Abstract:
OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2). We therefore hypothesized that haptoglobin type would be predictive of the effect of vitamin therapy on coronary atherosclerosis as assessed by angiography. RESEARCH DESIGN AND METHODS:We tested this hypothesis in the Women's Angiographic Vitamin and Estrogen (WAVE) trial, a prospective angiographic study of vitamins C and E with or without hormone replacement therapy (HRT) in postmenopausal women. Haptoglobin type was determined in 299 women who underwent baseline and follow-up angiography. The annualized change in the minimum luminal diameter (MLD) was examined in analyses stratified by vitamin use, haptoglobin type, and diabetes status. RESULTS:We found a significant benefit on the change in MLD with vitamin therapy as compared with placebo in Hp 1-1 subjects (0.079 +/- 0.040 mm, P = 0.049). This benefit was more marked in diabetic subjects (0.149 +/- 0.064 mm, P = 0.021). On the other hand, there was a trend toward a more rapid decrease in MLD with vitamin therapy in Hp 2-2 subjects, which was more marked in diabetic subjects (0.128 +/- 0.057 mm, P = 0.027). HRT had no effect on these outcomes. CONCLUSIONS:The relative benefit or harm of vitamin therapy on the progression of coronary artery stenoses in women in the WAVE study was dependent on haptoglobin type. This influence of haptoglobin type seemed to be stronger in women with diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BVdoi
10.2337/diacare.27.4.925subject
Has Abstractpub_date
2004-04-01 00:00:00pages
925-30issue
4eissn
0149-5992issn
1935-5548journal_volume
27pub_type
临床试验,杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS:This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with h...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1754
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To determine whether nurses' and NIDDM patients' communication styles during consultations are related to subsequent metabolic control and to examine factors influencing patterns of communication in these consultations. RESEARCH DESIGN AND METHODS:A total of 47 NIDDM patients participated in the study and co...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.5.714
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1481
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS:Conventional CVD risk factors (sex, age, smoking, plasma lipids, blood pressure, and metabolic control) and insul...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.25.7.1135
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To study the influence of position changes on 24-h ambulatory blood pressure (ABP) in normotensive or mildly hypertensive normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional evaluation of patients was staged according to the duration of diabetes (DD) and the presence...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.9.1624
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-0086
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.7.697
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.875
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The existence of an obese subgroup with a healthy metabolic profile and low diabetes risk has been proposed; yet long-term data are lacking. We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men. RESEARCH DESIGN AND M...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0955
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women. RESEARCH DESIGN AND METHODS:A population-based case-control study was conducted using 1,000 incident case subje...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2362
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.1067
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.4.1040
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to estimate how much at-risk individuals are willing to pay for type 2 diabetes primary prevention programs. RESEARCH DESIGN AND METHODS:An Internet-based, choice-format conjoint survey was presented to individuals at elevated risk for type 2 diabetes. Hypothetical diabetes risk...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-2221
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1632
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS:A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0764
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:In a few previous studies, cardiovascular disease (CVD) risk factors (RFs) have been shown to predict diabetes. Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity....
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.9.2234
更新日期:2004-09-01 00:00:00
abstract::The risk of severe hypoglycemia associated with the particular therapeutic approach of two University hospitals was assessed in 96% of all patients with insulin-dependent diabetes mellitus (IDDM) who had been admitted during a period of almost 3 yr to the diabetic wards of two hospitals and who participated in a struc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.3.268
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0553
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To examine racial variation in the poor control of GHb, a GHb value >9.5%, or GHb not tested in 1999 among Medicare beneficiaries aged 65-75 years enrolled in managed care plans. RESEARCH DESIGN AND METHODS:The National Committee on Quality Assurance provides person-level data regarding diabetes care service...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.12.3250
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration r...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.16.5.789
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between mental disorders and diabetes in a representative community sample. RESEARCH DESIGN AND METHODS:This was a cross-sectional study. Data on diabetes and HbA(1c) values were obtained by structured questionnaires and by laboratory assessments. Current psychiatric disorders w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.6.1841
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.2.182
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.23.9.1343
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40-75 years old with diabetes. RESEARCH DESIGN AND METHODS:The National Health and Nutrition Examination Survey (NHANES) was used ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1481
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS:From U.S. electronic medical...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-2045
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Many studies have shown that diabetes increases the risk of cardiovascular disease (CVD) in women to a greater extent than in men. One explanation could be that diabetes has more adverse effects on CVD risk factors in women than in men. We compared diabetes-associated differences in CVD risk factors in men an...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.21.8.1258
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.1.138
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1061
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To examine whether cardiovascular autonomic neuropathy (CAN) is an independent risk factor of cardiovascular disease (CVD) events during DCCT/EDIC. RESEARCH DESIGN AND METHODS:Standardized cardiovascular autonomic reflex tests (R-R response to paced breathing, Valsalva maneuver, postural changes in blood pre...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-1397
更新日期:2017-01-01 00:00:00
abstract::Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.10.3.337
更新日期:1987-05-01 00:00:00