The effect of ruboxistaurin on nephropathy in type 2 diabetes.

Abstract:

OBJECTIVE:Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS:A randomized, double-blind, placebo-controlled, multicenter, pilot study was performed to evaluate the effects of 32 mg/day ruboxistaurin for 1 year in persons (n = 123) with type 2 diabetes and persistent albuminuria (albumin-to-creatinine ratio [ACR] 200-2,000 mg/g), despite therapy with renin-angiotensin system inhibitors. The primary end point was a change in the ACR. Estimated glomerular filtration rate (eGFR) (four-component equation from the Modification of Diet in Renal Disease study) was also calculated. RESULTS:At baseline, urinary ACR was 764 +/- 427 mg/g (means +/- SD), and eGFR was 70 +/- 24 ml/min per 1.73 m2. Systolic and diastolic blood pressures were 135 +/- 14 and 75 +/- 9 mmHg, respectively. HbA(1c) was 8.0 +/- 1.2%. After 1 year, urinary ACR decreased significantly (-24 +/- 9%) in participants treated with ruboxistaurin (P = 0.020) and nonsignificantly (-9 +/- 11%) in the placebo group (P = 0.430). The ACR-lowering effect of ruboxistaurin appeared by 1 month. eGFR did not decline significantly in the ruboxistaurin group (-2.5 +/- 1.9 ml/min per 1.73 m2) (P = 0.185), whereas the placebo group lost significant eGFR over 1 year (-4.8 +/- 1.8 ml/min per 1.73 m2) (P = 0.009). Between-group differences for changes in ACR and eGFR were not statistically significant, but this pilot study was underpowered to determine such differences. CONCLUSIONS:In persons with type 2 diabetes and nephropathy, treatment with ruboxistaurin reduced albuminuria and maintained eGFR over 1 year. Ruboxistaurin may add benefit to established therapies for diabetic nephropathy.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Tuttle KR,Bakris GL,Toto RD,McGill JB,Hu K,Anderson PW

doi

10.2337/diacare.28.11.2686

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

2686-90

issue

11

eissn

0149-5992

issn

1935-5548

pii

28/11/2686

journal_volume

28

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Evaluation of patient's knowledge of diabetes self-care.

    abstract::A survey conducted at a Veterans Administration Hospital to evaluate patient capability for self-management found that over 35 per cent of the patients interviewed lacked any formal training. Seventeen patients had been placed on insulin without formal instruction. Almost one half the patients who claimed to have atte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.1.5.275

    authors: Miller LV,Goldstein J,Nicolaisen G

    更新日期:1978-09-01 00:00:00

  • Microalbuminuria, preeclampsia, and preterm delivery in pregnant women with type 1 diabetes: results from a nationwide Danish study.

    abstract:OBJECTIVE:To study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS:This was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertens...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1219

    authors: Jensen DM,Damm P,Ovesen P,Mølsted-Pedersen L,Beck-Nielsen H,Westergaard JG,Moeller M,Mathiesen ER

    更新日期:2010-01-01 00:00:00

  • Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study.

    abstract:OBJECTIVE:Transforming growth factor (TGF)-beta1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. We sought to examine the role of both urinary and circulating T...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.12.2320

    authors: Chaturvedi N,Schalkwijk CG,Abrahamian H,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期:2002-12-01 00:00:00

  • Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men.

    abstract:OBJECTIVE:To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes. RESEARCH DESIGN AND METHODS:We conducted an observational cohort study in male workers > or = 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake > or = 20...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0792

    authors: Shibata M,Kihara Y,Taguchi M,Tashiro M,Otsuki M

    更新日期:2007-11-01 00:00:00

  • Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.

    abstract:OBJECTIVE:Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metformin and metformin alone-in preserving or improving β-cell function in youth with impaired glucose tolerance (IGT) or recen...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc18-0787

    authors: RISE Consortium.

    更新日期:2018-08-01 00:00:00

  • Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report.

    abstract::Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.6.922

    authors: Bedalov A,Balasubramanyam A

    更新日期:1997-06-01 00:00:00

  • Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes.

    abstract:OBJECTIVE:To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS:Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin s...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2321

    authors: Kayaniyil S,Vieth R,Retnakaran R,Knight JA,Qi Y,Gerstein HC,Perkins BA,Harris SB,Zinman B,Hanley AJ

    更新日期:2010-06-01 00:00:00

  • Additional lunchtime basal insulin during insulin lispro intensive therapy in a randomized, multicenter, crossover study in adults : a real-life design.

    abstract:OBJECTIVE:This study was performed to evaluate whether an additional dose of NPH insulin at lunchtime might overcome the deleterious effects of waning basal insulinemia on pre-dinner and evening glucose values during insulin lispro intensive therapy with once daily basal insulin at night. RESEARCH DESIGN AND METHODS:T...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.25.4.712

    authors: Stades AM,Hoekstra JB,van den Tweel I,Erkelens DW,Holleman F,STABILITY Study Group.

    更新日期:2002-04-01 00:00:00

  • Back to basics in diagnosing diabetic polyneuropathy with the tuning fork!

    abstract:OBJECTIVE:Several national and international scoring systems are used to diagnose diabetic polyneuropathy (PNP). The variety in these scores and the lack of data on validity and predictive value has led to a comparison and validation of the scores with clinical standards for PNP to determine the most powerful measureme...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.9.2201

    authors: Meijer JW,Smit AJ,Lefrandt JD,van der Hoeven JH,Hoogenberg K,Links TP

    更新日期:2005-09-01 00:00:00

  • Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.

    abstract:OBJECTIVE:This study tested the hypothesis that genetically raised hyperglycemia increases coronary artery disease (CAD) risk separately from the risk conferred by type 2 diabetes as a whole. RESEARCH DESIGN AND METHODS:We conducted a Mendelian randomization (MR) analysis using summary-level statistics from the larges...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2625

    authors: Merino J,Leong A,Posner DC,Porneala B,Masana L,Dupuis J,Florez JC

    更新日期:2017-05-01 00:00:00

  • Long-term Diet Quality and Risk of Type 2 Diabetes Among Urban Chinese Adults.

    abstract:OBJECTIVE:Little evidence exists regarding long-term diet quality and the risk of type 2 diabetes among Asian populations, who have undergone a nutrition transition and a diabetes epidemic. RESEARCH DESIGN AND METHODS:A total of 117,919 Chinese men and women, 40-74 years old, free of diabetes, cardiovascular disease, ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1626

    authors: Yu D,Zheng W,Cai H,Xiang YB,Li H,Gao YT,Shu XO

    更新日期:2018-04-01 00:00:00

  • Can proopiomelanocortin methylation be used as an early predictor of metabolic syndrome?

    abstract:OBJECTIVE:The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association among birth weight, ponderal index, and cord blood methylation status. RESEARCH DESIGN AND METHODS:We collected pregnancy outcome ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1012

    authors: Yoo JY,Lee S,Lee HA,Park H,Park YJ,Ha EH,Kim YJ

    更新日期:2014-01-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.2.135

    authors: Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期:1983-03-01 00:00:00

  • Elevation of IgA levels in the non-insulin-dependent (type II) diabetic patient.

    abstract::Serum immunoglobulin (G, A, M) levels were performed on 66 patients with non-insulin-dependent (type II) diabetes mellitus (NIDDM). When compared with 30 age-matched normal controls and 32 hospitalized controls there was no significant difference between the mean IgG and IgM levels. The IgA levels were significantly h...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.4.6.636

    authors: Gill CW,Bush WS,Burleigh WM,Cooke-Gomes D

    更新日期:1981-11-01 00:00:00

  • Impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes.

    abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0541

    authors: Ly TT,Gallego PH,Davis EA,Jones TW

    更新日期:2009-10-01 00:00:00

  • Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial.

    abstract:OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0277

    authors: Lin J,Glynn RJ,Rifai N,Manson JE,Ridker PM,Nathan DM,Schaumberg DA

    更新日期:2008-12-01 00:00:00

  • Maternal and cord blood adiponectin multimeric forms in gestational diabetes mellitus: a prospective analysis.

    abstract:OBJECTIVE:To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0788

    authors: Ballesteros M,Simón I,Vendrell J,Ceperuelo-Mallafré V,Miralles RM,Albaiges G,Tinahones F,Megia A

    更新日期:2011-11-01 00:00:00

  • Outcomes of screening for diabetes in high-risk Hong Kong Chinese subjects.

    abstract:OBJECTIVE:To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes. RESEARCH DESIGN AND METHODS:A total of 1,649 Chinese subjects underwent screening for diabetes. They were asymptomatic but had known risk factors for diabetes, including a p...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.9.1290

    authors: Ko GT,Chan JC,Tsang LW,Yeung VT,Chow CC,Cockram CS

    更新日期:2000-09-01 00:00:00

  • Does knowing one's elevated glycemic status make a difference in macronutrient intake?

    abstract:OBJECTIVE:To determine whether macronutrient intake differs by awareness of glycemic status among people with diabetes and prediabetes. RESEARCH DESIGN AND METHODS:We used 24-h dietary recall and other data from 3,725 nonpregnant adults with diabetes or prediabetes aged ≥20 years from the morning fasting sample of the...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1342

    authors: Bardenheier BH,Cogswell ME,Gregg EW,Williams DE,Zhang Z,Geiss LS

    更新日期:2014-12-01 00:00:00

  • Use of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 1 Diabetes and Rates of Diabetic Ketoacidosis.

    abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1481

    authors: Hampp C,Swain RS,Horgan C,Dee E,Qiang Y,Dutcher SK,Petrone A,Chen Tilney R,Maro JC,Panozzo CA

    更新日期:2020-01-01 00:00:00

  • Effect of menopausal status on insulin-stimulated glucose disposal: comparison of middle-aged premenopausal and early postmenopausal women.

    abstract:OBJECTIVE:Studies in animal models suggest that ovarian hormone deficiency is associated with the development of insulin resistance. In women, ovarian hormone levels are dramatically reduced after the menopause transition. However, the effect of the menopause transition on insulin sensitivity is unclear. Thus, we exami...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.6.801

    authors: Toth MJ,Sites CK,Eltabbakh GH,Poehlman ET

    更新日期:2000-06-01 00:00:00

  • The validation of a diabetes patient knowledge test.

    abstract::Diabetes knowledge tests, used in conjunction with measures of patient attitudes and behaviors, can provide a useful basis for assessing educational needs and designing appropriate instructional experiences. Accurate decisions require instruments that measure patient knowledge of diabetes and its management with high ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.6.591

    authors: Hess GE,Davis WK

    更新日期:1983-11-01 00:00:00

  • Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities study.

    abstract:OBJECTIVE:Glycemic control (HbA(1c) [A1C]) is strongly associated with microvascular disease in individuals with diabetes, but its relation to macrovascular disease and atherosclerosis is less clear. This study examines the relationship between A1C, carotid intima-media thickness (IMT), and traditional cardiovascular r...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.28.8.1965

    authors: Selvin E,Coresh J,Golden SH,Boland LL,Brancati FL,Steffes MW,Atherosclerosis risk in communities study.

    更新日期:2005-08-01 00:00:00

  • Infant feeding in relation to islet autoimmunity and type 1 diabetes in genetically susceptible children: the MIDIA Study.

    abstract:OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1130

    authors: Lund-Blix NA,Stene LC,Rasmussen T,Torjesen PA,Andersen LF,Rønningen KS

    更新日期:2015-02-01 00:00:00

  • Reconciliation of Type 2 Diabetes Remission Rates in Studies of Roux-en-Y Gastric Bypass.

    abstract:OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemin...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0954

    authors: Isaman DJ,Rothberg AE,Herman WH

    更新日期:2016-12-01 00:00:00

  • Oral contraceptive use and association with glucose, insulin, and diabetes in young adult women: the CARDIA Study. Coronary Artery Risk Development in Young Adults.

    abstract:OBJECTIVE:We studied the associations between 1) current use of oral contraceptives (OCs) and 2) glucose levels, insulin levels, and diabetes in young women. RESEARCH DESIGN AND METHODS:Subjects were women (n = 1,940) in the Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective observational s...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.6.1027

    authors: Kim C,Siscovick DS,Sidney S,Lewis CE,Kiefe CI,Koepsell TD,CARDIA Study.

    更新日期:2002-06-01 00:00:00

  • Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria.

    abstract:OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0630

    authors: Ihara K,Skupien J,Kobayashi H,Md Dom ZI,Wilson JM,O'Neil K,Badger HS,Bowsman LM,Satake E,Breyer MD,Duffin KL,Krolewski AS

    更新日期:2020-11-01 00:00:00

  • Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin.

    abstract:OBJECTIVE:This study compares the time-action profile of inhaled insulin (INH; Exubera) with that of subcutaneously injected insulin lispro (ILP) or regular human insulin (RHI) in healthy volunteers. RESEARCH DESIGN AND METHODS:In this open-label, randomized, three-way, crossover study, 17 healthy male volunteers were...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.28.5.1077

    authors: Rave K,Bott S,Heinemann L,Sha S,Becker RH,Willavize SA,Heise T

    更新日期:2005-05-01 00:00:00

  • Characteristics associated with maintenance of mean A1C

    abstract:OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc12-2238

    authors: ORIGIN Trial Investigators.

    更新日期:2013-10-01 00:00:00

  • Dietary pectin and glycemic control in diabetes.

    abstract::Seventeen diabetic subjects requiring insulin and who exhibited glycemic stability over a 9-12-mo control period received 5 g of pectin with each meal and at bedtime for 3 mo. Hemoglobin A1c (HbA1c) and glycosylated serum protein were measured in each patient on multiple occasions to assess glycemic control. No clear-...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.2.143

    authors: Gardner DF,Schwartz L,Krista M,Merimee TJ

    更新日期:1984-03-01 00:00:00