Glycemic control and prevention of retinopathy in Japanese NIDDM patients. A 10-year follow-up study.

abstract：:This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...

journal_title：Diabetes care

authors： Siconolfi-Baez L,Banerji MA,Lebovitz HE

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:The study objective was to describe the effect of socioeconomic status (SES) on mortality among people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a population-based national electronic diabetes database for 35- to 84-year-olds in Scotland for 2001-2007 linked to mortality records. SES was deri...

journal_title：Diabetes care

authors： Walker JJ,Livingstone SJ,Colhoun HM,Lindsay RS,McKnight JA,Morris AD,Petrie JR,Philip S,Sattar N,Wild SH,Scottish Diabetes Research Network Epidemiology Group.

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:We evaluated whether the increasing number of genetic loci for coronary artery disease (CAD) identified in the general population could be used to predict the risk of major CAD events (MCE) among participants with type 2 diabetes at high cardiovascular risk. RESEARCH DESIGN AND METHODS:A weighted genetic ris...

journal_title：Diabetes care

authors： Morieri ML,Gao H,Pigeyre M,Shah HS,Sjaarda J,Mendonca C,Hastings T,Buranasupkajorn P,Motsinger-Reif AA,Rotroff DM,Sigal RJ,Marcovina SM,Kraft P,Buse JB,Wagner MJ,Gerstein HC,Mychaleckyj JC,Parè G,Doria A

更新日期：2018-11-01 00:00:00

abstract：:Japanese migrants and their offspring on the island of Hawaii and Japanese living in Hiroshima were examined for diabetes mellitus and its vascular complications. the same methods and investigators were used in both locations. Death certificates of Japanese and Caucasians dying on the island during the past 26 yr were...

journal_title：Diabetes care

authors： Kawate R,Yamakido M,Nishimoto Y,Bennett PH,Hamman RF,Knowler WC

更新日期：1979-03-01 00:00:00

abstract：:To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

journal_title：Diabetes care

authors： Samad AH,Ty Willing TS,Alberti KG,Taylor R

更新日期：1988-04-01 00:00:00

abstract：:The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

journal_title：Diabetes care

authors： Davis WK,Hess GE,Hiss RG

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Diabetes is one of the most common chronic diseases and a leading cause of morbidity and mortality in the U.S. Although our ability to treat diabetes and its associated complications has significantly improved, presentation with uncontrolled diabetes leading to ketoacidosis remains a significant problem. RES...

journal_title：Diabetes care

authors： Desai D,Mehta D,Mathias P,Menon G,Schubart UK

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the dose-response effects of pioglitazone on glycemic control, insulin sensitivity, and insulin secretion in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 58 diet-treated patients with type 2 diabetes (aged 54 +/- 1 years; 34 men and 24 women; BMI 31.5 +/- 0.6 kg/m(2)) ...

journal_title：Diabetes care

authors： Miyazaki Y,Matsuda M,DeFronzo RA

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Okubo M,Yamakido M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...

journal_title：Diabetes care

authors： Hampp C,Swain RS,Horgan C,Dee E,Qiang Y,Dutcher SK,Petrone A,Chen Tilney R,Maro JC,Panozzo CA

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diag...

journal_title：Diabetes care

authors： Juszczak A,Pavić T,Vučković F,Bennett AJ,Shah N,Pape Medvidović E,Groves CJ,Šekerija M,Chandler K,Burrows C,Rojnić Putarek N,Vučić Lovrenčić M,Ćuća Knežević J,James TJ,Gloyn AL,Lauc G,McCarthy MI,Owen KR,Gornik O

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:This study analyzed the lifetime health care expenditures and life years lost associated with diabetes in the U.S. RESEARCH DESIGN AND METHODS:Data from the National Health Interview Survey (NHIS), the Medical Expenditure Panel Survey from 1997 to 2000, and the NHIS Linked Mortality Public-use Files with a m...

journal_title：Diabetes care

authors： Leung MY,Pollack LM,Colditz GA,Chang SH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes. RESEARCH DESIGN AND METHODS:In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxyge...

journal_title：Diabetes care

authors： Nyström T,James SK,Lindahl B,Östlund O,Erlinge D,Herlitz J,Omerovic E,Mellbin L,Alfredsson J,Fröbert O,Jernberg T,Hofmann R,DETO2X-SWEDEHEART Investigators.

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess fertility in women with type 1 diabetes and the risk of congenital malformations in their offspring. RESEARCH DESIGN AND METHODS:This was a register-based cohort study in Sweden. All 5,978 women hospitalized for type 1 diabetes at age

journal_title：Diabetes care

authors： Jonasson JM,Brismar K,Sparén P,Lambe M,Nyrén O,Ostenson CG,Ye W

更新日期：2007-09-01 00:00:00

abstract：:Secondary failure to oral hypoglycemic agents (OHAs) is a possible outcome for non-insulin-dependent diabetes mellitus (NIDDM) patients and poses a serious therapeutic problem. In this study, we evaluated the effect of adding a single bedtime low-dose NPH insulin injection to the previous ineffective sulfonylurea ther...

journal_title：Diabetes care

authors： Trischitta V,Italia S,Borzi V,Tribulato A,Mazzarino S,Squatrito S,Vigneri R

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:To study the effect of water diuresis on renal medullary and cortical oxygenation in patients with diabetes using blood oxygenation level--dependent magnetic resonance imaging (BOLD MRI). RESEARCH DESIGN AND METHODS:Nine mild diabetic subjects (48 +/- 2.7 years of age, six women) and nine nondiabetic subjec...

journal_title：Diabetes care

authors： Epstein FH,Veves A,Prasad PV

更新日期：2002-03-01 00:00:00

abstract：:Seventeen diabetic subjects requiring insulin and who exhibited glycemic stability over a 9-12-mo control period received 5 g of pectin with each meal and at bedtime for 3 mo. Hemoglobin A1c (HbA1c) and glycosylated serum protein were measured in each patient on multiple occasions to assess glycemic control. No clear-...

journal_title：Diabetes care

authors： Gardner DF,Schwartz L,Krista M,Merimee TJ

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...

journal_title：Diabetes care

authors： Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARD...

journal_title：Diabetes care

authors： Wei GS,Coady SA,Goff DC Jr,Brancati FL,Levy D,Selvin E,Vasan RS,Fox CS

更新日期：2011-04-01 00:00:00

abstract：:Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

journal_title：Diabetes care

authors： Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate whether microalbuminuria or moderately decreased glomerular filtration rate (GFR) is a better predictor for the development and progression of retinopathy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients without cardiovascular diseases, ...

journal_title：Diabetes care

authors： Chen YH,Chen HS,Tarng DC

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The sulfonylurea (SU) glyburide may cause severe and prolonged episodes of hypoglycemia. We aimed at investigating the impact of glyburide on glucose counterregulatory hormones during stepwise hypoglycemic clamp studies. RESEARCH DESIGN AND METHODS:We performed stepwise hypoglycemic clamp studies in 16 healt...

journal_title：Diabetes care

authors： ter Braak EW,Appelman AM,van der Tweel I,Erkelens DW,van Haeften TW

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To estimate the within-person variability (SDi) for the overnight urinary albumin excretion rate (AER) in diabetic patients with persistent microalbuminuria. RESEARCH DESIGN AND METHODS:Thirteen normotensive diabetic patients in stable medical control, with normal renal function and without any associated ca...

journal_title：Diabetes care

authors： Phillipou G,Phillips PJ

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:We conducted a nested case-control investigation to examine whether elevated baseline concentrations of cystatin C predicted progression from normoglycemia to pre-diabetes over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS:In 2002-2004, 1,455 participants from the W...

journal_title：Diabetes care

authors： Donahue RP,Stranges S,Rejman K,Rafalson LB,Dmochowski J,Trevisan M

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...

journal_title：Diabetes care

authors： Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To assess trends in rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in U.S. diabetic and nondiabetic populations and disparities in NLEA rates within the diabetic population. RESEARCH DESIGN AND METHODS:We calculated NLEA hospitalization rates, by diabetes status, among persons ag...

journal_title：Diabetes care

authors： Li Y,Burrows NR,Gregg EW,Albright A,Geiss LS

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. RESEARCH DESIGN AND METHODS:Single 0.2 U/kg doses of insulin lispro and regular insulin...

journal_title：Diabetes care

authors： ter Braak EW,Woodworth JR,Bianchi R,Cerimele B,Erkelens DW,Thijssen JH,Kurtz D

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS:At ba...

journal_title：Diabetes care

authors： Fernandez C,Surma MA,Klose C,Gerl MJ,Ottosson F,Ericson U,Oskolkov N,Ohro-Melander M,Simons K,Melander O

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To assess the frequency and possible risk indicators of severe hypoglycemia in insulin-dependent (type I) diabetic patients with impaired kidney function. RESEARCH DESIGN AND METHODS:Retrospective follow-up examination of case subjects and control subjects with mean follow-up periods of 2.9 and 1.3 yr, respe...

journal_title：Diabetes care

authors： Mühlhauser I,Toth G,Sawicki PT,Berger M

更新日期：1991-04-01 00:00:00