Abstract:
OBJECTIVE:Incidence of type 2 diabetes might be associated with preexisting hypertension. There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients. RESEARCH DESIGN AND METHODS:Nondiabetic, otherwise healthy, hypertensive patients (N = 1,754, mean +/- SD age 52 +/- 11 years, 43% women) participated in a network over 3.4 +/- 1 years of follow-up. Blood pressure was considered uncontrolled if systolic was >or=140 mmHg and/or diastolic was >or=90 mmHg at the last outpatient visit. Diabetes was defined according to American Diabetes Association guidelines. RESULTS:Uncontrolled blood pressure despite antihypertensive treatment was found in 712 patients (41%). At baseline, patients with uncontrolled blood pressure were slightly younger than patients with controlled blood pressure (51 +/- 11 vs. 53 +/- 12 years, P < 0.001), with no differences in sex distribution, BMI, duration of hypertension, baseline blood pressure, fasting glucose, serum creatinine and potassium, lipid profile, or prevalence of metabolic syndrome. During follow-up, 109 subjects developed diabetes. Incidence of diabetes was significantly higher in patients with uncontrolled (8%) than in those with controlled blood pressure (4%, odds ratio 2.08, P < 0.0001). In Cox regression analysis controlling for baseline systolic blood pressure and BMI, family history of diabetes, and physical activity, uncontrolled blood pressure doubled the risk of incident diabetes (hazard ratio [HR] 2.10, P < 0.001), independently of significant effects of age (HR 1.02 per year, P = 0.03) and baseline fasting glucose (HR 1.10 per mg/dl, P < 0.001). CONCLUSIONS:In a large sample of treated nondiabetic hypertensive subjects, uncontrolled blood pressure is associated with twofold increased risk of incident diabetes independently of age, BMI, baseline blood pressure, or fasting glucose.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Izzo R,de Simone G,Chinali M,Iaccarino G,Trimarco V,Rozza F,Giudice R,Trimarco B,De Luca Ndoi
10.2337/dc08-1881subject
Has Abstractpub_date
2009-05-01 00:00:00pages
845-50issue
5eissn
0149-5992issn
1935-5548pii
dc08-1881journal_volume
32pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:We evaluated a program of performance measurement and monitoring by assessing care process, utilization of services, and outcomes. RESEARCH DESIGN AND METHODS:Information on 63,264 diabetic individuals who were continuously enrolled as members of Kaiser Permanente Southern California from 1 January 1994 to 3...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.2.192
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To determine the effect of diabetes on long-term survival after acute myocardial infarction and to compare its effect with that of a previous myocardial infarction. RESEARCH DESIGN AND METHODS:In a prospective cohort study, we followed 1,935 patients hospitalized with a confirmed acute myocardial infarction ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.24.8.1422
更新日期:2001-08-01 00:00:00
abstract::Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.9.923
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:Sulfonylureas block the activation of vascular potassium-dependent ATP channels and impair the vasodilating response to ischcmia in nondiabetic individuals, but it is not know whether this occurs in type 2 diabetic patients under chronic treatment with these drugs. Glimepiride, a new sulfonylurea, apparently ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.24.4.738
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-0086
更新日期:2007-07-01 00:00:00
abstract::Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.3.258
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:Troglitazone was recently reported to specifically promote the differentiation of pre-adipocytes into adipocytes in vitro in subcutaneous fat only, indicating a relation to insulin-resistance-improving action of troglitazone. To expand on this finding, we investigated at the clinical level how long-term admin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.22.6.908
更新日期:1999-06-01 00:00:00
abstract::The goal of this study was to evaluate a program of resistance weight training on cardiovascular risk factors, blood glucose management, and overall strength in diabetic subjects. A randomized crossover design was performed on eight male type I (insulin-dependent) diabetic subjects (mean +/- SD age 31 +/- 3.5 yr, heig...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.13.10.1039
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1793
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:Data from the national transplant database from 2000 to 2007 were analyzed. SPK recipients who had functioning allografts to 1-year post transplant (...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1718
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1427
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.827
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diabetes management is poorly understood. RESEARCH DESIGN AND METHODS:This was a prospective cohort study. A random sample o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1981
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Large prospective studies have demonstrated that optimum glycemic control is not routinely achieved in clinical practice. Barriers to optimal insulin therapy include hypoglycemia, weight gain, and suboptimal initiation and dose titration. This study compared two treatment algorithms for insulin glargine initi...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.28.6.1282
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care. RESEARCH DESIGN AND METHODS:We conducted a prospective, before/aft...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.11.3061
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To determine whether increasing doses (amounts) of beta-glucan present in an extruded breakfast cereal affect the glycemic and insulinemic responses in eight NIDDM subjects, compared with the same responses after a continental breakfast (bread, milk, cheese, ham). RESEARCH DESIGN AND METHODS:Breakfast cereal...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.8.831
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0083
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS:A total of 3,475 nondiabetic subjects aged 3-18 years were sampled i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1040
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:N-acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-1569
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:The current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non-intensive care unit (ICU) hospital setting. RESEARCH DESIGN AND METHODS:A total of 110 adults with typ...
journal_title:Diabetes care
pub_type: 评论,杂志文章
doi:10.2337/dc20-1016
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1834
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc16-2462
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.1.10
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0324
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Treatment of IDDM in youth emphasized balancing children's self-care autonomy with their psychological maturity. However, few data exist to guide clinicians or parents, and little is known about correlates of deviations from this ideal. RESEARCH DESIGN AND METHODS:In this cross-sectional study, IDDM self-car...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.2.119
更新日期:1996-02-01 00:00:00
abstract::We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests tha...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.574
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:Physical activity is a cornerstone of treatment for diabetes, yet people with diabetes perform less moderate and vigorous physical activity (MVPA) than people without diabetes. In contrast, whether differences in walking activity exist has been understudied. Diabetes-specific barriers to physical activity are...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1801
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.16.12.1565
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.10.1122
更新日期:1996-10-01 00:00:00
abstract::Morphologic characteristics of insulin precipitates were examined by both scanning and transmission electron microscopy. Insulin precipitate obtained after 1 wk of in vivo storage in an implanted dog reservoir was compared with insulin precipitate produced in vitro by isoelectric precipitation, acid-freeze-heat precip...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.1.25
更新日期:1982-01-01 00:00:00