Blood pressure and the risk of developing diabetes in african americans and whites: ARIC, CARDIA, and the framingham heart study.


OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, and the Framingham Heart Study offspring cohort. Overall, 10,893 participants (57% women; 23% African American) were categorized by baseline blood pressure (normal, prehypertension, hypertension) and examined for incident diabetes (median follow-up 8.9 years). RESULTS:Overall, 14.6% of African Americans and 7.9% of whites developed diabetes. Age-adjusted incidence was increasingly higher across increasing blood pressure groups (P values for trend: <0.05 for African American men; <0.001 for other race-sex groups). After adjustment for age, sex, BMI, fasting glucose, HDL cholesterol, and triglycerides, prehypertension or hypertension (compared with normal blood pressure) was associated with greater risks of diabetes in whites (hazard ratio [HR] for prehypertension: 1.32 [95% CI 1.09-1.61]; for hypertension: 1.25 [1.03-1.53]), but not African Americans (HR for prehypertension: 0.86 [0.63-1.17]; for hypertension: 0.92 [0.70-1.21]). HRs for developing diabetes among normotensive, prehypertensive, and hypertensive African Americans versus normotensive whites were: 2.75, 2.28, and 2.36, respectively (P values <0.001). CONCLUSIONS:In African Americans, higher diabetes incidence among hypertensive individuals may be explained by BMI, fasting glucose, triglyceride, and HDL cholesterol. In whites, prehypertension and hypertension are associated with greater risk of diabetes, beyond that explained by other risk factors. African Americans, regardless of blood pressure, have greater risks of developing diabetes than whites.


Diabetes Care


Diabetes care


Wei GS,Coady SA,Goff DC Jr,Brancati FL,Levy D,Selvin E,Vasan RS,Fox CS




Has Abstract


2011-04-01 00:00:00














  • Reduced heart rate variability among youth with type 1 diabetes: the SEARCH CVD study.

    abstract:OBJECTIVE:This study compared heart rate variability (HRV) parameters in youth with and without type 1 diabetes and explored potential contributors of altered HRV. RESEARCH DESIGN AND METHODS:HRV parameters were measured among 354 youth with type 1 diabetes (mean age 18.8 years, diabetes duration 9.8 years, and mean A...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Jaiswal M,Urbina EM,Wadwa RP,Talton JW,D'Agostino RB Jr,Hamman RF,Fingerlin TE,Daniels S,Marcovina SM,Dolan LM,Dabelea D

    更新日期:2013-01-01 00:00:00

  • Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

    abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

    更新日期:2006-11-01 00:00:00

  • The prevalence of diabetes in a Swedish population of 280,411 inhabitants. A report from the Skaraborg Diabetes Registry.

    abstract:OBJECTIVE:To estimate the prevalence of known diabetes in a Swedish county (Skaraborg) and to evaluate capture-recapture methods for validation of the diabetes prevalence. RESEARCH DESIGN AND METHODS:Four sources were used to find known diabetic patients: 1) the Skaraborg Diabetes Registry (SDR), a case-finding invent...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Berger B,Stenström G,Chang YF,Sundkvist G

    更新日期:1998-04-01 00:00:00

  • Cardiovascular risk factor control among veterans with diabetes: the ambulatory care quality improvement project.

    abstract:OBJECTIVE:To describe the extent to which hyperglycemia, hypertension, and dyslipidemia are currently detected, treated, and controlled in U.S. veterans with diabetes with and without ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS:A cohort of 3,769 veterans who self-reported diabetes and who received all he...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Smith NL,Chen L,Au DH,McDonell M,Fihn SD

    更新日期:2004-05-01 00:00:00

  • Combination insulin-sulfonylurea therapy.

    abstract::Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Lebovitz HE,Pasmantier R

    更新日期:1990-06-01 00:00:00

  • Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy.

    abstract:OBJECTIVE:Raloxifene hydrochloride is a selective estrogen receptor modulator that to date has not been shown to cause hypertriglyceridemia in normal, diabetic, or hypertriglyceridemic women. This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Carr MC,Knopp RH,Brunzell JD,Wheeler BS,Zhu X,Lakshmanan M,Rosen AS,Anderson PW

    更新日期:2005-07-01 00:00:00

  • Racial differences in the correlation between gonadal androgens and serum insulin levels.

    abstract:OBJECTIVE:We previously demonstrated a direct correlation between serum insulin levels and gonadal androgens (testosterone and androstenedione) in a group of obese hyperandrogenic predominantly black women. Subsequent work by others in predominantly white women showed conflicting results. To examine these potentially i...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Kitabchi AE,Imseis RE,Bush AJ,Williams-Cleaves B,Pourmotabbed G

    更新日期:1999-09-01 00:00:00

  • High Blood Pressure and Its Association With Incident Diabetes Over 10 Years in the Korean Genome and Epidemiology Study (KoGES).

    abstract:OBJECTIVE:No prospective, community-based cohort studies have investigated the association between blood pressure and diabetes in Asian ethnicity. We investigated this issue in a 10-year prospective, community-based study of Koreans. RESEARCH DESIGN AND METHODS:We studied whether high blood pressure was associated wit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Cho NH,Kim KM,Choi SH,Park KS,Jang HC,Kim SS,Sattar N,Lim S

    更新日期:2015-07-01 00:00:00

  • Screening for NIDDM in nonpregnant adults. A review of principles, screening tests, and recommendations.

    abstract::The economic burden of diabetes in the U.S. is now more than 90 billion dollars per year (113-115). In the diabetes community, there is a feeling that aggressive measures to detect diabetes in earlier stages may be warranted. Regardless of whether evidence is convincing that there are benefits from early detection of ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Engelgau MM,Aubert RE,Thompson TJ,Herman WH

    更新日期:1995-12-01 00:00:00

  • Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS).

    abstract:OBJECTIVE:The International Diabetes Mellitus Practice Study is a 5-year survey documenting changes in diabetes treatment practice in developing regions. RESEARCH DESIGN AND METHODS:Logistic regression analysis was used to identify factors for achieving A1C <7% in 11,799 patients (1,898 type 1 diabetic and 9,901 type ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Chan JC,Gagliardino JJ,Baik SH,Chantelot JM,Ferreira SR,Hancu N,Ilkova H,Ramachandran A,Aschner P,IDMPS Investigators.

    更新日期:2009-02-01 00:00:00

  • Metformin for obesity in children and adolescents: a systematic review.

    abstract:OBJECTIVE:To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes. RESEARCH DESIGN AND METHODS:We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subj...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Park MH,Kinra S,Ward KJ,White B,Viner RM

    更新日期:2009-09-01 00:00:00

  • Risk Factors for Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis....

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Perkins BA,Bebu I,de Boer IH,Molitch M,Tamborlane W,Lorenzi G,Herman W,White NH,Pop-Busui R,Paterson AD,Orchard T,Cowie C,Lachin JM,Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Com

    更新日期:2019-05-01 00:00:00

  • Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia.

    abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章


    authors: Gold AE,MacLeod KM,Frier BM

    更新日期:1994-07-01 00:00:00

  • Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state.

    abstract::The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Lewis GF,Steiner G

    更新日期:1996-04-01 00:00:00

  • Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study.

    abstract:OBJECTIVE:Improved appetite control, possibly mediated by exaggerated gut peptide responses to eating, may contribute to weight loss after Roux-en-Y gastric bypass (RYGB). This study compared brain responses to food ingestion between post-RYGB (RYGB), normal weight (NW), and obese (Ob) unoperated subjects and explored ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hunt KF,Dunn JT,le Roux CW,Reed LJ,Marsden PK,Patel AG,Amiel SA

    更新日期:2016-10-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.

    abstract:OBJECTIVE:Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metformin and metformin alone-in preserving or improving β-cell function in youth with impaired glucose tolerance (IGT) or recen...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: RISE Consortium.

    更新日期:2018-08-01 00:00:00

  • N-Glycan Profile and Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bermingham ML,Colombo M,McGurnaghan SJ,Blackbourn LAK,Vučković F,Pučić Baković M,Trbojević-Akmačić I,Lauc G,Agakov F,Agakova AS,Hayward C,Klarić L,Palmer CNA,Petrie JR,Chalmers J,Collier A,Green F,Lindsay RS,Macrury S

    更新日期:2018-01-01 00:00:00

  • Effectiveness of a behavioral weight control program for blacks and whites with NIDDM.

    abstract:OBJECTIVE:To compare the weight losses of black and white patients with NIDDM treated in a year-long behavioral weight loss program. RESEARCH DESIGN AND METHODS:Subjects were randomly assigned to a behavioral program that either used a low-calorie diet throughout or included two 12-week periods of a very-low calorie d...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wing RR,Anglin K

    更新日期:1996-05-01 00:00:00

  • Using Indirect Measures to Identify Geographic Hot Spots of Poor Glycemic Control: Cross-sectional Comparisons With an A1C Registry.

    abstract:OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee DC,Jiang Q,Tabaei BP,Elbel B,Koziatek CA,Konty KJ,Wu WY

    更新日期:2018-07-01 00:00:00

  • Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.

    abstract:OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

    更新日期:2000-08-01 00:00:00

  • Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study.

    abstract:OBJECTIVE:Dietary protein is an important modulator of glucose metabolism. However, studies regarding the association between dietary protein intake and gestational diabetes mellitus (GDM) risk are sparse. This study was to examine the association. RESEARCH DESIGN AND METHODS:Our study included 21,457 singleton pregna...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bao W,Bowers K,Tobias DK,Hu FB,Zhang C

    更新日期:2013-07-01 00:00:00

  • Natriuretic peptides, heart, and adipose tissue: new findings and future developments for diabetes research.

    abstract::Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the gener...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Gruden G,Landi A,Bruno G

    更新日期:2014-11-01 00:00:00

  • Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction.

    abstract:OBJECTIVE:To investigate the effects of fenofibrate and coenzyme Q(10) (CoQ) on diastolic function, ambulatory blood pressure (ABP), and heart rate (HR) in type 2 diabetic subjects with left ventricular diastolic dysfunction (LVDD). RESEARCH DESIGN AND METHODS:We randomized, double-blind, 74 subjects to fenofibrate 16...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Chew GT,Watts GF,Davis TM,Stuckey BG,Beilin LJ,Thompson PL,Burke V,Currie PJ

    更新日期:2008-08-01 00:00:00

  • Patients With Diabetes Without Significant Angiographic Coronary Artery Disease Have the Same Risk of Myocardial Infarction as Patients Without Diabetes in a Real-World Population Receiving Appropriate Prophylactic Treatment.

    abstract:OBJECTIVE:The risk of myocardial infarction (MI) in patients with diabetes is greater than for patients without diabetes. Consequently, prophylactic treatment is recommended for patients with diabetes and risk factors for ischemic heart disease. We aimed to estimate the risk of adverse cardiac events in patients with a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Olesen KKW,Madsen M,Egholm G,Thim T,Jensen LO,Raungaard B,Bøtker HE,Sørensen HT,Maeng M

    更新日期:2017-08-01 00:00:00

  • Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii.

    abstract::Japanese migrants and their offspring on the island of Hawaii and Japanese living in Hiroshima were examined for diabetes mellitus and its vascular complications. the same methods and investigators were used in both locations. Death certificates of Japanese and Caucasians dying on the island during the past 26 yr were...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kawate R,Yamakido M,Nishimoto Y,Bennett PH,Hamman RF,Knowler WC

    更新日期:1979-03-01 00:00:00

  • Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus.

    abstract::Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose and insulin profiles in eight subjects with insulin-dependent diabet...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Dimitriadis GD,Gerich JE

    更新日期:1983-07-01 00:00:00

  • Development of stable film test for rapid estimation of blood or plasma 3-hydroxybutyrate.

    abstract::A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Harano Y,Aoki T,Nakajima Y,Kojima H,Kosugi K,Harano A,Hidaka H,Yamada S,Uno S,Shigeta Y

    更新日期:1990-05-01 00:00:00

  • Use of an automated bolus calculator in MDI-treated type 1 diabetes: the BolusCal Study, a randomized controlled pilot study.

    abstract:OBJECTIVE:To investigate the effect of flexible intensive insulin therapy (FIIT) and an automated bolus calculator (ABC) in a Danish type 1 diabetes population treated with multiple daily injections. Furthermore, to test the feasibility of teaching FIIT in a 3-h structured course. RESEARCH DESIGN AND METHODS:The Bolus...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Schmidt S,Meldgaard M,Serifovski N,Storm C,Christensen TM,Gade-Rasmussen B,Nørgaard K

    更新日期:2012-05-01 00:00:00

  • Lowering of plasma glucose concentrations with bezafibrate in patients with moderately controlled NIDDM.

    abstract::The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). The study included 37 NIDDM patients with HbA1 concentrations greater than 8.5% and normal kidney and liver function who were being treated with diet alone or diet...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones IR,Swai A,Taylor R,Miller M,Laker MF,Alberti KG

    更新日期:1990-08-01 00:00:00