Research, development, production, and safety of biosynthetic human insulin.

abstract：OBJECTIVE:Plasma copeptin, a surrogate for vasopressin, was associated with albuminuria in population-based studies. These associations are consistent with the effect of vasopressin on albuminuria observed in humans and rodents. The objective of this study was to determine whether plasma copeptin is an independent mark...

journal_title：Diabetes care

authors： Velho G,Bouby N,Hadjadj S,Matallah N,Mohammedi K,Fumeron F,Potier L,Bellili-Munoz N,Taveau C,Alhenc-Gelas F,Bankir L,Marre M,Roussel R

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Successful disease management is heavily influenced by access to care issues and patient behavior. Screening tests to detect chronic complications are part of diabetes management and may be influenced by access to care or patient decisions. The objective of this research was to examine how strongly access to ...

journal_title：Diabetes care

authors： Dorsey R,Songer T,Zgibor J,Kelsey S,Ibrahim S,Orchard T

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To compare the weight losses of black and white patients with NIDDM treated in a year-long behavioral weight loss program. RESEARCH DESIGN AND METHODS:Subjects were randomly assigned to a behavioral program that either used a low-calorie diet throughout or included two 12-week periods of a very-low calorie d...

journal_title：Diabetes care

authors： Wing RR,Anglin K

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To compare the health service utilization and long-term outcomes of acute myocardial infarction (AMI) patients with and without diabetes in Ontario. RESEARCH DESIGN AND METHODS:We examined 25,697 patients from Ontario (6,052 and 19,645 patients with and without diabetes, respectively) who were hospitalized b...

journal_title：Diabetes care

authors： Alter DA,Khaykin Y,Austin PC,Tu JV,Hux JE

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:To determine whether reducing triglyceride concentrations in humans reduces serum insulin levels and consider the implications of this for the insulin resistance of hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Insulin and glucose levels were determined during an oral glucose tolerance test (OGTT) in 14 ...

journal_title：Diabetes care

authors： Steiner G

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...

journal_title：Diabetes care

authors： Bonds DE,Zaccaro DJ,Karter AJ,Selby JV,Saad M,Goff DC Jr

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:Pancreas transplantation (PTX) normalizes glucose and improves microvascular complications, but its impact on macrovascular disease is still debated. RESEARCH DESIGN AND METHODS:Carotid intima-media thickness (IMT), shown to correlate with cardiovascular disease (CVD) risk and events, was determined prospect...

journal_title：Diabetes care

authors： Larsen JL,Colling CW,Ratanasuwan T,Burkman TW,Lynch TG,Erickson JM,Lyden ER,Lane JT,Mack-Shipman LR

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To assess the utility of a point-of-care (POC) capillary blood glucose measurement as compared with routine clinical parameters in predicting undiagnosed diabetes in a low-resource rural India setting. RESEARCH DESIGN AND METHODS:Nine hundred and ninety-four participants aged >30 years and stratified by age ...

journal_title：Diabetes care

authors： Ritchie GE,Kengne AP,Joshi R,Chow C,Neal B,Patel A,Zoungas S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To assess the additional effect of sudden visceral fat reduction by omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in patients with grade III obesity (G-III O) undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB). RESEARCH DESIGN AND METHODS:Twenty-two patients were ...

journal_title：Diabetes care

authors： Herrera MF,Pantoja JP,Velázquez-Fernández D,Cabiedes J,Aguilar-Salinas C,García-García E,Rivas A,Villeda C,Hernández-Ramírez DF,Dávila A,Zaraín A

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:There is substantial evidence that glucose intolerance is associated with an increased risk of cardiovascular disease. However, it is not well established whether plasma glucose is independently related to atherosclerosis when glucose tolerance is normal and, if so, to which stage of the complex atherosclerot...

journal_title：Diabetes care

authors： Bonora E,Kiechl S,Willeit J,Oberhollenzer F,Egger G,Bonadonna R,Muggeo M

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with the fasting glucose test, compared with the oral glucose tolerance test (OGTT) for the reassessment of the carbohydrate metabolism status in postpartum women with a history of gestational diabetes mellitus (GDM). RESEARCH...

journal_title：Diabetes care

authors： Picón MJ,Murri M,Muñoz A,Fernández-García JC,Gomez-Huelgas R,Tinahones FJ

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may i...

journal_title：Diabetes care

authors： Teufel F,Geldsetzer P,Manne-Goehler J,Karlsson O,Koncz V,Deckert A,Theilmann M,Marcus ME,Ebert C,Seiglie JA,Agoudavi K,Andall-Brereton G,Gathecha G,Gurung MS,Guwatudde D,Houehanou C,Hwalla N,Kagaruki GB,Karki KB,Lab

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To compare the diagnostic accuracy and time expenditure of screening models based on glycated hemoglobin (HbA(1c)) level and psychometric measures for mood disorder (MD) among children with type 1 diabetes. RESEARCH DESIGN AND METHODS:With semistructured clinical interviews (Schedule for Affective Disorders ...

journal_title：Diabetes care

authors： Butwicka A,Fendler W,Zalepa A,Szadkowska A,Mianowska B,Gmitrowicz A,Młynarski W

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of new insulin glargine 300 units/mL (Gla-300) with glargine 100 units/mL (Gla-100) in people with type 2 diabetes on basal insulin (≥42 units/day) plus mealtime insulin. RESEARCH DESIGN AND METHODS:EDITION 1 (NCT01499082) was a 6-month, multinational, open-label, parallel-...

journal_title：Diabetes care

authors： Riddle MC,Bolli GB,Ziemen M,Muehlen-Bartmer I,Bizet F,Home PD,EDITION 1 Study Investigators.

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Limited information is available about glycemic outcomes with a closed-loop control (CLC) system compared with a predictive low-glucose suspend (PLGS) system. RESEARCH DESIGN AND METHODS:After 6 months of use of a CLC system in a randomized trial, 109 participants with type 1 diabetes (age range, 14-72 years...

journal_title：Diabetes care

authors： Brown SA,Beck RW,Raghinaru D,Buckingham BA,Laffel LM,Wadwa RP,Kudva YC,Levy CJ,Pinsker JE,Dassau E,Doyle FJ 3rd,Ambler-Osborn L,Anderson SM,Church MM,Ekhlaspour L,Forlenza GP,Levister C,Simha V,Breton MD,Kollman C,

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...

journal_title：Diabetes care

authors： Ryan EA,Paty BW,Senior PA,Lakey JR,Bigam D,Shapiro AM

更新日期：2005-02-01 00:00:00

abstract：:OBJECTIVE- We examined the influence of a moderately elevated serum ferritin level at entry to care on the risk of gestational diabetes mellitus (GDM) and a possible mechanism (increased iron stores versus inflammation). RESEARCH DESIGN AND METHODS- In a prospective observational study with 1,456 healthy pregnant wome...

journal_title：Diabetes care

authors： Chen X,Scholl TO,Stein TP

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP). RESEARCH DESIGN AND METHODS:A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tol...

journal_title：Diabetes care

authors： Church D,Halsall D,Meek C,Parker RA,Murphy HR,Simmons D

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To determine the effect of a high-protein (HP) diet compared with a low-protein (LP) diet on weight loss, resting energy expenditure (REE), and the thermic effect of food (TEF) in subjects with type 2 diabetes during moderate energy restriction. RESEARCH DESIGN AND METHODS:In this study, 26 obese subjects wi...

journal_title：Diabetes care

authors： Luscombe ND,Clifton PM,Noakes M,Parker B,Wittert G

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To study the effects of mental stress on the absorption kinetics of insulin and on glucose homeostasis and lipolysis in insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS:Nine IDDM patients were exposed to the Stroop color word conflict test (CWT) during 40 min after injection of 125I-la...

journal_title：Diabetes care

authors： Fernqvist-Forbes E,Linde B

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits. RESEARCH DESIGN AND METHODS:We studied the Eversense (Senseonics Inc.) implantable CGM sensor in 71 participant...

journal_title：Diabetes care

authors： Kropff J,Choudhary P,Neupane S,Barnard K,Bain SC,Kapitza C,Forst T,Link M,Dehennis A,DeVries JH

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes. RESEARCH DESIGN AND METHODS:We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, ...

journal_title：Diabetes care

authors： Yeh GY,Eisenberg DM,Kaptchuk TJ,Phillips RS

更新日期：2003-04-01 00:00:00

abstract：:Regulation of gene transcription is a major action of insulin. Most of the greater than 20 examples of this effect involve the stimulation of transcription, but a few involve an inhibition. The inhibition of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene has been studied in detail. Most of this ef...

journal_title：Diabetes care

authors： O'Brien RM,Granner DK

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathi...

journal_title：Diabetes care

authors： Kim ES,Moon SD,Kim HS,Lim DJ,Cho JH,Kwon HS,Ahn CW,Yoon KH,Kang MI,Cha BY,Son HY

更新日期：2011-06-01 00:00:00

abstract：:Seventeen diabetic subjects requiring insulin and who exhibited glycemic stability over a 9-12-mo control period received 5 g of pectin with each meal and at bedtime for 3 mo. Hemoglobin A1c (HbA1c) and glycosylated serum protein were measured in each patient on multiple occasions to assess glycemic control. No clear-...

journal_title：Diabetes care

authors： Gardner DF,Schwartz L,Krista M,Merimee TJ

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of diabetes in Tohono O'odham pregnancies, and to assess the efficacy of early prenatal diabetes screening in populations with high rates of diabetes. RESEARCH DESIGN AND METHODS:All Tohono O'odham women receiving prenatal care at the Sells Service Unit who delivered a viable baby...

journal_title：Diabetes care

authors： Livingston RC,Bachman-Carter K,Frank C,Mason WB

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...

journal_title：Diabetes care

authors： Scragg R,Sowers M,Bell C,Third National Health and Nutrition Examination Survey.

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...

journal_title：Diabetes care

authors： Rasmussen OW,Thomsen C,Hansen KW,Vesterlund M,Winther E,Hermansen K

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Incidence of type 2 diabetes might be associated with preexisting hypertension. There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients. RESEARCH DESIGN AND METHODS:...

journal_title：Diabetes care

authors： Izzo R,de Simone G,Chinali M,Iaccarino G,Trimarco V,Rozza F,Giudice R,Trimarco B,De Luca N

更新日期：2009-05-01 00:00:00