Abstract:
OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's Health Initiative Observational Study (WHI-OS). RESULTS:HGF levels positively correlated with BMI and homeostasis model assessment for insulin resistance. In the multivariable analysis comparing the highest tertile with the lowest tertile of HGF, the odds ratio for prevalent diabetes was 2.47 (95% CI [1.12-5.47], P for trend = 0.014) after accounting for age, race, BMI, and other risk factors for diabetes. CONCLUSIONS:HGF levels are associated with the presence of type 2 diabetes in postmenopausal women. Future studies should consider the prospective evaluation of the association of HGF with the development of type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GYdoi
10.2337/dc10-0710subject
Has Abstractpub_date
2010-09-01 00:00:00pages
2013-5issue
9eissn
0149-5992issn
1935-5548pii
dc10-0710journal_volume
33pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS:Data from the national transplant database from 2000 to 2007 were analyzed. SPK recipients who had functioning allografts to 1-year post transplant (...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1718
更新日期:2009-04-01 00:00:00
abstract::Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century. Like other biguanides, metformin can cause a lactic acidosis that is exceptionally rare but fatal. The likelihood of metformin-associated lactic acidosis is substantially higher in patients with kidney impai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-2534
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management. This study examined the effect of acute hypoglycemia on executive function in adults with and without diabetes. RESEARCH DESIGN AND ME...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0194
更新日期:2013-10-01 00:00:00
abstract::Glycated hemoglobin targets have been given in guidelines for the last three decades, mostly without change at around 6.5-7.0% (47-53 mmol/mol). Personalization of such targets has also long been advocated, but often with little and inappropriate guidance. More recently some have suggested higher targets might be indi...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dci19-0002
更新日期:2019-09-01 00:00:00
abstract::To evaluate the importance of dialysis in the determination of glycosylated hemoglobin (HbA1), we studied blood glucose and HbA1 in 38 insulin-dependent diabetic children during a morning fast and again 6 h postprandially. We used two methods to determine glycosylated hemoglobin: (1) the conventional macrocolumn metho...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.5.551
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:C242T polymorphi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.2.458
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS:Conventional CVD risk factors (sex, age, smoking, plasma lipids, blood pressure, and metabolic control) and insul...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.25.7.1135
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare clinical and biomechanical characteristics of balance in diabetic polyneuropathic elderly patients and normal age-matched subjects. RESEARCH DESIGN AND METHODS:Fifteen elderly with distal neuropathy (DNP) and 15 healthy age-matched subjects were evaluated with the b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.8.1187
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:Low vitamin D status is common among healthy black and white adolescents residing at southern U.S. latitudes with a year-round sunny climate. Thus we aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D] and cardiometabolic risk factors in this population. RESEARCH DESIGN AND MET...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1944
更新日期:2012-05-01 00:00:00
abstract::Mortality rates of two cohorts of patients with diabetes mellitus are estimated and compared. The Atlanta cohort is defined as all black patients receiving care at the diabetes clinic of Grady Memorial Hospital for the first time during calendar year 1971. The Memphis cohort is defined as all black patients referred f...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.4.341
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVE:Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1488
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of systematic patient evaluation and patient and provider feedback on the processes and intermediate outcomes of diabetes care in Independent Practice Association model internal medicine practices. RESEARCH DESIGN AND METHODS:Nine practices providing care to managed care patients were ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.26.10.2722
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1995
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To review the published literature and perform a meta-analysis summarizing the evidence in support of an inverse association between type 1 diabetes and the atopic disorders: asthma, eczema, and allergic rhinitis in children. RESEARCH DESIGN AND METHODS:MEDLINE, Web of Science, and PubMed were searched to id...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.26.9.2568
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:This study investigated whether intimacy and autonomy in mother-daughter interactions and relational aspects of the self are associated with metabolic control in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study included 88 girls with diabetes (mean age 14.9 +/- 2....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.3.709
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1365
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.29.1.20
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Delayed gastric emptying and/or gastrointestinal symptoms occur in 30-50% of diabetic patients. Known contributing factors are autonomic neuropathy and acute hyperglycemia, but the role of gastric autoimmunity has never been investigated, although 15-20% of type 1 diabetic patients exhibit parietal cell antib...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.5.912
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.10.1708
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to estimate how much at-risk individuals are willing to pay for type 2 diabetes primary prevention programs. RESEARCH DESIGN AND METHODS:An Internet-based, choice-format conjoint survey was presented to individuals at elevated risk for type 2 diabetes. Hypothetical diabetes risk...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-2221
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-0465
更新日期:2018-07-01 00:00:00
abstract::In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.72
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Low plasma testosterone levels are associated with hyperinsulinemia and glucose intolerance in men. However, it is unclear whether these abnormalities are related to the concomitant alteration in regional adipose tissue (AT) accumulation associated with reduced androgen levels. RESEARCH DESIGN AND METHODS:We...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.3.292
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:The use of thiazolidinedione (TZD) derivatives is associated with fluid retention, especially when combined with insulin. Because TZDs improve the metabolic effect of insulin, they may also reverse the blunted vascular response to insulin. We hypothesize that improvement of the action of insulin on vascular t...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.03.06.dc05-01467
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:Glycemic control using inhaled, dry-powder insulin plus a single injection of long-acting insulin was compared with a conventional regimen in patients with type 2 diabetes, which was previously managed with at least two daily insulin injections. RESEARCH DESIGN AND METHODS:Patients were randomized to 6 month...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.27.10.2356
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Failure to meet goals for glycemic control in primary care settings may be due in part to lack of information critical to guide intensification of therapy. Our objective is to determine whether rapid-turnaround A1c availability would improve intensification of diabetes therapy and reduce A1c levels in patient...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.26.4.1158
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0779
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:We evaluated the accuracy and stability of a capillary HbA1c collection system for use with a high-performance liquid chromatography analyzer. RESEARCH DESIGN AND METHODS:The collection system requires that 5 ul blood is drawn into a calibrated capillary tube, which is then placed into a vial of stabilizing ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.5.700
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:Arterial stiffness occurs early in the atherosclerotic process; however, few data are available concerning risk factors for arterial stiffness in youth with diabetes. We identified factors associated with arterial stiffness in youth with diabetes and assessed the effects of these factors on the relationship b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0747
更新日期:2010-04-01 00:00:00