Effects of BAYm 1099, new alpha-glucosidase inhibitor, on acute metabolic responses and metabolic control in NIDDM over 1 mo.

abstract：OBJECTIVE:To determine serum lipoprotein(a) in a large sample of IDDM and control children and to examine a possible association with puberty. RESEARCH DESIGN AND METHODS:Serum lipoprotein(a), apoB-100, and apoA-I were measured under identical conditions in 170 Caucasian children with IDDM aged 12.3 +/- 3.59 yr and 23...

journal_title：Diabetes care

authors： Couper JJ,Bates DJ,Cocciolone R,Magarey AM,Boulton TJ,Penfold JL,Ryall RG

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:To review the current knowledge about nonpharmacologic approaches in the prevention and early treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS:This study reviewed the research reports dealing with nonpharmacologic interventions aimed at preventing type 2 diabetes with early lifestyle interventions. ...

journal_title：Diabetes care

authors： Tuomilehto J

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:High triglyceride (TG) levels and low HDL cholesterol (HDL-C) levels are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL cholesterol (LDL-C) level. RESEARCH DESIGN AND METHODS:We studied 3,216 participants (40% men, 41% with diab...

journal_title：Diabetes care

authors： Lee JS,Chang PY,Zhang Y,Kizer JR,Best LG,Howard BV

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

journal_title：Diabetes care

authors： Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis. RESEARCH DESIGN AND METHODS:We cross-sectionally studied 849 Japanese men aged 50.3 +/- 8.5 years (range 20-78) with BMI 23.5 +/- 2.9 kg/m(2). Intimal-medial thickness ...

journal_title：Diabetes care

authors： Takami R,Takeda N,Hayashi M,Sasaki A,Kawachi S,Yoshino K,Takami K,Nakashima K,Akai A,Yamakita N,Yasuda K

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

journal_title：Diabetes care

authors： Sharp LK,Lipsky MS

更新日期：1999-12-01 00:00:00

abstract：:Serum immunoglobulin (G, A, M) levels were performed on 66 patients with non-insulin-dependent (type II) diabetes mellitus (NIDDM). When compared with 30 age-matched normal controls and 32 hospitalized controls there was no significant difference between the mean IgG and IgM levels. The IgA levels were significantly h...

journal_title：Diabetes care

authors： Gill CW,Bush WS,Burleigh WM,Cooke-Gomes D

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVE:In recent years, a growing number of people with type 1 diabetes gained access to real-time continuous glucose monitoring (rtCGM). Long-term benefits of rtCGM are unclear because of a lack of large studies of long duration. We evaluated whether real-world rtCGM use up to 24 months offered benefits, particular...

journal_title：Diabetes care

authors： Charleer S,De Block C,Nobels F,Radermecker RP,Lowyck I,Mullens A,Scarnière D,Spincemaille K,Strivay M,Weber E,Taes Y,Vercammen C,Keymeulen B,Mathieu C,Gillard P,RESCUE Trial Investigators.

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome R...

journal_title：Diabetes care

authors： Dhatariya K,Bain SC,Buse JB,Simpson R,Tarnow L,Kaltoft MS,Stellfeld M,Tornøe K,Pratley RE,LEADER Publication Committee on behalf of the LEADER Trial Investigators.

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

journal_title：Diabetes care

authors： Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To assess the additional effect of sudden visceral fat reduction by omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in patients with grade III obesity (G-III O) undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB). RESEARCH DESIGN AND METHODS:Twenty-two patients were ...

journal_title：Diabetes care

authors： Herrera MF,Pantoja JP,Velázquez-Fernández D,Cabiedes J,Aguilar-Salinas C,García-García E,Rivas A,Villeda C,Hernández-Ramírez DF,Dávila A,Zaraín A

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Large prospective studies have demonstrated that optimum glycemic control is not routinely achieved in clinical practice. Barriers to optimal insulin therapy include hypoglycemia, weight gain, and suboptimal initiation and dose titration. This study compared two treatment algorithms for insulin glargine initi...

journal_title：Diabetes care

authors： Davies M,Storms F,Shutler S,Bianchi-Biscay M,Gomis R,ATLANTUS Study Group.

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Diagnostic criteria in fulminant type 1 diabetes, a novel subtype of type 1 diabetes, remain unclear. RESEARCH DESIGN AND METHODS:We analyzed basal and longitudinal changes of serum C-peptide levels during a 75-g oral glucose tolerance test (OGTT) in 125 consecutively recruited patients with type 1 diabetes ...

journal_title：Diabetes care

authors： Tanaka S,Endo T,Aida K,Shimura H,Yokomori N,Kaneshige M,Furuya F,Amemiya S,Mochizuki M,Nakanishi K,Kobayashi T

更新日期：2004-08-01 00:00:00

abstract：:Insulin resistance is the cornerstone for the development of non-insulin-dependent diabetes mellitus (NIDDM). Free fatty acids (FFAs) cause insulin resistance in muscle and liver and increase hepatic gluconeogenesis and lipoprotein production and perhaps decrease hepatic clearance of insulin. It is suggested that the ...

journal_title：Diabetes care

authors： Björntorp P

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...

journal_title：Diabetes care

authors： Ovalle F,Bell DS

更新日期：2004-11-01 00:00:00

abstract：:This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...

journal_title：Diabetes care

authors： Tonino RP,Minaker KL,Rowe JW

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...

journal_title：Diabetes care

authors： Li R,Zhang P,Barker LE,Hoerger TJ

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600...

journal_title：Diabetes care

authors： Tuccori M,Wu JW,Yin H,Majdan A,Azoulay L

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Treatment guidelines for diabetes have become increasingly stringent as most research shows that more aggressive intervention reduces the risks for complications. Community data on the effect of these interventions are lacking. RESEARCH DESIGN AND METHODS:Changes in the pharmacologic treatment of diabetes, b...

journal_title：Diabetes care

authors： Looker HC,Krakoff J,Andre V,Kobus K,Nelson RG,Knowler WC,Hanson RL

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:This study describes changes in the distribution of cigarette smoking and in physicians' advice to quit smoking among the U.S. population with and without diabetes from the mid-1970s to 1990. RESEARCH DESIGN AND METHODS:Data on self-reported smoking status, physicians' advice to quit smoking, history of diab...

journal_title：Diabetes care

authors： Malarcher AM,Ford ES,Nelson DE,Chrismon JH,Mowery P,Merritt RK,Herman WH

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To estimate incidence rates of diabetes and associated risk factors among participants of the Strong Heart Study. RESEARCH DESIGN AND METHODS:Of the 4,549 Strong Heart Study participants examined at baseline, 3,638 returned for a similar examination after an average of 4 years. The 1985 World Health Organiza...

journal_title：Diabetes care

authors： Lee ET,Welty TK,Cowan LD,Wang W,Rhoades DA,Devereux R,Go O,Fabsitz R,Howard BV

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To longitudinally characterize changes in insulin sensitivity in obese women during and after pregnancy. RESEARCH DESIGN AND METHODS:Six glucose-tolerant obese women underwent a 4-h euglycemic-hyperinsulinemic (500-600 pmol/l) clamping during the second (22.5 +/- 2 weeks [mean +/- SD]) and third trimester (3...

journal_title：Diabetes care

authors： Sivan E,Chen X,Homko CJ,Reece EA,Boden G

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism is unknown. We examined associations of gestational diabetes mellitus (GDM) not confounded by treatment with childhood glycemia in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RES...

journal_title：Diabetes care

authors： Lowe WL Jr,Scholtens DM,Kuang A,Linder B,Lawrence JM,Lebenthal Y,McCance D,Hamilton J,Nodzenski M,Talbot O,Brickman WJ,Clayton P,Ma RC,Tam WH,Dyer AR,Catalano PM,Lowe LP,Metzger BE,HAPO Follow-up Study Cooperative Res

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A(1c) (HbA(1c)) target of <7% in people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted an ...

journal_title：Diabetes care

authors： Giugliano D,Maiorino MI,Bellastella G,Chiodini P,Ceriello A,Esposito K

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:To determine whether the association between depressive symptoms and glycemic control is mediated by blood glucose monitoring (BGM). RESEARCH DESIGN AND METHODS:A total of 276 adolescents with type 1 diabetes (mean age +/- SD, 15.6 +/- 1.4 years) completed a measure of depressive symptoms. Sociodemographic a...

journal_title：Diabetes care

authors： McGrady ME,Laffel L,Drotar D,Repaske D,Hood KK

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To describe the changes in demographics, antidiabetic treatment, and glycemic control among the prevalent U.S. adult diagnosed type 2 diabetes population between the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and the initial release of NHANES 1999-2000. RESEARCH DESIGN AND METH...

journal_title：Diabetes care

authors： Koro CE,Bowlin SJ,Bourgeois N,Fedder DO

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of coll...

journal_title：Diabetes care

authors： Pilemann-Lyberg S,Rasmussen DGK,Hansen TW,Tofte N,Winther SA,Holm Nielsen S,Theilade S,Karsdal MA,Genovese F,Rossing P

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Yamakido M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To 1) compare associations of diet-quality scores, which were inversely associated with cardiovascular disease, with incident type 2 diabetes and 2) test for differences in absolute-risk reduction across various strata. RESEARCH DESIGN AND METHODS:Men from the Health Professionals Follow-Up Study, who were i...

journal_title：Diabetes care

authors： de Koning L,Chiuve SE,Fung TT,Willett WC,Rimm EB,Hu FB

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Left ventricular remodeling occurs immediately after MI, involving structural changes in noninfarcted segment. However, the residual left ventricular pump function in NIDDM patients after acute MI has not been clarified. The purpose of this study was to evaluate the difference in the process of left ventricul...

journal_title：Diabetes care

authors： Iwasaka T,Takahashi N,Nakamura S,Sugiura T,Tarumi N,Kimura Y,Okubo N,Taniguchi H,Matsui Y,Inada M

更新日期：1992-11-01 00:00:00