Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography.

Abstract:

OBJECTIVE:The performance of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) was compared in screening for diabetes by an oral glucose tolerance test (OGTT) in patients undergoing coronary angiography (CAG). RESEARCH DESIGN AND METHODS:Patients without known diabetes admitted for CAG were eligible. OGTT and HbA1c were assessed 2-4 weeks after hospital discharge. The performance of HbA1c and FPG was evaluated by using receiver operating characteristic (ROC) analysis. RESULTS:Diabetes was diagnosed in 83 of 400 patients (20.8%). The area under the ROC curve was higher for FPG than for HbA1c (0.81 vs. 0.73, P = 0.032). We proposed a screening algorithm and validated it in another 170 patients. Overall, this algorithm reduced the number of OGTTs by 71.4% (sensitivity 74.4%, specificity 100%). CONCLUSIONS:FPG performed better than HbA1c in screening for diabetes in patients undergoing CAG. A screening algorithm might help to reduce the number of OGTTs.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Wang JS,Lee IT,Lee WJ,Lin SY,Fu CP,Ting CT,Lee WL,Liang KW,Sheu WH

doi

10.2337/dc12-1434

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

1138-40

issue

5

eissn

0149-5992

issn

1935-5548

pii

dc12-1434

journal_volume

36

pub_type

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