The long-term effects of chlorpropamide on insulin, C-peptide, and proinsulin secretion.

Abstract:

:It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with chlorpropamide for over 3 mo. Of these, 9 were also studied after 1 yr. Improvement in glucose tolerance was associated with an increase in fasting and postglucose serum insulin and C-peptide concentration. We conclude that at least for over 1 yr chlorpropamide increases insulin secretion. After 3 and 12 mo the fasting proinsulin percentage of immunoreactive insulin was increased.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Elkeles RS,Heding LG,Paisey RB

doi

10.2337/diacare.5.4.427

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

427-9

issue

4

eissn

0149-5992

issn

1935-5548

journal_volume

5

pub_type

杂志文章
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