Abstract:
OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical records, 101,104 AA and 505,336 WC subjects with type 2 diabetes diagnosed between 2000 and 2017 were identified (mean follow-up 5.3 years). Among those without ASCVD at diagnosis, risk of ASCVD and three-point major adverse cardiovascular events (MACE-3) (heart failure, myocardial infarction, or stroke) was evaluated between ethnicities by age-groups. RESULTS:The proportion of patients diagnosed at <50 years of age increased during 2012-2017 (AA 34-38%, WC 26-29%). Depression prevalence increased during 2000-2017 (AA 15-23%, WC 20-34%), with an increasing trend for CM at diagnosis in both groups. Compared with WC, the adjusted MACE-3 risk was significantly higher in AA across all age-groups, more pronounced in the 18-39-year age-group (hazard ratio 95% CI 1.42, 1.88), and in patients with and without depression. AAs had a 17% (1.05, 1.31) significantly higher adjusted ASCVD risk in the 18-39-year age-group only. Depression was independently associated with ASCVD and MACE-3 risk in both ethnic groups across all age-groups. Other comorbidities were independently associated with ASCVD and MACE-3 risk only among WCs. CONCLUSIONS:AAs have higher cardiovascular risk compared with WCs, particularly in early-onset type 2 diabetes. CM and depression at diabetes diagnosis have been increasing over the past two decades in both ethnic groups. Strategies for screening and optimal management of CM and depression, particularly in early-onset type 2 diabetes, may result in a lower cardiovascular risk.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SKdoi
10.2337/dc20-2045subject
Has Abstractpub_date
2021-01-01 00:00:00pages
231-239issue
1eissn
0149-5992issn
1935-5548pii
dc20-2045journal_volume
44pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0297
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To assess the performance of the Micral-Test II immunologic test strip for the detection of microalbuminuria, a multicenter evaluation in eight European study sites was performed. RESEARCH DESIGN AND METHODS:Using both the Micral-Test II test strip and the routine method for the determination of albumin conc...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.20.11.1642
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.4.1040
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc06-0513
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1991
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Adopt a multidisciplinary approach to evaluate a virtually supervised home-based high-intensity interval training (Home-HIT) intervention in people with type 1 diabetes. RESEARCH DESIGN AND METHODS:Eleven individuals with type 1 diabetes (seven women; age 30 ± 3 years; [Formula: see text] 2.5 ± 0.2 L/min; du...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0871
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:We investigated the efficacy and safety of the sodium glucose cotransporter 2 inhibitor, empagliflozin, added to multiple daily injections of insulin (MDI insulin) in obese patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS:Patients inadequately controlled on MDI insulin ± metformin (...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-3055
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS:We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2277
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The levels of the surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholesterol precursors) in serum have suggested that in adult type 1 diabetes, cholesterol absorption is high and synthesis is low compared with type 2 diabetic or control subjects. Accordingly, these ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-2235
更新日期:2006-10-01 00:00:00
abstract::Neuropathic foot ulceration is a major medical and economic problem among diabetic patients, and the traditional treatment involves bed rest with complete freedom from weight-bearing. We have investigated the use of walking plaster casts in the management of seven diabetic patients with long-standing, chronic plantar ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.2.149
更新日期:1986-03-01 00:00:00
abstract::A diabetic woman presented with diabetic ketoacidosis after demonstrating immediate-type hypersensitivity to heterologous insulin. She had had interrupted insulin therapy in the past. Insulin requirements during the course of treatment for the acidosis suggested marked resistance, with 50,000 U of insulin needed in th...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.3.276
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1227
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that breast-feeding is a protective factor against IDDM and that early exposure to cow's milk is a risk factor for the disease. RESEARCH DESIGN AND METHODS:A case-control study was conducted in São Paulo, Brazil. A total of 346 diabetic children, aged < 18 years, were identified in two...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.8.1256
更新日期:1997-08-01 00:00:00
abstract::Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.10.3.337
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To examine the hypothesis that hyperinsulinemia among relatives of NIDDM probands will increase the prevalence of DLPs, we measured insulin levels and examined the frequency of DLPs among NIDDM pedigree members. RESEARCH DESIGN AND METHODS:We performed 2-h 75-g OGTTs and measured lipid and insulin levels of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.10.1285
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To determine whether macronutrient intake differs by awareness of glycemic status among people with diabetes and prediabetes. RESEARCH DESIGN AND METHODS:We used 24-h dietary recall and other data from 3,725 nonpregnant adults with diabetes or prediabetes aged ≥20 years from the morning fasting sample of the...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1342
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess fertility in women with type 1 diabetes and the risk of congenital malformations in their offspring.
RESEARCH DESIGN AND METHODS:This was a register-based cohort study in Sweden. All 5,978 women hospitalized for type 1 diabetes at age journal_title:Diabetes care pub_type: 杂志文章 doi:10.2337/dc06-2574 更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Neonatal diabetes is a heterogeneous group of disorders with diabetes manifestation in the first 6 months of life. The most common etiology in permanent neonatal diabetes is mutations of the ATP-sensitive K(+) channel subunits; in transient neonatal diabetes, chromosome 6q24 abnormalities are the most common ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0549
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1669
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of gastric emptying on postprandial insulin requirement in insulin-dependent diabetes mellitus (IDDM) patients with and without gastroparesis. RESEARCH DESIGN AND METHODS:Postprandial insulin requirement and gastric emptying were simultaneously evaluated in five IDDM patients with gast...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.8.901
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To determine whether diabetes risk is influenced by which parent (a parental history of diabetes is a well-documented risk factor for NIDDM) is reported to have diabetes. RESEARCH DESIGN AND METHODS:We compared the prevalence of NIDDM and IGT for 4914 subjects according to their parental history of diabetes ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.9.1262
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:Recurrence of plantar foot ulcers is a common and major problem in diabetes but not well understood. Foot biomechanics and patient behavior may be important. The aim was to identify risk factors for ulcer recurrence and to establish targets for ulcer prevention. RESEARCH DESIGN AND METHODS:As part of a footw...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2470
更新日期:2014-06-01 00:00:00
abstract::Insulin resistance is the cornerstone for the development of non-insulin-dependent diabetes mellitus (NIDDM). Free fatty acids (FFAs) cause insulin resistance in muscle and liver and increase hepatic gluconeogenesis and lipoprotein production and perhaps decrease hepatic clearance of insulin. It is suggested that the ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.12.1132
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus pho...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.18.5.631
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:Diabetes surveillance often requires manual medical chart reviews to confirm status and type. This project aimed to create an electronic health record (EHR)-based procedure for improving surveillance efficiency through automation of case identification. RESEARCH DESIGN AND METHODS:Youth (<20 years old) with ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0063
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2024
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.7.895
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study. RESEARCH DESIGN AND METHODS:Baseline risk factors and CHD at follow-up were assessed in 2,329 type 1 diabetic patients without ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.2.530
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS:We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/d...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1223
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the relative value of plasma glucose (PG) at different time points in assessing glucose control of type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Glycemic profiles, i.e., PG at prebreakfast (8:00 A.M.), prelunch (11:00 A.M.), postlunch (2:00 P.M.), and extended postlunch (5:00 P.M.) times ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.12.1822
更新日期:1997-12-01 00:00:00