Abstract:
OBJECTIVE:This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima-media thickness (IMT). RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS:Patients with DPN had higher CAVI than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001). CONCLUSIONS:DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Kim ES,Moon SD,Kim HS,Lim DJ,Cho JH,Kwon HS,Ahn CW,Yoon KH,Kang MI,Cha BY,Son HYdoi
10.2337/dc10-2222subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1403-5issue
6eissn
0149-5992issn
1935-5548pii
dc10-2222journal_volume
34pub_type
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