Abstract:
:Malfunction of portable continuous subcutaneous insulin infusion (CSII) systems may result in either ketoacidosis or serious hypoglycemia. To determine the types and frequencies of infusion system failure and the resulting clinical consequences, we recorded their occurrences in a 1-yr prospective study of 127 patients who were using insulin infusion pumps in a clinical practice setting. Of the 127 patients, 109 (86%) experienced at least one infusion system failure during the study. Most of the infusion system failures (96%) occurred in the syringe, infusion tube and connections, or subcutaneous infusion site. Virtually all malfunctions resulted in interruption of insulin flow, and most were associated with temporary loss of diabetes control. Equipment malfunction was documented in 6 of 7 patients who used insulin pumps and were treated in our hospital for diabetic ketoacidosis during the study. Pump "runaway" was not observed. We conclude that infusion system malfunction resulting in interruption of insulin flow is a common occurrence, is often associated with temporary hyperglycemia, and may account for some of the increased incidence of diabetic ketoacidosis previously described in these patients.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Mecklenburg RS,Guinn TS,Sannar CA,Blumenstein BAdoi
10.2337/diacare.9.4.351subject
Has Abstractpub_date
1986-07-01 00:00:00pages
351-5issue
4eissn
0149-5992issn
1935-5548journal_volume
9pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To determine the impact of changes to treatment on the incidence of severe hypoglycemia and its risk factors in a large population-based cohort of children with type 1 diabetes. RESEARCH DESIGN AND METHODS:The cohort consisted of 1,335 children (age at entry 9.5 +/- 4.3 years [mean +/- SD], range 0-18), yiel...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.10.2293
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To determine whether, reflecting trends in other chronic complications, incident hospitalization for diabetes-related foot ulcer (DFU) has declined over recent decades in type 2 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 2 diabetes from the community-based Fremantle Diabetes Study phases I ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1743
更新日期:2021-01-13 00:00:00
abstract:OBJECTIVE:To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS:Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP abov...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.8.1002
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN AND METHODS:This article reports a planned secondary analysis of SF in 90 patie...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1714
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:This study examined associations between BMI and mortality in individuals with normoglycemia, impaired fasting glucose (IFG), newly diagnosed diabetes, and prevalent diabetes and identified BMI ranges associated with the lowest mortality in each group. RESEARCH DESIGN AND METHODS:A total of 12,815,006 adults...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-1458
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.03.06.dc05-1006
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To examine central nervous system involvement as a possible complication of diabetes by performing a comprehensive neuropsychological evaluation of relatively young (age < 55 years) NIDDM patients and a group of control subjects. RESEARCH DESIGN AND METHODS:A cross-sectional comparative study of 28 patients,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.1.32
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.2.241
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:Preclinical data suggest that linagliptin, a dipeptidyl peptidase-4 inhibitor, may lower urinary albumin excretion. The ability of linagliptin to lower albuminuria on top of renin-angiotensin-aldosterone system (RAAS) inhibition in humans was analyzed by pooling data from four similarly designed, 24-week, ran...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0323
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome R...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc18-1094
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1427
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To explore the nature of functional impairment in older people with diabetes. RESEARCH DESIGN AND METHODS:A population-based case-control study with detailed assessment of diabetes and functional status was undertaken. RESULTS:Altogether, 403 case subjects and 403 matched control subjects were studied (medi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-1784
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship of impaired glucose tolerance (IGT) at baseline to coronary heart disease (CHD) incidence, and cardiovascular disease (CVD) and total mortality at follow-up, and to analyze whether the relationship is independent of the subsequent development of diabetes during follow-up. RESEARC...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.10.2910
更新日期:2003-10-01 00:00:00
abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.7.538
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:Insulin and glucose levels in response to premeal insulin lispro or repaglinide were evaluated in adult patients with cystic fibrosis-related diabetes (CFRD) without fasting hyperglycemia. RESEARCH DESIGN AND METHODS:Seven patients with CFRD were fed 1,000-kcal liquid mixed meals. Three study conditions were...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.10.1706
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To provide evidence-based options on how to intensify basal insulin, we explored head-to-head prandial interventions in overweight patients with type 2 diabetes inadequately controlled on basal insulin glargine with or without 1-3 oral antidiabetic agents (OADs). RESEARCH DESIGN AND METHODS:Patients were ran...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-0014
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To determine whether adults diagnosed with type 2 diabetes from age 18 to 44 years more aggressively develop clinical complications after diagnosis than adults diagnosed at >or=45 years of age. RESEARCH DESIGN AND METHODS:We compared outcomes among 7844 adults in a health maintenance organization who were ne...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.11.2999
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:In diabetes, the persistence of hyperglycemia has been reported to cause increased production of oxygen free radicals through glucose autooxidation and nonenzymatic glycation. The aim of this study was to determine whether oxidative cellular damage occurs at the clinical onset of diabetes and in later stages ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.10.1736
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the relative value of plasma glucose (PG) at different time points in assessing glucose control of type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Glycemic profiles, i.e., PG at prebreakfast (8:00 A.M.), prelunch (11:00 A.M.), postlunch (2:00 P.M.), and extended postlunch (5:00 P.M.) times ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.12.1822
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally; however, the clinical and epidemiological data on the association of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.5.624
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.2.344
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To estimate the long-run mortality effects of Hurricanes Katrina and Rita on seniors with diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective cohort analysis of Medicare enrollment and claims data covering four states and ∼10 years. Affected individuals were identified by whether they lived in...
journal_title:Diabetes care
pub_type: 历史文章,杂志文章
doi:10.2337/dc19-0567
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To describe a glucose abnormality in AIDS that is characterized by transient NIDDM followed by hyperinsulinemic normoglycemia. RESEARCH DESIGN AND METHODS:A 36-yr-old Hispanic man with AIDS was on long-standing aerosolized pentamidine therapy in 1986. He received a course of intravenous pentamidine 5 mo befo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.6.931
更新日期:1993-06-01 00:00:00
abstract::This study describes the pharmacokinetics of three intermediate-acting insulin preparations, NPH porcine insulin, NPH human insulin (recombinant DNA), and "Depot-A" insulin, a mixture of 20% regular and 80% NPH human insulin from Eli Lilly and Company. Metabolic healthy normal weight volunteers were selected for the s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.2.s43
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the possibility of replacing quantitative albumin excretion rate (AER) measurements with rapid screening tests for microalbuminuria. RESEARCH DESIGN AND METHODS:Dipstick-negative specimens from 363 consecutive insulin-dependent diabetes mellitus (IDDM) and 46 non-insulin-dependent diabetes mellit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.14.7.591
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:Impaired awareness of hypoglycemia (IAH) and recurrent severe hypoglycemia (RSH) remain problematic for people with type 1 diabetes (T1D), despite major therapeutic advances. We explored beliefs around hypo- and hyperglycemia in adults with T1D with, and without, IAH and RSH. RESEARCH DESIGN AND METHODS:A cr...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc19-0002
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Anti-programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations, including acute-onset type 1 diabetes. Acquired generalized lipodystrophy (AGL) is a rare disease, believ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-2535
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Increased Hb and ferritin have been associated with gestational diabetes mellitus (GDM). This study was performed to determine whether the prevalence of GDM is influenced by iron deficiency anemia. RESEARCH DESIGN AND METHODS:In a retrospective case-control study, 242 women with iron deficiency anemia (Hb<10...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.3.650
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed. RESEARCH DESIGN AND METHODS:A total of 72 healthy individuals (22-56 years) were enrolle...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc08-1723
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to assess the efficacy and safety of repaglinide compared with placebo in the treatment of patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a phase II multicenter, double-blind, placebo-controlled, randomized, dose-adjustment and maintenance trial. After scre...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.21.11.1897
更新日期:1998-11-01 00:00:00