Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.


OBJECTIVE:We sought to determine whether an oral disposition index (DI(O)) predicts the development of diabetes over a 10-year period. First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function. RESEARCH DESIGN AND METHODS:A total of 613 Japanese-American subjects (322 men and 291 women) underwent a 75-g oral glucose tolerance test (OGTT) at baseline, 5 years, and 10 years. Insulin sensitivity was estimated as 1/fasting insulin or homeostasis model assessment of insulin sensitivity (HOMA-S). Insulin response was estimated as the change in insulin divided by change in glucose from 0 to 30 min (DeltaI(0-30)/DeltaG(0-30)). RESULTS:DeltaI(0-30)/DeltaG(0-30) demonstrated a curvilinear relationship with 1/fasting insulin and HOMA-S with a left and downward shift as glucose tolerance deteriorated. The confidence limits for the slope of the log(e)-transformed estimates included -1 for DeltaI(0-30)/DeltaG(0-30) versus 1/fasting insulin for all glucose tolerance groups, consistent with a hyperbolic relationship. When HOMA-S was used as the insulin sensitivity measure, the confidence limits for the slope included -1 only for subjects with normal glucose tolerance (NGT) or impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) but not diabetes. On the basis of this hyperbolic relationship, the product of DeltaI(0-30)/DeltaG(0-30) and 1/fasting insulin was calculated (DI(O)) and decreased from NGT to IFG/IGT to diabetes (P < 0.001). Among nondiabetic subjects at baseline, baseline DI(O) predicted cumulative diabetes at 10 years (P < 0.001) independent of age, sex, BMI, family history of diabetes, and baseline fasting and 2-h glucose concentrations. CONCLUSIONS:The DI(O) provides a measure of beta-cell function adjusted for insulin sensitivity and is predictive of development of diabetes over 10 years.


Diabetes Care


Diabetes care


Utzschneider KM,Prigeon RL,Faulenbach MV,Tong J,Carr DB,Boyko EJ,Leonetti DL,McNeely MJ,Fujimoto WY,Kahn SE




Has Abstract


2009-02-01 00:00:00














  • Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study.

    abstract:OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

    更新日期:2011-03-01 00:00:00

  • Effects of repeated hypoglycemia on cognitive function: a psychometrically validated reanalysis of the Diabetes Control and Complications Trial data.

    abstract:OBJECTIVE:To test the conclusion that there is no association between multiple episodes of severe hypoglycemia and cognitive decrements by reanalyzing the data from the Diabetes Control and Complications Trial (DCCT) with psychometrically validated cognitive factors and to conduct a novel analysis of the association be...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Austin EJ,Deary IJ

    更新日期:1999-08-01 00:00:00

  • Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.

    abstract:OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D

    更新日期:2015-06-01 00:00:00

  • Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

    abstract:OBJECTIVE:The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS:Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-ba...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Stellato RK,Feldman HA,Hamdy O,Horton ES,McKinlay JB

    更新日期:2000-04-01 00:00:00

  • Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry.

    abstract:OBJECTIVE:Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes. RESEARCH D...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Han D,Rozanski A,Gransar H,Sharir T,Einstein AJ,Fish MB,Ruddy TD,Kaufmann PA,Sinusas AJ,Miller EJ,Bateman TM,Dorbala S,Di Carli M,Liang JX,Hu LH,Germano G,Dey D,Berman DS,Slomka PJ

    更新日期:2020-02-01 00:00:00

  • PEPCK gene as model of inhibitory effects of insulin on gene transcription.

    abstract::Regulation of gene transcription is a major action of insulin. Most of the greater than 20 examples of this effect involve the stimulation of transcription, but a few involve an inhibition. The inhibition of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene has been studied in detail. Most of this ef...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: O'Brien RM,Granner DK

    更新日期:1990-03-01 00:00:00

  • Measuring diabetes self-care: a psychometric analysis of the Self-Care Inventory-Revised with adults.

    abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Weinger K,Butler HA,Welch GW,La Greca AM

    更新日期:2005-06-01 00:00:00

  • Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions.

    abstract:OBJECTIVE:We aimed at analyzing the frequency, clinical characteristics, and trends associated with the occurrence of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes on the basis of long-term follow-up data. RESEARCH DESIGN AND METHODS:A total of 106 pediatric diabetes centers in Germany and Austria partic...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Neu A,Hofer SE,Karges B,Oeverink R,Rosenbauer J,Holl RW,DPV Initiative and the German BMBF Competency Network for Diabetes Mellitus.

    更新日期:2009-09-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

  • Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects.

    abstract:OBJECTIVE:We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS:A tot...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tsunekawa T,Hayashi T,Suzuki Y,Matsui-Hirai H,Kano H,Fukatsu A,Nomura N,Miyazaki A,Iguchi A

    更新日期:2003-02-01 00:00:00

  • Microalbuminuria. Invalidity of simple concentration-based screening tests for early nephropathy due to urinary volumes of diabetic patients.

    abstract:OBJECTIVE:To evaluate the possibility of replacing quantitative albumin excretion rate (AER) measurements with rapid screening tests for microalbuminuria. RESEARCH DESIGN AND METHODS:Dipstick-negative specimens from 363 consecutive insulin-dependent diabetes mellitus (IDDM) and 46 non-insulin-dependent diabetes mellit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kouri TT,Viikari JS,Mattila KS,Irjala KM

    更新日期:1991-07-01 00:00:00

  • Measures of arterial stiffness in youth with type 1 and type 2 diabetes: the SEARCH for diabetes in youth study.

    abstract:OBJECTIVE:Arterial stiffness occurs early in the atherosclerotic process; however, few data are available concerning risk factors for arterial stiffness in youth with diabetes. We identified factors associated with arterial stiffness in youth with diabetes and assessed the effects of these factors on the relationship b...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wadwa RP,Urbina EM,Anderson AM,Hamman RF,Dolan LM,Rodriguez BL,Daniels SR,Dabelea D,SEARCH Study Group.

    更新日期:2010-04-01 00:00:00

  • The short-term impact of a continuing medical education program on providers' attitudes toward treating diabetes.

    abstract:OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Sharp LK,Lipsky MS

    更新日期:1999-12-01 00:00:00

  • Diabetes in employer-sponsored health insurance.

    abstract:OBJECTIVE:To examine medical and mental health care expenditures for large numbers of individuals with diabetes enrolled in employment-sponsored insurance plans. RESEARCH DESIGN AND METHODS:Health insurance billing data for approximately 1.3 million individuals enrolled in health insurance plans sponsored by 862 large...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Peele PB,Lave JR,Songer TJ

    更新日期:2002-11-01 00:00:00

  • Pulse pressure and prediction of incident foot ulcers in type 2 diabetes.

    abstract:OBJECTIVE:To assess the relevance of pulse pressure as a predictor of foot ulcers in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:A cohort study was performed on a consecutive series of 1,945 type 2 diabetic outpatients without a foot ulcer at baseline. Incident foot ulcers were identified through the regiona...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Monami M,Vivarelli M,Desideri CM,Colombi C,Marchionni N,Mannucci E

    更新日期:2009-05-01 00:00:00

  • BMI and All-Cause Mortality in Normoglycemia, Impaired Fasting Glucose, Newly Diagnosed Diabetes, and Prevalent Diabetes: A Cohort Study.

    abstract:OBJECTIVE:This study examined associations between BMI and mortality in individuals with normoglycemia, impaired fasting glucose (IFG), newly diagnosed diabetes, and prevalent diabetes and identified BMI ranges associated with the lowest mortality in each group. RESEARCH DESIGN AND METHODS:A total of 12,815,006 adults...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Lee EY,Lee YH,Yi SW,Shin SA,Yi JJ

    更新日期:2017-08-01 00:00:00

  • The impact of a decade of changing treatment on rates of severe hypoglycemia in a population-based cohort of children with type 1 diabetes.

    abstract:OBJECTIVE:To determine the impact of changes to treatment on the incidence of severe hypoglycemia and its risk factors in a large population-based cohort of children with type 1 diabetes. RESEARCH DESIGN AND METHODS:The cohort consisted of 1,335 children (age at entry 9.5 +/- 4.3 years [mean +/- SD], range 0-18), yiel...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Bulsara MK,Holman CD,Davis EA,Jones TW

    更新日期:2004-10-01 00:00:00

  • Impact of Lowering BMI Cut Points as Recommended in the Revised American Diabetes Association's Standards of Medical Care in Diabetes-2015 on Diabetes Screening in Asian Americans.

    abstract:OBJECTIVE:This study estimated the screening prevalence of prediabetes and diabetes using a lower BMI cutoff of 23 kg/m(2) in Asians in the U.S. using the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012. RESEARCH DESIGN AND METHODS:A cross-sectional analysis was conducted of non-Hispanic As...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Hsia DS,Larrivee S,Cefalu WT,Johnson WD

    更新日期:2015-11-01 00:00:00

  • Release of platelet plasminogen activator inhibitor 1 in whole blood is increased in patients with type II diabetes.

    abstract:OBJECTIVE:To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS:We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in pl...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Jokl R,Klein RL,Lopes-Virella MF,Colwell JA

    更新日期:1995-08-01 00:00:00

  • Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood.

    abstract:OBJECTIVE:Gestational diabetes mellitus has been associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models. We assessed the associations of maternal random glucose concentrations across the full ran...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wahab RJ,Jaddoe VWV,Roest AAW,Toemen L,Gaillard R

    更新日期:2020-09-01 00:00:00

  • Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction.

    abstract:OBJECTIVE:Preclinical data suggest that linagliptin, a dipeptidyl peptidase-4 inhibitor, may lower urinary albumin excretion. The ability of linagliptin to lower albuminuria on top of renin-angiotensin-aldosterone system (RAAS) inhibition in humans was analyzed by pooling data from four similarly designed, 24-week, ran...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Groop PH,Cooper ME,Perkovic V,Emser A,Woerle HJ,von Eynatten M

    更新日期:2013-11-01 00:00:00

  • Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study.

    abstract:OBJECTIVE:The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study. RESEARCH DESIGN AND METHODS:Baseline risk factors and CHD at follow-up were assessed in 2,329 type 1 diabetic patients without ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Soedamah-Muthu SS,Chaturvedi N,Toeller M,Ferriss B,Reboldi P,Michel G,Manes C,Fuller JH,EURODIAB Prospective Complications Study Group.

    更新日期:2004-02-01 00:00:00

  • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

    abstract:OBJECTIVE:The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes. The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析


    authors: Tönjes A,Scholz M,Loeffler M,Stumvoll M

    更新日期:2006-11-01 00:00:00

  • No Evidence of Increase in Calcitonin Concentrations or Development of C-Cell Malignancy in Response to Liraglutide for Up to 5 Years in the LEADER Trial.

    abstract:OBJECTIVE:To describe the changes in serum levels of calcitonin in liraglutide- and placebo-treated patients in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results-A Long Term Evaluation (LEADER) trial over a 3.5-5-year period. RESEARCH DESIGN AND METHODS:Patients (n = 9,340) wi...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Hegedüs L,Sherman SI,Tuttle RM,von Scholten BJ,Rasmussen S,Karsbøl JD,Daniels GH,LEADER Publication Committee on behalf of the LEADER Trial Investigators.

    更新日期:2018-03-01 00:00:00

  • Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes: A Predefined Subgroup Analysis From the DETO2X-AMI Trial.

    abstract:OBJECTIVE:To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes. RESEARCH DESIGN AND METHODS:In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxyge...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Nyström T,James SK,Lindahl B,Östlund O,Erlinge D,Herlitz J,Omerovic E,Mellbin L,Alfredsson J,Fröbert O,Jernberg T,Hofmann R,DETO2X-SWEDEHEART Investigators.

    更新日期:2019-11-01 00:00:00

  • Psychosocial correlates of survival in diabetes.

    abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Davis WK,Hess GE,Hiss RG

    更新日期:1988-07-01 00:00:00

  • Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort.

    abstract:OBJECTIVE:Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS:At ba...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Fernandez C,Surma MA,Klose C,Gerl MJ,Ottosson F,Ericson U,Oskolkov N,Ohro-Melander M,Simons K,Melander O

    更新日期:2020-02-01 00:00:00

  • Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study.

    abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YT

    更新日期:2010-01-01 00:00:00

  • Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes.

    abstract:OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ferrannini E,Veltkamp SA,Smulders RA,Kadokura T

    更新日期:2013-05-01 00:00:00

  • Depressive symptoms and occurrence of type 2 diabetes among Japanese men.

    abstract:OBJECTIVE:To examine the relationship between depressive symptoms and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for t...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kawakami N,Takatsuka N,Shimizu H,Ishibashi H

    更新日期:1999-07-01 00:00:00