Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D).

Abstract:

OBJECTIVE:To investigate 1-year outcomes of a national diabetes prevention program in Finland. RESEARCH DESIGN AND METHODS:Altogether 10,149 individuals at high risk for diabetes were identified with the Finnish Diabetes Risk Score (FINDRISC; scoring ≥15 points), by a history of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), cardiovascular disease, or gestational diabetes mellitus in 400 primary health care centers. One-year follow-up data were available for 2,798 participants who were nondiabetic at baseline (919 men and 1,879 women, aged 56.0 ± 9.9 and 54.0 ± 10.7 years [mean ± SD] with BMI 30.9 ± 4.6 and 31.6 ± 5.4 kg/m(2)). RESULTS:The incidence of diabetes was 2.0 and 1.2% in men and women with normal glucose tolerance at baseline, 13.5 and 7.4% in those with IFG, and 16.1 and 11.3% in those with IGT, respectively. Altogether 17.5% of the subjects lost ≥ 5% weight with no sex difference. The relative risk of diabetes was 0.31 (95% CI 0.16-0.59) in the group who lost ≥ 5% weight, 0.72 (0.46-1.13) in the group who lost 2.5-4.9% weight, and 1.10 (0.77-1.58) in the group who gained ≥ 2.5% compared with the group who maintained weight. CONCLUSIONS:The FIN-D2D was the first national effort to implement the prevention of diabetes in a primary health care setting. Methods for recruiting high-risk subjects were simple and easy to use. Moderate weight loss in this very high-risk group was especially effective in reducing risk of diabetes among those participating in the program.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Saaristo T,Moilanen L,Korpi-Hyövälti E,Vanhala M,Saltevo J,Niskanen L,Jokelainen J,Peltonen M,Oksa H,Tuomilehto J,Uusitupa M,Keinänen-Kiukaanniemi S

doi

10.2337/dc10-0410

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

2146-51

issue

10

eissn

0149-5992

issn

1935-5548

pii

dc10-0410

journal_volume

33

pub_type

杂志文章
  • Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction.

    abstract:OBJECTIVE:To determine the effect of diabetes on long-term survival after acute myocardial infarction and to compare its effect with that of a previous myocardial infarction. RESEARCH DESIGN AND METHODS:In a prospective cohort study, we followed 1,935 patients hospitalized with a confirmed acute myocardial infarction ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.24.8.1422

    authors: Mukamal KJ,Nesto RW,Cohen MC,Muller JE,Maclure M,Sherwood JB,Mittleman MA

    更新日期:2001-08-01 00:00:00

  • American Diabetes Association's Fourth International Workshop-Conference on Gestational Diabetes Mellitus: summary and discussion. Therapeutic interventions.

    abstract::This review summarizes Session IV: Therapeutic Interventions of the Fourth International Gestational Diabetes Workshop and suggests intervention protocols based on the presentations at this meeting and the literature. The opinions of the six presenters and their interpretation of the review of the literature in their ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Jovanovic L

    更新日期:1998-08-01 00:00:00

  • Variability of urinary albumin excretion in patients with microalbuminuria.

    abstract:OBJECTIVE:To estimate the within-person variability (SDi) for the overnight urinary albumin excretion rate (AER) in diabetic patients with persistent microalbuminuria. RESEARCH DESIGN AND METHODS:Thirteen normotensive diabetic patients in stable medical control, with normal renal function and without any associated ca...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.17.5.425

    authors: Phillipou G,Phillips PJ

    更新日期:1994-05-01 00:00:00

  • Psychosocial and socioeconomic risk factors for premature death in young people with type 1 diabetes.

    abstract:OBJECTIVE:Mortality from acute diabetes-related events is greatly raised in young adults with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths from acute events separately from deaths due to other causes. RESEARCH DESIGN AND METHODS:This study had a nested case-control design. The c...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.7.1618

    authors: Laing SP,Jones ME,Swerdlow AJ,Burden AC,Gatling W

    更新日期:2005-07-01 00:00:00

  • Food Insecurity, Food "Deserts," and Glycemic Control in Patients With Diabetes: A Longitudinal Analysis.

    abstract:OBJECTIVE:Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diabetes management is poorly understood. RESEARCH DESIGN AND METHODS:This was a prospective cohort study. A random sample o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1981

    authors: Berkowitz SA,Karter AJ,Corbie-Smith G,Seligman HK,Ackroyd SA,Barnard LS,Atlas SJ,Wexler DJ

    更新日期:2018-06-01 00:00:00

  • Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians.

    abstract:OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.4.271

    authors: Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

    更新日期:1991-04-01 00:00:00

  • Immune Checkpoint Inhibitor-Associated Diabetes: A Single-Institution Experience.

    abstract:OBJECTIVE:To characterize immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS:Retrospective chart review of 18 patients with new-onset ICI-DM following anti-programmed cell death protein 1 (PD-1)/anti-programmed cell death protein ligand 1 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0609

    authors: Byun DJ,Braunstein R,Flynn J,Zheng J,Lefkowitz RA,Kanbour S,Girotra M

    更新日期:2020-12-01 00:00:00

  • Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies.

    abstract:OBJECTIVE:Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS:We conducted a PubMed databa...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审

    doi:10.2337/dc11-0518

    authors: Dong JY,Xun P,He K,Qin LQ

    更新日期:2011-09-01 00:00:00

  • Prevalence of diabetes and ethnic differences in cardiovascular risk factors. The 1992 Singapore National Health Survey.

    abstract:OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.2.241

    authors: Tan CE,Emmanuel SC,Tan BY,Jacob E

    更新日期:1999-02-01 00:00:00

  • Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children.

    abstract:OBJECTIVE:To characterize the insulin sensitivity of overweight and obese 5- to 10-year-old (Tanner stage 1-3) African-American children screened for participation in a diabetes prevention study and to identify the association of insulin sensitivity with obesity, hyperlipidemia, and hypertension. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.8.1359

    authors: Young-Hyman D,Schlundt DG,Herman L,De Luca F,Counts D

    更新日期:2001-08-01 00:00:00

  • Spanish diabetes self-management with and without automated telephone reinforcement: two randomized trials.

    abstract:OBJECTIVE:To determine 1) whether participants in the Spanish Diabetes Self-Management Program (SDSMP), when compared at 6 months to randomized control subjects, would demonstrate improvements in health status, health behaviors, and self-efficacy; and 2) whether SDSMP participants receiving monthly automated telephone ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1313

    authors: Lorig K,Ritter PL,Villa F,Piette JD

    更新日期:2008-03-01 00:00:00

  • Clustering of cardiovascular risk factors associated with the insulin resistance syndrome: assessment by principal component analysis in young hyperandrogenic women.

    abstract:OBJECTIVE:Hyperinsulinemia is often associated with several metabolic abnormalities and increased blood pressure, which are risk factors for cardiovascular disease. It has been hypothesized that insulin resistance may underlie all these features. However, recent data suggest that some links between insulin resistance a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.29.02.06.dc05-1478

    authors: Zanolin ME,Tosi F,Zoppini G,Castello R,Spiazzi G,Dorizzi R,Muggeo M,Moghetti P

    更新日期:2006-02-01 00:00:00

  • Decreased skin wrinkling in diabetes mellitus.

    abstract::Skin wrinkling, which may be dependent on peripheral autonomic innervation, was assessed in 100 normal and 42 diabetic subjects using a temperature-controlled water bath with immersion of the hands for 30 min. Markedly decreased skin wrinkling was observed in diabetic subjects and in manual workers, but did not correl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.3.224

    authors: Clark CV,Pentland B,Ewing DJ,Clarke BF

    更新日期:1984-05-01 00:00:00

  • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.

    abstract::There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis....

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.27.3.813

    authors: Pickup JC

    更新日期:2004-03-01 00:00:00

  • Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.

    abstract:OBJECTIVE:Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two approaches-glargine followed by metformin and metformin alone-in preserving or improving β-cell function in youth with impaired glucose tolerance (IGT) or recen...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc18-0787

    authors: RISE Consortium.

    更新日期:2018-08-01 00:00:00

  • N-Glycan Profile and Kidney Disease in Type 1 Diabetes.

    abstract:OBJECTIVE:Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1042

    authors: Bermingham ML,Colombo M,McGurnaghan SJ,Blackbourn LAK,Vučković F,Pučić Baković M,Trbojević-Akmačić I,Lauc G,Agakov F,Agakova AS,Hayward C,Klarić L,Palmer CNA,Petrie JR,Chalmers J,Collier A,Green F,Lindsay RS,Macrury S

    更新日期:2018-01-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.2.135

    authors: Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期:1983-03-01 00:00:00

  • The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank.

    abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc18-0289

    authors: Au Yeung SL,Luo S,Schooling CM

    更新日期:2018-09-01 00:00:00

  • High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes.

    abstract:OBJECTIVE:To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Levels of AGE-LDL and oxLDL in ICs were measured i...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-2040

    authors: Lopes-Virella MF,Baker NL,Hunt KJ,Lyons TJ,Jenkins AJ,Virella G,DCCT\/EDIC Study Group.

    更新日期:2012-06-01 00:00:00

  • Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE).

    abstract:OBJECTIVE:The Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial reported neutral effects of insulin glargine on cardiovascular outcomes and cancers and reduced incident diabetes in high-cardiovascular risk adults with dysglycemia after 6.2 years of active treatment. Omega-3 fatty acids had neutral eff...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc15-1676

    authors: ORIGIN Trial Investigators.

    更新日期:2016-05-01 00:00:00

  • Specific relation between abdominal obesity and early-phase hyperglycemia is modulated by hepatic insulin resistance in healthy older women.

    abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1365

    authors: DiPietro L,Dziura J,Yeckel CW

    更新日期:2010-01-01 00:00:00

  • Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy.

    abstract:OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.10.1545

    authors: Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

    更新日期:2000-10-01 00:00:00

  • Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes.

    abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc13-0669

    authors: Hägg S,Thorn LM,Putaala J,Liebkind R,Harjutsalo V,Forsblom CM,Gordin D,Tatlisumak T,Groop PH,FinnDiane Study Group.

    更新日期:2013-12-01 00:00:00

  • The Memphis diabetes continuing care program.

    abstract::Since 1963 a network of nurse-operated, physician-backed decentralized clinics has provided continuing care for more than 5000 diabetic patients referred from the medical center clinics. Protocols that provide therapy goals and management details are used by the nurses and nutritionists in this network. To reduce frag...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.2.382

    authors: Runyan JW Jr,Zwaag RV,Joyner MB,Miller ST

    更新日期:1980-03-01 00:00:00

  • PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.

    abstract:OBJECTIVE:A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance. Dietary carbohydrate (CHO) modulates the genetic effect on insulin resistance. We examined whether 2-year weight-loss diets modify the effect of PCSK7 genetic variants on chang...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-0473

    authors: Huang T,Huang J,Qi Q,Li Y,Bray GA,Rood J,Sacks FM,Qi L

    更新日期:2015-03-01 00:00:00

  • Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: results from the German Diabetes Study (GDS).

    abstract:OBJECTIVE:Altered immune reactivity precedes and accompanies type 1 and type 2 diabetes. We hypothesized that the metabolic phenotype relates to the systemic cellular immune status. RESEARCH DESIGN AND METHODS:A total of 194 metabolically well-controlled patients with type 1 diabetes (n = 62, mean diabetes duration 1....

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0316

    authors: Menart-Houtermans B,Rütter R,Nowotny B,Rosenbauer J,Koliaki C,Kahl S,Simon MC,Szendroedi J,Schloot NC,Roden M,German Diabetes Study Group.

    更新日期:2014-08-01 00:00:00

  • Efficacy of insulin analogs in achieving the hemoglobin A1c target of

    abstract:OBJECTIVE:Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A(1c) (HbA(1c)) target of <7% in people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted an ...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc10-1710

    authors: Giugliano D,Maiorino MI,Bellastella G,Chiodini P,Ceriello A,Esposito K

    更新日期:2011-02-01 00:00:00

  • Using the BRAVO Risk Engine to Predict Cardiovascular Outcomes in Clinical Trials With Sodium-Glucose Transporter 2 Inhibitors.

    abstract:OBJECTIVE:This study evaluated the ability of the Building, Relating, Assessing, and Validating Outcomes (BRAVO) risk engine to accurately project cardiovascular outcomes in three major clinical trials-BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME), C...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0227

    authors: Shao H,Shi L,Fonseca VA

    更新日期:2020-07-01 00:00:00

  • Effects of Vildagliptin and Metformin on Blood Pressure and Heart Rate Responses to Small Intestinal Glucose in Type 2 Diabetes.

    abstract:OBJECTIVE:To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 k...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2391

    authors: Wu T,Trahair LG,Little TJ,Bound MJ,Zhang X,Wu H,Sun Z,Horowitz M,Rayner CK,Jones KL

    更新日期:2017-05-01 00:00:00

  • Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy.

    abstract:OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2174

    authors: Lajer M,Jorsal A,Tarnow L,Parving HH,Rossing P

    更新日期:2010-07-01 00:00:00