Abstract:
OBJECTIVE:To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS:We searched MEDLINE and EMBASE databases through August 2015. We conducted a qualitative review of cross-sectional and prospective studies. Additionally, meta-analyses of metabolite markers, with data estimates from at least three prospective studies, and type 2 diabetes risk were conducted, and multivariable-adjusted relative risks of type 2 diabetes were calculated per study-specific SD difference in a given metabolite. RESULTS:We identified 27 cross-sectional and 19 prospective publications reporting associations of metabolites and prediabetes and/or type 2 diabetes. Carbohydrate (glucose and fructose), lipid (phospholipids, sphingomyelins, and triglycerides), and amino acid (branched-chain amino acids, aromatic amino acids, glycine, and glutamine) metabolites were higher in individuals with type 2 diabetes compared with control subjects. Prospective studies provided evidence that blood concentrations of several metabolites, including hexoses, branched-chain amino acids, aromatic amino acids, phospholipids, and triglycerides, were associated with the incidence of prediabetes and type 2 diabetes. We meta-analyzed results from eight prospective studies that reported risk estimates for metabolites and type 2 diabetes, including 8,000 individuals of whom 1,940 had type 2 diabetes. We found 36% higher risk of type 2 diabetes per study-specific SD difference for isoleucine (pooled relative risk 1.36 [1.24-1.48]; I(2) = 9.5%), 36% for leucine (1.36 [1.17-1.58]; I(2) = 37.4%), 35% for valine (1.35 [1.19-1.53]; I(2) = 45.8%), 36% for tyrosine (1.36 [1.19-1.55]; I(2) = 51.6%), and 26% for phenylalanine (1.26 [1.10-1.44]; I(2) = 56%). Glycine and glutamine were inversely associated with type 2 diabetes risk (0.89 [0.81-0.96] and 0.85 [0.82-0.89], respectively; both I(2) = 0.0%). CONCLUSIONS:In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Guasch-Ferré M,Hruby A,Toledo E,Clish CB,Martínez-González MA,Salas-Salvadó J,Hu FBdoi
10.2337/dc15-2251subject
Has Abstractpub_date
2016-05-01 00:00:00pages
833-46issue
5eissn
0149-5992issn
1935-5548pii
39/5/833journal_volume
39pub_type
杂志文章,meta分析,评审相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS:We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/d...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1223
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2302
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Insulin resistance plays a part in diabetic nephropathy (DN). The association between the peroxisome proliferator-activated receptor γ Pro to Ala alteration at codon 12 (Pro12Ala) polymorphism and the risk of insulin resistance has been confirmed. The association between the polymorphism and DN risk has also ...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc11-2142
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults. RESEARCH DESIGN AND METHODS:A total of 4,497 Americans, aged 18-30 years, who had no diabetes at baseline, were prospectively examined for incid...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0994
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To determine the impact of chronic exercise training initiated later in life upon development of metabolic markers of cardiovascular disease risk. RESEARCH DESIGN AND METHODS:Two inception cohorts of previously sedentary healthy adults aged 55-75 years at baseline (1989), one initiating regular supervised ph...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.28.3.694
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To describe the changes in demographics, antidiabetic treatment, and glycemic control among the prevalent U.S. adult diagnosed type 2 diabetes population between the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and the initial release of NHANES 1999-2000. RESEARCH DESIGN AND METH...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.1.17
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The analysis used the IQVI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2213
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS:Urinary ET-1-LI substance was determined by radioimmunoa...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.17.4.263
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2572
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incidence of type 2 diabetes in subjects with impaired glucose metabolism (...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-2224
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI. RESEARCH DESIGN AND METHODS:...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.11.3129
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.17.7.697
更新日期:1994-07-01 00:00:00
abstract::In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.600
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND METHODS:One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2290
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To compare the effect of morning and bedtime NPH insulin combined with daytime sulfonylurea on glycemic control in non-insulin-dependent diabetes mellitus (NIDDM) patients no longer responding to treatment with sulfonylureas alone. RESEARCH DESIGN AND METHODS:Twenty-four NIDDM patients who fulfilled these cr...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.15.7.831
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:We assessed the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes. RESEARCH DESIGN AND METHODS:As part of preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, we ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc13-1634
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To test the utility of homeostasis model assessment (HOMA) in predicting insulin sensitivity [x10(- 4) min(-1)/(microIU/ml)] in children and to develop and compare two new prediction equations for insulin sensitivity in children using demographic and anthropometric measures in the presence or absence of fasti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.7.1203
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To determine whether, after adjustment for glycemia and other selected covariates, hemoglobin A1c (HbA1c) differed among adults from six Hispanic/Latino heritage groups (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) and between Hispanic/Latino and non-Hispanic white adults wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-2579
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To estimate the within-person variability (SDi) for the overnight urinary albumin excretion rate (AER) in diabetic patients with persistent microalbuminuria. RESEARCH DESIGN AND METHODS:Thirteen normotensive diabetic patients in stable medical control, with normal renal function and without any associated ca...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.17.5.425
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:Few multiple lifestyle behavior change programs have been designed to reduce the risk of coronary heart disease in postmenopausal women with type 2 diabetes. This study tested the effectiveness of the Mediterranean Lifestyle Program (MLP), a comprehensive lifestyle self-management program (Mediterranean low-s...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.8.2288
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1203
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.5.1019
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.6.1346
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To determine whether there is a familial abnormality in erythrocyte Na/Li countertransport (CT) kinetics in the approximate one-third of type 1 diabetic patients that succumb to a familial predisposition to nephropathy. RESEARCH DESIGN AND METHODS:Erythrocyte Na/Li CT kinetics were measured in nondiabetic fi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.3.527
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated with poorer cognition, but the association of SH with cognitive function in late life is unknown. Given the increasing life expectancy in people with T1D, understanding the role of SH in brain health is crucial. RESEARCH DESIGN AN...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0906
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To assess the association of hypoglycemic treatment regimens with cardiovascular adverse events and mortality in a large population of type 2 diabetic patients at increased cardiovascular risk. RESEARCH DESIGN AND METHODS:This analysis included 8,192 overweight patients with type 2 diabetes from the Sibutram...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0027
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A total of 1,268 type 2 diabetic patients whose diabetes was diagnosed within the past 5 years and who had no recent hypoglyce...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-2248
更新日期:2008-10-01 00:00:00
abstract::OBJECTIVE To determine if glucose and C-peptide values obtained as part of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study could be used to estimate insulin sensitivity during late pregnancy. RESEARCH DESIGN AND METHODS A total of 78 women enrolled in the HAPO study were recruited for this ancillary study...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc09-1463
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of diabetes in Tohono O'odham pregnancies, and to assess the efficacy of early prenatal diabetes screening in populations with high rates of diabetes. RESEARCH DESIGN AND METHODS:All Tohono O'odham women receiving prenatal care at the Sells Service Unit who delivered a viable baby...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.1.318
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:This study compared diabetes Treatment As Usual (TAU) with Pathways To Change (PTC), an intervention developed from the Transtheoretical Model of Change (TTM), to determine whether the PTC intervention would result in greater readiness to change, greater increases in self-care, and improved diabetes control. ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.3.732
更新日期:2003-03-01 00:00:00