Abstract:
OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excretion rate, blood pressure, glycemic control, and lipids were measured on entry and at the end of the study. Of the patients, 19 normoalbuminuric and 8 microalbuminuric (73%) patients had no history of antihypertensive treatment. RESULTS:The glomerular filtration rate was significantly reduced during the follow-up period (-1.34 +/- 0.54 ml.min-1.1.73 m-2 [mean +/- SE], P < 0.02). The rate of decline varied considerably in normoalbuminuric and microalbuminuric patients (from -13.5 to 4.3 and from -7.0 to 4.2 ml.min-1.1.73 m-2 per year, respectively) but was on average not accelerated in normoalbuminuric or microalbuminuric patients (-1.3 +/- 0.7 and -1.5 +/- 0.8 ml.min-1.1.73 m-2 per year, respectively). Significant correlations were observed between the glomerular filtration rate fall rate and initial systolic blood pressure (r = -0.47, P < 0.01; patients without antihypertensive treatment: r = -0.42, P = 0.03) but not diastolic blood pressure. In a stepwise multiple linear regression analysis, baseline systolic blood pressure significantly determined the fall rate of the glomerular filtration rate (regression coefficient = -0.050, SE = 0.018, P = 0.011; patients without antihypertensive treatment: regression coefficient = -0.047, SE = 0.021, P = 0.030). CONCLUSIONS:In these type II diabetic patients neither normoalbuminuria nor microalbuminuria are at an average associated with an accelerated decline in kidney function. Still, systolic blood pressure is a determining factor for the rate of decline in the glomerular filtration rate. A longer follow-up time with consecutive glomerular filtration rate measurements are needed to determine the long-term implications of normoalbuminuria and microalbuminuria on kidney function in type II diabetic patients.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Nielsen S,Schmitz A,Rehling M,Mogensen CEdoi
10.2337/diacare.16.11.1427subject
Has Abstractpub_date
1993-11-01 00:00:00pages
1427-32issue
11eissn
0149-5992issn
1935-5548journal_volume
16pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:There is a well-documented gap between diabetes care guidelines and the services received by patients in most health care settings. This report presents 12-month follow-up results from a computer-assisted, patient-centered intervention to improve the level of recommended services patients received from a vari...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.28.1.33
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1711
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.7.912
更新日期:2000-07-01 00:00:00
abstract::We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.3.245
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-1997
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Adopt a multidisciplinary approach to evaluate a virtually supervised home-based high-intensity interval training (Home-HIT) intervention in people with type 1 diabetes. RESEARCH DESIGN AND METHODS:Eleven individuals with type 1 diabetes (seven women; age 30 ± 3 years; [Formula: see text] 2.5 ± 0.2 L/min; du...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0871
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Reduced heart rate variability (HRV) and increased heart rate (HR) have been associated with cardiovascular mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) increase HR, and studies have suggested that they may reduce HRV. We examined the effect of the GLP-1 RA liraglutide on HRV and diurnal v...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-1580
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.621
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To assess the acceptability of specially designed socks to provide satisfactory pressure relief in the insensitive, high-risk, diabetic foot. We have conducted a longitudinal multicenter patient evaluation study to assess the acceptability of such hosiery in neuropathic diabetic patients. RESEARCH DESIGN AND...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.16.8.1190
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:To determine whether the association between depressive symptoms and glycemic control is mediated by blood glucose monitoring (BGM). RESEARCH DESIGN AND METHODS:A total of 276 adolescents with type 1 diabetes (mean age +/- SD, 15.6 +/- 1.4 years) completed a measure of depressive symptoms. Sociodemographic a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-2111
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The present study was designed to assess the effect of magnesium plus zinc, vitamins C plus E, and a combination of these micronutrients on nephropathy indexes in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:In a randomized, double-blind, placebo-controlled clinical trial, 69 type 2 diabetic patient...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.28.10.2458
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS:We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in pl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.8.1150
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To study determinants of incident hyperglycemia in rural Indian mothers 6 years after delivery. RESEARCH DESIGN AND METHODS:The Pune Maternal Nutrition Study collected information in six villages near Pune on prepregnant characteristics and nutrition, physical activity, and glucose tolerance during pregnancy...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-0329
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.1.138
更新日期:2003-01-01 00:00:00
abstract::It would be advantageous to be able to measure glycosylated hemoglobin (GHb) from a sample of blood dried on paper and sent to the physician by the patient. Indeed, such a technique has been introduced by Isolab (Akron, OH). We tested the validity of the method to determine whether applying the blood to paper and imme...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.3.352
更新日期:1987-05-01 00:00:00
abstract::To quantify the association of abnormal glucose tolerance with hypertension and postural hypotension, 2480 men and women aged 50-89 yr from a defined population were evaluated by oral glucose tolerance and measurements of supine, seated, and standing blood pressure. In both sexes, adults with impaired glucose toleranc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.2.119
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:To promote foot screening of inpatients with diabetes, we simplified sensory testing to lightly touching the tips of the first, third, and fifth toes (the Ipswich Touch Test [IpTT]). RESEARCH DESIGN AND METHODS:Respective performances of the IpTT and 10-g monofilament (MF) were compared with a vibration perc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0156
更新日期:2011-07-01 00:00:00
abstract::Our objective was to define glomerular filtration rate (GFR) and renal plasma flow (RPF) in Black Americans with non-insulin-dependent diabetes mellitus (NIDDM). This was a cross-sectional study of 71 Black NIDDM patients with diagnosed diabetes duration from 1 mo to 21 yr. Hyperglycemia was regulated and stabilized b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.11.1186
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:To determine whether increasing doses (amounts) of beta-glucan present in an extruded breakfast cereal affect the glycemic and insulinemic responses in eight NIDDM subjects, compared with the same responses after a continental breakfast (bread, milk, cheese, ham). RESEARCH DESIGN AND METHODS:Breakfast cereal...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.8.831
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc15-1117
更新日期:2015-11-01 00:00:00
abstract::The prevalence of obesity among Hispanic American populations is generally greater than among white populations in the United States. Among Mexican Americans, the prevalence of obesity was higher than among either Cuban Americans or Puerto Ricans. It is well known that the prevalence of diabetes increases with increas...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.7.691
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:To provide an overview of the Department of Veterans Affairs (VA) research activities, highlighting diabetes-related research. RESEARCH DESIGN AND METHODS:Diabetes is an important component of the VA research portfolio. All four VA research services support aspects of diabetes research. VA diabetes research ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.suppl_2.b95
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the Trial...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-2787
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks. RESEARCH DESIGN AND METHODS:A total of 175 eugonadal type 1 diabetic patients (age 32.8 ± 8.4 years) and 151 age- and BMI-matched control subjects (age 32.6 ± 4.5 years) w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0764
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy and safety of prandial Technosphere inhaled insulin (TI), an inhaled insulin with a distinct time action profile, in insulin-naïve type 2 diabetes (T2D) inadequately controlled on oral antidiabetes agents (OADs). RESEARCH DESIGN AND METHODS:Subjects with T2D with HbA1c levels ≥7.5...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc15-0629
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1256
更新日期:2019-07-01 00:00:00
abstract::This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.2
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS:In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.1.95
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc18-0289
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc06-0564
更新日期:2006-11-01 00:00:00