Blood pressure and the risk of developing diabetes in african americans and whites: ARIC, CARDIA, and the framingham heart study.


OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, and the Framingham Heart Study offspring cohort. Overall, 10,893 participants (57% women; 23% African American) were categorized by baseline blood pressure (normal, prehypertension, hypertension) and examined for incident diabetes (median follow-up 8.9 years). RESULTS:Overall, 14.6% of African Americans and 7.9% of whites developed diabetes. Age-adjusted incidence was increasingly higher across increasing blood pressure groups (P values for trend: <0.05 for African American men; <0.001 for other race-sex groups). After adjustment for age, sex, BMI, fasting glucose, HDL cholesterol, and triglycerides, prehypertension or hypertension (compared with normal blood pressure) was associated with greater risks of diabetes in whites (hazard ratio [HR] for prehypertension: 1.32 [95% CI 1.09-1.61]; for hypertension: 1.25 [1.03-1.53]), but not African Americans (HR for prehypertension: 0.86 [0.63-1.17]; for hypertension: 0.92 [0.70-1.21]). HRs for developing diabetes among normotensive, prehypertensive, and hypertensive African Americans versus normotensive whites were: 2.75, 2.28, and 2.36, respectively (P values <0.001). CONCLUSIONS:In African Americans, higher diabetes incidence among hypertensive individuals may be explained by BMI, fasting glucose, triglyceride, and HDL cholesterol. In whites, prehypertension and hypertension are associated with greater risk of diabetes, beyond that explained by other risk factors. African Americans, regardless of blood pressure, have greater risks of developing diabetes than whites.


Diabetes Care


Diabetes care


Wei GS,Coady SA,Goff DC Jr,Brancati FL,Levy D,Selvin E,Vasan RS,Fox CS




Has Abstract


2011-04-01 00:00:00














  • Increased urinary endothelin-1-like immunoreactivity excretion in NIDDM patients with albuminuria.

    abstract:OBJECTIVE:To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS:Urinary ET-1-LI substance was determined by radioimmunoa...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee YJ,Shin SJ,Tsai JH

    更新日期:1994-04-01 00:00:00

  • Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM patients.

    abstract:OBJECTIVE:To explore the hypothesis that a relationship exists between free radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND METHODS:The use of the total radical-trapping antioxidant parameter (TRAP) has very recently been proposed to explore the antioxidant property of a plasma and their...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ceriello A,Bortolotti N,Pirisi M,Crescentini A,Tonutti L,Motz E,Russo A,Giacomello R,Stel G,Taboga C

    更新日期:1997-10-01 00:00:00

  • Incidence of type 1 diabetes in Lithuanians aged 0-39 years varies by the urban-rural setting, and the time change differs for men and women during 1991-2000.

    abstract:OBJECTIVE:Type 1 diabetes has been associated with factors related to welfare and social class. During the past decade, Lithuania has experienced a transition period, leading to dramatic changes in the socioeconomic structure of the society. RESEARCH DESIGN AND METHODS:Incidence in the group aged 0-39 years by urban-r...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Pundziute-Lyckå A,Urbonaite B,Ostrauskas R,Zalinkevicius R,Dahlquist GG

    更新日期:2003-03-01 00:00:00

  • Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS:We searched MEDLINE and EMBASE databases through August 2015. We conducted a q...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审


    authors: Guasch-Ferré M,Hruby A,Toledo E,Clish CB,Martínez-González MA,Salas-Salvadó J,Hu FB

    更新日期:2016-05-01 00:00:00

  • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

    abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Matsuda M,DeFronzo RA

    更新日期:1999-09-01 00:00:00

  • Plasma adiponectin and endogenous glucose production in humans.

    abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

    更新日期:2003-12-01 00:00:00

  • Impact of diabetes among revascularized patients in Japan and the U.S.

    abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kohsaka S,Goto M,Nagai T,Lee VV,Elayda M,Furukawa Y,Fukushima M,Komeda M,Sakata R,Ohsugi M,Fukuda K,Wilson JM,Kita T,Kimura T

    更新日期:2012-03-01 00:00:00

  • Closing the gap: the problem of diabetes mellitus in the United States. The Carter Center of Emory University.

    abstract::Diabetes mellitus is a major public health problem and a leading cause of death, disability, and cost in the United States. We review the epidemiology of diabetes and its complications, the costs of diabetes, and discuss intervention strategies to reduce the burden of diabetes in the United States. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审



    更新日期:1985-07-01 00:00:00

  • Absence of adverse effects of severe hypoglycemia on cognitive function in school-aged children with diabetes over 18 months.

    abstract:OBJECTIVE:Some children with type 1 diabetes may be at risk of cognitive impairments, but mechanisms of this effect have not been confirmed. The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months. RESEARCH DESIG...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Wysocki T,Harris MA,Mauras N,Fox L,Taylor A,Jackson SC,White NH

    更新日期:2003-04-01 00:00:00

  • Impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes.

    abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ly TT,Gallego PH,Davis EA,Jones TW

    更新日期:2009-10-01 00:00:00

  • Differential association between biomarkers of subclinical inflammation and painful polyneuropathy: results from the KORA F4 study.

    abstract:OBJECTIVE:Inflammatory processes have been implicated in the pathogenesis of painful neuropathy in rodents, but the relationship between inflammatory biomarkers and painful distal sensorimotor polyneuropathy (DSPN) has not been assessed in population-based studies. Therefore, we investigated whether circulating levels ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Herder C,Bongaerts BW,Rathmann W,Heier M,Kowall B,Koenig W,Thorand B,Roden M,Meisinger C,Ziegler D

    更新日期:2015-01-01 00:00:00

  • A biethnic community survey of cognition in participants with type 2 diabetes, impaired glucose tolerance, and normal glucose tolerance: the New Mexico Elder Health Survey.

    abstract:OBJECTIVE:To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lindeman RD,Romero LJ,LaRue A,Yau CL,Schade DS,Koehler KM,Baumgartner RN,Garry PJ,New Mexico Elder Health Survey.

    更新日期:2001-09-01 00:00:00

  • Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial.

    abstract:OBJECTIVE:To compare the efficacy and safety of once-weekly semaglutide 1.0 mg s.c. with exenatide extended release (ER) 2.0 mg s.c. in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS:In this phase 3a, open-label, parallel-group, randomized controlled trial, 813 subjects with type 2 diabetes taking oral ant...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ahmann AJ,Capehorn M,Charpentier G,Dotta F,Henkel E,Lingvay I,Holst AG,Annett MP,Aroda VR

    更新日期:2018-02-01 00:00:00

  • Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes.

    abstract:OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: White NH,Chase HP,Arslanian S,Tamborlane WV,4030 Study Group.

    更新日期:2009-03-01 00:00:00

  • Clinical evaluation of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers.

    abstract:OBJECTIVE:To evaluate the utility of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS:Nineteen subjects with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) and foot ulcers were randomly assig...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Blackman JD,Senseng D,Quinn L,Mazzone T

    更新日期:1994-04-01 00:00:00

  • Comparison of the effects of three insulinotropic drugs on plasma insulin levels after a standard meal.

    abstract:OBJECTIVE:To compare the effects of repaglinide, glipizide, and glibenclamide on insulin secretion and postprandial glucose after a single standard 500-kcal test meal. RESEARCH DESIGN AND METHODS:A total of 12 type 2 diabetic patients with early diabetes (mean HbA(1c) of 6.1%) and 12 matched control subjects were enro...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Cozma LS,Luzio SD,Dunseath GJ,Langendorg KW,Pieber T,Owens DR

    更新日期:2002-08-01 00:00:00

  • Does knowing one's elevated glycemic status make a difference in macronutrient intake?

    abstract:OBJECTIVE:To determine whether macronutrient intake differs by awareness of glycemic status among people with diabetes and prediabetes. RESEARCH DESIGN AND METHODS:We used 24-h dietary recall and other data from 3,725 nonpregnant adults with diabetes or prediabetes aged ≥20 years from the morning fasting sample of the...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bardenheier BH,Cogswell ME,Gregg EW,Williams DE,Zhang Z,Geiss LS

    更新日期:2014-12-01 00:00:00

  • Repaglinide/troglitazone combination therapy: improved glycemic control in type 2 diabetes.

    abstract:OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Raskin P,Jovanovic L,Berger S,Schwartz S,Woo V,Ratner R

    更新日期:2000-07-01 00:00:00

  • Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.

    abstract:OBJECTIVE:The objective of this study was to examine the associations between the severity of hepatic steatosis and dyslipidemia in type 2 diabetes, including circulating apolipoprotein B100 (apoB) concentrations and lipoprotein particle size and numbers. RESEARCH DESIGN AND METHODS:Computed tomography imaging was use...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Toledo FG,Sniderman AD,Kelley DE

    更新日期:2006-08-01 00:00:00

  • The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue.

    abstract:OBJECTIVE:The sympathetic nervous system and thiazolidinediones control lipid metabolism and have been implicated in body weight regulation. This study was conducted to determine whether the simultaneous activation of these two signaling systems might synergize to exert beneficial effects on the expression of key genes...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Bogacka I,Gettys TW,de Jonge L,Nguyen T,Smith JM,Xie H,Greenway F,Smith SR

    更新日期:2007-05-01 00:00:00

  • Decreased polymorphonuclear leukocyte deformability in NIDDM.

    abstract:OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Pécsvarády Z,Fisher TC,Darwin CH,Fabók A,Maqueda TS,Saad MF,Meiselman HJ

    更新日期:1994-01-01 00:00:00

  • Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study.

    abstract:OBJECTIVE:To assess the efficacy of a lifestyle intervention program that can be readily translated into clinical practice for obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The study consisted of a 12-month randomized controlled trial of 147 health plan members with type 2 diabetes and obesity (BMI ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf AM,Conaway MR,Crowther JQ,Hazen KY,L Nadler J,Oneida B,Bovbjerg VE,Improving Control with Activity and Nutrition (ICAN) Study.

    更新日期:2004-07-01 00:00:00

  • Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study.

    abstract:OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Hanley AJ,Wagenknecht LE,Festa A,D'Agostino RB Jr,Haffner SM

    更新日期:2007-07-01 00:00:00

  • Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S.

    abstract:OBJECTIVE:The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group-specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this syndrome using the IDF definition a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ford ES

    更新日期:2005-11-01 00:00:00

  • Risk Factors for Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis....

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Perkins BA,Bebu I,de Boer IH,Molitch M,Tamborlane W,Lorenzi G,Herman W,White NH,Pop-Busui R,Paterson AD,Orchard T,Cowie C,Lachin JM,Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Com

    更新日期:2019-05-01 00:00:00

  • The dynamics of diabetes among birth cohorts in the U.S.

    abstract::OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated trends in diabetes prevalence across cohorts born 1910-1989 and provide the first estimates of age-specific diabetes incidence using nationally representative, measured data. RESEARCH DESIGN AND METHOD...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fishman EI,Stokes A,Preston SH

    更新日期:2014-04-01 00:00:00

  • Anaphylaxis and immunologic insulin resistance in a diabetic woman with ketoacidosis.

    abstract::A diabetic woman presented with diabetic ketoacidosis after demonstrating immediate-type hypersensitivity to heterologous insulin. She had had interrupted insulin therapy in the past. Insulin requirements during the course of treatment for the acidosis suggested marked resistance, with 50,000 U of insulin needed in th...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ross JM,Murali MR,DeLara TC,Cheron RG

    更新日期:1984-05-01 00:00:00

  • Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study.

    abstract:OBJECTIVE:Transforming growth factor (TGF)-beta1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. We sought to examine the role of both urinary and circulating T...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Chaturvedi N,Schalkwijk CG,Abrahamian H,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期:2002-12-01 00:00:00

  • Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes.

    abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Hägg S,Thorn LM,Putaala J,Liebkind R,Harjutsalo V,Forsblom CM,Gordin D,Tatlisumak T,Groop PH,FinnDiane Study Group.

    更新日期:2013-12-01 00:00:00

  • Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study).

    abstract:OBJECTIVE:Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregest...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Knorr S,Bytoft B,Lohse Z,Boisen AB,Clausen TD,Jensen RB,Damm P,Beck-Nielsen H,Holst JJ,Hartmann B,Møller HJ,Højlund K,Gravholt CH,Jensen DM

    更新日期:2019-08-01 00:00:00