Clinical evaluation of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers.

Abstract:

OBJECTIVE:To evaluate the utility of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS:Nineteen subjects with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) and foot ulcers were randomly assigned to the polymeric dressing or conventional wet-to-dry saline dressings. Subjects had foot ulcer site measurements performed every 3 weeks. The subjects using conventional therapy were allowed to cross over to polymeric dressing after 2 months. RESULTS:At the end of 2 months, in the patients using the polymeric dressing, ulcer size was reduced to 35 +/- 16% of baseline. The patients on conventional therapy had an ulcer size of 105 +/- 28% of baseline (P < 0.03, polymeric vs. conventional). Patients initially treated with wet-to-dry saline were crossed over into the polymeric membrane treatment and demonstrated a decrease to 35 +/- 11% of baseline size (p < 0.02) after an additional 2 months. CONCLUSIONS:The semipermeable polymeric membrane dressing is a useful therapeutic option for treating uncomplicated chronic diabetic foot ulcers.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Blackman JD,Senseng D,Quinn L,Mazzone T

doi

10.2337/diacare.17.4.322

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

322-5

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.2337/diacare.25.10.1795

    authors: Fuchsjäger-Mayrl G,Pleiner J,Wiesinger GF,Sieder AE,Quittan M,Nuhr MJ,Francesconi C,Seit HP,Francesconi M,Schmetterer L,Wolzt M

    更新日期:2002-10-01 00:00:00

  • Infant feeding in relation to islet autoimmunity and type 1 diabetes in genetically susceptible children: the MIDIA Study.

    abstract:OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1130

    authors: Lund-Blix NA,Stene LC,Rasmussen T,Torjesen PA,Andersen LF,Rønningen KS

    更新日期:2015-02-01 00:00:00

  • Psychosocial correlates of survival in diabetes.

    abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.7.538

    authors: Davis WK,Hess GE,Hiss RG

    更新日期:1988-07-01 00:00:00

  • Glucose as the Fifth Vital Sign: A Randomized Controlled Trial of Continuous Glucose Monitoring in a Non-ICU Hospital Setting.

    abstract:OBJECTIVE:The current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non-intensive care unit (ICU) hospital setting. RESEARCH DESIGN AND METHODS:A total of 110 adults with typ...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章

    doi:10.2337/dc20-1016

    authors: Fortmann AL,Spierling Bagsic SR,Talavera L,Garcia IM,Sandoval H,Hottinger A,Philis-Tsimikas A

    更新日期:2020-11-01 00:00:00

  • Immune Checkpoint Inhibitor-Associated Diabetes: A Single-Institution Experience.

    abstract:OBJECTIVE:To characterize immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS:Retrospective chart review of 18 patients with new-onset ICI-DM following anti-programmed cell death protein 1 (PD-1)/anti-programmed cell death protein ligand 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0609

    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00

  • Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.

    abstract:OBJECTIVE:We sought to determine whether an oral disposition index (DI(O)) predicts the development of diabetes over a 10-year period. First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function. RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1478

    authors: Utzschneider KM,Prigeon RL,Faulenbach MV,Tong J,Carr DB,Boyko EJ,Leonetti DL,McNeely MJ,Fujimoto WY,Kahn SE

    更新日期:2009-02-01 00:00:00

  • Effect of temperament on metabolic control in children with diabetes mellitus.

    abstract::Fifty-one children with insulin-dependent diabetes mellitus (IDDM) and 24 healthy sibling controls were compared on one of two temperament questionnaires completed by parents. Children with IDDM did not provide a characteristic temperament profile or show any problem areas. A regression analysis to predict diabetic co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.1.77

    authors: Rovet JF,Ehrlich RM

    更新日期:1988-01-01 00:00:00

  • Evaluation of nonfasting tests to screen for childhood and adolescent dysglycemia.

    abstract:OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0827

    authors: Lee JM,Gebremariam A,Wu EL,LaRose J,Gurney JG

    更新日期:2011-12-01 00:00:00

  • Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus.

    abstract:OBJECTIVE:To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM. RESEARCH DESIGN AND METHODS:Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 antibodies were measured in 145 pregnant women with GDM, 33 with impa...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.1.81

    authors: Dozio N,Beretta A,Belloni C,Castiglioni M,Rosa S,Bosi E,Bonifacio E

    更新日期:1997-01-01 00:00:00

  • Accelerated insulin degradation: an alternate mechanism for insulin resistance.

    abstract::We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.5.414

    authors: Kitabchi AE,Stentz FB,Cole C,Duckworth WC

    更新日期:1979-09-01 00:00:00

  • Effect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial Investigators.

    abstract:OBJECTIVE:Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated. RE...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.10.1478

    authors: Levin SR,Coburn JW,Abraira C,Henderson WG,Colwell JA,Emanuele NV,Nuttall FQ,Sawin CT,Comstock JP,Silbert CK

    更新日期:2000-10-01 00:00:00

  • Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.1.138

    authors: Hamilton J,Cummings E,Zdravkovic V,Finegood D,Daneman D

    更新日期:2003-01-01 00:00:00

  • Rising incidence of type 2 diabetes in children in the U.K.

    abstract:OBJECTIVE:To estimate the incidence of type 2 diabetes in children <17 years of age and to investigate the relationship of diabetes with increasing childhood obesity in the U.K. and the Republic of Ireland (ROI). RESEARCH DESIGN AND METHODS:Active monthly reporting of cases by consultant pediatricians occurred through...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1813

    authors: Haines L,Wan KC,Lynn R,Barrett TG,Shield JP

    更新日期:2007-05-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

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    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.22.1.33

    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study.

    abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1321

    authors: Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YT

    更新日期:2010-01-01 00:00:00

  • Gestational diabetes mellitus: NICE for the U.S.? A comparison of the American Diabetes Association and the American College of Obstetricians and Gynecologists guidelines with the U.K. National Institute for Health and Clinical Excellence guidelines.

    abstract:OBJECTIVE:To compare recent U.S. and U.K. guidelines on gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:The guidelines from the American Diabetes Association, the American College of Obstetricians and Gynecologists, and the National Institute for Health and Clinical Excellence (NICE) in the U.K. were ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1376

    authors: Simmons D,McElduff A,McIntyre HD,Elrishi M

    更新日期:2010-01-01 00:00:00

  • Insulin withholding for weight control in women with diabetes.

    abstract:OBJECTIVE:To provide a description of the clinical characteristics that distinguish individuals who withhold insulin for weight control from those who do not. Some individuals with insulin-dependent diabetes mellitus (IDDM) control their weight by withholding insulin and purging excessive calories. This process places ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.10.1186

    authors: Biggs MM,Basco MR,Patterson G,Raskin P

    更新日期:1994-10-01 00:00:00

  • Suppressive effect of insulin infusion on chemokines and chemokine receptors.

    abstract:OBJECTIVE:In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2193

    authors: Ghanim H,Korzeniewski K,Sia CL,Abuaysheh S,Lohano T,Chaudhuri A,Dandona P

    更新日期:2010-05-01 00:00:00

  • Personal computer programs to assist with self-monitoring of blood glucose and self-adjustment of insulin dosage.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.1.61

    authors: Pernick NL,Rodbard D

    更新日期:1986-01-01 00:00:00

  • The effect of ruboxistaurin on nephropathy in type 2 diabetes.

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    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.28.11.2686

    authors: Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

    更新日期:2005-11-01 00:00:00

  • Decreased skin wrinkling in diabetes mellitus.

    abstract::Skin wrinkling, which may be dependent on peripheral autonomic innervation, was assessed in 100 normal and 42 diabetic subjects using a temperature-controlled water bath with immersion of the hands for 30 min. Markedly decreased skin wrinkling was observed in diabetic subjects and in manual workers, but did not correl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.3.224

    authors: Clark CV,Pentland B,Ewing DJ,Clarke BF

    更新日期:1984-05-01 00:00:00

  • Cardiovascular risk factor control among veterans with diabetes: the ambulatory care quality improvement project.

    abstract:OBJECTIVE:To describe the extent to which hyperglycemia, hypertension, and dyslipidemia are currently detected, treated, and controlled in U.S. veterans with diabetes with and without ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS:A cohort of 3,769 veterans who self-reported diabetes and who received all he...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.suppl_2.b33

    authors: Smith NL,Chen L,Au DH,McDonell M,Fihn SD

    更新日期:2004-05-01 00:00:00

  • Central processing of gut pain in diabetic patients with gastrointestinal symptoms.

    abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0324

    authors: Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Egsgaard LL,Arendt-Nielsen L,Drewes AM

    更新日期:2009-07-01 00:00:00

  • Cyclosporin therapy for prevention and cure of IDDM. Epidemiological perspective of benefits and risks.

    abstract::Cyclosporin and other immunosuppressive agents have been proposed as a preventive treatment against the development of insulin-dependent diabetes mellitus (IDDM) in relatives at increased risk for the disease, based on the understanding that its etiology is an ongoing process of autoimmune beta-cell destruction. We us...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,评审

    doi:10.2337/diacare.13.7.776

    authors: Lipton R,LaPorte RE,Becker DJ,Dorman JS,Orchard TJ,Atchison J,Drash AL

    更新日期:1990-07-01 00:00:00

  • Abnormal nerve conduction in impotent patients with diabetes mellitus.

    abstract::The etiology of impotence in the diabetic population has not been clearly defined. To assess this problem, 24 impotent diabetic subjects, 21 nonimpotent diabetic subjects, and 10 subjects with psychogenic impotence were compared with nocturnal monitoring of penile tumescence and rigidity, penile arterial blood flow, a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.7.449

    authors: Daniels JS

    更新日期:1989-07-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.322

    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • Changes in Statin Use Among U.S. Adults With Diabetes: A Population-Based Analysis of NHANES 2011-2018.

    abstract:OBJECTIVE:To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40-75 years old with diabetes. RESEARCH DESIGN AND METHODS:The National Health and Nutrition Examination Survey (NHANES) was used ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1481

    authors: Leino AD,Dorsch MP,Lester CA

    更新日期:2020-12-01 00:00:00

  • Clustering of cardiovascular risk factors associated with the insulin resistance syndrome: assessment by principal component analysis in young hyperandrogenic women.

    abstract:OBJECTIVE:Hyperinsulinemia is often associated with several metabolic abnormalities and increased blood pressure, which are risk factors for cardiovascular disease. It has been hypothesized that insulin resistance may underlie all these features. However, recent data suggest that some links between insulin resistance a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.29.02.06.dc05-1478

    authors: Zanolin ME,Tosi F,Zoppini G,Castello R,Spiazzi G,Dorizzi R,Muggeo M,Moghetti P

    更新日期:2006-02-01 00:00:00

  • Deviation from developmentally appropriate self-care autonomy. Association with diabetes outcomes.

    abstract:OBJECTIVE:Treatment of IDDM in youth emphasized balancing children's self-care autonomy with their psychological maturity. However, few data exist to guide clinicians or parents, and little is known about correlates of deviations from this ideal. RESEARCH DESIGN AND METHODS:In this cross-sectional study, IDDM self-car...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.19.2.119

    authors: Wysocki T,Taylor A,Hough BS,Linscheid TR,Yeates KO,Naglieri JA

    更新日期:1996-02-01 00:00:00

  • In patients with acute myocardial infarction, the impact of hyperglycemia as a risk factor for mortality is not homogeneous across age-groups.

    abstract:OBJECTIVE:To assess the impact of hyperglycemia in different age-groups of patients with acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS:A total of 2,027 patients with AMI were categorized into one of five age-groups: <50 years (n = 301), ≥50 and <60 (n = 477), ≥60 and <70 (n = 545), ≥70 and <80 (n = 49...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1170

    authors: Nicolau JC,Serrano CV Jr,Giraldez RR,Baracioli LM,Moreira HG,Lima F,Franken M,Kalil R,Ramires JA,Giugliano RP

    更新日期:2012-01-01 00:00:00