Abstract:
OBJECTIVE:In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation. RESEARCH DESIGN AND METHODS:In vivo platelet activation was compared in four groups of age-matched adolescents: type 1 diabetes (T1D, n = 15), type 2 diabetes (T2D; n = 15), control subjects with normal BMI (n = 14), and overweight/obese control subjects (n = 13). Platelet surface activation markers and plasma levels of soluble activation markers were measured and compared among groups. RESULTS:Increased expression of all activation markers was observed in T2D compared with either control group (P < 0.05); levels of soluble markers were also higher in T2D than in T1D (P < 0.05). There were no differences in marker expression between the nondiabetic control groups. CONCLUSIONS:Platelet activation in adolescents with T2D may be a marker for the risk of CVD development in early adulthood.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Israels SJ,McNicol A,Dean HJ,Cognasse F,Sellers EAdoi
10.2337/dc13-2718subject
Has Abstractpub_date
2014-08-01 00:00:00pages
2400-3issue
8eissn
0149-5992issn
1935-5548pii
dc13-2718journal_volume
37pub_type
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