Dissociation of insulin absorption and blood flow during massage of a subcutaneous injection site.

abstract：OBJECTIVE:Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incidence of type 2 diabetes in subjects with impaired glucose metabolism (...

journal_title：Diabetes care

authors： van der Zijl NJ,Moors CC,Goossens GH,Hermans MM,Blaak EE,Diamant M

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

journal_title：Diabetes care

authors： Nielsen S,Schmitz O,Orskov H,Mogensen CE

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...

journal_title：Diabetes care

authors： Koskinen LK,Lahtela JT,Koivula TA

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Exercise tolerance in patients with diabetes is frequently impaired due to noncardiac disease such as claudication and polyneuropathy. This study assesses the prognostic value of dobutamine stress myocardial perfusion imaging in patients with diabetes. RESEARCH DESIGN AND METHODS:A total of 207 consecutive d...

journal_title：Diabetes care

authors： Schinkel AF,Elhendy A,van Domburg RT,Bax JJ,Vourvouri EC,Sozzi FB,Valkema R,Roelandt JR,Poldermans D

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:This trial compared the efficacy and safety of the first oral glucagon-like peptide 1 (GLP-1) receptor agonist, oral semaglutide, as monotherapy with placebo in patients with type 2 diabetes managed by diet and exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand...

journal_title：Diabetes care

authors： Aroda VR,Rosenstock J,Terauchi Y,Altuntas Y,Lalic NM,Morales Villegas EC,Jeppesen OK,Christiansen E,Hertz CL,Haluzík M,PIONEER 1 Investigators.

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes is associated with increased plasma concentrations of coagulation and inflammation markers. Different studies have shown that treatment with hydroxymethylglutaryl-CoA reductase inhibitors (statins) is associated with antithrombotic and anti-inflammatory effects in addition to a cholesterol-low...

journal_title：Diabetes care

authors： Sommeijer DW,MacGillavry MR,Meijers JC,Van Zanten AP,Reitsma PH,Ten Cate H

更新日期：2004-02-01 00:00:00

abstract：:Severe hypoglycemia (SH) is a significant problem for many patients with type I diabetes and presents a major barrier to optimal diabetes control. A critical task facing diabetes research is to understand, predict, and reduce the risk of SH in insulin-treated patients. The purpose of this article is to propose a biops...

journal_title：Diabetes care

authors： Gonder-Frederick L,Cox D,Kovatchev B,Schlundt D,Clarke W

更新日期：1997-04-01 00:00:00

abstract：:In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

journal_title：Diabetes care

authors： Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Arterial stiffness occurs early in the atherosclerotic process; however, few data are available concerning risk factors for arterial stiffness in youth with diabetes. We identified factors associated with arterial stiffness in youth with diabetes and assessed the effects of these factors on the relationship b...

journal_title：Diabetes care

authors： Wadwa RP,Urbina EM,Anderson AM,Hamman RF,Dolan LM,Rodriguez BL,Daniels SR,Dabelea D,SEARCH Study Group.

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Although the Diabetes Prevention Program (DPP) and the Finnish Diabetes Prevention Study (FDPS) demonstrated that weight loss from lifestyle change reduces type 2 diabetes incidence in patients with prediabetes, the translation into community settings has been difficult. The objective of this study is to repo...

journal_title：Diabetes care

authors： Katula JA,Vitolins MZ,Rosenberger EL,Blackwell CS,Morgan TM,Lawlor MS,Goff DC Jr

更新日期：2011-07-01 00:00:00

abstract：:Based on the results of the Diabetes Prevention Program Outcomes Study (DPPOS), in which metformin significantly decreased the development of diabetes in individuals with baseline fasting plasma glucose (FPG) concentrations of 110-125 vs. 100-109 mg/dL (6.1-6.9 vs. 5.6-6.0 mmol/L) and A1C levels 6.0-6.4% (42-46 mmol/m...

journal_title：Diabetes care

authors： Davidson MB

更新日期：2020-09-01 00:00:00

abstract：:Six hundred fifteen children (310 with diabetes, 106 nondiabetic siblings, and 199 nonsibling controls) were examined for the presence of joint contractures. Forty children had contractures: 8.4 per cent of those with diabetes and 4.6 per cent of those without diabetes. Contractures were present, however, in 9.4 per c...

journal_title：Diabetes care

authors： Traisman HS,Traisman ES,Marr TJ,Wise J

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:Cost-effectiveness analyses have reported that intensive glucose control is not cost-effective in older patients with new-onset diabetes. However, these analyses have had limited data on patient preferences concerning diabetic health states. We examined how the cost- effectiveness of intensive glucose control...

journal_title：Diabetes care

authors： Huang ES,Shook M,Jin L,Chin MH,Meltzer DO

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Serine-threonine kinase STK11 catalyzes the AMP-activated protein kinase complex. We tested the hypothesis that a gene variant in STK11 contributes to variation in insulin sensitivity and metformin efficacy. RESEARCH DESIGN AND METHODS:We studied the effects of a single nucleotide polymorphism (SNP) (rs81116...

journal_title：Diabetes care

authors： López-Bermejo A,Díaz M,Morán E,de Zegher F,Ibáñez L

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...

journal_title：Diabetes care

authors： DiPietro L,Dziura J,Yeckel CW

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...

journal_title：Diabetes care

authors： Ravussin E,Valencia ME,Esparza J,Bennett PH,Schulz LO

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the relative value of plasma glucose (PG) at different time points in assessing glucose control of type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Glycemic profiles, i.e., PG at prebreakfast (8:00 A.M.), prelunch (11:00 A.M.), postlunch (2:00 P.M.), and extended postlunch (5:00 P.M.) times ...

journal_title：Diabetes care

authors： Avignon A,Radauceanu A,Monnier L

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To examine if dual replacement with insulin and rhIGF-I, recombinant human insulin-like growth factor I (rhIGF-I) may be safe and result in improved metabolic control and reduced insulin usage. RESEARCH DESIGN AND METHODS:Forty-three patients with IDDM were randomized to receive a daily injection of rhIGF-I ...

journal_title：Diabetes care

authors： Quattrin T,Thrailkill K,Baker L,Litton J,Dwigun K,Rearson M,Poppenheimer M,Giltinan D,Gesundheit N,Martha P Jr

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Dyslipidemia contributes to the progression of microvascular disease in diabetes. However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes. RESEARCH D...

journal_title：Diabetes care

authors： Thomas MC,Rosengård-Bärlund M,Mills V,Rönnback M,Thomas S,Forsblom C,Cooper ME,Taskinen MR,Viberti G,Groop PH

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis. RESEARCH DESIGN AND METHODS:We cross-sectionally studied 849 Japanese men aged 50.3 +/- 8.5 years (range 20-78) with BMI 23.5 +/- 2.9 kg/m(2). Intimal-medial thickness ...

journal_title：Diabetes care

authors： Takami R,Takeda N,Hayashi M,Sasaki A,Kawachi S,Yoshino K,Takami K,Nakashima K,Akai A,Yamakita N,Yasuda K

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Stress hyperglycemia increases the risk of mortality and poor outcomes in patients with acute myocardial infarction (AMI). We aimed to assess effects of intravenous nicorandil administered before reperfusion on AMI patients with stress hyperglycemia. RESEARCH DESIGN AND METHODS:This study consisted of 158 co...

journal_title：Diabetes care

authors： Ishii H,Ichimiya S,Kanashiro M,Amano T,Matsubara T,Murohara T

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. We aimed to investigate the association between TIR and mortality in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 6,225 adult patients with type 2 d...

journal_title：Diabetes care

authors： Lu J,Wang C,Shen Y,Chen L,Zhang L,Cai J,Lu W,Zhu W,Hu G,Xia T,Zhou J

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Obesity is associated with alterations in corticolimbic-striatal brain regions involved in food motivation and reward. Stress and the presence of food cues may each motivate eating and engage corticolimibic-striatal neurocircuitry. It is unknown how these factors interact to influence brain responses and whet...

journal_title：Diabetes care

authors： Jastreboff AM,Sinha R,Lacadie C,Small DM,Sherwin RS,Potenza MN

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...

journal_title：Diabetes care

authors： Boulé NG,Robert C,Bell GJ,Johnson ST,Bell RC,Lewanczuk RZ,Gabr RQ,Brocks DR

更新日期：2011-07-01 00:00:00

abstract：:Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulin-dependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlati...

journal_title：Diabetes care

authors： Mehl TD,Wenzel SE,Russell B,Gardner D,Merimee TJ

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2)...

journal_title：Diabetes care

authors： Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BV

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To examine mortality rates and causes of death among subjects diagnosed with type 1 diabetes aged

journal_title：Diabetes care

authors： Feltbower RG,Bodansky HJ,Patterson CC,Parslow RC,Stephenson CR,Reynolds C,McKinney PA

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Persistently islet autoAb+ siblings and offspring (n =...

journal_title：Diabetes care

authors： Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...

journal_title：Diabetes care

authors： Bays HE,Roth EM,McKenney JM,Kelly MT,Thakker KM,Setze CM,Obermeyer K,Sleep DJ

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in ty...

journal_title：Diabetes care

authors： Hermansen K,Søndergaard M,Høie L,Carstensen M,Brock B

更新日期：2001-02-01 00:00:00