Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.

Abstract:

OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. RESULTS:Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01). CONCLUSIONS:Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new "marker" for cardiovascular risk.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bardini G,Dicembrini I,Cresci B,Rotella CM

doi

10.2337/dc09-1342

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

411-3

issue

2

eissn

0149-5992

issn

1935-5548

pii

dc09-1342

journal_volume

33

pub_type

杂志文章
  • Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women.

    abstract:OBJECTIVE:Some evidence suggests an inverse association between type 2 diabetes and androgens in men and a positive association between type 2 diabetes and androgens in women. The purpose of this community-based study was to evaluate sex differences in the association between endogenous total and bioavailable estrogen ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.7.912

    authors: Goodman-Gruen D,Barrett-Connor E

    更新日期:2000-07-01 00:00:00

  • Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome.

    abstract:OBJECTIVE:Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.11.3129

    authors: Marfella R,Siniscalchi M,Esposito K,Sellitto A,De Fanis U,Romano C,Portoghese M,Siciliano S,Nappo F,Sasso FC,Mininni N,Cacciapuoti F,Lucivero G,Giunta R,Verza M,Giugliano D

    更新日期:2003-11-01 00:00:00

  • The Prognostic Significance of Diabetes and Microvascular Complications in Patients With Heart Failure With Preserved Ejection Fraction.

    abstract:OBJECTIVE:This study examined the prognostic significance of diabetes and microvascular complications in patients with heart failure with preserved ejection fraction (HFpEF). RESEARCH DESIGN AND METHODS:This analysis included 3,385 patients (mean age 69 ± 9.6 years; 49% male; 89% white) with HFpEF from the Treatment o...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc17-0755

    authors: Sandesara PB,O'Neal WT,Kelli HM,Samman-Tahhan A,Hammadah M,Quyyumi AA,Sperling LS

    更新日期:2018-01-01 00:00:00

  • Barriers to eye care among people aged 40 years and older with diagnosed diabetes, 2006-2010.

    abstract::OBJECTIVE We examine barriers to receiving recommended eye care among people aged ≥40 years with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed 2006-2010 Behavioral Risk Factor Surveillance System data from 22 states (n = 27,699). Respondents who had not sought eye care in the preceding 12 months were ask...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1507

    authors: Chou CF,Sherrod CE,Zhang X,Barker LE,Bullard KM,Crews JE,Saaddine JB

    更新日期:2014-01-01 00:00:00

  • Waist circumference and waist-to-hip ratio are related to gestational glucose tolerance.

    abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.509

    authors: Branchtein L,Schmidt MI,Mengue SS,Reichelt AJ,Matos MC,Duncan BB

    更新日期:1997-04-01 00:00:00

  • Relationships between metabolic syndrome and other baseline factors and the efficacy of ezetimibe/simvastatin and atorvastatin in patients with type 2 diabetes and hypercholesterolemia.

    abstract:OBJECTIVE:To investigate relationships between baseline factors and treatment-associated efficacy changes in type 2 diabetes. RESEARCH DESIGN:AND METHODS Multivariable analyses of treatment response in 1,229 type 2 diabetic patients with hypercholesterolemia who received ezetimibe/simvastatin or atorvastatin in a rand...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1762

    authors: Goldberg RB,Guyton JR,Mazzone T,Weinstock RS,Polis AB,Tipping D,Tomassini JE,Tershakovec AM

    更新日期:2010-05-01 00:00:00

  • Trends in health care expenditure in U.S. adults with diabetes: 2002-2011.

    abstract:OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-0369

    authors: Ozieh MN,Bishu KG,Dismuke CE,Egede LE

    更新日期:2015-10-01 00:00:00

  • Markers of platelet activation are increased in adolescents with type 2 diabetes.

    abstract:OBJECTIVE:In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation. RESEARCH DESIGN AND METHODS:In vivo platelet activation was compared in...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-2718

    authors: Israels SJ,McNicol A,Dean HJ,Cognasse F,Sellers EA

    更新日期:2014-08-01 00:00:00

  • Prediction of type 1 diabetes in the general population.

    abstract:OBJECTIVE:To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS:A total of 3,475 nondiabetic subjects aged 3-18 years were sampled i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1040

    authors: Knip M,Korhonen S,Kulmala P,Veijola R,Reunanen A,Raitakari OT,Viikari J,Akerblom HK

    更新日期:2010-06-01 00:00:00

  • Blood pressure and the risk of developing diabetes in african americans and whites: ARIC, CARDIA, and the framingham heart study.

    abstract:OBJECTIVE:We examined the association between high blood pressure and incident type 2 diabetes in African Americans and whites aged 35-54 years at baseline. RESEARCH DESIGN AND METHODS:We combined data from the Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARD...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-1786

    authors: Wei GS,Coady SA,Goff DC Jr,Brancati FL,Levy D,Selvin E,Vasan RS,Fox CS

    更新日期:2011-04-01 00:00:00

  • Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults.

    abstract:OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1227

    authors: Carson AP,Reynolds K,Fonseca VA,Muntner P

    更新日期:2010-01-01 00:00:00

  • A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.

    abstract:OBJECTIVE:Serine-threonine kinase STK11 catalyzes the AMP-activated protein kinase complex. We tested the hypothesis that a gene variant in STK11 contributes to variation in insulin sensitivity and metformin efficacy. RESEARCH DESIGN AND METHODS:We studied the effects of a single nucleotide polymorphism (SNP) (rs81116...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1750

    authors: López-Bermejo A,Díaz M,Morán E,de Zegher F,Ibáñez L

    更新日期:2010-07-01 00:00:00

  • Closing the gap: the problem of diabetes mellitus in the United States. The Carter Center of Emory University.

    abstract::Diabetes mellitus is a major public health problem and a leading cause of death, disability, and cost in the United States. We review the epidemiology of diabetes and its complications, the costs of diabetes, and discuss intervention strategies to reduce the burden of diabetes in the United States. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.8.4.391

    authors:

    更新日期:1985-07-01 00:00:00

  • Can self-rated health scores be used for risk prediction in patients with type 2 diabetes?

    abstract:OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1391

    authors: Hayes AJ,Clarke PM,Glasziou PG,Simes RJ,Drury PL,Keech AC

    更新日期:2008-04-01 00:00:00

  • Dissociation of microangiopathy and macroangiopathy in patients with type 2 diabetes.

    abstract:OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.9.1451

    authors: Yamamoto M,Egusa G,Okubo M,Yamakido M

    更新日期:1998-09-01 00:00:00

  • Concordance for type 1 diabetes in identical twins is affected by insulin genotype.

    abstract:OBJECTIVE:Monozygotic twins are usually discordant (only one twin affected) for type 1 diabetes. Discordance for disease between such twins implies a role for nongenetically determined factors but could also be influenced by a decreased load of diabetes susceptibility genes. The aim of this study was to determine wheth...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.5.838

    authors: Metcalfe KA,Hitman GA,Rowe RE,Hawa M,Huang X,Stewart T,Leslie RD

    更新日期:2001-05-01 00:00:00

  • Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii.

    abstract::Japanese migrants and their offspring on the island of Hawaii and Japanese living in Hiroshima were examined for diabetes mellitus and its vascular complications. the same methods and investigators were used in both locations. Death certificates of Japanese and Caucasians dying on the island during the past 26 yr were...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.2.161

    authors: Kawate R,Yamakido M,Nishimoto Y,Bennett PH,Hamman RF,Knowler WC

    更新日期:1979-03-01 00:00:00

  • Development and validation of a questionnaire to assess carbohydrate and insulin-dosing knowledge in youth with type 1 diabetes.

    abstract::OBJECTIVE The American Diabetes Association advocates insulin regimens for youth with type 1 diabetes that involve adjusting insulin dose based on carbohydrate intake and blood glucose level. Implementing these regimens requires knowledge about carbohydrate content of foods and subsequent calculations of insulin dose,...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0390

    authors: Koontz MB,Cuttler L,Palmert MR,O'Riordan M,Borawski EA,McConnell J,Kern EO

    更新日期:2010-03-01 00:00:00

  • Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

    abstract:OBJECTIVE:We assessed the extent to which both standard and alternative indexes from 2-h oral glucose tolerance testing predict type 1 diabetes and whether oral glucose tolerance tests (OGTTs) predict type 1 diabetes in individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:The prediction of type 1 dia...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc06-1615

    authors: Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS,Diabetes Prevention Trial-Type 1 Study Group.

    更新日期:2007-01-01 00:00:00

  • A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos.

    abstract:OBJECTIVE:We aimed to identify hemoglobin A1c (HbA1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA1c in U.S. Hispanics/Latinos with diverse genetic ancestries. RESEARCH DESIGN AND METHODS:We conducted a genome-wide association study (GWAS) of HbA1c in 9,636 U.S. Hispa...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0168

    authors: Moon JY,Louie TL,Jain D,Sofer T,Schurmann C,Below JE,Lai CQ,Aviles-Santa ML,Talavera GA,Smith CE,Petty LE,Bottinger EP,Chen YI,Taylor KD,Daviglus ML,Cai J,Wang T,Tucker KL,Ordovás JM,Hanis CL,Loos RJF,Schneiderm

    更新日期:2019-09-01 00:00:00

  • A randomized trial of an intervention to improve self-care behaviors of African-American women with type 2 diabetes: impact on physical activity.

    abstract:OBJECTIVE:To determine whether a culturally appropriate clinic- and community-based intervention for African-American women with type 2 diabetes will increase moderate-intensity physical activity (PA). RESEARCH DESIGN AND METHODS:In this randomized controlled trial conducted at seven practices in central North Carolin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.25.9.1576

    authors: Keyserling TC,Samuel-Hodge CD,Ammerman AS,Ainsworth BE,Henríquez-Roldán CF,Elasy TA,Skelly AH,Johnston LF,Bangdiwala SI

    更新日期:2002-09-01 00:00:00

  • Incidences, treatments, outcomes, and sex effect on survival in patients with end-stage renal disease by diabetes status in Australia and New Zealand (1991 2005).

    abstract:OBJECTIVE:We aimed to update the epidemiology of type 1 and type 2 diabetic patients among the incident end-stage renal disease (ESRD) population in Australia and New Zealand (ANZ) and to determine whether outcome is worse for diabetic women, as described in the general population. RESEARCH DESIGNS AND METHODS:All res...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0895

    authors: Villar E,Chang SH,McDonald SP

    更新日期:2007-12-01 00:00:00

  • The role of the National Diabetes Advisory Board in diabetes management.

    abstract::The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:

    authors: Genuth SM

    更新日期:1994-06-01 00:00:00

  • Predictors of glycemic control in insulin-using adults with type 2 diabetes.

    abstract:OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.3.273

    authors: Nichols GA,Hillier TA,Javor K,Brown JB

    更新日期:2000-03-01 00:00:00

  • Global Disability Burdens of Diabetes-Related Lower-Extremity Complications in 1990 and 2016.

    abstract:OBJECTIVE:No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap. RESEARCH DESIGN AND METHODS:GBD 2016 data, including prevalence and years lived with dis...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1614

    authors: Zhang Y,Lazzarini PA,McPhail SM,van Netten JJ,Armstrong DG,Pacella RE

    更新日期:2020-05-01 00:00:00

  • Long-term metformin use is associated with decreased risk of breast cancer.

    abstract:OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1791

    authors: Bodmer M,Meier C,Krähenbühl S,Jick SS,Meier CR

    更新日期:2010-06-01 00:00:00

  • Fatty acid composition of serum lipid fractions in type 2 diabetic patients with microalbuminuria.

    abstract:OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.3.613

    authors: Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

    更新日期:2003-03-01 00:00:00

  • Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation.

    abstract:OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.9.988

    authors: Tran MP,Larsen JL,Duckworth WC,Ruby EI,Miller SA,Frisbie K,Taylor RJ,Stratta RJ

    更新日期:1994-09-01 00:00:00

  • Rising incidence of type 2 diabetes in children in the U.K.

    abstract:OBJECTIVE:To estimate the incidence of type 2 diabetes in children <17 years of age and to investigate the relationship of diabetes with increasing childhood obesity in the U.K. and the Republic of Ireland (ROI). RESEARCH DESIGN AND METHODS:Active monthly reporting of cases by consultant pediatricians occurred through...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1813

    authors: Haines L,Wan KC,Lynn R,Barrett TG,Shield JP

    更新日期:2007-05-01 00:00:00

  • Frequency and determinants of diabetes patient education among adults in the U.S. population.

    abstract:OBJECTIVE:To determine the proportion of adults with diabetes in the U.S. who have received diabetes patient education and to assess factors that determine whether patients receive this education. RESEARCH DESIGN AND METHODS:A questionnaire on diabetes was administered to a representative sample of 2,405 diabetic indi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.17.8.852

    authors: Coonrod BA,Betschart J,Harris MI

    更新日期:1994-08-01 00:00:00