Changes in treatment adherence and glycemic control during the transition to adolescence in type 1 diabetes.

Abstract:

OBJECTIVE:To test models of unidirectional and bidirectional change between treatment adherence and glycemic control in youth with type 1 diabetes. RESEARCH DESIGN AND METHODS:We conducted a 2-year longitudinal, multisite study of 225 youth with type 1 diabetes recruited at the cusp of adolescence (aged 9-11 years) to describe the mutual influences of glycemic control as measured by HbA(1c) and treatment adherence as measured by blood glucose monitoring frequency (BGMF) during the transition to adolescence. RESULTS:HbA(1c) increased from 8.2 to 8.6% (P < 0.001) and BGMF decreased from 4.9 to 4.5 checks per day (P < 0.02) during the 2-year period. Changes in the BGMF slope predicted changes in HbA(1c). A change (increase) in HbA(1c) was associated with a change (decrease) in BGMF of 1.26 (P < 0.001) after controlling for covariates. CONCLUSIONS:The magnitude of the effect of declining treatment adherence (BGMF) on glycemic control in young adolescents may be even greater than declines observed among older adolescents. BGMF offers a powerful tool for targeted management of glycemic control for type 1 diabetes during the critical transition to adolescence.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Rausch JR,Hood KK,Delamater A,Shroff Pendley J,Rohan JM,Reeves G,Dolan L,Drotar D

doi

10.2337/dc11-2163

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1219-24

issue

6

eissn

0149-5992

issn

1935-5548

pii

dc11-2163

journal_volume

35

pub_type

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