The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women.

Abstract:

OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2). We therefore hypothesized that haptoglobin type would be predictive of the effect of vitamin therapy on coronary atherosclerosis as assessed by angiography. RESEARCH DESIGN AND METHODS:We tested this hypothesis in the Women's Angiographic Vitamin and Estrogen (WAVE) trial, a prospective angiographic study of vitamins C and E with or without hormone replacement therapy (HRT) in postmenopausal women. Haptoglobin type was determined in 299 women who underwent baseline and follow-up angiography. The annualized change in the minimum luminal diameter (MLD) was examined in analyses stratified by vitamin use, haptoglobin type, and diabetes status. RESULTS:We found a significant benefit on the change in MLD with vitamin therapy as compared with placebo in Hp 1-1 subjects (0.079 +/- 0.040 mm, P = 0.049). This benefit was more marked in diabetic subjects (0.149 +/- 0.064 mm, P = 0.021). On the other hand, there was a trend toward a more rapid decrease in MLD with vitamin therapy in Hp 2-2 subjects, which was more marked in diabetic subjects (0.128 +/- 0.057 mm, P = 0.027). HRT had no effect on these outcomes. CONCLUSIONS:The relative benefit or harm of vitamin therapy on the progression of coronary artery stenoses in women in the WAVE study was dependent on haptoglobin type. This influence of haptoglobin type seemed to be stronger in women with diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BV

doi

10.2337/diacare.27.4.925

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

925-30

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
  • Metabolic consequences of hepatic steatosis in overweight and obese adolescents.

    abstract:OBJECTIVE:To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS:This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with h...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1754

    authors: Wicklow BA,Wittmeier KD,MacIntosh AC,Sellers EA,Ryner L,Serrai H,Dean HJ,McGavock JM

    更新日期:2012-04-01 00:00:00

  • Provider-patient communication and metabolic control.

    abstract:OBJECTIVE:To determine whether nurses' and NIDDM patients' communication styles during consultations are related to subsequent metabolic control and to examine factors influencing patterns of communication in these consultations. RESEARCH DESIGN AND METHODS:A total of 47 NIDDM patients participated in the study and co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.5.714

    authors: Street RL Jr,Piziak VK,Carpentier WS,Herzog J,Hejl J,Skinner G,McLellan L

    更新日期:1993-05-01 00:00:00

  • Use of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 1 Diabetes and Rates of Diabetic Ketoacidosis.

    abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1481

    authors: Hampp C,Swain RS,Horgan C,Dee E,Qiang Y,Dutcher SK,Petrone A,Chen Tilney R,Maro JC,Panozzo CA

    更新日期:2020-01-01 00:00:00

  • HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study.

    abstract:OBJECTIVE:To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS:Conventional CVD risk factors (sex, age, smoking, plasma lipids, blood pressure, and metabolic control) and insul...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.7.1135

    authors: Bonora E,Formentini G,Calcaterra F,Lombardi S,Marini F,Zenari L,Saggiani F,Poli M,Perbellini S,Raffaelli A,Cacciatori V,Santi L,Targher G,Bonadonna R,Muggeo M

    更新日期:2002-07-01 00:00:00

  • Variations of ambulatory blood pressure with position in patients with type 1 diabetes: influence of disease duration and microangiopathy in a pilot study.

    abstract:OBJECTIVE:To study the influence of position changes on 24-h ambulatory blood pressure (ABP) in normotensive or mildly hypertensive normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional evaluation of patients was staged according to the duration of diabetes (DD) and the presence...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.9.1624

    authors: Benhamou PY,Mouret S,Quesada JL,Boizel R,Baguet JP,Halimi S,Mallion JM

    更新日期:2001-09-01 00:00:00

  • Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study.

    abstract:OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-0086

    authors: Hanley AJ,Wagenknecht LE,Festa A,D'Agostino RB Jr,Haffner SM

    更新日期:2007-07-01 00:00:00

  • Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia.

    abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.7.697

    authors: Gold AE,MacLeod KM,Frier BM

    更新日期:1994-07-01 00:00:00

  • Incomplete elimination of the ABBOS epitope of bovine serum albumin under simulated gastrointestinal conditions of infants.

    abstract:OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.5.875

    authors: Alting AC,Meijer RJ,van Beresteijn EC

    更新日期:1997-05-01 00:00:00

  • Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men.

    abstract:OBJECTIVE:The existence of an obese subgroup with a healthy metabolic profile and low diabetes risk has been proposed; yet long-term data are lacking. We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0955

    authors: Arnlöv J,Sundström J,Ingelsson E,Lind L

    更新日期:2011-01-01 00:00:00

  • Moderate-intensity physical activity ameliorates the breast cancer risk in diabetic women.

    abstract:OBJECTIVE:To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women. RESEARCH DESIGN AND METHODS:A population-based case-control study was conducted using 1,000 incident case subje...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2362

    authors: Torres-Mejía G,Angeles-Llerenas A,Ortega-Olvera C,Lazcano-Ponce E,Ziv E,Pulido-Rodríguez J,García-Solis Mde J,Murillo-Zamora E,Vázquez-Lara J,Romieu I

    更新日期:2012-12-01 00:00:00

  • Effects of a traditional lifestyle on obesity in Pima Indians.

    abstract:OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.9.1067

    authors: Ravussin E,Valencia ME,Esparza J,Bennett PH,Schulz LO

    更新日期:1994-09-01 00:00:00

  • Ethnic and racial differences in diabetes care: The Insulin Resistance Atherosclerosis Study.

    abstract:OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.26.4.1040

    authors: Bonds DE,Zaccaro DJ,Karter AJ,Selby JV,Saad M,Goff DC Jr

    更新日期:2003-04-01 00:00:00

  • High-risk individuals' willingness to pay for diabetes risk-reduction programs.

    abstract:OBJECTIVE:The purpose of this study was to estimate how much at-risk individuals are willing to pay for type 2 diabetes primary prevention programs. RESEARCH DESIGN AND METHODS:An Internet-based, choice-format conjoint survey was presented to individuals at elevated risk for type 2 diabetes. Hypothetical diabetes risk...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2221

    authors: Johnson FR,Manjunath R,Mansfield CA,Clayton LJ,Hoerger TJ,Zhang P

    更新日期:2006-06-01 00:00:00

  • Challenges to healthy eating for people with diabetes in a low-income, minority neighborhood.

    abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1632

    authors: Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

    更新日期:2013-10-01 00:00:00

  • Low bone mineral density and its predictors in type 1 diabetic patients evaluated by the classic statistics and artificial neural network analysis.

    abstract:OBJECTIVE:To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS:A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0764

    authors: Eller-Vainicher C,Zhukouskaya VV,Tolkachev YV,Koritko SS,Cairoli E,Grossi E,Beck-Peccoz P,Chiodini I,Shepelkevich AP

    更新日期:2011-10-01 00:00:00

  • Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.

    abstract:OBJECTIVE:In a few previous studies, cardiovascular disease (CVD) risk factors (RFs) have been shown to predict diabetes. Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity....

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.9.2234

    authors: D'Agostino RB Jr,Hamman RF,Karter AJ,Mykkanen L,Wagenknecht LE,Haffner SM,Insulin Resistance Atherosclerosis Study Investigators.

    更新日期:2004-09-01 00:00:00

  • Incidence and management of severe hypoglycemia in 434 adults with insulin-dependent diabetes mellitus.

    abstract::The risk of severe hypoglycemia associated with the particular therapeutic approach of two University hospitals was assessed in 96% of all patients with insulin-dependent diabetes mellitus (IDDM) who had been admitted during a period of almost 3 yr to the diabetic wards of two hospitals and who participated in a struc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.3.268

    authors: Mühlhauser I,Berger M,Sonnenberg G,Koch J,Jörgens V,Schernthaner G,Scholz V,Pädagogin D

    更新日期:1985-05-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0553

    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Racial variation in the control of diabetes among elderly medicare managed care beneficiaries.

    abstract:OBJECTIVE:To examine racial variation in the poor control of GHb, a GHb value >9.5%, or GHb not tested in 1999 among Medicare beneficiaries aged 65-75 years enrolled in managed care plans. RESEARCH DESIGN AND METHODS:The National Committee on Quality Assurance provides person-level data regarding diabetes care service...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.12.3250

    authors: McBean AM,Huang Z,Virnig BA,Lurie N,Musgrave D

    更新日期:2003-12-01 00:00:00

  • Effect of aldose reductase inhibitor (tolrestat) on urinary albumin excretion rate and glomerular filtration rate in IDDM subjects with nephropathy.

    abstract:OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration r...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.16.5.789

    authors: Passariello N,Sepe J,Marrazzo G,De Cicco A,Peluso A,Pisano MC,Sgambato S,Tesauro P,D'Onofrio F

    更新日期:1993-05-01 00:00:00

  • On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and Examination Survey.

    abstract:OBJECTIVE:To determine the relationship between mental disorders and diabetes in a representative community sample. RESEARCH DESIGN AND METHODS:This was a cross-sectional study. Data on diabetes and HbA(1c) values were obtained by structured questionnaires and by laboratory assessments. Current psychiatric disorders w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.6.1841

    authors: Kruse J,Schmitz N,Thefeld W,German National Health Interview and Examination Survey.

    更新日期:2003-06-01 00:00:00

  • Subclinical and clinical eating disorders in IDDM negatively affect metabolic control.

    abstract:OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.2.182

    authors: Affenito SG,Backstrand JR,Welch GW,Lammi-Keefe CJ,Rodriguez NR,Adams CH

    更新日期:1997-02-01 00:00:00

  • Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

    abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.23.9.1343

    authors: Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

    更新日期:2000-09-01 00:00:00

  • Changes in Statin Use Among U.S. Adults With Diabetes: A Population-Based Analysis of NHANES 2011-2018.

    abstract:OBJECTIVE:To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40-75 years old with diabetes. RESEARCH DESIGN AND METHODS:The National Health and Nutrition Examination Survey (NHANES) was used ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1481

    authors: Leino AD,Dorsch MP,Lester CA

    更新日期:2020-12-01 00:00:00

  • Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.

    abstract:OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-2045

    authors: Dibato JE,Montvida O,Zaccardi F,Sargeant JA,Davies MJ,Khunti K,Paul SK

    更新日期:2021-01-01 00:00:00

  • Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. The Strong Heart Study.

    abstract:OBJECTIVE:Many studies have shown that diabetes increases the risk of cardiovascular disease (CVD) in women to a greater extent than in men. One explanation could be that diabetes has more adverse effects on CVD risk factors in women than in men. We compared diabetes-associated differences in CVD risk factors in men an...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.21.8.1258

    authors: Howard BV,Cowan LD,Go O,Welty TK,Robbins DC,Lee ET

    更新日期:1998-08-01 00:00:00

  • Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.1.138

    authors: Hamilton J,Cummings E,Zdravkovic V,Finegood D,Daneman D

    更新日期:2003-01-01 00:00:00

  • High levels of education are associated with an increased risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study.

    abstract:OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1061

    authors: Olsson L,Ahlbom A,Grill V,Midthjell K,Carlsson S

    更新日期:2011-01-01 00:00:00

  • Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

    abstract:OBJECTIVE:To examine whether cardiovascular autonomic neuropathy (CAN) is an independent risk factor of cardiovascular disease (CVD) events during DCCT/EDIC. RESEARCH DESIGN AND METHODS:Standardized cardiovascular autonomic reflex tests (R-R response to paced breathing, Valsalva maneuver, postural changes in blood pre...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-1397

    authors: Pop-Busui R,Braffett BH,Zinman B,Martin C,White NH,Herman WH,Genuth S,Gubitosi-Klug R,DCCT\/EDIC Research Group.

    更新日期:2017-01-01 00:00:00

  • Randomized prospective trial of pure porcine and conventional bovine/porcine insulin.

    abstract::Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.10.3.337

    authors: Asplin C,Raghu P,Clemons P,Lyen K,Tatpati O,McKnight B,Baker L,Guthrie R,Sperling M,Palmer J

    更新日期:1987-05-01 00:00:00