Abstract:
OBJECTIVE:Epidemiological evidence suggests that genetic factors can affect the course of type 1 diabetes complications produced by long-lasting hyperglycemia. In this review, the current strategies applicable to identifying these genetic factors are examined, as are recent findings on the genetics of diabetic nephropathy and whether these are applicable to type 1 diabetes patient care. RESEARCH DESIGN AND METHODS:Whole-genome screening and candidate gene strategies can be applied to the genetics of type 1 diabetes complications. The search for candidate genes can focus on enzymes involved in glucose metabolism or on those affecting non-glycemic-dependent vascular risk. For each candidate, the level of evidence may vary from case-control to intervention studies. Literature on diabetic complications and a possible role for genetics was examined systematically. RESULTS:The most significant results were obtained regarding a role for polymorphisms of the renin-angiotensin system in diabetic nephropathy. Several studies suggest a role for angiotensin I converting enzyme insertion/deletion polymorphism in the development of renal complications. However, the level of evidence is currently not sufficient to recommend treatment strategy based on this or any other polymorphism. CONCLUSIONS:The search for a genetic basis of type 1 diabetes complications is an important avenue to examine their pathophysiologies. However, it is still premature to apply the current findings in this domain to type 1 diabetes patient care.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Marre Msubject
Has Abstractpub_date
1999-03-01 00:00:00pages
B53-8eissn
0149-5992issn
1935-5548journal_volume
22 Suppl 2pub_type
杂志文章,评审相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To describe the relative contributions of neurological and vascular abnormalities to the overall risk of diabetic foot ulceration. RESEARCH DESIGN AND METHODS:A case-control study of diabetic veterans from the Seattle Veterans Affairs Medical Center was conducted using data collected from 46 patients with di...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.2.216
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:Predictors of insulin resistance have hitherto only been examined in cross-sectional studies without information on lifestyle factors. Few researchers have measured insulin sensitivity directly and compared different metabolic and lifestyle predictors in a large population. RESEARCH DESIGN AND METHODS:Our ai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-0360
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To investigate the metabolic effects of metformin, as compared with placebo, in type 2 diabetic patients intensively treated with insulin. RESEARCH DESIGN AND METHODS:Metformin improves glycemic control in poorly controlled type 2 diabetic patients. Its effect in type 2 diabetic patients who are intensively ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.25.12.2133
更新日期:2002-12-01 00:00:00
abstract::Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in l...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.6.922
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.12.1929
更新日期:1999-12-01 00:00:00
abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.6.449
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2513
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1632
更新日期:2013-10-01 00:00:00
abstract::Glucose homeostasis is physiologically maintained by the balance between glucose production by the liver and glucose utilization by the peripheral tissues. Insulin controls hepatic glucose production and promotes glucose utilization by the skeletal muscle. In non-insulin-dependent diabetes mellitus (NIDDM), postabsorp...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.15.3.430
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1888
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare different outcome measures in the audit of management of diabetic foot ulcers RESEARCH DESIGN AND METHODS:Data collected prospectively in a consecutive cohort of patients referred to a specialist multidisciplinary foot care clinic between 1 January 2000 and 31 Decembe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0306
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.6.930
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2193
更新日期:2010-05-01 00:00:00
abstract::Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century. Like other biguanides, metformin can cause a lactic acidosis that is exceptionally rare but fatal. The likelihood of metformin-associated lactic acidosis is substantially higher in patients with kidney impai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-2534
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.9.1067
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications. Contemporary prospective data on the evolution of macrovascular and late microvascular complications of type 1 diabetes are limited. The Epidemio...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.22.1.99
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between disordered eating attitudes and behaviors, BMI, and glycemic control in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a cross-sectional design, 152 adolescents (ages 11-19 years) completed three scales from the Eating Disorders Inventory (EDI): Body Diss...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.4.678
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2210
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Diet is the cornerstone treatment of patients with gestational diabetes mellitus (GDM), but its role in maternal and newborn outcomes has been scarcely studied. The purpose of this study was to analyze the efficacy of dietary interventions on maternal or newborn outcomes in patients with GDM. RESEARCH DESIGN...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc14-1530
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract::Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin secretory defects ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc15-0642
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1834
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metformin and metformin alone-in preserving or improving β-cell function in youth with impaired glucose tolerance (IGT) or recen...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc18-0787
更新日期:2018-08-01 00:00:00
abstract::A rapid paper-strip test for the semiquantitating 3-hydroxybutyrate (3-OHBA) has been developed. The color develops within 5 min after applying the serum to the paper strip, and the purple color was read either visually or by reflectance meter. This can detect 3-OHBA levels as low as 0.1 mmol/L up to 2.0 mmol/L. The m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.5.481
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To determine the effect of treatment with insulin aspart compared with NPH insulin, together with metformin/placebo and rosiglitazone/placebo. The hypothesis was that combined correction of major pathogenetic defects in type 2 diabetes would result in optimal glycemic control. RESEARCH DESIGN AND METHODS:Thi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc10-0531
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS:We searched MEDLINE and EMBASE databases through August 2015. We conducted a q...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc15-2251
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for the development of type 2 diabetes in the mother and is responsible for morbidity in the child. To better identify women at risk of developing GDM we examined sociodemographic correlates and changes in the prevalence of GDM among...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1038
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:Diet therapy in gestational diabetes mellitus (GDM) has focused on carbohydrate restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low-carbohydrate/higher-fat (LC/CONV) diet, hypothesizing that a higher-complex carbohydrate/lower-fat (CHOICE) diet ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-0515
更新日期:2016-01-01 00:00:00
abstract::A 51-yr-old, nonobese, male patient presented with hyperglycemia and a recent 40-pound weight loss. Severe insulin resistance was documented in studies in which high amounts of insulin were infused using the Biostator GCIIS. Diabetic control was finally achieved with subcutaneous injections of 470 U of insulin per day...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.2.3.275
更新日期:1979-05-01 00:00:00
abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0520
更新日期:2013-11-01 00:00:00