Rarefaction of the peripheral nerve network in diabetic patients is associated with a pronounced reduction of terminal Schwann cells.

abstract：OBJECTIVE:To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM. RESEARCH DESIGN AND METHODS:Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 antibodies were measured in 145 pregnant women with GDM, 33 with impa...

journal_title：Diabetes care

authors： Dozio N,Beretta A,Belloni C,Castiglioni M,Rosa S,Bosi E,Bonifacio E

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:With increasing life expectancy in the U.S., it is important to know whether a longer life expectancy means a longer healthy life span or a prolonged period of later-life morbidity. This study examines changes in lifetime without diabetes, a leading cause of morbidity in later life. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Cunningham SA,Riosmena F,Wang J,Boyle JP,Rolka DB,Geiss LS

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:The specific aims of the present study were to report on the level of personal beliefs and social and environmental barriers across different regimen areas and patient subgroups and on the relationship of personal models and perceived barriers to the level of self-management. RESEARCH DESIGN AND METHODS:This...

journal_title：Diabetes care

authors： Glasgow RE,Hampson SE,Strycker LA,Ruggiero L

更新日期：1997-04-01 00:00:00

abstract：:Core Outcome Sets (COS) contain an agreed minimum set of outcomes to be measured and reported in all studies in a specific area, with the objective of standardizing outcome reporting. COS may minimize research waste by identifying outcomes important to key stakeholders, allowing for improved evidence synthesis, and fa...

journal_title：Diabetes care

authors： Egan AM,Bogdanet D,Biesty L,Kgosidialwa O,McDonagh C,O'Shea C,O'Shea PM,Devane D,Dunne FP,INSPIRED research group.

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

journal_title：Diabetes care

authors： Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...

journal_title：Diabetes care

authors： Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SK

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To determine the role of growth hormone (GH) in the development of diabetic retinopathy. RESEARCH DESIGN AND METHODS:Medical records of 1,423 patients who had undergone insulin tolerance tests (1976-1991) at the Mayo Clinic were examined, and diabetic subjects were identified as either GH-deficient (GH incre...

journal_title：Diabetes care

authors： Alzaid AA,Dinneen SF,Melton LJ 3rd,Rizza RA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the University of Texas (UT) and Site, Ischemia, Neuropathy, Bacterial Infection, and Depth (SINBAD) foot ulcer scores in predicting ulcer outcome within a routine diabetes foot clinic. RESEARCH DESIGN AND METHODS:From 2006 to 2018, data were collected from all patients a...

journal_title：Diabetes care

authors： Leese GP,Soto-Pedre E,Schofield C

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Hyperinsulinemia is often associated with several metabolic abnormalities and increased blood pressure, which are risk factors for cardiovascular disease. It has been hypothesized that insulin resistance may underlie all these features. However, recent data suggest that some links between insulin resistance a...

journal_title：Diabetes care

authors： Zanolin ME,Tosi F,Zoppini G,Castello R,Spiazzi G,Dorizzi R,Muggeo M,Moghetti P

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the presence and correlates of clinically relevant cognitive impairment in middle-aged adults with childhood-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:During 2010-2013, 97 adults diagnosed with T1D and aged <18 years (age and duration 49 ± 7 and 41 ± 6 ...

journal_title：Diabetes care

authors： Nunley KA,Rosano C,Ryan CM,Jennings JR,Aizenstein HJ,Zgibor JC,Costacou T,Boudreau RM,Miller R,Orchard TJ,Saxton JA

更新日期：2015-09-01 00:00:00

abstract：:Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obe...

journal_title：Diabetes care

authors： Mohan V,Snehalatha C,Ramachandran A,Jayashree R,Viswanathan M

更新日期：1985-01-01 00:00:00

abstract：:Diabetes has been identified as an important risk factor for mortality and rates of progression to acute respiratory distress syndrome (ARDS) in hospitalized patients with coronavirus disease 2019 (COVID-19). However, many recent reports on this topic reflect hurried approaches and have lacked careful epidemiologic de...

journal_title：Diabetes care

authors： Selvin E,Juraschek SP

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2)...

journal_title：Diabetes care

authors： Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BV

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...

journal_title：Diabetes care

authors： Zhou K,Donnelly LA,Morris AD,Franks PW,Jennison C,Palmer CN,Pearson ER

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknown. Increased demand due to obesity and/or insuli...

journal_title：Diabetes care

authors： Røder ME,Dinesen B,Hartling SG,Houssa P,Vestergaard H,Sodoyez-Goffaux F,Binder C

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...

journal_title：Diabetes care

authors： Maser RE,Mitchell BD,Vinik AI,Freeman R

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicent...

journal_title：Diabetes care

authors： Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

更新日期：2005-11-01 00:00:00

abstract：:In this study, 18 type I (insulin-dependent) diabetic subjects aged 22-35 yr (mean age 29.3) and within 10 yr of diagnosis (mean 7.7) performed a battery of cognitive and psychomotor tasks under conditions of hypoglycemia (50 mg/dl), normoglycemia (100 mg/dl), and hyperglycemia (300 mg/dl). Blood glucose levels during...

journal_title：Diabetes care

authors： Hoffman RG,Speelman DJ,Hinnen DA,Conley KL,Guthrie RA,Knapp RK

更新日期：1989-03-01 00:00:00

abstract：:This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...

journal_title：Diabetes care

authors： Chance RE,Frank BH

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Diabetes has held steady as the seventh leading cause of death in the U.S. since 2006. While aggregated data provide insights into how the country as a whole, or even as states, is faring with respect to diabetes mortality, disaggregation provides data that may facilitate targeted interventions and community ...

journal_title：Diabetes care

authors： Hunt BR,Whitman S,Henry CA

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The association between changes in triglyceride concentrations over time and diabetes is unknown. We assessed whether two triglyceride determinations obtained 5 years apart can predict incident type 2 diabetes. RESEARCH DESIGN AND METHODS:Triglyceride levels at baseline (time 1) and 5 years later (time 2), f...

journal_title：Diabetes care

authors： Tirosh A,Shai I,Bitzur R,Kochba I,Tekes-Manova D,Israeli E,Shochat T,Rudich A

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...

journal_title：Diabetes care

authors： Schumacher MC,Maxwell TM,Wu LL,Hunt SC,Williams RR,Elbein SC

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may i...

journal_title：Diabetes care

authors： Teufel F,Geldsetzer P,Manne-Goehler J,Karlsson O,Koncz V,Deckert A,Theilmann M,Marcus ME,Ebert C,Seiglie JA,Agoudavi K,Andall-Brereton G,Gathecha G,Gurung MS,Guwatudde D,Houehanou C,Hwalla N,Kagaruki GB,Karki KB,Lab

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...

journal_title：Diabetes care

authors： Prando R,Cheli V,Melga P,Giusti R,Ciuchi E,Odetti P

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of adiposity in the relationship between specific and surrogate estimates of insulin-mediated glucose uptake (IMGU) in a large nondiabetic population. RESEARCH DESIGN AND METHODS:Healthy volunteers were classified by BMI into normal weight (<25.0 kg/m(2), n = 208), overweight (25.0-29.9 ...

journal_title：Diabetes care

authors： Kim SH,Abbasi F,Reaven GM

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...

journal_title：Diabetes care

authors： Pécsvarády Z,Fisher TC,Darwin CH,Fabók A,Maqueda TS,Saad MF,Meiselman HJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the prevalence of both impaired fasting glucose (IFG) and diabetes between hepatitis C virus (HCV)-infected patients and patients with other liver diseases but anti-HCV-, taking into account the degree of liver damage. RESEARCH DESIGN AND METHODS:A total of 642 consecutiv...

journal_title：Diabetes care

authors： Lecube A,Hernández C,Genescà J,Esteban JI,Jardí R,Simó R

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

journal_title：Diabetes care

authors： Ozieh MN,Bishu KG,Dismuke CE,Egede LE

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...

journal_title：Diabetes care

authors： Bradley C,Eschwège E,de Pablos-Velasco P,Parhofer KG,Simon D,Vandenberghe H,Gönder-Frederick L

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Many patients with early diabetes remain untreated. Our objectives were to identify clinical predictors of 1) worsening glycemic control and 2) medical treatment initiation in response to worsening glycemic control among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:We identified 5,804 type 2 di...

journal_title：Diabetes care

authors： Pani LN,Nathan DM,Grant RW

更新日期：2008-03-01 00:00:00