U-500 regular insulin: clinical experience and pharmacokinetics in obese, severely insulin-resistant type 2 diabetic patients.

abstract：OBJECTIVE:Diabetes and its complications disproportionately affect African Americans and Hispanics. Complications could be prevented with appropriate medical care. We compared five processes of care and three outcomes of care among African Americans, Hispanics, and non-Hispanic whites. RESEARCH DESIGN AND METHODS:We u...

journal_title：Diabetes care

authors： Bonds DE,Zaccaro DJ,Karter AJ,Selby JV,Saad M,Goff DC Jr

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...

journal_title：Diabetes care

authors： Maser RE,Mitchell BD,Vinik AI,Freeman R

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely obese patients through mechanisms beyond just weight loss, and it may benefit less obese diabetic patients. We determined the long-term impact of RYGB on patients with diabetes and only class I obesity. RESEARCH DESIGN AND METHODS:Sixty-...

journal_title：Diabetes care

authors： Cohen RV,Pinheiro JC,Schiavon CA,Salles JE,Wajchenberg BL,Cummings DE

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...

journal_title：Diabetes care

authors： Hunt KJ,Baker NL,Cleary PA,Klein R,Virella G,Lopes-Virella MF,DCCT\/EDIC Group of Investigators.

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the association between foot ulcers (DFU) and lower-extremity amputation (LEA) and chronic kidney disease (CKD) in patients with diabetes. RESARCH DESIGN AND METHODS: This was a retrospective cohort study of individuals enrolled between 2002 and 2006 who were aged >...

journal_title：Diabetes care

authors： Margolis DJ,Hofstad O,Feldman HI

更新日期：2008-07-01 00:00:00

abstract：:Enzymatic electrodes are described for the specific and sensitive determination of glucose in blood. The probes are based on the conversion of B-D-glucose by glucose oxidase chemically attached to the surface of a Pt electrode. The peroxide liberated is sensed by measurement of the current generated at +0.7 volts vs. ...

journal_title：Diabetes care

authors： Guilbault GG

更新日期：1982-05-01 00:00:00

abstract：:The plasma glucose and plasma free insulin profiles of six totally insulin-dependent diabetic patients were compared during periods of 4 days in hospital under a conventional insulin therapy (ICIT) comprising 4 daily injections of regular insulin and under continuous subcutaneous insulin infusion (CSII). Two profiles ...

journal_title：Diabetes care

authors： Buysschaert M,Marchand E,Ketelslegers JM,Lambert AE

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The current study aimed to investigate whether microalbuminuria or moderately decreased glomerular filtration rate (GFR) is a better predictor for the development and progression of retinopathy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients without cardiovascular diseases, ...

journal_title：Diabetes care

authors： Chen YH,Chen HS,Tarng DC

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes. RESEARCH D...

journal_title：Diabetes care

authors： Han D,Rozanski A,Gransar H,Sharir T,Einstein AJ,Fish MB,Ruddy TD,Kaufmann PA,Sinusas AJ,Miller EJ,Bateman TM,Dorbala S,Di Carli M,Liang JX,Hu LH,Germano G,Dey D,Berman DS,Slomka PJ

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, the objective of this study was to further analyze whether, and to what extent, use of metformin is associ...

journal_title：Diabetes care

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The intraoral tactile sensitivity (ITS) of diabetic and nondiabetic subjects was compared. The effects of age, ethnicity, sex, and intraoral site were considered. RESEARCH DESIGN AND METHODS:The sample comprised 589 participants of the Oral Health: San Antonio Longitudinal Study of Aging. A total of 107 subj...

journal_title：Diabetes care

authors： Shinkai RS,Hatch JP,Cornell JE,Yeh CK

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:In an open-label trial, participants randomized to receive either liraglutide (1.2 or 1.8 mg/day) or sitagliptin (100 mg/day), each added to metformin, ...

journal_title：Diabetes care

authors： Pratley RE,Nauck MA,Bailey T,Montanya E,Filetti S,Garber AJ,Thomsen AB,Furber S,Davies M,1860-LIRA-DPP-4 Study Group.

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To determine if nephropathy in NIDDM is associated with cellular markers for hypertension. RESEARCH DESIGN AND METHODS:We compared 11 patients with clinical diabetic nephropathy with 15 control subjects with no diabetic nephropathy. The patients were white and had had NIDDM for > or = 9 yr and serum creatini...

journal_title：Diabetes care

authors： Herman WH,Prior DE,Yassine MD,Weder AB

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy. RESEARCH DESIGN AND METHODS:A total of 189 type 1 diabetic patients from the Finnish Diabetic Nephropat...

journal_title：Diabetes care

authors： Saraheimo M,Forsblom C,Fagerudd J,Teppo AM,Pettersson-Fernholm K,Frystyk J,Flyvbjerg A,Groop PH,FinnDiane study group.

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...

journal_title：Diabetes care

authors： Hamdy O,Abou-Elenin K,LoGerfo FW,Horton ES,Veves A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:We assessed the extent to which both standard and alternative indexes from 2-h oral glucose tolerance testing predict type 1 diabetes and whether oral glucose tolerance tests (OGTTs) predict type 1 diabetes in individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:The prediction of type 1 dia...

journal_title：Diabetes care

authors： Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS,Diabetes Prevention Trial-Type 1 Study Group.

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors. RESEARCH DESIGN AND METHODS:Demographic and diabetes self-management factors were measured in 415 subjects followed prospectively for 4-6.5 years of type 1 diabetes duration as participants in ...

journal_title：Diabetes care

authors： Allen C,LeCaire T,Palta M,Daniels K,Meredith M,D'Alessio DJ,Wisconsin Diabetes Registry Project.

更新日期：2001-11-01 00:00:00

abstract：:This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their re...

journal_title：Diabetes care

authors： Permutt MA,Chirgwin J,Rotwein P,Giddings S

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:To compare diabetes prevalence among Asian Americans by World Health Organization and U.S. BMI classifications. RESEARCH DESIGN AND METHODS:Data on Asian American adults (n = 7,414) from the National Health Interview Survey for 1997-2005 were analyzed. Diabetes prevalence was estimated across weight and ethn...

journal_title：Diabetes care

authors： Oza-Frank R,Ali MK,Vaccarino V,Narayan KM

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:With increasing life expectancy in the U.S., it is important to know whether a longer life expectancy means a longer healthy life span or a prolonged period of later-life morbidity. This study examines changes in lifetime without diabetes, a leading cause of morbidity in later life. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Cunningham SA,Riosmena F,Wang J,Boyle JP,Rolka DB,Geiss LS

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To assess prospectively the effect of benchmarking on quality of primary care for patients with type 2 diabetes by using three major modifiable cardiovascular risk factors as critical quality indicators. RESEARCH DESIGN AND METHODS:Primary care physicians treating patients with type 2 diabetes in six Europea...

journal_title：Diabetes care

authors： Hermans MP,Elisaf M,Michel G,Muls E,Nobels F,Vandenberghe H,Brotons C,OPTIMISE International Steering Committee.

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

journal_title：Diabetes care

authors： Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

journal_title：Diabetes care

authors： Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

更新日期：1998-11-01 00:00:00

abstract：:A state diabetes commission and university diabetes program in Kentucky jointly studied the social and economic impact of diabetes mellitus and its complications on the Commonwealth. This investigation revealed that diabetes was a more serious public health problem than previously supposed. Active, diagnosed diabetes ...

journal_title：Diabetes care

authors： Leichter SB,Hernandez C,Fisher A,Collins P,Courtney A

更新日期：1982-03-01 00:00:00

abstract：:Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...

journal_title：Diabetes care

authors： Asplin C,Raghu P,Clemons P,Lyen K,Tatpati O,McKnight B,Baker L,Guthrie R,Sperling M,Palmer J

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS:This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with h...

journal_title：Diabetes care

authors： Wicklow BA,Wittmeier KD,MacIntosh AC,Sellers EA,Ryner L,Serrai H,Dean HJ,McGavock JM

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Altered immune reactivity precedes and accompanies type 1 and type 2 diabetes. We hypothesized that the metabolic phenotype relates to the systemic cellular immune status. RESEARCH DESIGN AND METHODS:A total of 194 metabolically well-controlled patients with type 1 diabetes (n = 62, mean diabetes duration 1....

journal_title：Diabetes care

authors： Menart-Houtermans B,Rütter R,Nowotny B,Rosenbauer J,Koliaki C,Kahl S,Simon MC,Szendroedi J,Schloot NC,Roden M,German Diabetes Study Group.

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To examine the predictors of lower extremity amputation in patients with NIDDM. RESEARCH DESIGN AND METHODS:At baseline, risk factors for amputation were determined in 1,044 NIDDM patients (571 men, 473 women) aged 45 to 64 years. These patients were followed up to 7 years with respect to amputation. RESULT...

journal_title：Diabetes care

authors： Lehto S,Rönnemaa T,Pyörälä K,Laakso M

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:To evaluate temporal trends in rates of initial lower extremity amputation (ILEA) among patients with diabetes in the Veterans Health Administration (VHA). RESEARCH DESIGN AND METHODS:Retrospective administrative data analysis of VHA clinic users with diabetes in fiscal years (FY) 2000 to 2004 (1 October 199...

journal_title：Diabetes care

authors： Tseng CL,Rajan M,Miller DR,Lafrance JP,Pogach L

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To determine, after 1 yr of follow-up in type II diabetes patients, whether a statistically and clinically significant difference can be achieved in HbA1c between a standard therapy group and an intensively treated group, while maintaining HbA1c levels in both groups within ranges acceptable in regular commun...

journal_title：Diabetes care

authors： Abraira C,Emanuele N,Colwell J,Henderson W,Comstock J,Levin S,Nuttall F,Sawin C

更新日期：1992-11-01 00:00:00