Abstract:
OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood drawn from 2,919 adults aged 74 ± 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were initially administered in 1989 or 1996. Incident DM was defined through 2010 by medication use or blood glucose levels. Risks were assessed by Cox proportional hazards. RESULTS:In biomarker analyses, 287 DM cases occurred during 30,825 person-years. Both t-16:1n9 (extreme quartile hazard ratio 1.59 [95% CI 1.04-2.42], P-trend = 0.04) and t-18:1 (1.91 [1.20-3.03], P-trend = 0.01) levels were associated with higher incident DM after adjustment for de novo lipogenesis fatty acids. In dietary analyses, 407 DM cases occurred during 50,105 person-years. Incident DM was positively associated with consumption of total TFAs (1.38 [1.03-1.86], P-trend = 0.02), t-18:1 (1.32 [1.00-1.76], P-trend = 0.04), and t-18:2 (1.41 [1.05-1.89], P-trend = 0.02). After further adjustment for other dietary habits, however, the associations of estimated dietary TFA with DM were attenuated, and only nonsignificant positive trends remained. CONCLUSIONS:Among older adults, plasma phospholipid t-16:1n9 and t-18:1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian Ddoi
10.2337/dc14-2101subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1099-107issue
6eissn
0149-5992issn
1935-5548pii
dc14-2101journal_volume
38pub_type
杂志文章,多中心研究,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract::OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc09-0455
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determine...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.11.1796
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To study how type 2 diabetes adversely affects brain volumes, changes in volume, and cognitive function. RESEARCH DESIGN AND METHODS:Regional brain volumes and ischemic lesion volumes in 1,366 women, aged 72-89 years, were measured with structural brain magnetic resonance imaging (MRI). Repeat scans were col...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0555
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To provide evidence-based options on how to intensify basal insulin, we explored head-to-head prandial interventions in overweight patients with type 2 diabetes inadequately controlled on basal insulin glargine with or without 1-3 oral antidiabetic agents (OADs). RESEARCH DESIGN AND METHODS:Patients were ran...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-0014
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:The objective of this analysis was to evaluate the impact of several classes of oral antihyperglycemic therapy relative to sulfonylurea monotherapy on all-cause mortality among a cohort of patients with diabetes from the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:A retrospective cohort...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2272
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-0669
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To examine trends in diabetes prevalence in the U.S. RESEARCH DESIGN AND METHODS:This study was conducted via telephone surveys in states that participated in the Behavioral Risk Factor Surveillance System between 1990 and 1998. The participants consisted of noninstitutionalized adults aged 18 years or older...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.9.1278
更新日期:2000-09-01 00:00:00
abstract::Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.3.258
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to identify predictors of the onset of disturbed eating behavior (DEB) in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective study, participants completed the Children's Eating Disorder Examination interview and self-report measures at baselin...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0333
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Evaluate the efficacy and safety of the dual sodium-glucose cotransporter 1 (SGLT1) and SGLT2 inhibitor sotagliflozin in combination with optimized insulin in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The inTandem1 trial, a double-blind, 52-week phase 3 trial, randomized North American adults with T...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc18-0343
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:The relationship between coronary endothelial function and insulin resistance remains speculative. We sought to determine whether pioglitazone, an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist, improves cardiac endothelial function in individuals with type 2 diabetes. RE...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.5.1145
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Patients were randomly assigned to three groups and received pl...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-1589
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0630
更新日期:2020-11-01 00:00:00
abstract::Two insulin-dependent diabetic subjects treated with pork and beef insulin during a period of 6 mo developed severe local reactions. Both patients had an important allergic history (asthma, urticaria, drug reactions, rhinitis). Skin-testing revealed type I allergy to beef and pork insulin. Specific IgE-insulin binding...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.2.s168
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and incidence of diabetes in Alaska Natives and the incidence of cerebrovascular accidents (stroke), myocardial infarction (MI), end-stage renal disease (ESRD), lower-extremity amputations (LEA), and mortality over a 6- to 8-year period. RESEARCH DESIGN AND METHODS:The data derive...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.3.314
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:Women exhibit exaggerated renal hemodynamic responses to hyperglycemia, which may promote kidney disease progression. Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus. R...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1305
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes. RESEARCH DESIGN AND METHODS:We performed a nested case-control study from the EURODIAB Prospective Complications St...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.7.2165
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:We examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS:Between 1989 and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-0137
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.7.1751
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late-gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age). RESEARCH DESIGN AND METHODS:The relationships between morning nonfasting TG measured early ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.12.1550
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.5.386
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:The current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non-intensive care unit (ICU) hospital setting. RESEARCH DESIGN AND METHODS:A total of 110 adults with typ...
journal_title:Diabetes care
pub_type: 评论,杂志文章
doi:10.2337/dc20-1016
更新日期:2020-11-01 00:00:00
abstract::This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.3.2
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.12.2043
更新日期:2001-12-01 00:00:00
abstract::Third-party reimbursement for outpatient education services and for new health care technologies in diabetes is an issue of concern to educators, administrators, and others in the diabetes health care system. Reimbursement for outpatient education has been obtained from 11 Blue Cross/Blue Shield plans in nine states, ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.3.291
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes. RESEARCH DESIGN AND METHODS:We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.26.4.1277
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS:We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI abov...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-2331
更新日期:2017-05-01 00:00:00
abstract::In this study, 18 type I (insulin-dependent) diabetic subjects aged 22-35 yr (mean age 29.3) and within 10 yr of diagnosis (mean 7.7) performed a battery of cognitive and psychomotor tasks under conditions of hypoglycemia (50 mg/dl), normoglycemia (100 mg/dl), and hyperglycemia (300 mg/dl). Blood glucose levels during...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.3.193
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:Microalbuminuria can reflect the progress of microvascular complications and may be predictive of macrovascular disease in type 2 diabetes. The effect of intensive glycemic control on microalbuminuria in patients in the U.S. who have had type 2 diabetes for several years has not previously been evaluated. RE...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.23.10.1478
更新日期:2000-10-01 00:00:00