Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes.

abstract：OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

journal_title：Diabetes care

authors： Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

更新日期：1997-07-01 00:00:00

abstract：:Severe hypoglycemia (SH) is a significant problem for many patients with type I diabetes and presents a major barrier to optimal diabetes control. A critical task facing diabetes research is to understand, predict, and reduce the risk of SH in insulin-treated patients. The purpose of this article is to propose a biops...

journal_title：Diabetes care

authors： Gonder-Frederick L,Cox D,Kovatchev B,Schlundt D,Clarke W

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS:At ba...

journal_title：Diabetes care

authors： Fernandez C,Surma MA,Klose C,Gerl MJ,Ottosson F,Ericson U,Oskolkov N,Ohro-Melander M,Simons K,Melander O

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...

journal_title：Diabetes care

authors： Burrows NR,Li Y,Gregg EW,Geiss LS

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that breast-feeding is a protective factor against IDDM and that early exposure to cow's milk is a risk factor for the disease. RESEARCH DESIGN AND METHODS:A case-control study was conducted in São Paulo, Brazil. A total of 346 diabetic children, aged < 18 years, were identified in two...

journal_title：Diabetes care

authors： Gimeno SG,de Souza JM

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:The effect of therapeutic strategies on cardiovascular (CV) disease can be evaluated by monitoring changes in CV risk biomarkers. This study investigated the effect of a structured self-monitoring of blood glucose (SMBG) protocol and the resulting improvements in glycemic control on changes in high-sensitivit...

journal_title：Diabetes care

authors： Schnell O,Amann-Zalan I,Jelsovsky Z,Moritz A,Bermejo JL,Parkin CG,Schweitzer MA,Fisher L,Polonsky WH

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To assess the prognostic role of ambulatory 24-h pulse pressure (PP) on various vascular events in relatively young type 2 diabetic subjects under 60 years of age. RESEARCH DESIGN AND METHODS:In this prospective study, 237 type 2 diabetic subjects without any history of vascular complications were analyzed. ...

journal_title：Diabetes care

authors： Nakano S,Konishi K,Furuya K,Uehara K,Nishizawa M,Nakagawa A,Kigoshi T,Uchida K

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...

journal_title：Diabetes care

authors： Zhu J,Volkening LK,Laffel LM

更新日期：2020-01-01 00:00:00

abstract：:Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

journal_title：Diabetes care

authors： Lebovitz HE,Pasmantier R

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:Some children with type 1 diabetes may be at risk of cognitive impairments, but mechanisms of this effect have not been confirmed. The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months. RESEARCH DESIG...

journal_title：Diabetes care

authors： Wysocki T,Harris MA,Mauras N,Fox L,Taylor A,Jackson SC,White NH

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:Because a pseudonormal pattern of ventricular filling has never been considered in studies that reported a prevalence of left ventricular diastolic dysfunction (LVDD) between 20 and 40%, our aim was to more completely evaluate the prevalence of LVDD in subjects with diabetes. RESEARCH DESIGN AND METHODS:We s...

journal_title：Diabetes care

authors： Poirier P,Bogaty P,Garneau C,Marois L,Dumesnil JG

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...

journal_title：Diabetes care

authors： Seligman HK,Jacobs EA,López A,Tschann J,Fernandez A

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether intraperitoneal insulin (IPII) decreases the levels of circulating chylomicron remnants in patients with insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS:Eight nonobese, normolipidemic IDDM patients were studied twice: before (while on subcutaneous insulin) and 6...

journal_title：Diabetes care

authors： Georgopoulos A,Saudek CD

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND ME...

journal_title：Diabetes care

authors： Bitz C,Toubro S,Larsen TM,Harder H,Rennie KL,Jebb SA,Astrup A

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To determine the role of growth hormone (GH) in the development of diabetic retinopathy. RESEARCH DESIGN AND METHODS:Medical records of 1,423 patients who had undergone insulin tolerance tests (1976-1991) at the Mayo Clinic were examined, and diabetic subjects were identified as either GH-deficient (GH incre...

journal_title：Diabetes care

authors： Alzaid AA,Dinneen SF,Melton LJ 3rd,Rizza RA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 dia...

journal_title：Diabetes care

authors： Herder C,Brunner EJ,Rathmann W,Strassburger K,Tabák AG,Schloot NC,Witte DR

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...

journal_title：Diabetes care

authors： Bradley C,Eschwège E,de Pablos-Velasco P,Parhofer KG,Simon D,Vandenberghe H,Gönder-Frederick L

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:While there is growing evidence on the effectiveness of structured care for diabetic patients in trial settings, standard population level evaluations may misestimate intervention benefits due to patient selection. In order to account for potential biases in measuring intervention benefits, we tested the impa...

journal_title：Diabetes care

authors： Chevreul K,Brunn M,Cadier B,Nolte E,Durand-Zaleski I

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...

journal_title：Diabetes care

authors： Garg SK,Potts RO,Ackerman NR,Fermi SJ,Tamada JA,Chase HP

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To prospectively examine the effect of weight loss 1 year after laparoscopic adjustable gastric band surgery on a broad range of health outcomes in 50 diabetic subjects. RESEARCH DESIGN AND METHODS:A total of 50 (17 men, 33 women) of 51 patients with type 2 diabetes, from a total of 500 consecutive patients,...

journal_title：Diabetes care

authors： Dixon JB,O'Brien PE

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...

journal_title：Diabetes care

authors： Lin J,Glynn RJ,Rifai N,Manson JE,Ridker PM,Nathan DM,Schaumberg DA

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 ...

journal_title：Diabetes care

authors： Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:This study was performed to evaluate whether an additional dose of NPH insulin at lunchtime might overcome the deleterious effects of waning basal insulinemia on pre-dinner and evening glucose values during insulin lispro intensive therapy with once daily basal insulin at night. RESEARCH DESIGN AND METHODS:T...

journal_title：Diabetes care

authors： Stades AM,Hoekstra JB,van den Tweel I,Erkelens DW,Holleman F,STABILITY Study Group.

更新日期：2002-04-01 00:00:00

abstract：:Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obe...

journal_title：Diabetes care

authors： Mohan V,Snehalatha C,Ramachandran A,Jayashree R,Viswanathan M

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate factors associated with depression in type 1 and type 2 diabetes and test whether these differ from factors associated with depression in the nondiabetic population. RESEARCH DESIGN AND METHODS:In an unselected population study comprising 60,869 individuals, poten...

journal_title：Diabetes care

authors： Engum A,Mykletun A,Midthjell K,Holen A,Dahl AA

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:We evaluated whether the increasing number of genetic loci for coronary artery disease (CAD) identified in the general population could be used to predict the risk of major CAD events (MCE) among participants with type 2 diabetes at high cardiovascular risk. RESEARCH DESIGN AND METHODS:A weighted genetic ris...

journal_title：Diabetes care

authors： Morieri ML,Gao H,Pigeyre M,Shah HS,Sjaarda J,Mendonca C,Hastings T,Buranasupkajorn P,Motsinger-Reif AA,Rotroff DM,Sigal RJ,Marcovina SM,Kraft P,Buse JB,Wagner MJ,Gerstein HC,Mychaleckyj JC,Parè G,Doria A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To provide reliable data on the incidence of insulin-dependent diabetes mellitus (IDDM) in children (< 15 years of age) in Avellaneda, Argentina. RESEARCH DESIGN AND METHODS:A registry was established in Avellaneda, Argentina. The first registry was started in 1989, retrospective data collection was updated ...

journal_title：Diabetes care

authors： Sereday MS,Martí ML,Damiano MM,Moser ME

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia. It is therefore important to design variability measures that are equally predictive of low a...

journal_title：Diabetes care

authors： Kovatchev BP,Otto E,Cox D,Gonder-Frederick L,Clarke W

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...

journal_title：Diabetes care

authors： Tansey MJ,Tsalikian E,Beck RW,Mauras N,Buckingham BA,Weinzimer SA,Janz KF,Kollman C,Xing D,Ruedy KJ,Steffes MW,Borland TM,Singh RJ,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossov...

journal_title：Diabetes care

authors： Wolever TM,Jenkins DJ,Vuksan V,Jenkins AL,Wong GS,Josse RG

更新日期：1992-04-01 00:00:00