Abstract:
OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive pediatric TrialNet participants (ages 1.6-18.6 years at baseline). Cumulative excess BMI (ceBMI) was calculated for each participant based on longitudinally accumulated BMI ≥85th age- and sex-adjusted percentile. Recursive partitioning analysis and multivariable modeling defined the age cut point differentiating the risk for progression to multiple positive autoantibodies. RESULTS:At baseline, 175 children (25%) had a BMI ≥85th percentile. ceBMI range was -9.2 to 15.6 kg/m2 (median -1.91), with ceBMI ≥0 kg/m2 corresponding to persistently elevated BMI ≥85th percentile. Younger age increased the progression to multiple autoantibodies, with age cutoff of 9 years defined by recursive partitioning analysis. Although ceBMI was not significantly associated with progression from single to multiple autoantibodies overall, there was an interaction with ceBMI ≥0 kg/m2, age, and HLA (P = 0.009). Among children ≥9 years old without HLA DR3-DQ2 and DR4-DQ8, ceBMI ≥0 kg/m2 increased the rate of progression from single to multiple positive autoantibodies (hazard ratio 7.32, P = 0.004) and conferred a risk similar to that in those with T1D-associated HLA haplotypes. In participants <9 years old, the effect of ceBMI on progression to multiple autoantibodies was not significant regardless of HLA type. CONCLUSIONS:These data support that elevated BMI may exacerbate islet autoimmunity prior to clinical T1D, particularly in children with lower risk based on age and HLA. Interventions to maintain normal BMI may prevent or delay the progression of islet autoimmunity.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Ferrara-Cook C,Geyer SM,Evans-Molina C,Libman IM,Becker DJ,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.doi
10.2337/dc19-1167subject
Has Abstractpub_date
2020-03-01 00:00:00pages
580-587issue
3eissn
0149-5992issn
1935-5548pii
dc19-1167journal_volume
43pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To describe a glucose abnormality in AIDS that is characterized by transient NIDDM followed by hyperinsulinemic normoglycemia. RESEARCH DESIGN AND METHODS:A 36-yr-old Hispanic man with AIDS was on long-standing aerosolized pentamidine therapy in 1986. He received a course of intravenous pentamidine 5 mo befo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.6.931
更新日期:1993-06-01 00:00:00
abstract::We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests tha...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.574
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.1067
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:This study compared diabetes Treatment As Usual (TAU) with Pathways To Change (PTC), an intervention developed from the Transtheoretical Model of Change (TTM), to determine whether the PTC intervention would result in greater readiness to change, greater increases in self-care, and improved diabetes control. ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.3.732
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1490
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.509
更新日期:1997-04-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of visual impairment and preventable blindness, and represents a significant socioeconomic cost for health care systems worldwide. Therefore, new approaches beyond current standards of diabetes care are needed. Based on the crucial pathogenic role of vascular endothelial growt...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc13-2002
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:A1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while ma...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-2782
更新日期:2016-06-01 00:00:00
abstract::Of the 30,300 mothers who attended consecutively at the antenatal clinic during an 11-yr period, 3063 mothers screened positive using clinical criteria for potential diabetes in pregnancy. These 3063 mothers had a glucose tolerance test (GTT), of which 661 were judged abnormal. At different times an oral GTT, cortison...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.3.3.440
更新日期:1980-05-01 00:00:00
abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practic...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc21-S009
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that microalbuminuria may show an independent statistical association with diabetic neuropathy. RESEARCH DESIGN AND METHODS:An observational study of a prospectively identified cohort was conducted at the University Medical Center. The cohort consisted of 78 consecutive diabetic patien...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.4.528
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2193
更新日期:2010-05-01 00:00:00
abstract::Malfunction of portable continuous subcutaneous insulin infusion (CSII) systems may result in either ketoacidosis or serious hypoglycemia. To determine the types and frequencies of infusion system failure and the resulting clinical consequences, we recorded their occurrences in a 1-yr prospective study of 127 patients...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.4.351
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:To summarize the frequency of physician adherence to consensus recommendations for prevention of diabetic complications. RESEARCH DESIGN AND METHODS:Survey data from a nationwide stratified probability sample of primary-care physicians were analyzed. Adherence to recommendations were reported by physician sp...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1507
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:We examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS:Between 1989 and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-0137
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS:We analyzed data from a large representative sample of ad...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1582
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.1.70
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The study objective was to describe the effect of socioeconomic status (SES) on mortality among people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a population-based national electronic diabetes database for 35- to 84-year-olds in Scotland for 2001-2007 linked to mortality records. SES was deri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1862
更新日期:2011-05-01 00:00:00
abstract::Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.6.922
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:Previous studies have suggested that diabetes increases the risk of Parkinson disease (PD); however, this has not been conclusively established. We analyzed the risk of PD based on baseline glucose tolerance status in a large-scale cohort representative of the general Korean population. RESEARCH DESIGN AND M...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0760
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine whether, reflecting trends in other chronic complications, incident hospitalization for diabetes-related foot ulcer (DFU) has declined over recent decades in type 2 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 2 diabetes from the community-based Fremantle Diabetes Study phases I ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1743
更新日期:2021-01-13 00:00:00
abstract:OBJECTIVE:Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS:High-throughput ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc14-0850
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan. RESEARCH DESIGN AND METHODS:A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Pro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1258
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Low plasma testosterone levels are associated with hyperinsulinemia and glucose intolerance in men. However, it is unclear whether these abnormalities are related to the concomitant alteration in regional adipose tissue (AT) accumulation associated with reduced androgen levels. RESEARCH DESIGN AND METHODS:We...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.3.292
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1627
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Plasma leptin, an important signal for the regulation of energy stores, is known to be influenced by many hormonal factors, but may also be affected by behavioral and environmental factors. The purpose of this study was to investigate the impact of lifestyle (diet composition, level of physical activity) on p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.3.413
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregest...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0571
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metformin and metformin alone-in preserving or improving β-cell function in youth with impaired glucose tolerance (IGT) or recen...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc18-0787
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS:We randomly selected 2,662 Mexican-Americans and 1,595 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.10.1851
更新日期:2002-10-01 00:00:00
abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:
更新日期:1984-05-01 00:00:00