A prognostic role of mean 24-h pulse pressure level for cardiovascular events in type 2 diabetic subjects under 60 years of age.

Abstract:

OBJECTIVE:To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS:In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. After excluding 9 dropout subjects, 228 subjects (mean age, 46 years; 69% men; mean follow-up period, 100 months) entered the study. RESULTS:Distribution of 24-h PP for all subjects showed left skewed data, indicating that there may be a diabetic subgroup that had a wide PP. Therefore, further analysis was performed by stratifying the diabetic subjects by quartile of 24-h PP. Outcomes for the widest quartile (n = 58; cut point = 53.3 mmHg) was then compared with those from the other narrower quartiles (n = 170). In the diabetic subjects with a wide PP, cardiovascular events occurred more frequently than those in the diabetic subjects with a narrow one (20.7 vs. 4.1%; P < 0.001), resulting in the significant difference in the cumulative incidence of cardiovascular events (P < 0.001, log-rank test), but not cerebrovascular events, between the two subgroups. The Cox model revealed that a wide 24-h PP at baseline independently predicted subsequent cardiovascular events but not cerebrovascular events. By contrast, only duration of diabetes was the risk factor for cerebrovascular events. CONCLUSIONS:This study showed that a wide 24-h PP is predictive for cardiovascular events in relatively young diabetic subjects.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Nakano S,Konishi K,Furuya K,Uehara K,Nishizawa M,Nakagawa A,Kigoshi T,Uchida K

doi

10.2337/diacare.28.1.95

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

95-100

issue

1

eissn

0149-5992

issn

1935-5548

pii

28/1/95

journal_volume

28

pub_type

杂志文章
  • Increased risk factors for coronary artery disease in Japanese subjects with hyperinsulinemia or glucose intolerance.

    abstract:OBJECTIVE:To understand the interrelationship of coronary artery disease (CAD) risk factors including hyperlipidemia, hypertension, and glucose intolerance to prevent and better manage this disease. RESEARCH DESIGN AND METHODS:We performed a 100-g oral glucose tolerance test in 2,113 subjects, and we evaluated their p...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.2.107

    authors: Yamada N,Yoshinaga H,Sakurai N,Shimano H,Gotoda T,Ohashi Y,Yazaki Y,Kosaka K

    更新日期:1994-02-01 00:00:00

  • Effect of socioeconomic status on mortality among people with type 2 diabetes: a study from the Scottish Diabetes Research Network Epidemiology Group.

    abstract:OBJECTIVE:The study objective was to describe the effect of socioeconomic status (SES) on mortality among people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a population-based national electronic diabetes database for 35- to 84-year-olds in Scotland for 2001-2007 linked to mortality records. SES was deri...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1862

    authors: Walker JJ,Livingstone SJ,Colhoun HM,Lindsay RS,McKnight JA,Morris AD,Petrie JR,Philip S,Sattar N,Wild SH,Scottish Diabetes Research Network Epidemiology Group.

    更新日期:2011-05-01 00:00:00

  • Aspirin use and counseling about aspirin among patients with diabetes.

    abstract:OBJECTIVE:Despite being a safe, effective therapy for lowering cardiovascular risk, only 20% of diabetic patients were using aspirin in the early 1990s. This study examines current physician practices and the use of aspirin therapy by individuals with diabetes. RESEARCH DESIGN AND METHODS:A random sample of diabetic p...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.6.965

    authors: Krein SL,Vijan S,Pogach LM,Hogan MM,Kerr EA

    更新日期:2002-06-01 00:00:00

  • Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects.

    abstract:OBJECTIVE:There is enough evidence that physical activity is an effective therapeutic tool in the management of type 2 diabetes. The present study was designed to validate a counseling strategy that could be used by physicians in their daily outpatient practice to promote the adoption and maintenance of physical activi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.2.404

    authors: Di Loreto C,Fanelli C,Lucidi P,Murdolo G,De Cicco A,Parlanti N,Santeusanio F,Brunetti P,De Feo P

    更新日期:2003-02-01 00:00:00

  • Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial.

    abstract:OBJECTIVE:Glycemic control using inhaled, dry-powder insulin plus a single injection of long-acting insulin was compared with a conventional regimen in patients with type 2 diabetes, which was previously managed with at least two daily insulin injections. RESEARCH DESIGN AND METHODS:Patients were randomized to 6 month...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.27.10.2356

    authors: Hollander PA,Blonde L,Rowe R,Mehta AE,Milburn JL,Hershon KS,Chiasson JL,Levin SR

    更新日期:2004-10-01 00:00:00

  • The clinical pharmacology of human insulin (Novo) in normal subjects.

    abstract::Neutral regular human insulin (Novo) (derived from porcine insulin) and porcine insulin were administered by subcutaneous (s.c.) injection into the anterior abdominal wall in two different groups of six normal male subjects. The insulin dosage was 0.075 IU/kg body wt; diluting medium was used to obtain control values....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Owens DR,Jones MK,Birtwell AJ,Jones IR,Hayes TM,Heding LG

    更新日期:1983-03-01 00:00:00

  • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet.

    abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1765

    authors: Chan DC,Watts GF,Gan SK,Ooi EM,Barrett PH

    更新日期:2010-05-01 00:00:00

  • The effect of oral antidiabetic agents on A1C levels: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Previous reviews of the effect of oral antidiabetic (OAD) agents on A1C levels summarized studies with varying designs and methodological approaches. Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels. RESEARCH DESIGN AND METHODS:The Excerpta Medica (EMBASE), the...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审

    doi:10.2337/dc09-1727

    authors: Sherifali D,Nerenberg K,Pullenayegum E,Cheng JE,Gerstein HC

    更新日期:2010-08-01 00:00:00

  • The action profile of lispro is not blunted by mixing in the syringe with NPH insulin.

    abstract:OBJECTIVE:To assess the effect of mixing the insulin analog lispro (Humalog) with NPH (Humulin I) before injection on lispro's fast, short action profile. RESEARCH DESIGN AND METHODS:A total of 12 healthy volunteers received subcutaneous abdominal injections of 0.1 U/kg regular insulin and 0.2 U/kg NPH insulin as foll...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.21.12.2098

    authors: Joseph SE,Korzon-Burakowska A,Woodworth JR,Evans M,Hopkins D,Janes JM,Amiel SA

    更新日期:1998-12-01 00:00:00

  • Pharmacological treatment of the pathogenetic defects in type 2 diabetes: the randomized multicenter South Danish Diabetes Study.

    abstract:OBJECTIVE:To determine the effect of treatment with insulin aspart compared with NPH insulin, together with metformin/placebo and rosiglitazone/placebo. The hypothesis was that combined correction of major pathogenetic defects in type 2 diabetes would result in optimal glycemic control. RESEARCH DESIGN AND METHODS:Thi...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc10-0531

    authors: Gram J,Henriksen JE,Grodum E,Juhl H,Hansen TB,Christiansen C,Yderstræde K,Gjessing H,Hansen HM,Vestergaard V,Hangaard J,Beck-Nielsen H

    更新日期:2011-01-01 00:00:00

  • Adult respiratory distress syndrome complicating severely uncontrolled diabetes mellitus: report of nine cases and a review of the literature.

    abstract::We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests tha...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.6.574

    authors: Carroll P,Matz R

    更新日期:1982-11-01 00:00:00

  • Longitudinal development of left ventricular diastolic function in patients with type 2 diabetes.

    abstract:OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0779

    authors: Venskutonyte L,Jarnert C,Rydén L,Kjellström B

    更新日期:2014-11-01 00:00:00

  • Diabetes is associated with dramatically decreased survival in female but not male subjects with cystic fibrosis.

    abstract:OBJECTIVE:Survival analysis was performed on a prospectively followed cohort of patients with cystic fibrosis (CF) to determine the impact of the development of diabetes on survival. RESEARCH DESIGN AND METHODS:Clinical data were retrieved for patients diagnosed with CF-related diabetes (CFRD) at the Minnesota CF Cent...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.9.2141

    authors: Milla CE,Billings J,Moran A

    更新日期:2005-09-01 00:00:00

  • Mediators of lifestyle behavior change in Native Hawaiians: initial findings from the Native Hawaiian Diabetes Intervention Program.

    abstract:OBJECTIVE:To examine the association of stage of change with diet and exercise behaviors in response to a lifestyle intervention for Native Hawaiians (NHs). RESEARCH DESIGN AND METHODS:A family ('ohana) support lifestyle intervention was compared with a standard intervention in NHs with or at risk for diabetes in two ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.10.1770

    authors: Mau MK,Glanz K,Severino R,Grove JS,Johnson B,Curb JD

    更新日期:2001-10-01 00:00:00

  • Dissociation of insulin absorption and blood flow during massage of a subcutaneous injection site.

    abstract::Nine healthy volunteers with normal body weights were injected subcutaneously with 125I-labeled soluble human insulin (10 U) in one thigh and 133Xe in the contralateral thigh for the measurement of subcutaneous blood flow on 2 consecutive mornings. On one of the days, standardized massage of both injection sites was p...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.9.6.570

    authors: Linde B

    更新日期:1986-11-01 00:00:00

  • Use of Antihyperglycemic Medications in U.S. Adults: An Analysis of the National Health and Nutrition Examination Survey.

    abstract:OBJECTIVE:1) To examine trends in the use of diabetes medications and 2) to determine whether physicians individualize diabetes treatment as recommended by the American Diabetes Association (ADA). RESEARCH DESIGN AND METHODS:We conducted a retrospective, cross-sectional analysis of 2003-2016 National Health and Nutrit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-2424

    authors: Le P,Chaitoff A,Misra-Hebert AD,Ye W,Herman WH,Rothberg MB

    更新日期:2020-06-01 00:00:00

  • Diabetes in a northern Minnesota Chippewa Tribe. Prevalence and incidence of diabetes and incidence of major complications, 1986-1988.

    abstract:OBJECTIVE:To determine the prevalence and incidence of diabetes, and the incidence of major diabetic complications, in a Chippewa Indian population. RESEARCH DESIGN AND METHODS:The format was a longitudinal population study that used active community and health center-based surveillance. The setting was a North Americ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.1.266

    authors: Rith-Najarian SJ,Valway SE,Gohdes DM

    更新日期:1993-01-01 00:00:00

  • Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan.

    abstract:OBJECTIVE:No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan. RESEARCH DESIGN AND METHODS:A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Pro...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1258

    authors: Lai SW,Lin CL,Liao KF

    更新日期:2019-01-01 00:00:00

  • Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule.

    abstract:OBJECTIVE:To create a simple prediction rule that could perform as well as the 2-h postchallenge plasma glucose (PCPG) test to predict those at risk for diabetes. We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort. RESEARCH DESIGN AND METHODS:A cross-se...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.2.404

    authors: Kanaya AM,Wassel Fyr CL,de Rekeneire N,Shorr RI,Schwartz AV,Goodpaster BH,Newman AB,Harris T,Barrett-Connor E

    更新日期:2005-02-01 00:00:00

  • Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers.

    abstract::Diabetic foot ulcers remain a major health care problem. They are common, result in considerable suffering, frequently recur, and are associated with high mortality, as well as considerable health care costs. While national and international guidance exists, the evidence base for much of routine clinical care is thin....

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-1836

    authors: Jeffcoate WJ,Vileikyte L,Boyko EJ,Armstrong DG,Boulton AJM

    更新日期:2018-04-01 00:00:00

  • Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load.

    abstract::Type II diabetic subjects were given 50 g protein, 50 g glucose, or 50 g glucose with 50 g protein as a single meal in random sequence. The plasma glucose and insulin response was determined over the subsequent 5 h. The plasma glucose area above the baseline following a glucose meal was reduced 34% when protein was gi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.7.5.465

    authors: Nuttall FQ,Mooradian AD,Gannon MC,Billington C,Krezowski P

    更新日期:1984-09-01 00:00:00

  • Pancreas transplantation improves vascular disease in patients with type 1 diabetes.

    abstract:OBJECTIVE:Pancreas transplantation (PTX) normalizes glucose and improves microvascular complications, but its impact on macrovascular disease is still debated. RESEARCH DESIGN AND METHODS:Carotid intima-media thickness (IMT), shown to correlate with cardiovascular disease (CVD) risk and events, was determined prospect...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.7.1706

    authors: Larsen JL,Colling CW,Ratanasuwan T,Burkman TW,Lynch TG,Erickson JM,Lyden ER,Lane JT,Mack-Shipman LR

    更新日期:2004-07-01 00:00:00

  • Association of pretransplant glycemic control with posttransplant outcomes in diabetic kidney transplant recipients.

    abstract:OBJECTIVE:Observational studies have yielded inconsistent findings regarding the association of hemoglobin A(1c) (HbA(1c)) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0906

    authors: Molnar MZ,Huang E,Hoshino J,Krishnan M,Nissenson AR,Kovesdy CP,Kalantar-Zadeh K

    更新日期:2011-12-01 00:00:00

  • Plasma adiponectin and endogenous glucose production in humans.

    abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.12.3315

    authors: Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

    更新日期:2003-12-01 00:00:00

  • Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia.

    abstract:OBJECTIVE:Sulfonylureas block the activation of vascular potassium-dependent ATP channels and impair the vasodilating response to ischcmia in nondiabetic individuals, but it is not know whether this occurs in type 2 diabetic patients under chronic treatment with these drugs. Glimepiride, a new sulfonylurea, apparently ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.24.4.738

    authors: Spallarossa P,Schiavo M,Rossettin P,Cordone S,Olivotti L,Cordera R,Brunelli C

    更新日期:2001-04-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

    abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.22.1.33

    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.20.7.1134

    authors: Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

    更新日期:1997-07-01 00:00:00

  • Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

    abstract:OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1834

    authors: Cnop M,Vidal J,Hull RL,Utzschneider KM,Carr DB,Schraw T,Scherer PE,Boyko EJ,Fujimoto WY,Kahn SE

    更新日期:2007-03-01 00:00:00

  • The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration.

    abstract:OBJECTIVE:To promote foot screening of inpatients with diabetes, we simplified sensory testing to lightly touching the tips of the first, third, and fifth toes (the Ipswich Touch Test [IpTT]). RESEARCH DESIGN AND METHODS:Respective performances of the IpTT and 10-g monofilament (MF) were compared with a vibration perc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0156

    authors: Rayman G,Vas PR,Baker N,Taylor CG Jr,Gooday C,Alder AI,Donohoe M

    更新日期:2011-07-01 00:00:00

  • Heart rate variability in diabetes: relationship to age and duration of the disease.

    abstract::Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.64

    authors: Masaoka S,Lev-Ran A,Hill LR,Vakil G,Hon EH

    更新日期:1985-01-01 00:00:00