Abstract:
OBJECTIVE:The aim of this study was to determine whether the use of meal bolus alarms would result in fewer missed meal boluses per week in youth with type 1 diabetes using continuous subcutaneous insulin infusion (CSII) therapy. RESEARCH DESIGN AND METHODS:This was a randomized trial of 48 youth using CSII, who were in suboptimal glycemic control with HbA(1c) (A1C) values > or =8.0%. Twenty-four subjects were randomized to use a Deltec Cozmo insulin pump with meal bolus alarms (experimental group), while the other 24 subjects continued use of their current insulin pumps (control group) without meal bolus alarms. RESULTS:After 3 months of study, the number of missed meal boluses per week was significantly lower in the experimental group (from 4.9 +/- 3.7 to 2.5 +/- 2.5; P = 0.0005) but not significantly lower in the control group (from 4.3 +/- 2.7 to 4.2 +/- 3.9; P = 0.7610). Also after 3 months, the mean A1C value of the experimental group declined significantly (from 9.32 +/- 1.12 to 8.86 +/- 1.10; P = 0.0430). No significant decline in A1C was present for the control group (from 8.93 +/- 1.04 to 8.67 +/- 1.17; P = 0.1940). After 6 months of study, the significant decline in A1C from baseline in the experimental group was no longer present. Pooling of all available data from the control and experimental groups showed that at baseline and 3 and 6 months, the number of missed meal boluses per week was significantly correlated with A1C values. CONCLUSIONS:While meal bolus alarms may have the potential to improve suboptimal glycemic control in youth using CSII, our results demonstrated that these alarms had only a transient, modest effect in doing so.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Chase HP,Horner B,McFann K,Yetzer H,Gaston J,Banion C,Fiallo-Scharer R,Slover R,Klingensmith Gdoi
10.2337/diacare.2951012subject
Has Abstractpub_date
2006-05-01 00:00:00pages
1012-5issue
5eissn
0149-5992issn
1935-5548pii
29/5/1012journal_volume
29pub_type
杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-0509
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:This study compares the time-action profile of inhaled insulin (INH; Exubera) with that of subcutaneously injected insulin lispro (ILP) or regular human insulin (RHI) in healthy volunteers. RESEARCH DESIGN AND METHODS:In this open-label, randomized, three-way, crossover study, 17 healthy male volunteers were...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.5.1077
更新日期:2005-05-01 00:00:00
abstract::Group clinics are becoming popular as a new care model in diabetes care. This evidence synthesis, using realist review methodology, examined the role of group clinics in meeting the complex needs of young people living with diabetes. Following Realist And Meta-narrative Evidence Synthesis-Evolving Standards (RAMESES) ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc18-2005
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:We performed a retrospective analysis of a national cohort of veterans with diabetes to better understand regional, geographic, and racial/ethnic variation in diabetes control as measured by HbA(1c). RESEARCH DESIGN AND METHODS:A retrospective cohort study was conducted in a national cohort of 690,968 vetera...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1504
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.6.965
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.988
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.827
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late-gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age). RESEARCH DESIGN AND METHODS:The relationships between morning nonfasting TG measured early ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.12.1550
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:Diabetes is associated with oxidative stress and increased mortality, but a possible correlation between leukocyte-endothelium interactions, oxidative stress, and silent myocardial ischemia (SMI) is yet to be confirmed. RESEARCH DESIGN AND METHODS:Mitochondrial dysfunction and interactions between leukocytes...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1224
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The study objective was to describe the effect of socioeconomic status (SES) on mortality among people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a population-based national electronic diabetes database for 35- to 84-year-olds in Scotland for 2001-2007 linked to mortality records. SES was deri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1862
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc09-2104
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for the development of type 2 diabetes in the mother and is responsible for morbidity in the child. To better identify women at risk of developing GDM we examined sociodemographic correlates and changes in the prevalence of GDM among...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1038
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether a strategy of aggressive cardiovascular risk management reduced the mortality associated with diabetic foot ulceration. RESEARCH DESIGN AND METHODS:After an initial audit of outcomes demonstrating a high mortality rate in 404 diabetic foot ulcer patients wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1242
更新日期:2008-11-01 00:00:00
abstract::Many of the family psychosocial variables significantly related to child abuse are also significantly related to insulin-dependent diabetes mellitus (IDDM) control. These variables are reviewed, and an increased child abuse risk factor for children with IDDM is discussed. Behavioral indicators of families experiencing...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.9.3.302
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:Subjects with type 1 diabetes are at high risk for many long-term complications, including early mortality and coronary artery disease (CAD). Few data are available on which to base goal levels for two major risk factors, namely blood pressure and lipid/lipoproteins. The objective of this study was to determi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.6.1053
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-2207
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits. RESEARCH DESIGN AND METHODS:We studied the Eversense (Senseonics Inc.) implantable CGM sensor in 71 participant...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2337/dc16-1525
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We assessed the association between different blood lipid measures and risk of fatal/nonfatal coronary heart disease (CHD). RESEARCH DESIGN AND METHODS:We conducted an observational study of patients with type 2 diabetes from the Swedish National Diabetes Register. Baseline LDL cholesterol, non-HDL cholester...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0209
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To determine whether diabetes risk is influenced by which parent (a parental history of diabetes is a well-documented risk factor for NIDDM) is reported to have diabetes. RESEARCH DESIGN AND METHODS:We compared the prevalence of NIDDM and IGT for 4914 subjects according to their parental history of diabetes ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.9.1262
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:High levels of dietary fiber, especially soluble fiber, are recommended to lower serum cholesterol levels and improve glycemic control in patients with type 2 diabetes. It is not clear, however, how high levels of fiber affect mineral balance. RESEARCH DESIGN AND METHODS:In a randomized crossover study, 13 p...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-0126
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes. RESEARCH DESIGN AND METHODS:We performed a nested case-control study from the EURODIAB Prospective Complications St...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.7.2165
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:This was a prospective follow-up study as a part of the nationwide Finnish Diabetic Nephropathy Study; 1,330 type 1 diabetic pat...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2306
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year. RESEARCH DESIGN AND METHODS:Sixty-eight individuals (mean age 13.3 ± 5.7 ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc13-1074
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine whether ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) protect against lower-respiratory tract infections complicating type 2 diabetes. RESEARCH DESIGN AND METHODS:Of 1,732 participants with diabetes recruited to the longitudinal observational Fremantle Diabetes Study Phase II (FD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0895
更新日期:2020-09-01 00:00:00
abstract::In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.12.3.179
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.509
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility that leptin levels may be predictive of the risk of ischemic heart disease (IHD) through the relationship of leptin to body fat. RESEARCH DESIGN AND METHODS:The Quebec Cardiovascular Study cohort consisted of 2,103 French-Canadian men without IHD in 1985 who were followed until...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.5.782
更新日期:1998-05-01 00:00:00
abstract::We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing inc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.6.528
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVE:Diet therapy in gestational diabetes mellitus (GDM) has focused on carbohydrate restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low-carbohydrate/higher-fat (LC/CONV) diet, hypothesizing that a higher-complex carbohydrate/lower-fat (CHOICE) diet ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-0515
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of known diabetes in a Swedish county (Skaraborg) and to evaluate capture-recapture methods for validation of the diabetes prevalence. RESEARCH DESIGN AND METHODS:Four sources were used to find known diabetic patients: 1) the Skaraborg Diabetes Registry (SDR), a case-finding invent...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.4.546
更新日期:1998-04-01 00:00:00