Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire Register of diabetes in children and young adults.

abstract：OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

journal_title：Diabetes care

authors： Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The risk of cardiovascular death before the age of 40 is 20-fold higher in patients with type 1 diabetes mellitus (T1DM). Endothelial progenitor cells (EPCs) predict cardiovascular morbidity and mortality in patients without diabetes. We hypothesized that EPCs are modified in children with T1DM and are relate...

journal_title：Diabetes care

authors： Hörtenhuber T,Rami-Mehar B,Satler M,Nagl K,Höbaus C,Höllerl F,Koppensteiner R,Schernthaner G,Schober E,Schernthaner GH

更新日期：2013-06-01 00:00:00

abstract：:The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). The study included 37 NIDDM patients with HbA1 concentrations greater than 8.5% and normal kidney and liver function who were being treated with diet alone or diet...

journal_title：Diabetes care

authors： Jones IR,Swai A,Taylor R,Miller M,Laker MF,Alberti KG

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:This study investigated whether intimacy and autonomy in mother-daughter interactions and relational aspects of the self are associated with metabolic control in adolescent girls with type 1 diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study included 88 girls with diabetes (mean age 14.9 +/- 2....

journal_title：Diabetes care

authors： Maharaj S,Daneman D,Olmsted M,Rodin G

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To determine serum lipoprotein(a) in a large sample of IDDM and control children and to examine a possible association with puberty. RESEARCH DESIGN AND METHODS:Serum lipoprotein(a), apoB-100, and apoA-I were measured under identical conditions in 170 Caucasian children with IDDM aged 12.3 +/- 3.59 yr and 23...

journal_title：Diabetes care

authors： Couper JJ,Bates DJ,Cocciolone R,Magarey AM,Boulton TJ,Penfold JL,Ryall RG

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk. RESEARCH DESIGN AND METHODS:Children were up to 10 years of age and scre...

journal_title：Diabetes care

authors： Vehik K,Lynch KF,Schatz DA,Akolkar B,Hagopian W,Rewers M,She JX,Simell O,Toppari J,Ziegler AG,Lernmark Å,Bonifacio E,Krischer JP,TEDDY Study Group.

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:A genetic risk score (GRS) comprised of single nucleotide polymorphisms (SNPs) and metabolite biomarkers have each been shown, separately, to predict incident type 2 diabetes. We tested whether genetic and metabolite markers provide complementary information for type 2 diabetes prediction and, together, impro...

journal_title：Diabetes care

authors： Walford GA,Porneala BC,Dauriz M,Vassy JL,Cheng S,Rhee EP,Wang TJ,Meigs JB,Gerszten RE,Florez JC

更新日期：2014-09-01 00:00:00

abstract：:In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

journal_title：Diabetes care

authors： Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

更新日期：1987-05-01 00:00:00

abstract：:In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...

journal_title：Diabetes care

authors： Agner E,Thorsteinsson B,Eriksen M

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS:Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the ...

journal_title：Diabetes care

authors： Ferrannini E,Murthy AC,Lee YH,Muscelli E,Weiss S,Ostroff RM,Sattar N,Williams SA,Ganz P

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Malabsorptive bariatric surgery (biliopancreatic diversion and biliointestinal bypass [BIBP]) reduces serum cholesterol levels more than restrictive surgery (adjustable gastric banding [AGB]), and this is thought to be due to greater weight loss. Our aim was to evaluate the changes of cholesterol metabolism i...

journal_title：Diabetes care

authors： Benetti A,Del Puppo M,Crosignani A,Veronelli A,Masci E,Frigè F,Micheletto G,Panizzo V,Pontiroli AE

更新日期：2013-06-01 00:00:00

abstract：:Malfunction of portable continuous subcutaneous insulin infusion (CSII) systems may result in either ketoacidosis or serious hypoglycemia. To determine the types and frequencies of infusion system failure and the resulting clinical consequences, we recorded their occurrences in a 1-yr prospective study of 127 patients...

journal_title：Diabetes care

authors： Mecklenburg RS,Guinn TS,Sannar CA,Blumenstein BA

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for t...

journal_title：Diabetes care

authors： Bakker AJ

更新日期：1999-02-01 00:00:00

abstract：:We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...

journal_title：Diabetes care

authors： Schultz JS,Mansouri S,Goldstein IJ

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...

journal_title：Diabetes care

authors： Boyko EJ,Seelig AD,Ahroni JH

更新日期：2018-04-01 00:00:00

abstract：:Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life. Subcutaneous insulin absorption is influenced by many factors, among which the associated state of insulin (hexameric) in p...

journal_title：Diabetes care

authors： Brange J,Owens DR,Kang S,Vølund A

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs. thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH D...

journal_title：Diabetes care

authors： Rosenstock J,Fonseca VA,Gross JL,Ratner RE,Ahrén B,Chow FC,Yang F,Miller D,Johnson SL,Stewart MW,Leiter LA,Harmony 6 Study Group.

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...

journal_title：Diabetes care

authors： de Rekeneire N,Rooks RN,Simonsick EM,Shorr RI,Kuller LH,Schwartz AV,Harris TB,Health, Aging and Body Composition Study.

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To study the relationship between the prevalence of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) across populations of the Pacific Ocean region to assess whether variability in those two proportions followed some predictable pattern related to modernization of life-styl...

journal_title：Diabetes care

authors： Dowse GK,Zimmet PZ,King H

更新日期：1991-11-01 00:00:00

abstract：:This study describes and characterizes a putative sulfonylurea receptor. The radioligand used was [3H]glipizide (9 Ci/mmol). The beta-cell plasma membranes were derived from a transplantable rat insulinoma generated by subcutaneous injection of RINm5F cells and purified by ultracentrifugation on a 15-55% sucrose gradi...

journal_title：Diabetes care

authors： Siconolfi-Baez L,Banerji MA,Lebovitz HE

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Proteoglycan metabolism is altered in diabetic patients. The xylosyltransferases (XTs) are the initial and rate-limiting enzymes in the biosynthesis of the glycosaminoglycan chains in proteoglycans. Here, we analyzed whether the changed proteoglycan metabolism leads to altered serum XT levels in diabetic pati...

journal_title：Diabetes care

authors： Götting C,Kuhn J,Kleesiek K

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

journal_title：Diabetes care

authors： Nakagami T,Kawahara R,Hori S,Omori Y

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...

journal_title：Diabetes care

authors： Hadamitzky M,Hein F,Meyer T,Bischoff B,Martinoff S,Schömig A,Hausleiter J

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...

journal_title：Diabetes care

authors： Goldstein BJ,Feinglos MN,Lunceford JK,Johnson J,Williams-Herman DE,Sitagliptin 036 Study Group.

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS:A population-based nationwide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at <15 years of...

journal_title：Diabetes care

authors： Saeed M,Tapia G,Ariansen I,Stene LC,Seljeflot I,Tell GS,Skrivarhaug T,Joner G

更新日期：2021-01-06 00:00:00

abstract：OBJECTIVE:Recurrence of plantar foot ulcers is a common and major problem in diabetes but not well understood. Foot biomechanics and patient behavior may be important. The aim was to identify risk factors for ulcer recurrence and to establish targets for ulcer prevention. RESEARCH DESIGN AND METHODS:As part of a footw...

journal_title：Diabetes care

authors： Waaijman R,de Haart M,Arts ML,Wever D,Verlouw AJ,Nollet F,Bus SA

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...

journal_title：Diabetes care

authors： Cnop M,Vidal J,Hull RL,Utzschneider KM,Carr DB,Schraw T,Scherer PE,Boyko EJ,Fujimoto WY,Kahn SE

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

journal_title：Diabetes care

authors： ORIGIN Trial Investigators.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossov...

journal_title：Diabetes care

authors： Wolever TM,Jenkins DJ,Vuksan V,Jenkins AL,Wong GS,Josse RG

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00