A comparison of the effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type II diabetes.

Abstract:

OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investigation comparing the effects of linseed oil (LO) with FO supplementation was undertaken in subjects with type II diabetes. RESEARCH DESIGN AND METHODS:Eleven subjects with type II diabetes were given supplements with LO and FO for 3 months each in a randomized double-blind crossover fashion after 3 months of olive oil placebo. Oils were given as 35 mg FA.kg body wt-1.day-1. After each 3-month period, fasting glucose and insulin levels, HbA1c, lipid profiles, insulin sensitivity (SI), glucose effectiveness (SG), and acute insulin response to glucose (AIRG) were evaluated. RESULTS:HbA1c and lipid values were within the normal range at randomization. Repeated measures analysis of variance testing found no significant differences in weight; fasting glucose and insulin levels; HbA1c; total, LDL, and HDL cholesterol levels; SI; SG; or AIRG with either active oil. FO was associated with significant reductions in triglycerides and a trend toward decreased SI. CONCLUSIONS:In a population with well-controlled type II diabetes, 3 months of FO but not LO resulted in lowered triglyceride levels. Neither LO nor FO significantly affected glycemic control, cholesterol values, SG, or insulin secretion, while a nonsignificant trend toward decreased insulin sensitivity was found with FO.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

McManus RM,Jumpson J,Finegood DT,Clandinin MT,Ryan EA

doi

10.2337/diacare.19.5.463

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

463-7

issue

5

eissn

0149-5992

issn

1935-5548

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验
  • Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects.

    abstract:OBJECTIVE:Long-term exposure to alcohol is associated with an improvement in insulin sensitivity. At this time, however, there is no definitive proof that alcohol per se has an effect on the insulin sensitivity index (S(i)) in type 2 diabetes patients. The aim of the present study was to assess the role of acute modera...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.6.1369

    authors: Avogaro A,Watanabe RM,Dall'Arche A,De Kreutzenberg SV,Tiengo A,Pacini G

    更新日期:2004-06-01 00:00:00

  • Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2237

    authors: Ley SH,Chavarro JE,Li M,Bao W,Hinkle SN,Wander PL,Rich-Edwards J,Olsen S,Vaag A,Damm P,Grunnet LG,Mills JL,Hu FB,Zhang C

    更新日期:2020-04-01 00:00:00

  • Influence of insertion/deletion polymorphism in the ACE-I gene on the progression of diabetic glomerulopathy in type 1 diabetic patients with microalbuminuria.

    abstract:OBJECTIVE:To investigate the influence of the insertion/deletion polymorphism of the ACE gene on the progression of early diabetic glomerulopathy in patients with and without antihypertensive treatment (AHT). RESEARCH DESIGN AND METHODS:There were 30 microalbuminuric patients with >5 years of type 1 diabetes who had r...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.23.4.544

    authors: Rudberg S,Rasmussen LM,Bangstad HJ,Osterby R

    更新日期:2000-04-01 00:00:00

  • Interaction between plastic catheter tubings and regular insulin preparations used for continuous subcutaneous insulin-infusion therapy.

    abstract::In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.3.348

    authors: Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

    更新日期:1987-05-01 00:00:00

  • Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study.

    abstract:OBJECTIVE:The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:The study population consisted of 22778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. I...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.10.2785

    authors: Carlsson S,Hammar N,Grill V,Kaprio J

    更新日期:2003-10-01 00:00:00

  • Development of stable film test for rapid estimation of blood or plasma 3-hydroxybutyrate.

    abstract::A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.5.522

    authors: Harano Y,Aoki T,Nakajima Y,Kojima H,Kosugi K,Harano A,Hidaka H,Yamada S,Uno S,Shigeta Y

    更新日期:1990-05-01 00:00:00

  • Association between fine particulate matter and diabetes prevalence in the U.S.

    abstract:OBJECTIVE:Recent studies have drawn attention to the adverse effects of ambient air pollutants such as particulate matter 2.5 (PM2.5) on human health. We evaluated the association between PM2.5 exposure and diabetes prevalence in the U.S. and explored factors that may influence this relationship. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0698

    authors: Pearson JF,Bachireddy C,Shyamprasad S,Goldfine AB,Brownstein JS

    更新日期:2010-10-01 00:00:00

  • Biologic and quality-of-life outcomes from the Mediterranean Lifestyle Program: a randomized clinical trial.

    abstract:OBJECTIVE:Few multiple lifestyle behavior change programs have been designed to reduce the risk of coronary heart disease in postmenopausal women with type 2 diabetes. This study tested the effectiveness of the Mediterranean Lifestyle Program (MLP), a comprehensive lifestyle self-management program (Mediterranean low-s...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.8.2288

    authors: Toobert DJ,Glasgow RE,Strycker LA,Barrera M Jr,Radcliffe JL,Wander RC,Bagdade JD

    更新日期:2003-08-01 00:00:00

  • C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

    abstract:OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-0465

    authors: Shields BM,McDonald TJ,Oram R,Hill A,Hudson M,Leete P,Pearson ER,Richardson SJ,Morgan NG,Hattersley AT,TIGI Consortium.

    更新日期:2018-07-01 00:00:00

  • Adiponectin trajectories before type 2 diabetes diagnosis: Whitehall II study.

    abstract:OBJECTIVE:The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS:In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nest...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2263

    authors: Tabák AG,Carstensen M,Witte DR,Brunner EJ,Shipley MJ,Jokela M,Roden M,Kivimäki M,Herder C

    更新日期:2012-12-01 00:00:00

  • Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians.

    abstract:OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.4.271

    authors: Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

    更新日期:1991-04-01 00:00:00

  • Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women.

    abstract:OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc15-1385

    authors: Espeland MA,Brinton RD,Hugenschmidt C,Manson JE,Craft S,Yaffe K,Weitlauf J,Vaughan L,Johnson KC,Padula CB,Jackson RD,Resnick SM,WHIMS Study Group.

    更新日期:2015-12-01 00:00:00

  • Suppressive effect of insulin infusion on chemokines and chemokine receptors.

    abstract:OBJECTIVE:In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2193

    authors: Ghanim H,Korzeniewski K,Sia CL,Abuaysheh S,Lohano T,Chaudhuri A,Dandona P

    更新日期:2010-05-01 00:00:00

  • Elevated cystatin C concentration and progression to pre-diabetes: the Western New York study.

    abstract:OBJECTIVE:We conducted a nested case-control investigation to examine whether elevated baseline concentrations of cystatin C predicted progression from normoglycemia to pre-diabetes over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS:In 2002-2004, 1,455 participants from the W...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0040

    authors: Donahue RP,Stranges S,Rejman K,Rafalson LB,Dmochowski J,Trevisan M

    更新日期:2007-07-01 00:00:00

  • Normalization of the IGF-IGFBP axis by sustained nightly insulinization in type 1 diabetes.

    abstract:OBJECTIVE:We sought to test the hypothesis that start of insulin glargine with sustained nightly insulin action results in changes in circulating concentrations of IGF-I and IGF binding proteins (IGFBPs) in adolescents with type 1 diabetes-changes that may support improvement of A1C. RESEARCH DESIGN AND METHODS:Twelve...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-2328

    authors: Ekström K,Salemyr J,Zachrisson I,Carlsson-Skwirut C,Ortqvist E,Bang P

    更新日期:2007-06-01 00:00:00

  • Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.

    abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2043

    authors: Al-Delaimy WK,Willett WC,Manson JE,Speizer FE,Hu FB

    更新日期:2001-12-01 00:00:00

  • Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy.

    abstract:OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.10.1545

    authors: Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

    更新日期:2000-10-01 00:00:00

  • Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial.

    abstract:OBJECTIVE:Given the role of gut microbiota in regulating metabolism, probiotics administered during pregnancy might prevent gestational diabetes mellitus (GDM). This question has not previously been studied in high-risk overweight and obese pregnant women. We aimed to determine whether probiotics (Lactobacillus rhamnos...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc18-2248

    authors: Callaway LK,McIntyre HD,Barrett HL,Foxcroft K,Tremellen A,Lingwood BE,Tobin JM,Wilkinson S,Kothari A,Morrison M,O'Rourke P,Pelecanos A,Dekker Nitert M

    更新日期:2019-03-01 00:00:00

  • Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes.

    abstract:OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1115

    authors: Reaven PD,Sacks J,Investigators for the Veterans Affairs Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2.

    更新日期:2004-05-01 00:00:00

  • Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study.

    abstract:OBJECTIVE:To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS:SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2324

    authors: Dabelea D,Pihoker C,Talton JW,D'Agostino RB Jr,Fujimoto W,Klingensmith GJ,Lawrence JM,Linder B,Marcovina SM,Mayer-Davis EJ,Imperatore G,Dolan LM,SEARCH for Diabetes in Youth Study.

    更新日期:2011-07-01 00:00:00

  • Effect of longitudinal changes in visceral fat area and other anthropometric indices to the changes in metabolic risk factors in Japanese men: the Hitachi Health Study.

    abstract:OBJECTIVE:The effects of longitudinal changes in the visceral fat area (VFA), and other anthropometric indices, on the risk factors of metabolic syndrome were not studied. We calculated the changes in metabolic risk factors in relation to changes in certain anthropometric indices in a large-scale study of Japanese men....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1320

    authors: Matsushita Y,Nakagawa T,Yamamoto S,Takahashi Y,Yokoyama T,Mizoue T,Noda M

    更新日期:2012-05-01 00:00:00

  • High levels of education are associated with an increased risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study.

    abstract:OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1061

    authors: Olsson L,Ahlbom A,Grill V,Midthjell K,Carlsson S

    更新日期:2011-01-01 00:00:00

  • Intraperitoneal insulin delivery decreases the levels of chylomicron remnants in patients with IDDM.

    abstract:OBJECTIVE:To investigate whether intraperitoneal insulin (IPII) decreases the levels of circulating chylomicron remnants in patients with insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS:Eight nonobese, normolipidemic IDDM patients were studied twice: before (while on subcutaneous insulin) and 6...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.11.1295

    authors: Georgopoulos A,Saudek CD

    更新日期:1994-11-01 00:00:00

  • Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in taiwan.

    abstract:OBJECTIVE:To study the effect of birth weight on risk of type 2 diabetes in the schoolchildren in Taiwan. RESEARCH DESIGN AND METHODS:From 1992 to 1997, all schoolchildren aged 6-18 years were screened for diabetes in Taiwan Province. This cohort consisted of 1,966 patients with diabetes and 1,780 randomly selected su...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.2.343

    authors: Wei JN,Sung FC,Li CY,Chang CH,Lin RS,Lin CC,Chiang CC,Chuang LM

    更新日期:2003-02-01 00:00:00

  • Pancreatic Effects of Liraglutide or Sitagliptin in Overweight Patients With Type 2 Diabetes: A 12-Week Randomized, Placebo-Controlled Trial.

    abstract:OBJECTIVE:To assess the mechanistic effects of the glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide and the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin on (exocrine) pancreatic physiology and morphology. RESEARCH DESIGN AND METHODS:For this randomized, double-blind, parallel-group trial, 55 patien...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-0836

    authors: Smits MM,Tonneijck L,Muskiet MH,Kramer MH,Pieters-van den Bos IC,Vendrik KE,Hoekstra T,Bruno MJ,Diamant M,van Raalte DH,Cahen DL

    更新日期:2017-03-01 00:00:00

  • Clinical evaluation of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers.

    abstract:OBJECTIVE:To evaluate the utility of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS:Nineteen subjects with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) and foot ulcers were randomly assig...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.17.4.322

    authors: Blackman JD,Senseng D,Quinn L,Mazzone T

    更新日期:1994-04-01 00:00:00

  • Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh type 2 diabetes study.

    abstract:OBJECTIVE:People with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Hypoglycemia is a candidate risk factor, but the direction of association between episodes of severe hypoglycemia and cognitive decline in type 2 diabetes remains uncertain. RESEARCH DESIGN AND METHODS:In the Edi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1384

    authors: Feinkohl I,Aung PP,Keller M,Robertson CM,Morling JR,McLachlan S,Deary IJ,Frier BM,Strachan MW,Price JF,Edinburgh Type 2 Diabetes Study (ET2DS) Investigators.

    更新日期:2014-02-01 00:00:00

  • The diagnosis of gestational diabetes.

    abstract::The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Coustan DR,Carpenter MW

    更新日期:1998-08-01 00:00:00

  • Rarefaction of the peripheral nerve network in diabetic patients is associated with a pronounced reduction of terminal Schwann cells.

    abstract:OBJECTIVE:Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1832

    authors: Reinisch CM,Traxler H,Piringer S,Tangl S,Nader A,Tschachler E

    更新日期:2008-06-01 00:00:00

  • Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial.

    abstract:OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-0509

    authors: Wing RR,Espeland MA,Clark JM,Hazuda HP,Knowler WC,Pownall HJ,Unick J,Wadden T,Wagenknecht L,Action for Health in Diabetes (Look AHEAD) Study Group.

    更新日期:2016-08-01 00:00:00