Markers of platelet activation are increased in adolescents with type 2 diabetes.

Abstract:

OBJECTIVE:In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation. RESEARCH DESIGN AND METHODS:In vivo platelet activation was compared in four groups of age-matched adolescents: type 1 diabetes (T1D, n = 15), type 2 diabetes (T2D; n = 15), control subjects with normal BMI (n = 14), and overweight/obese control subjects (n = 13). Platelet surface activation markers and plasma levels of soluble activation markers were measured and compared among groups. RESULTS:Increased expression of all activation markers was observed in T2D compared with either control group (P < 0.05); levels of soluble markers were also higher in T2D than in T1D (P < 0.05). There were no differences in marker expression between the nondiabetic control groups. CONCLUSIONS:Platelet activation in adolescents with T2D may be a marker for the risk of CVD development in early adulthood.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Israels SJ,McNicol A,Dean HJ,Cognasse F,Sellers EA

doi

10.2337/dc13-2718

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

2400-3

issue

8

eissn

0149-5992

issn

1935-5548

pii

dc13-2718

journal_volume

37

pub_type

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