Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes.

Abstract:

OBJECTIVE:To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults. RESEARCH DESIGN AND METHODS:A total of 4,497 Americans, aged 18-30 years, who had no diabetes at baseline, were prospectively examined for incident diabetes based on quintiles of magnesium intake. We also investigated the associations between magnesium intake and inflammatory markers, i.e., high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and fibrinogen, and the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS:During the 20-year follow-up, 330 incident cases of diabetes were identified. Magnesium intake was inversely associated with incidence of diabetes after adjustment for potential confounders. The multivariable-adjusted hazard ratio of diabetes for participants in the highest quintile of magnesium intake was 0.53 (95% CI, 0.32-0.86; P(trend) < 0.01) compared with those in the lowest quintile. Consistently, magnesium intake was significantly inversely associated with hs-CRP, IL-6, fibrinogen, and HOMA-IR, and serum magnesium levels were inversely correlated with hs-CRP and HOMA-IR. CONCLUSIONS:Magnesium intake was inversely longitudinally associated with incidence of diabetes in young American adults. This inverse association may be explained, at least in part, by the inverse correlations of magnesium intake with systemic inflammation and insulin resistance.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Kim DJ,Xun P,Liu K,Loria C,Yokota K,Jacobs DR Jr,He K

doi

10.2337/dc10-0994

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

2604-10

issue

12

eissn

0149-5992

issn

1935-5548

pii

dc10-0994

journal_volume

33

pub_type

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