Abstract:
:This study compares the utility of nonenzymatically glycosylated serum proteins (lys-GSP) to glycosylated hemoglobins (HbA1a-c) as control indices of glucose homeostasis in patients with IDDM. The diagnostic value of lys-GSP was also examined in patients with non-insulin-dependent diabetes mellitus, in subjects with impaired glucose tolerance, and in two patients with insulinoma. The intraindividual fluctuation of lys-GSP in normoglycemic subjects is very small, resulting in an interindividual range of 3.0 +/- 0.3 lysine-bound glucose/mg protein (means +/- SD, N = 52). HbA1a-c with a normal range of 6.4 +/- 0.9% (N = 52) shows greater variability. In IDDM there is no overlap of lys-GSP levels between the normal and the diabetic range at the 95% confidence level. In patients treated with an open-loop insulin delivery system failure of normalization of the glucose balance was clearly discernible by an elevation of GSP. In contrast, in about 40% of the patients with incomplete glycemic control the HbA1a-c levels fell within the normal range. The utility of lys-GSP for diagnosis of diabetes is compared with the results of 60 oral glucose tolerance tests. Two patients suffering from insulinoma displayed decreased lys-GSP values. From these results it appears that determination of lys-GSP represents a more sensitive parameter for long-term control than HbA1a-c and is suitable for monitoring even small fluctuations of blood glucose.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Schleicher ED,Gerbitz KD,Dolhofer R,Reindl E,Wieland OH,Edelmann E,Haslbeck M,Kemmler W,Walter H,Mehnert Hdoi
10.2337/diacare.7.6.548subject
Has Abstractpub_date
1984-11-01 00:00:00pages
548-56issue
6eissn
0149-5992issn
1935-5548journal_volume
7pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Existing physical examination scoring systems for distal diabetic polyneuropathy (PNP) do not fulfill all of the following criteria: validity, manageability, predictive value, and hierarchy The aim of this study was to adapt the Neuropathy Disability Score (NDS) to diagnose PNP in diabetes so that it fulfills...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.6.750
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.12.2813
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of new insulin glargine 300 units/mL (Gla-300) with glargine 100 units/mL (Gla-100) in people with type 2 diabetes on basal insulin (≥42 units/day) plus mealtime insulin. RESEARCH DESIGN AND METHODS:EDITION 1 (NCT01499082) was a 6-month, multinational, open-label, parallel-...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-0991
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Successful disease management is heavily influenced by access to care issues and patient behavior. Screening tests to detect chronic complications are part of diabetes management and may be influenced by access to care or patient decisions. The objective of this research was to examine how strongly access to ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1279
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-0181
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0520
更新日期:2013-11-01 00:00:00
abstract::This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.22.7.1201
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To examine associations between A1C concentration and mortality in a New Zealand population. RESEARCH DESIGN AND METHODS:During a Hepatitis Foundation screening campaign for hepatitis B (1999-2001), participants were offered A1C testing. The participants were anonymously linked to the national mortality coll...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2374
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of flexible intensive insulin therapy (FIIT) and an automated bolus calculator (ABC) in a Danish type 1 diabetes population treated with multiple daily injections. Furthermore, to test the feasibility of teaching FIIT in a 3-h structured course. RESEARCH DESIGN AND METHODS:The Bolus...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-2044
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To study the effect of vitamin E supplementation on platelet hyperaggregability in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:Written informed consent according to the Institutional Review Board on Human Experimentation guidelines was obtained from diabetic patients (n = 29) and their age-matched ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.21.9.1511
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:We evaluated a program of performance measurement and monitoring by assessing care process, utilization of services, and outcomes. RESEARCH DESIGN AND METHODS:Information on 63,264 diabetic individuals who were continuously enrolled as members of Kaiser Permanente Southern California from 1 January 1994 to 3...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.2.192
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To determine if differing beliefs about high blood glucose exist and are associated with blood glucose control among rural African-Americans. RESEARCH DESIGN AND METHODS:A community-based sample of rural African-Americans completed a survey, and a subsample underwent a subsequent screening that included gluc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.3.330
更新日期:2000-03-01 00:00:00
abstract::It has generally been assumed that oral candidiasis occurs with increased frequency in patients with diabetes mellitus. To evaluate this, we compared the frequency and severity of oral Candida colonization in 60 patients with insulin-dependent diabetes mellitus (IDDM) admitted to a low-intensity-care diabetes unit wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.5.607
更新日期:1987-09-01 00:00:00
abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.6.449
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN AND METHODS:This article reports a planned secondary analysis of SF in 90 patie...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1714
更新日期:2011-02-01 00:00:00
abstract::OBJECTIVE Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp 30) once daily (OD), twice daily (b.i.d.), and three times daily (t.i.d.) were compared with other insulin regimens in two crossover glucose clamp studies of insulin-treated type 2 diabetic patients. RESEARCH DESIGNS AND METHODS Study 1 consist...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0097
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS:Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6....
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.28.10.2400
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Diet therapy in gestational diabetes mellitus (GDM) has focused on carbohydrate restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low-carbohydrate/higher-fat (LC/CONV) diet, hypothesizing that a higher-complex carbohydrate/lower-fat (CHOICE) diet ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-0515
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND ME...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.10.2416
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess fertility in women with type 1 diabetes and the risk of congenital malformations in their offspring.
RESEARCH DESIGN AND METHODS:This was a register-based cohort study in Sweden. All 5,978 women hospitalized for type 1 diabetes at age journal_title:Diabetes care pub_type: 杂志文章 doi:10.2337/dc06-2574 更新日期:2007-09-01 00:00:00
abstract::A higher prevalence of stroke is found in the patient with both diagnosed and undiagnosed diabetes and glucose intolerance. Because of local cerebral acidosis caused by ischemia and hyperglycemia, morbidity and mortality from a stroke are increased. Most studies show that individuals with admission serum glucose > 120...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.17.3.213
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known. RESEARCH DESIGN AND METHODS:A sample of 1,117 consecutively recruited patients was drawn...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2278
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of topical human recombinant basic fibroblast growth factor (bFGF) on the healing of diabetic neurotrophic foot ulcers. RESEARCH DESIGN AND METHODS:Seventeen diabetic patients suffering from chronic neuropathic ulcer of the plantar surface of the foot entered a pilot, random...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.1.64
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy. RESEARCH DESIGN AND METHODS:Population-based study using data from the Multi-Ethnic Study of Atherosclerosis (MESA), comprising 5,976 individuals (whites, blacks, Hispanics, and Chinese) residing in six...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1528
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Age, diabetes, and elevated inflammatory markers independently increase the risk of functional decline. We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes. RESEARCH DESIGN AND METHODS:We analyzed data from ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0245
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:This study was performed to ascertain whether insulin resistance with respect to protein metabolism is an additional primary metabolic abnormality affecting insulin-resistant offspring of type 2 diabetic parents, along with insulin resistance with respect to glucose and lipid metabolism. RESEARCH DESIGN AND ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.11.2716
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS:We searched MEDLINE and EMBASE databases through August 2015. We conducted a q...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc15-2251
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between subclinical cardiac dysfunction and aerobic exercise capacity (peak VO2) in adults with type 2 diabetes (T2D), a group at high risk of developing heart failure. RESEARCH DESIGN AND METHODS:Cross-sectional study. We prospectively enrolled a multiethnic cohort of asymptomatic...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0706
更新日期:2020-09-01 00:00:00
abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc19-S014
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0304
更新日期:2020-07-01 00:00:00