Prognostic value of dobutamine-atropine stress myocardial perfusion imaging in patients with diabetes.

Abstract:

OBJECTIVE:Exercise tolerance in patients with diabetes is frequently impaired due to noncardiac disease such as claudication and polyneuropathy. This study assesses the prognostic value of dobutamine stress myocardial perfusion imaging in patients with diabetes. RESEARCH DESIGN AND METHODS:A total of 207 consecutive diabetic patients who were unable to undergo exercise stress testing underwent dobutamine-atropine stress myocardial perfusion imaging. Follow-up was successful in 206 of 207 (99.5%) patients. A total of 12 patients underwent early (<60 days) revascularization and were excluded from the analysis. End points during follow-up were hard cardiac events, defined as cardiac death and nonfatal myocardial infarction. RESULTS:Abnormal myocardial perfusion was detected in 125 (64%) patients. During 4.1 +/- 2.4 years of follow-up, 73 (38%) deaths occurred, 36 (49%) of which were due to cardiac causes. Nonfatal myocardial infarction occurred in 7 (4%) patients, and 45 (23%) patients underwent late coronary revascularization. Cardiac death occurred in 2 of 69 (3%) patients with normal myocardial perfusion and in 34 of 125 (27%) patients with perfusion abnormalities (P < 0.0001). A multivariable Cox proportional hazard model demonstrated that, in addition to clinical and stress test data, an abnormal scan had an incremental prognostic value for prediction of cardiac death (hazard ratio 7.2, 95% CI 1.7-30). The summed stress score was an important predictor of cardiac death; the hazard ratio was 1.2 (95% CI 1.07-1.34) per one-unit increment. CONCLUSIONS:Dobutamine-atropine stress myocardial perfusion imaging provides additional prognostic information incremental to clinical data in patients with diabetes who are unable to undergo exercise stress testing.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Schinkel AF,Elhendy A,van Domburg RT,Bax JJ,Vourvouri EC,Sozzi FB,Valkema R,Roelandt JR,Poldermans D

doi

10.2337/diacare.25.9.1637

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1637-43

issue

9

eissn

0149-5992

issn

1935-5548

journal_volume

25

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

    doi:10.2337/diacare.4.6.627

    authors: Leichter SB,Nieman JA,Moore RW,Collins P,Rhodes A

    更新日期:1981-11-01 00:00:00

  • Decreased release of lipoprotein lipase is associated with vascular endothelial damage in NIDDM patients with microalbuminuria.

    abstract:OBJECTIVE:To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.11.2016

    authors: Kashiwazaki K,Hirano T,Yoshino G,Kurokawa M,Tajima H,Adachi M

    更新日期:1998-11-01 00:00:00

  • Genetics and the prediction of complications in type 1 diabetes.

    abstract:OBJECTIVE:Epidemiological evidence suggests that genetic factors can affect the course of type 1 diabetes complications produced by long-lasting hyperglycemia. In this review, the current strategies applicable to identifying these genetic factors are examined, as are recent findings on the genetics of diabetic nephropa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Marre M

    更新日期:1999-03-01 00:00:00

  • Disability-Free Life-Years Lost Among Adults Aged ≥50 Years With and Without Diabetes.

    abstract:OBJECTIVE:To quantify the impact of diabetes status on healthy and disabled years of life for older adults in the U.S. and provide a baseline from which to evaluate ongoing national public health efforts to prevent and control diabetes and disability. RESEARCH DESIGN AND METHODS:Adults (n = 20,008) aged 50 years and o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-1095

    authors: Bardenheier BH,Lin J,Zhuo X,Ali MK,Thompson TJ,Cheng YJ,Gregg EW

    更新日期:2016-07-01 00:00:00

  • Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III).

    abstract:OBJECTIVE:Among postmenopausal women, those with diabetes experience more cardiovascular diseases than those without diabetes. We examine the relationship of hormone replacement therapy (HRT) with indicators of lipid and glucose metabolism using a national sample of diabetic and nondiabetic postmenopausal women. RESEA...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.10.1675

    authors: Crespo CJ,Smit E,Snelling A,Sempos CT,Andersen RE,NHANES III.

    更新日期:2002-10-01 00:00:00

  • Determinants of racial/ethnic disparities in incidence of diabetes in postmenopausal women in the U.S.: The Women's Health Initiative 1993-2009.

    abstract:OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0412

    authors: Ma Y,Hébert JR,Manson JE,Balasubramanian R,Liu S,Lamonte MJ,Bird CE,Ockene JK,Qiao Y,Olendzki B,Schneider KL,Rosal MC,Sepavich DM,Wactawski-Wende J,Stefanick ML,Phillips LS,Ockene IS,Kaplan RC,Sarto GE,Garcia L,Ho

    更新日期:2012-11-01 00:00:00

  • Postprandial oscillatory patterns of blood glucose and insulin in NIDDM. Abnormal diurnal insulin secretion patterns and glucose homeostasis independent of obesity.

    abstract::Compared with control subjects, non-insulin-dependent diabetes mellitus (NIDDM) subjects had both quantitative and qualitative abnormalities in blood insulin and glucose concentrations. The purpose of this study was to determine whether and to what extent normally observed multiphasic patterns of insulin and glucose r...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.10.709

    authors: Calles-Escandon J,Jaspan J,Robbins DC

    更新日期:1989-11-01 00:00:00

  • Provider-patient communication and metabolic control.

    abstract:OBJECTIVE:To determine whether nurses' and NIDDM patients' communication styles during consultations are related to subsequent metabolic control and to examine factors influencing patterns of communication in these consultations. RESEARCH DESIGN AND METHODS:A total of 47 NIDDM patients participated in the study and co...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.5.714

    authors: Street RL Jr,Piziak VK,Carpentier WS,Herzog J,Hejl J,Skinner G,McLellan L

    更新日期:1993-05-01 00:00:00

  • Effects of a home-based walking intervention on mobility and quality of life in people with diabetes and peripheral arterial disease: a randomized controlled trial.

    abstract:OBJECTIVE:Determine the efficacy of a home-based walking intervention to improve walking ability and quality of life in people with diabetes and peripheral arterial disease (PAD). RESEARCH DESIGN AND METHODS:We conducted a randomized, controlled, single-blind trial within university-affiliated clinics in our local com...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2399

    authors: Collins TC,Lunos S,Carlson T,Henderson K,Lightbourne M,Nelson B,Hodges JS

    更新日期:2011-10-01 00:00:00

  • Family functioning and metabolic control of school-aged children with IDDM.

    abstract::The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.409

    authors: Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

    更新日期:1989-06-01 00:00:00

  • Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

    abstract:OBJECTIVE:To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS:We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.7.1086

    authors: Shen GQ,Ikegami H,Kawaguchi Y,Fujisawa T,Hamada Y,Ueda H,Shintani M,Nojima K,Kawabata Y,Yamada K,Babaya N,Ogihara T

    更新日期:1998-07-01 00:00:00

  • Distinct Patterns of Daily Glucose Variability by Pubertal Status in Youth With Type 1 Diabetes.

    abstract:OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0083

    authors: Zhu J,Volkening LK,Laffel LM

    更新日期:2020-01-01 00:00:00

  • The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance.

    abstract:OBJECTIVE:To investigate the effect of parenteral insulin therapy on endogenous insulin secretion in the Diabetes Prevention Trial-Type 1 (DPT-1). RESEARCH DESIGN AND METHODS:In the parenteral insulin arm of DPT-1, subjects without diabetes at high risk of future type 1 diabetes randomized to active treatment received...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-1825

    authors: Hao W,Greenbaum CJ,Krischer JP,Cuthbertson D,Marks JB,Palmer JP

    更新日期:2015-05-01 00:00:00

  • Nonremovable, windowed, fiberglass cast boot in the treatment of diabetic plantar ulcers: efficacy, safety, and compliance.

    abstract:OBJECTIVE:To compare the efficacy, safety, and compliance of a nonremovable fiberglass cast boot and off-loading shoes in the treatment of diabetic plantar ulcers. RESEARCH DESIGN AND METHODS:Patients (n = 93) with noninfected, nonischemic plantar ulcers were included in this prospective nonrandomized study. Treatment...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.26.10.2848

    authors: Ha Van G,Siney H,Hartmann-Heurtier A,Jacqueminet S,Greau F,Grimaldi A

    更新日期:2003-10-01 00:00:00

  • Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study.

    abstract:OBJECTIVE:The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals. RESEARCH DESIGN AND METHODS:Baseline data from the Health, Aging and Body Composition study included 3,075 well-fun...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2327

    authors: de Rekeneire N,Peila R,Ding J,Colbert LH,Visser M,Shorr RI,Kritchevsky SB,Kuller LH,Strotmeyer ES,Schwartz AV,Vellas B,Harris TB

    更新日期:2006-08-01 00:00:00

  • Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition Study.

    abstract:OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.26.7.1986

    authors: de Rekeneire N,Rooks RN,Simonsick EM,Shorr RI,Kuller LH,Schwartz AV,Harris TB,Health, Aging and Body Composition Study.

    更新日期:2003-07-01 00:00:00

  • Ethnic differences in correlates of microalbuminuria in NIDDM. The role of the acute-phase response.

    abstract:OBJECTIVE:To investigate whether microalbuminuria is associated with markers of the acute-phase response in NIDDM and whether there are ethnic differences in this association among the three main racial groups in Malaysia. RESEARCH DESIGN AND METHODS:NIDDM patients of Chinese, Indian, and Malay origin attending a diab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.3.385

    authors: Islam N,Kazmi F,Chusney GD,Mattock MB,Zaini A,Pickup JC

    更新日期:1998-03-01 00:00:00

  • Efficacy of feedback from quarterly laboratory comparison in maintaining quality of a hospital capillary blood glucose monitoring program.

    abstract:OBJECTIVE:A 1-year randomized prospective study was conducted to investigate the efficacy of feedback from split-sample testing as part of a capillary blood glucose quality assurance program. RESEARCH DESIGN AND METHODS:A total of 124 nurses were randomized to either group A (quarterly comparisons with feedback) or gr...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.2.168

    authors: Jones HE,Cleave B,Zinman B,Szalai JP,Nichol HL,Hoffman BR

    更新日期:1996-02-01 00:00:00

  • Characteristics associated with maintenance of mean A1C

    abstract:OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc12-2238

    authors: ORIGIN Trial Investigators.

    更新日期:2013-10-01 00:00:00

  • Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

    abstract:OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1167

    authors: Ferrara-Cook C,Geyer SM,Evans-Molina C,Libman IM,Becker DJ,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.

    更新日期:2020-03-01 00:00:00

  • Rapid progression of albumin excretion is an independent predictor of cardiovascular mortality in patients with type 2 diabetes and microalbuminuria.

    abstract:OBJECTIVE:In patients with type 2 diabetes, microalbuminuria is associated with an increase in predominantly cardiovascular mortality. Considerable interindividual variability in the rate of progression of microalbuminuria exists. The prognostic significance of rate of progression of microalbuminuria with regard to car...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2097

    authors: Spoelstra-de Man AM,Brouwer CB,Stehouwer CD,Smulders YM

    更新日期:2001-12-01 00:00:00

  • Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

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    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-1397

    authors: Pop-Busui R,Braffett BH,Zinman B,Martin C,White NH,Herman WH,Genuth S,Gubitosi-Klug R,DCCT\/EDIC Research Group.

    更新日期:2017-01-01 00:00:00

  • Oral contraceptive use and association with glucose, insulin, and diabetes in young adult women: the CARDIA Study. Coronary Artery Risk Development in Young Adults.

    abstract:OBJECTIVE:We studied the associations between 1) current use of oral contraceptives (OCs) and 2) glucose levels, insulin levels, and diabetes in young women. RESEARCH DESIGN AND METHODS:Subjects were women (n = 1,940) in the Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective observational s...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.6.1027

    authors: Kim C,Siscovick DS,Sidney S,Lewis CE,Kiefe CI,Koepsell TD,CARDIA Study.

    更新日期:2002-06-01 00:00:00

  • Adult respiratory distress syndrome complicating severely uncontrolled diabetes mellitus: report of nine cases and a review of the literature.

    abstract::We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests tha...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.6.574

    authors: Carroll P,Matz R

    更新日期:1982-11-01 00:00:00

  • Challenges to healthy eating for people with diabetes in a low-income, minority neighborhood.

    abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1632

    authors: Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

    更新日期:2013-10-01 00:00:00

  • Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy.

    abstract:OBJECTIVE:To improve prognosis, it is important to predict the incidence of renal failure and cardiovascular disease in type 2 diabetic patients before the progression to advanced nephropathy. We investigated the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP), which is associated with rena...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1298

    authors: Araki S,Haneda M,Koya D,Sugaya T,Isshiki K,Kume S,Kashiwagi A,Uzu T,Maegawa H

    更新日期:2013-05-01 00:00:00

  • Controlled trial of a multifaceted intervention for improving quality of care for rural patients with type 2 diabetes.

    abstract:OBJECTIVE:Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care. RESEARCH DESIGN AND METHODS:We conducted a prospective, before/aft...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.11.3061

    authors: Majumdar SR,Guirguis LM,Toth EL,Lewanczuk RZ,Lee TK,Johnson JA

    更新日期:2003-11-01 00:00:00

  • Lipid testing among patients with diabetes who receive diabetes care from primary care physicians.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.5.1369

    authors: Massing MW,Henley NS,Carter-Edwards L,Schenck AP,Simpson RJ Jr

    更新日期:2003-05-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.3.322

    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • Should we be more aggressive in the therapy against cardiovascular risk factors? Should we prescribe statin and aspirin for every diabetic patient, or is it time for a polypill?

    abstract::The reality of primary and secondary prevention of cardiovascular complications in people with diabetes is alarming, even in developed countries with a well-structured medical system. Even though therapeutic targets have been more clearly defined during the last decades, their implementation is still suboptimal. Finan...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-s254

    authors: Stirban AO,Tschoepe D

    更新日期:2008-02-01 00:00:00