Abstract:
OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 years before its diagnosis. RESEARCH DESIGN AND METHODS:Fifty-four DPT-1 participants (22 in the parenteral trial and 32 in the oral trial) were studied. All had oral glucose tolerance tests (OGTTs) at 6-month intervals from approximately 30 to 6 months before diagnosis. The vast majority also had OGTTs at diagnosis. Changes in OGTT glucose and C-peptide indexes from 30 to 6 months before diagnosis were examined by calculating slopes of the indexes for each individual over that time period. Changes from 6 months before diagnosis to diagnosis were examined by paired comparisons of the OGTT metabolic indexes between the time points. RESULTS:Glucose levels increased gradually from 30 to 6 months before diagnosis in both the parenteral and oral groups (P < 0.001 for all indexes). Area under the curve (AUC) C-peptide (P < 0.05) and AUC C-peptide-to-AUC glucose ratio (P < 0.001) values decreased in the oral group; peak C-peptide-to-2-h glucose ratio values decreased in both groups (P < 0.001). In participants who also had OGTTs at diagnosis, AUC C-peptide (parenteral group, P < 0.05) and peak C-peptide (oral group, P < 0.05) values decreased from the last 6 months before diagnosis; stimulated C-peptide-to-glucose ratio values decreased in both groups (P < 0.001). Conversely, fasting C-peptide levels increased in both groups (oral group, P < 0.01). Fasting C-peptide-to-fasting glucose ratio values remained constant throughout the 30-month follow-up. CONCLUSIONS:These data indicate that over a period of at least 2 years, glucose tolerance gradually deteriorates as stimulated C-peptide levels slowly decline in a substantial number of individuals who develop type 1 diabetes. However, fasting C-peptide levels are maintained, even at diagnosis.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JSdoi
10.2337/diacare.29.03.06.dc05-1006subject
Has Abstractpub_date
2006-03-01 00:00:00pages
643-9issue
3eissn
0149-5992issn
1935-5548pii
29/3/643journal_volume
29pub_type
杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To provide a description of the clinical characteristics that distinguish individuals who withhold insulin for weight control from those who do not. Some individuals with insulin-dependent diabetes mellitus (IDDM) control their weight by withholding insulin and purging excessive calories. This process places ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.17.10.1186
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:Long-term exposure to alcohol is associated with an improvement in insulin sensitivity. At this time, however, there is no definitive proof that alcohol per se has an effect on the insulin sensitivity index (S(i)) in type 2 diabetes patients. The aim of the present study was to assess the role of acute modera...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.6.1369
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS:A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insuli...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2102
更新日期:2008-05-01 00:00:00
abstract::Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mix...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.5.418
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-1335
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.6.834
更新日期:1995-06-01 00:00:00
abstract::Skin wrinkling, which may be dependent on peripheral autonomic innervation, was assessed in 100 normal and 42 diabetic subjects using a temperature-controlled water bath with immersion of the hands for 30 min. Markedly decreased skin wrinkling was observed in diabetic subjects and in manual workers, but did not correl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.3.224
更新日期:1984-05-01 00:00:00
abstract::A major problem in replacing insulin in type I diabetes mellitus is that currently no depot preparation exists that is capable of mimicking the background insulin secretion of the healthy pancreas. Because all of the currently available intermediate- or long-acting insulin preparations have a peaked-action profile, ex...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.16.3.71
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS:A population-based nationwide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at <15 years of...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1712
更新日期:2021-01-06 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.10.1708
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.9.1567
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS:Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mil...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1810
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Diabetes has held steady as the seventh leading cause of death in the U.S. since 2006. While aggregated data provide insights into how the country as a whole, or even as states, is faring with respect to diabetes mortality, disaggregation provides data that may facilitate targeted interventions and community ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0988
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Diet is the cornerstone treatment of patients with gestational diabetes mellitus (GDM), but its role in maternal and newborn outcomes has been scarcely studied. The purpose of this study was to analyze the efficacy of dietary interventions on maternal or newborn outcomes in patients with GDM. RESEARCH DESIGN...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc14-1530
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. We investigated whether dietary fat, which modula...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1741
更新日期:2009-04-01 00:00:00
abstract::Significant data suggest that overt hyperglycemia, either observed with or without a prior diagnosis of diabetes, contributes to an increase in mortality and morbidity in hospitalized patients. In this regard, goal-directed insulin therapy has remained as the standard of care for achieving and maintaining glycemic con...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2060
更新日期:2013-07-01 00:00:00
abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS:We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.6.1346
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulce...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2209
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2671
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Assessing updated incidence of type 1 diabetes in 0- to 14-year-old children in Liguria, a Northwest region of Italy. RESEARCH DESIGN AND METHODS:Incident cases were recorded prospectively from 1989 to 1998. Incidence rates (IRs) were standardized to the 1999 world population using the direct method. The ind...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.6.1786
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Under the auspices of the National Institutes of Health, American Diabetes Association, and World Health Organization, expert committees lowered the fasting plasma glucose (FPG) concentration diagnostic for diabetes from 7.8 to 7.0 mmol/l and defined 6.1-6.9 mmol/l as impaired fasting glucose (IFG) and <6.1 m...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.28.11.2626
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.8.1179
更新日期:1993-08-01 00:00:00
abstract::To evaluate the development of autonomic neuropathy, 23 patients with a moderate (group A) and 18 patients with a long (group B) duration of diabetes and without symptoms of autonomic neuropathy were re-investigated 6 yr after the initial studies. Autonomic nerve function was evaluated from heart reactions to deep bre...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.2.129
更新日期:1985-03-01 00:00:00
abstract::There was a need to design a questionnaire that could accurately assess the activity patterns of Native Americans to evaluate the relationship between physical activity and diabetes. Such a questionnaire was developed and implemented into the data collection scheme of the prospective Pima Indian Study of Arizona. The ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.4.401
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To report U.S. national population-based rates and trends in diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) among adults, in both the emergency department (ED) and inpatient settings. RESEARCH DESIGN AND METHODS:We analyzed data from 1 January 2006 through 30 September 2015 from the N...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2449
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Epidemiological studies and randomized clinical trials have demonstrated in various populations that resting heart rate (RHR) was an independent predictor of cardiovascular (CV) risk and all-cause mortality. However, few data specifically evaluated the relationship between RHR and long-term CV and renal compl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2468
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0541
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:Raloxifene hydrochloride is a selective estrogen receptor modulator that to date has not been shown to cause hypertriglyceridemia in normal, diabetic, or hypertriglyceridemic women. This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.28.7.1555
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2000-04-01 00:00:00