Insulin-resistant diabetes with insulin receptor autoantibodies in a male patient without acanghosis nigricans.

abstract：OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

journal_title：Diabetes care

authors： Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Large subcutaneous fat cells associate with insulin resistance and high risk of developing type 2 diabetes. We investigated if changes in fat cell volume and fat mass correlate with improvements in the metabolic risk profile after bariatric surgery in obese patients. RESEARCH DESIGN AND METHODS:Fat cell volu...

journal_title：Diabetes care

authors： Andersson DP,Eriksson Hogling D,Thorell A,Toft E,Qvisth V,Näslund E,Thörne A,Wirén M,Löfgren P,Hoffstedt J,Dahlman I,Mejhert N,Rydén M,Arner E,Arner P

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

journal_title：Diabetes care

authors： Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:This study examined whether lipids modify the relationship between intensive glucose control (INT) and diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS:The incidence and progression of DR were assessed in 858 of 1,791 participants with 7-field stereoscopic fundus photographs at baseline and 5 years lat...

journal_title：Diabetes care

authors： Azad N,Bahn GD,Emanuele NV,Agrawal L,Ge L,Reda D,Klein R,Reaven PD,Hayward R,VADT Study Group.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of lixisenatide versus placebo on glycemic control in older patients with type 2 diabetes uncontrolled on their current antidiabetic treatment. RESEARCH DESIGN AND METHODS:In this phase III, double-blind, randomized, placebo-controlled, two-arm, parallel-group, multicenter...

journal_title：Diabetes care

authors： Meneilly GS,Roy-Duval C,Alawi H,Dailey G,Bellido D,Trescoli C,Manrique Hurtado H,Guo H,Pilorget V,Perfetti R,Simpson H,GetGoal-O Trial Investigators.

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:This study estimated the screening prevalence of prediabetes and diabetes using a lower BMI cutoff of 23 kg/m(2) in Asians in the U.S. using the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012. RESEARCH DESIGN AND METHODS:A cross-sectional analysis was conducted of non-Hispanic As...

journal_title：Diabetes care

authors： Hsia DS,Larrivee S,Cefalu WT,Johnson WD

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To estimate the long-run mortality effects of Hurricanes Katrina and Rita on seniors with diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective cohort analysis of Medicare enrollment and claims data covering four states and ∼10 years. Affected individuals were identified by whether they lived in...

journal_title：Diabetes care

authors： Quast T,Andel R,Sadhu AR

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether an oral disposition index (DI(O)) predicts the development of diabetes over a 10-year period. First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function. RESEARCH DESIGN ...

journal_title：Diabetes care

authors： Utzschneider KM,Prigeon RL,Faulenbach MV,Tong J,Carr DB,Boyko EJ,Leonetti DL,McNeely MJ,Fujimoto WY,Kahn SE

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardio...

journal_title：Diabetes care

authors： Nakamura A,Shikata K,Hiramatsu M,Nakatou T,Kitamura T,Wada J,Itoshima T,Makino H

更新日期：2005-12-01 00:00:00

abstract：:The risk of severe hypoglycemia associated with the particular therapeutic approach of two University hospitals was assessed in 96% of all patients with insulin-dependent diabetes mellitus (IDDM) who had been admitted during a period of almost 3 yr to the diabetic wards of two hospitals and who participated in a struc...

journal_title：Diabetes care

authors： Mühlhauser I,Berger M,Sonnenberg G,Koch J,Jörgens V,Schernthaner G,Scholz V,Pädagogin D

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Long-term exposure to alcohol is associated with an improvement in insulin sensitivity. At this time, however, there is no definitive proof that alcohol per se has an effect on the insulin sensitivity index (S(i)) in type 2 diabetes patients. The aim of the present study was to assess the role of acute modera...

journal_title：Diabetes care

authors： Avogaro A,Watanabe RM,Dall'Arche A,De Kreutzenberg SV,Tiengo A,Pacini G

更新日期：2004-06-01 00:00:00

abstract：:Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

journal_title：Diabetes care

authors： Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：:Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT. In this review, we discuss whether intensive lifestyle interventions that delay o...

journal_title：Diabetes care

authors： Chakkera HA,Weil EJ,Pham PT,Pomeroy J,Knowler WC

更新日期：2013-05-01 00:00:00

abstract：:Adjustment algorithms for conventional insulin therapy must be tested for safety and efficacy before clinical implementation. We did this by computer simulation. Accordingly, a computer simulator of human intermediary metabolism created 10 randomly chosen diabetic subjects for study. All were well defined with respect...

journal_title：Diabetes care

authors： Albisser AM,Sozzi S,Strack TR

更新日期：1990-04-01 00:00:00

abstract：:OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the devel...

journal_title：Diabetes care

authors： Warne DK,Charles MA,Hanson RL,Jacobsson LT,McCance DR,Knowler WC,Pettitt DJ

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS:A tot...

journal_title：Diabetes care

authors： Dabelea D,Mayer-Davis EJ,Lamichhane AP,D'Agostino RB Jr,Liese AD,Vehik KS,Narayan KM,Zeitler P,Hamman RF

更新日期：2008-07-01 00:00:00

abstract：:To assess the possible value of the use of high-purity pork insulin (HPPI) in the United States, the serum insulin (I), pancreatic polypeptide (PP), glucagon (G), and somatostatin (SRIF) antibody binding characteristics have been determined in 90 conventional insulin-treated diabetic subjects and related to their degr...

journal_title：Diabetes care

authors： Asplin CM,Hollander P,Pecoraro RE,Brodsky J,Palmer JP

更新日期：1981-05-01 00:00:00

abstract：:It would be advantageous to be able to measure glycosylated hemoglobin (GHb) from a sample of blood dried on paper and sent to the physician by the patient. Indeed, such a technique has been introduced by Isolab (Akron, OH). We tested the validity of the method to determine whether applying the blood to paper and imme...

journal_title：Diabetes care

authors： Broussolle C,Saudek CD

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...

journal_title：Diabetes care

authors： Katakami N,Takahara M,Kaneto H,Shimizu I,Ohno K,Ishibashi F,Osonoi T,Kashiwagi A,Kawamori R,Shimomura I,Matsuhisa M,Yamasaki Y

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2)...

journal_title：Diabetes care

authors： Levy AP,Friedenberg P,Lotan R,Ouyang P,Tripputi M,Higginson L,Cobb FR,Tardif JC,Bittner V,Howard BV

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Diagnostic criteria in fulminant type 1 diabetes, a novel subtype of type 1 diabetes, remain unclear. RESEARCH DESIGN AND METHODS:We analyzed basal and longitudinal changes of serum C-peptide levels during a 75-g oral glucose tolerance test (OGTT) in 125 consecutively recruited patients with type 1 diabetes ...

journal_title：Diabetes care

authors： Tanaka S,Endo T,Aida K,Shimura H,Yokomori N,Kaneshige M,Furuya F,Amemiya S,Mochizuki M,Nakanishi K,Kobayashi T

更新日期：2004-08-01 00:00:00

abstract：:Fifty-one insulin-dependent diabetic patients, 26 children and 25 adults, participated in an open uncontrolled study of the safety and efficacy of human insulin (Novo). The patients, who had previously been treated exclusively with porcine insulin, were followed in two outpatient clinics during a 3-mo study period. Du...

journal_title：Diabetes care

authors： Lyngsøe J,Vestermark S

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...

journal_title：Diabetes care

authors： Tan CE,Emmanuel SC,Tan BY,Jacob E

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To determine whether impairments in neurocognitive functioning are detectable at type 1 diabetes diagnosis and associated with subsequent glycemic control. RESEARCH DESIGN AND METHODS:Children/adolescents (N = 147) aged 5-18 years completed neuropsychological testing during their inpatient hospitalization fo...

journal_title：Diabetes care

authors： Schwartz DD,Axelrad ME,Anderson BJ

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Thiazolidinediones (TZDs) and metformin are insulin-sensitizing antihyperglycemic agents with reported benefits on atherosclerosis. Despite extensive use in patients with diabetes and cardiovascular disease, there is a paucity of outcomes data with metformin and none yet with TZDs. We sought to determine the ...

journal_title：Diabetes care

authors： Inzucchi SE,Masoudi FA,Wang Y,Kosiborod M,Foody JM,Setaro JF,Havranek EP,Krumholz HM

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and incidence of diabetes, and the incidence of major diabetic complications, in a Chippewa Indian population. RESEARCH DESIGN AND METHODS:The format was a longitudinal population study that used active community and health center-based surveillance. The setting was a North Americ...

journal_title：Diabetes care

authors： Rith-Najarian SJ,Valway SE,Gohdes DM

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

journal_title：Diabetes care

authors： Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...

journal_title：Diabetes care

authors： Koskinen LK,Lahtela JT,Koivula TA

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:The goal was to assess the 1-year efficacy and safety of the addition of pioglitazone or metformin to existing sulfonylurea (SU) therapy in patients with inadequately controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:In this multicenter, double-blind study, patients were randomized to receive either pi...

journal_title：Diabetes care

authors： Hanefeld M,Brunetti P,Schernthaner GH,Matthews DR,Charbonnel BH,QUARTET Study Group.

更新日期：2004-01-01 00:00:00