Abstract:
OBJECTIVE:To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossover design. Both diets were of similar composition (57% carbohydrate, 23% fat, and 34 g/day dietary fiber), but the low-GI diet had a GI of 58 compared with 86 for the high-GI diet. RESULTS:Small and similar amounts of weight were lost on both diets: 2.5 kg on high-GI diet and 1.8 kg on low-GI diet. On the low-GI diet, the mean level of serum fructosamine, as an index of overall blood glucose control, was lower than on the high-GI diet by 8% (P less than 0.05), and total serum cholesterol was lower by 7% (P less than 0.01). CONCLUSIONS:In overweight patients with NIDDM, reducing diet GI improves overall blood glucose and lipid control.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Wolever TM,Jenkins DJ,Vuksan V,Jenkins AL,Wong GS,Josse RGdoi
10.2337/diacare.15.4.562subject
Has Abstractpub_date
1992-04-01 00:00:00pages
562-4issue
4eissn
0149-5992issn
1935-5548journal_volume
15pub_type
临床试验,杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM. RESEARCH DESIGN AND METHODS:Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 antibodies were measured in 145 pregnant women with GDM, 33 with impa...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.1.81
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS:Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-ba...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.4.490
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Numerous studies have suggested a decreased risk of cancer in patients with diabetes on metformin. Because different comparison groups were used, the effect magnitude is difficult to estimate. Therefore, the objective of this study was to further analyze whether, and to what extent, use of metformin is associ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc11-0857
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Longitudinal changes in GAD antibody (Ab) and ICA512/IA-2 (ICA512) Ab were examined in relation to age at the onset of diabetes and autoimmunity against the thyroid gland. RESEARCH DESIGN AND METHODS:GADAb, ICA512Ab, and antithyroid autoantibody were examined at onset in 40 juvenile-onset IDDM patients (17 m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.1.49
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of the diabetic retinopathy (DR) screening with digital camera by endocrinologists with that by specialist and resident ophthalmologists in terms of sensitivity, specificity, and level of "loss of chance." RESEARCH DESIGN AND METHODS:In a cross-sectional study, 500 adult diabetic pati...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1373
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1793
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To characterize the insulin sensitivity of overweight and obese 5- to 10-year-old (Tanner stage 1-3) African-American children screened for participation in a diabetes prevention study and to identify the association of insulin sensitivity with obesity, hyperlipidemia, and hypertension. RESEARCH DESIGN AND M...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.8.1359
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion. We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydr...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-2302
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To study the effect of birth weight on risk of type 2 diabetes in the schoolchildren in Taiwan. RESEARCH DESIGN AND METHODS:From 1992 to 1997, all schoolchildren aged 6-18 years were screened for diabetes in Taiwan Province. This cohort consisted of 1,966 patients with diabetes and 1,780 randomly selected su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.2.343
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues. RESEARCH DESIGN AND METHODS:Four focus groups were held, two with adult type 1 diabetic patients ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1718
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA(1c) diagnostic criteria in groups categorized by different baseline HbA(1c) levels. RESEARCH DESIGN AND METHODS:Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat H...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2326
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine whether adolescents with type 1 diabetes have left ventricular functional changes at rest and during acute exercise and whether these changes are affected by metabolic control and diabetes duration. RESEARCH DESIGN AND METHODS:The study evaluated 53 adolescents with type 1 diabetes and 22 contro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2331
更新日期:2012-10-01 00:00:00
abstract::Mortality rates of two cohorts of patients with diabetes mellitus are estimated and compared. The Atlanta cohort is defined as all black patients receiving care at the diabetes clinic of Grady Memorial Hospital for the first time during calendar year 1971. The Memphis cohort is defined as all black patients referred f...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.4.341
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVE:To examine trends in diabetes prevalence in the U.S. RESEARCH DESIGN AND METHODS:This study was conducted via telephone surveys in states that participated in the Behavioral Risk Factor Surveillance System between 1990 and 1998. The participants consisted of noninstitutionalized adults aged 18 years or older...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.9.1278
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0304
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To examine patterns of sugar-sweetened beverage (SSB) consumption among U.S. adults with type 2 diabetes in 2003-2006. RESEARCH DESIGN AND METHODS:We analyzed 24-h dietary recall data from the National Health and Nutrition Examination Survey 2003-2006 to estimate SSB consumption levels among 1,090 adults (ag...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1687
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:We sought to test the hypothesis that start of insulin glargine with sustained nightly insulin action results in changes in circulating concentrations of IGF-I and IGF binding proteins (IGFBPs) in adolescents with type 1 diabetes-changes that may support improvement of A1C. RESEARCH DESIGN AND METHODS:Twelve...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2328
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.6.930
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Reduced heart rate variability (HRV) and increased heart rate (HR) have been associated with cardiovascular mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) increase HR, and studies have suggested that they may reduce HRV. We examined the effect of the GLP-1 RA liraglutide on HRV and diurnal v...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-1580
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To examine the association of stage of change with diet and exercise behaviors in response to a lifestyle intervention for Native Hawaiians (NHs). RESEARCH DESIGN AND METHODS:A family ('ohana) support lifestyle intervention was compared with a standard intervention in NHs with or at risk for diabetes in two ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.10.1770
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1518
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To determine if nephropathy in NIDDM is associated with cellular markers for hypertension. RESEARCH DESIGN AND METHODS:We compared 11 patients with clinical diabetic nephropathy with 15 control subjects with no diabetic nephropathy. The patients were white and had had NIDDM for > or = 9 yr and serum creatini...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.5.815
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0761
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.12.1929
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2572
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine whether an educational intervention for medical house staff improves blood glucose (BG) in hospitalized patients. RESEARCH DESIGN AND METHODS:All 116 medicine residents at an academic medical center were assigned to online or classroom training on inpatient dysglycemia in fall 2008. Both groups ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0517
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To assess the effect of mixing the insulin analog lispro (Humalog) with NPH (Humulin I) before injection on lispro's fast, short action profile. RESEARCH DESIGN AND METHODS:A total of 12 healthy volunteers received subcutaneous abdominal injections of 0.1 U/kg regular insulin and 0.2 U/kg NPH insulin as foll...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.21.12.2098
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:A1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while ma...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-2782
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess racial/ethnic variation in access to health care, use of particular health care services, presence of cardiovascular risk factors, and perceptions of health and impairment among women at risk for type 2 diabetes because of their histories of gestational diabetes mellitu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2523
更新日期:2007-06-01 00:00:00
abstract::A semiclosed loop, bedside insulin infusion system using a simple basal infusion algorithm consisting of a linear transition between two insulin delivery rates as blood glucose (BG) increases has been developed. A theoretical study using computer simulation has now been undertaken to examine the effect of BG sampling ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.6.553
更新日期:1985-11-01 00:00:00