Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study.

Abstract:

OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehensive health check-ups annually for 5 years, were categorized into four groups by the presence of impaired fasting glucose and NAFLD at baseline. The association between NAFLD and incident diabetes was evaluated separately in groups with normal and impaired fasting glucose. RESULTS:For 4 years, the incidence of diabetes in the NAFLD group was 9.9% compared with 3.7% in the non-NAFLD group, with multivariable-adjusted hazard ratio of 1.33 (95% CI 1.07-1.66). However, this higher risk for diabetes only existed in the impaired fasting glucose group. CONCLUSIONS:Our study suggests that NAFLD has an independent and additive effect on the development of diabetes under conditions of impaired insulin secretion.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

doi

10.2337/dc10-1991

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

727-9

issue

3

eissn

0149-5992

issn

1935-5548

pii

dc10-1991

journal_volume

34

pub_type

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