Abstract:
:In this study, 18 type I (insulin-dependent) diabetic subjects aged 22-35 yr (mean age 29.3) and within 10 yr of diagnosis (mean 7.7) performed a battery of cognitive and psychomotor tasks under conditions of hypoglycemia (50 mg/dl), normoglycemia (100 mg/dl), and hyperglycemia (300 mg/dl). Blood glucose levels during testing were precisely maintained at the preselected level via a Biostator insulin/glucose-infusion system. The order of glycemic level was counterbalanced across subjects in a single-blinded design. Performance on tasks requiring visual tracking, visuomotor speed, concentration, and planning ability (pursuit rotor and trails B) were significantly impaired under conditions of hypoglycemia compared with normoglycemic levels. Visual reaction time was not significantly impaired under conditions of hypoglycemia or hyperglycemia.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hoffman RG,Speelman DJ,Hinnen DA,Conley KL,Guthrie RA,Knapp RKdoi
10.2337/diacare.12.3.193subject
Has Abstractpub_date
1989-03-01 00:00:00pages
193-7issue
3eissn
0149-5992issn
1935-5548journal_volume
12pub_type
临床试验,杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally; however, the clinical and epidemiological data on the association of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.5.624
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes. RESEARC...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.22.3.463
更新日期:1999-03-01 00:00:00
abstract::The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.3.316
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes. RESEARCH DESIGN AND METHODS:We s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.1.5
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc14-2585
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METH...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1654
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Existing physical examination scoring systems for distal diabetic polyneuropathy (PNP) do not fulfill all of the following criteria: validity, manageability, predictive value, and hierarchy The aim of this study was to adapt the Neuropathy Disability Score (NDS) to diagnose PNP in diabetes so that it fulfills...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.6.750
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the prevalence of diabetes in pregnancy (gestational diabetes mellitus [GDM] and NIDDM) and to identify risk factors in the development of GDM in a native population in northwestern Ontario, Canada. RESEARCH DESIGN AND METHODS:A retrospective analysis of 1,305 singl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.9.1422
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors. RESEARCH DESIGN AND METHODS:Demographic and diabetes self-management factors were measured in 415 subjects followed prospectively for 4-6.5 years of type 1 diabetes duration as participants in ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.24.11.1878
更新日期:2001-11-01 00:00:00
abstract::OBJECTIVE To examine the use of mammography and Papanicolaou (Pap) smear among women with diabetes and to identify predictors of adherence to these tests. RESEARCH DESIGN AND METHODS We analyzed data of a nationally representative sample of Spanish women. Diabetes status was self-reported. Screenings were assessed ask...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0479
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:This study examined the prognostic significance of diabetes and microvascular complications in patients with heart failure with preserved ejection fraction (HFpEF). RESEARCH DESIGN AND METHODS:This analysis included 3,385 patients (mean age 69 ± 9.6 years; 49% male; 89% white) with HFpEF from the Treatment o...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-0755
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between lifestyle counseling in primary care settings and clinical outcomes in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied hyperglycemic adults with diabetes treated at primary care practices between 2000 and 2014. We analyzed the relationshi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0629
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of parenteral insulin therapy on endogenous insulin secretion in the Diabetes Prevention Trial-Type 1 (DPT-1). RESEARCH DESIGN AND METHODS:In the parenteral insulin arm of DPT-1, subjects without diabetes at high risk of future type 1 diabetes randomized to active treatment received...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-1825
更新日期:2015-05-01 00:00:00
abstract::Core Outcome Sets (COS) contain an agreed minimum set of outcomes to be measured and reported in all studies in a specific area, with the objective of standardizing outcome reporting. COS may minimize research waste by identifying outcomes important to key stakeholders, allowing for improved evidence synthesis, and fa...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc20-1621
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Advanced glycation end products (AGEs) are a risk factor for diabetic complications. We have developed an assay method for N-(carboxymethyl)valine (CMV) of the hemoglobin (CMV-Hb), which is an AGE generated from HbA1c. Herein we describe the clinical utility of CMV-Hb measurement for the diagnosis of diabetic...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.5.891
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.6.965
更新日期:1999-06-01 00:00:00
abstract::The scientific literature demonstrates that fat replacers have a reasonable certainty of no harm. Whether they help produce desired health outcomes, i.e., decreased risk of coronary heart disease and certain types of cancer related to excess fat intake, weight reduction, changes in lipid profile, improved glycemic con...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.11.1294
更新日期:1996-11-01 00:00:00
abstract::In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.319
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0072
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Many studies have shown that diabetes increases the risk of cardiovascular disease (CVD) in women to a greater extent than in men. One explanation could be that diabetes has more adverse effects on CVD risk factors in women than in men. We compared diabetes-associated differences in CVD risk factors in men an...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.21.8.1258
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic accuracy and time expenditure of screening models based on glycated hemoglobin (HbA(1c)) level and psychometric measures for mood disorder (MD) among children with type 1 diabetes. RESEARCH DESIGN AND METHODS:With semistructured clinical interviews (Schedule for Affective Disorders ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0160
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap. RESEARCH DESIGN AND METHODS:GBD 2016 data, including prevalence and years lived with dis...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1614
更新日期:2020-05-01 00:00:00
abstract::Based on the results of the Diabetes Prevention Program Outcomes Study (DPPOS), in which metformin significantly decreased the development of diabetes in individuals with baseline fasting plasma glucose (FPG) concentrations of 110-125 vs. 100-109 mg/dL (6.1-6.9 vs. 5.6-6.0 mmol/L) and A1C levels 6.0-6.4% (42-46 mmol/m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2221
更新日期:2020-09-01 00:00:00
abstract::The prevalence of carotid artery occlusive disease (CAOD) in a population of adults with diabetes mellitus was determined, and factors associated with its presence were identified. By oculoplethysmography and phonoangiography, 20% of the population studied had detectable CAOD. Univariate analyses revealed that patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.3.274
更新日期:1983-05-01 00:00:00
abstract::Neutral regular human insulin (Novo) (derived from porcine insulin) and porcine insulin were administered by subcutaneous (s.c.) injection into the anterior abdominal wall in two different groups of six normal male subjects. The insulin dosage was 0.075 IU/kg body wt; diluting medium was used to obtain control values....
journal_title:Diabetes care
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVE:Studies in animal models suggest that ovarian hormone deficiency is associated with the development of insulin resistance. In women, ovarian hormone levels are dramatically reduced after the menopause transition. However, the effect of the menopause transition on insulin sensitivity is unclear. Thus, we exami...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.6.801
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To compare diabetes prevalence among Asian Americans by World Health Organization and U.S. BMI classifications. RESEARCH DESIGN AND METHODS:Data on Asian American adults (n = 7,414) from the National Health Interview Survey for 1997-2005 were analyzed. Diabetes prevalence was estimated across weight and ethn...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0573
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:In general, breast-feeding positively influences development of psychomotor function and cognition in children. Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development. Recently, we observed a dose-dependent negative effect of early neonatal ingestion of breast milk from diabeti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.3.573
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc16-2655
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.1.70
更新日期:2003-01-01 00:00:00