Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.


OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood drawn from 2,919 adults aged 74 ± 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were initially administered in 1989 or 1996. Incident DM was defined through 2010 by medication use or blood glucose levels. Risks were assessed by Cox proportional hazards. RESULTS:In biomarker analyses, 287 DM cases occurred during 30,825 person-years. Both t-16:1n9 (extreme quartile hazard ratio 1.59 [95% CI 1.04-2.42], P-trend = 0.04) and t-18:1 (1.91 [1.20-3.03], P-trend = 0.01) levels were associated with higher incident DM after adjustment for de novo lipogenesis fatty acids. In dietary analyses, 407 DM cases occurred during 50,105 person-years. Incident DM was positively associated with consumption of total TFAs (1.38 [1.03-1.86], P-trend = 0.02), t-18:1 (1.32 [1.00-1.76], P-trend = 0.04), and t-18:2 (1.41 [1.05-1.89], P-trend = 0.02). After further adjustment for other dietary habits, however, the associations of estimated dietary TFA with DM were attenuated, and only nonsignificant positive trends remained. CONCLUSIONS:Among older adults, plasma phospholipid t-16:1n9 and t-18:1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.


Diabetes Care


Diabetes care


Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D




Has Abstract


2015-06-01 00:00:00














  • Diastolic function is reduced in adolescents with type 1 diabetes in response to exercise.

    abstract:OBJECTIVE:To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCH DESIGN AND METHODS:The study evaluated 53 adolescents with type 1 diabetes and 22 contro...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Gusso S,Pinto TE,Baldi JC,Robinson E,Cutfield WS,Hofman PL

    更新日期:2012-10-01 00:00:00

  • Risk and recurrence of serious adverse outcomes in the first and second pregnancies of women with preexisting diabetes.

    abstract:OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Tennant PW,Bilous RW,Prathapan S,Bell R

    更新日期:2015-04-01 00:00:00

  • The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis.

    abstract:OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Maser RE,Mitchell BD,Vinik AI,Freeman R

    更新日期:2003-06-01 00:00:00

  • Familial aggregation of medial arterial calcification in Pima Indians with and without diabetes.

    abstract:OBJECTIVE:Little is known about medial arterial calcification (MAC) other than its association with age, sex, diabetes, and diabetes complications. Familial aggregation of this disorder was studied to determine the importance of potential genetic factors and to assess whether such familial aggregation was independent o...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Narayan KM,Pettitt DJ,Hanson RL,Bennett PH,Fernandes RJ,De Courten M,Rose FA,Knowler WC

    更新日期:1996-09-01 00:00:00

  • Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Campbell-Thompson ML,Filipp SL,Grajo JR,Nambam B,Beegle R,Middlebrooks EH,Gurka MJ,Atkinson MA,Schatz DA,Haller MJ

    更新日期:2019-02-01 00:00:00

  • Using Indirect Measures to Identify Geographic Hot Spots of Poor Glycemic Control: Cross-sectional Comparisons With an A1C Registry.

    abstract:OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee DC,Jiang Q,Tabaei BP,Elbel B,Koziatek CA,Konty KJ,Wu WY

    更新日期:2018-07-01 00:00:00

  • Primary prevention of diabetes mellitus.

    abstract::Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Zimmet PZ

    更新日期:1988-03-01 00:00:00

  • Clinical evaluation of a personalized artificial pancreas.

    abstract:OBJECTIVE:An artificial pancreas (AP) that automatically regulates blood glucose would greatly improve the lives of individuals with diabetes. Such a device would prevent hypo- and hyperglycemia along with associated long- and short-term complications as well as ease some of the day-to-day burden of frequent blood gluc...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Dassau E,Zisser H,Harvey RA,Percival MW,Grosman B,Bevier W,Atlas E,Miller S,Nimri R,Jovanovic L,Doyle FJ 3rd

    更新日期:2013-04-01 00:00:00

  • The diagnosis of gestational diabetes.

    abstract::The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Coustan DR,Carpenter MW

    更新日期:1998-08-01 00:00:00

  • Increased urinary endothelin-1-like immunoreactivity excretion in NIDDM patients with albuminuria.

    abstract:OBJECTIVE:To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS:Urinary ET-1-LI substance was determined by radioimmunoa...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee YJ,Shin SJ,Tsai JH

    更新日期:1994-04-01 00:00:00

  • Plasma adiponectin and endogenous glucose production in humans.

    abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

    更新日期:2003-12-01 00:00:00

  • Insulin gene mutations as cause of diabetes in children negative for five type 1 diabetes autoantibodies.

    abstract:OBJECTIVE:Heterozygous, gain-of-function mutations of the insulin gene can cause permanent diabetes with onset ranging from the neonatal period through adulthood. The aim of our study was to screen for the insulin gene in patients who had been clinically classified as type 1 diabetic but who tested negative for type 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bonfanti R,Colombo C,Nocerino V,Massa O,Lampasona V,Iafusco D,Viscardi M,Chiumello G,Meschi F,Barbetti F

    更新日期:2009-01-01 00:00:00

  • Altered postprandial insulin requirement in IDDM patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of gastric emptying on postprandial insulin requirement in insulin-dependent diabetes mellitus (IDDM) patients with and without gastroparesis. RESEARCH DESIGN AND METHODS:Postprandial insulin requirement and gastric emptying were simultaneously evaluated in five IDDM patients with gast...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Ishii M,Nakamura T,Kasai F,Onuma T,Baba T,Takebe K

    更新日期:1994-08-01 00:00:00

  • Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.

    abstract::Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin secretory defects ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Mudaliar S,Polidori D,Zambrowicz B,Henry RR

    更新日期:2015-12-01 00:00:00

  • Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM.

    abstract:OBJECTIVE:To clarify the relationship between the angiotensin I-converting enzyme (ACE) gene polymorphism and diabetic micro- and macroangiopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:We examined 267 NIDDM patients with various stages of diabetic retinopathy, 61 ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fujisawa T,Ikegami H,Shen GQ,Yamato E,Takekawa K,Nakagawa Y,Hamada Y,Ueda H,Rakugi H,Higaki J

    更新日期:1995-07-01 00:00:00

  • Clinical impact of prandial state, exercise, and site preparation on the equivalence of alternative-site blood glucose testing.

    abstract:OBJECTIVE:To determine whether clinically significant differences exist in fasting blood glucose (BG) at the forearm, palm, and thigh relative to the fingertip; to assess the impact of prandial status by comparing BG between alternative sites and the fingertip at several time intervals after carbohydrate intake; to ass...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bina DM,Anderson RL,Johnson ML,Bergenstal RM,Kendall DM

    更新日期:2003-04-01 00:00:00

  • Insulin resistance syndrome in the elderly: assessment of functional, biochemical, metabolic, and inflammatory status.

    abstract:OBJECTIVE:Hyperinsulinemic euglycemia, or insulin resistance syndrome (IRS), is associated with increased morbidity and mortality. Although thought to be associated with proinflammatory states, little work has been done in this area. Here, we determined the impact of IRS on functional, biochemical, metabolic, and infla...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Banks WA,Willoughby LM,Thomas DR,Morley JE

    更新日期:2007-09-01 00:00:00

  • Glucose Variability in a 26-Week Randomized Comparison of Mealtime Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants With Type 2 Diabetes at High Cardiovascular Risk.

    abstract:OBJECTIVE:A1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while ma...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: FLAT-SUGAR Trial Investigators.

    更新日期:2016-06-01 00:00:00

  • Transient neonatal diabetes, ZFP57, and hypomethylation of multiple imprinted loci: a detailed follow-up.

    abstract:OBJECTIVE:Transient neonatal diabetes mellitus 1 (TNDM1) is the most common cause of diabetes presenting at birth. Approximately 5% of the cases are due to recessive ZFP57 mutations, causing hypomethylation at the TNDM locus and other imprinted loci (HIL). This has consequences for patient care because it has impact on...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Boonen SE,Mackay DJ,Hahnemann JM,Docherty L,Grønskov K,Lehmann A,Larsen LG,Haemers AP,Kockaerts Y,Dooms L,Vu DC,Ngoc CT,Nguyen PB,Kordonouri O,Sundberg F,Dayanikli P,Puthi V,Acerini C,Massoud AF,Tümer Z,Temple IK

    更新日期:2013-03-01 00:00:00

  • Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial.

    abstract:OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Wing RR,Espeland MA,Clark JM,Hazuda HP,Knowler WC,Pownall HJ,Unick J,Wadden T,Wagenknecht L,Action for Health in Diabetes (Look AHEAD) Study Group.

    更新日期:2016-08-01 00:00:00

  • Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects.

    abstract:OBJECTIVE:There is enough evidence that physical activity is an effective therapeutic tool in the management of type 2 diabetes. The present study was designed to validate a counseling strategy that could be used by physicians in their daily outpatient practice to promote the adoption and maintenance of physical activi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Di Loreto C,Fanelli C,Lucidi P,Murdolo G,De Cicco A,Parlanti N,Santeusanio F,Brunetti P,De Feo P

    更新日期:2003-02-01 00:00:00

  • U-500 regular insulin: clinical experience and pharmacokinetics in obese, severely insulin-resistant type 2 diabetic patients.

    abstract:OBJECTIVE:To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study,...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Davidson MB,Navar MD,Echeverry D,Duran P

    更新日期:2010-02-01 00:00:00

  • Plasma leptin concentrations in Pima Indians living in drastically different environments.

    abstract:OBJECTIVE:Plasma leptin, an important signal for the regulation of energy stores, is known to be influenced by many hormonal factors, but may also be affected by behavioral and environmental factors. The purpose of this study was to investigate the impact of lifestyle (diet composition, level of physical activity) on p...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fox C,Esparza J,Nicolson M,Bennett PH,Schulz LO,Valencia ME,Ravussin E

    更新日期:1999-03-01 00:00:00

  • Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.

    abstract:OBJECTIVE:Visfatin is a novel adipokine that is predominantly secreted by visceral adipose tissue. Accumulation of visceral adipose tissue is also associated with iron metabolism. Despite the coincidence of visfatin expression in iron-rich tissues, no study has investigated the possible interaction of visfatin with par...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fernández-Real JM,Moreno JM,Chico B,López-Bermejo A,Ricart W

    更新日期:2007-03-01 00:00:00

  • Changes in diabetes self-care behaviors make a difference in glycemic control: the Diabetes Stages of Change (DiSC) study.

    abstract:OBJECTIVE:This study compared diabetes Treatment As Usual (TAU) with Pathways To Change (PTC), an intervention developed from the Transtheoretical Model of Change (TTM), to determine whether the PTC intervention would result in greater readiness to change, greater increases in self-care, and improved diabetes control. ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones H,Edwards L,Vallis TM,Ruggiero L,Rossi SR,Rossi JS,Greene G,Prochaska JO,Zinman B,Diabetes Stages of Change (DiSC) Study.

    更新日期:2003-03-01 00:00:00

  • Association of pretransplant glycemic control with posttransplant outcomes in diabetic kidney transplant recipients.

    abstract:OBJECTIVE:Observational studies have yielded inconsistent findings regarding the association of hemoglobin A(1c) (HbA(1c)) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear....

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Molnar MZ,Huang E,Hoshino J,Krishnan M,Nissenson AR,Kovesdy CP,Kalantar-Zadeh K

    更新日期:2011-12-01 00:00:00

  • Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study.

    abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Volpato S,Ferrucci L,Blaum C,Ostir G,Cappola A,Fried LP,Fellin R,Guralnik JM

    更新日期:2003-01-01 00:00:00

  • Association of Maternal Folate and Vitamin B12 in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study.

    abstract:OBJECTIVE:To investigate the association of folate and vitamin B12 in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS:The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vita...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Chen X,Zhang Y,Chen H,Jiang Y,Wang Y,Wang D,Li M,Dou Y,Sun X,Huang G,Yan W

    更新日期:2021-01-01 00:00:00

  • Increased foot pressures after great toe amputation in diabetes.

    abstract:OBJECTIVE:To compare peak pressures on the sole of the foot in non-insulin-dependent diabetic patients with isolated, unilateral amputations of the great toe and first metatarsal with the patients' contralateral, intact foot. RESEARCH DESIGN AND METHODS:Eleven patients with a unilateral great toe and partial first met...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lavery LA,Lavery DC,Quebedeax-Farnham TL

    更新日期:1995-11-01 00:00:00

  • Nonadherence to Insulin Therapy Detected by Bluetooth-Enabled Pen Cap Is Associated With Poor Glycemic Control.

    abstract:OBJECTIVE:To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS:Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections pe...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Munshi MN,Slyne C,Greenberg JM,Greaves T,Lee A,Carl S,Atakov-Castillo A,Toschi E

    更新日期:2019-06-01 00:00:00