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Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries.

Abstract：

OBJECTIVE:The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent. RESEARCH DESIGN AND METHODS:We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and diabetes using multilevel mixed-effects logistic regression models. We estimated ORs for the pooled sample, major world regions, and individual countries, in addition to stratifying all analyses by sex. We examined heterogeneity by individual-level characteristics. RESULTS:Our sample included 554,122 individuals across 25 population-based surveys. Average height was 161.7 cm (95% CI 161.2-162.3), and the crude prevalence of diabetes was 7.5% (95% CI 6.9-8.2). We found no relationship between adult height and diabetes across LMICs globally or in most world regions. When stratifying our sample by country and sex, we found an inverse association between adult height and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model specifications. CONCLUSIONS:Adult height is not associated with diabetes across LMICs. Environmental factors in early life reflected in attained adult height likely differ from those predisposing individuals for diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Teufel F,Geldsetzer P,Manne-Goehler J,Karlsson O,Koncz V,Deckert A,Theilmann M,Marcus ME,Ebert C,Seiglie JA,Agoudavi K,Andall-Brereton G,Gathecha G,Gurung MS,Guwatudde D,Houehanou C,Hwalla N,Kagaruki GB,Karki KB,Lab

doi

10.2337/dc20-0019

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2403-2410

issue

eissn

0149-5992

issn

1935-5548

pii

dc20-0019

journal_volume

pub_type

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Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries.