K,Harano A,Hidaka H,Yamada S,Uno S,Shigeta Y

    更新日期:1990-05-01 00:00:00

  • Advances toward the implantable artificial pancreas for treatment of diabetes.

    abstract::Recent research on development of the implantable artificial pancreas for treatment of diabetes is reviewed, based on a Medline literature search that focused on glucose sensors, insulin pumps, and pump control systems. To achieve a closed feedback loop, a clinically applicable implantable artificial pancreas requires...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.21.3.444

    authors: Jaremko J,Rorstad O

    更新日期:1998-03-01 00:00:00

  • Blood pressure and the risk of developing diabetes in african americans and whites: ARIC, CARDIA, and the framingham heart study.

    abstract:OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARD...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1786

    authors: Wei GS,Coady SA,Goff DC Jr,Brancati FL,Levy D,Selvin E,Vasan RS,Fox CS

    更新日期:2011-04-01 00:00:00

  • Surveillance in Florida of continuous subcutaneous insulin infusion use in cohort.

    abstract::Because of concerns about safety and expense associated with continuous subcutaneous insulin infusion (CSII), all people who had used CSII as of July 1982 were identified. Annual follow-up has resulted in data for up to 61 mo. Of the 92 nonpregnant registrees, 31 were less than 20 yr old, 36 were 20-29, and 25 were 30...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.6.591

    authors: Deeb LC,Williams PE

    更新日期:1986-11-01 00:00:00

  • Sexual dysfunction in Jordanian diabetic women.

    abstract:OBJECTIVE:To estimate the prevalence of female sexual dysfunction (FSD) in diabetic and nondiabetic Jordanian women. RESEARCH DESIGN AND METHODS:Data were collected from 1,137 married women using the Arabic translation of the Female Sexual Function Index questionnaire. RESULTS:Prevalence of sexual dysfunction in diab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0081

    authors: Abu Ali RM,Al Hajeri RM,Khader YS,Shegem NS,Ajlouni KM

    更新日期:2008-08-01 00:00:00

  • Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: the ARPEGGIO trial.

    abstract::OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc09-0455

    authors: Hollander PA,Amod A,Litwak LE,Chaudhari U,ARPEGGIO Study Group.

    更新日期:2010-03-01 00:00:00

  • Mediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.

    abstract:OBJECTIVE:To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc15-1117

    authors: Díaz-López A,Babio N,Martínez-González MA,Corella D,Amor AJ,Fitó M,Estruch R,Arós F,Gómez-Gracia E,Fiol M,Lapetra J,Serra-Majem L,Basora J,Basterra-Gortari FJ,Zanon-Moreno V,Muñoz MÁ,Salas-Salvadó J,PREDIMED Study Inves

    更新日期:2015-11-01 00:00:00

  • The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis.

    abstract:OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.26.6.1895

    authors: Maser RE,Mitchell BD,Vinik AI,Freeman R

    更新日期:2003-06-01 00:00:00

  • Durable Effects of iGlarLixi Up to 52 Weeks in Type 2 Diabetes: The LixiLan-G Extension Study.

    abstract:OBJECTIVE:In the LixiLan-G trial, switching to iGlarLixi, a once-daily titratable fixed-ratio combination of insulin glargine 100 units/mL and the glucagon-like peptide 1 receptor agonist (GLP-1 RA) lixisenatide, improved glucose control in type 2 diabetes uncontrolled with GLP-1 RAs over 26 weeks versus continuing pri...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-2023

    authors: Blonde L,Rosenstock J,Frias J,Birkenfeld AL,Niemoeller E,Souhami E,Ji C,Del Prato S,Aroda VR

    更新日期:2021-01-19 00:00:00

  • Prevalence of diabetes and hypertension in a rural population of Bangladesh.

    abstract::OBJECTIVE--To determine the prevalence of non-insulin-dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT), and hypertension in a rural community of Bangladesh. RESEARCH DESIGN AND METHODS--A cluster sampling of 1,005 subjects > 15 years of age in the rural community of Dohar was investigated. Capilla...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.4.555

    authors: Abu Sayeed M,Banu A,Khan AR,Hussain MZ

    更新日期:1995-04-01 00:00:00

  • Use of tactile techniques for self-monitoring of blood glucose in visually impaired patients with diabetes mellitus.

    abstract::Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.4.313

    authors: Prior JC,Alojado NC,Hunt JA,Begg IS

    更新日期:1984-07-01 00:00:00

  • Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study.

    abstract:OBJECTIVE:Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes. RESEARCH DESIGN AND METHODS:We performed a nested case-control study from the EURODIAB Prospective Complications St...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.26.7.2165

    authors: Schram MT,Chaturvedi N,Schalkwijk C,Giorgino F,Ebeling P,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study.

    更新日期:2003-07-01 00:00:00

  • Decreased polymorphonuclear leukocyte deformability in NIDDM.

    abstract:OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.1.57

    authors: Pécsvarády Z,Fisher TC,Darwin CH,Fabók A,Maqueda TS,Saad MF,Meiselman HJ

    更新日期:1994-01-01 00:00:00