Abstract:
:It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with chlorpropamide for over 3 mo. Of these, 9 were also studied after 1 yr. Improvement in glucose tolerance was associated with an increase in fasting and postglucose serum insulin and C-peptide concentration. We conclude that at least for over 1 yr chlorpropamide increases insulin secretion. After 3 and 12 mo the fasting proinsulin percentage of immunoreactive insulin was increased.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Elkeles RS,Heding LG,Paisey RBdoi
10.2337/diacare.5.4.427subject
Has Abstractpub_date
1982-07-01 00:00:00pages
427-9issue
4eissn
0149-5992issn
1935-5548journal_volume
5pub_type
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