Abstract:
OBJECTIVE:Whether ACE inhibition is useful for type 2 diabetic patients with micro- and macroalbuminuria remains unknown. The Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria, Cardiovascular Events and Ramipril (DIABHYCAR) Study was set up to address this issue through a multicenter double-blind parallel placebo-controlled > or = 3-year trial in Europe and North Africa. In this article, we report the characteristics of the randomized patients. RESEARCH DESIGN AND METHODS:The main selection criteria were as follows: men or women aged > or = 50 years with type 2 diabetes treated with oral antidiabetic drugs, with or without hypertension, with a plasma creatinine level < 150 mumol/l, and with persistent micro- or macroalbuminuria, as assessed centrally by two successive urine samples containing a urinary albumin concentration > or = 20 mg/l. Patient characteristics were studied by comparing patients who were randomized to those who were not, taking their geographical origin into account. RESULTS:There were 25,455 patients screened for urinary albumin (20,296 from France, 918 from Germany, 1,019 from Northwest Europe, 969 from Central Europe, 959 from Mediterranean Europe, and 1,294 from North Africa). Of these patients, 4,937 were randomized. Compared with the nonrandomized patients, the randomized patients were older, more often men, more obese, had higher systolic/diastolic blood pressure and plasma glucose, smoked more tobacco, drank more alcohol, and had complications more frequently. Using a logistic regression analysis, all the above-mentioned items appeared as independent determinants for randomization into the study, with the exception of alcohol intake. The contribution of each item varied slightly from one geographical origin to another. CONCLUSIONS:The physical, biological, and behavioral characteristics create a poor renal and cardiovascular prognosis for the type 2 diabetic patients randomized to the DIABHYCAR Study because of micro- and macroalbuminuria. Testing the usefulness of ACE inhibition for the type 2 diabetic patients with microalbuminuria seems feasible through the DIABHYCAR Study.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Marre M,Lièvre M,Vasmant D,Gallois Y,Hadjadj S,Reglier JC,Chatellier G,Mann J,Viberti GC,Passa Psubject
Has Abstractpub_date
2000-04-01 00:00:00pages
B40-8eissn
0149-5992issn
1935-5548journal_volume
23 Suppl 2pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-1997
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Defects in insulin secretion and insulin action are the major abnormalities in the development of type 2 diabetes. In middle-aged subjects, elevated plasma proinsulin has been found to predict type 2 diabetes. Therefore, our aim was to study the longitudinal relationships between baseline determinations of in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.6.1433
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors. RESEARCH DESIGN AND METHODS:Demographic and diabetes self-management factors were measured in 415 subjects followed prospectively for 4-6.5 years of type 1 diabetes duration as participants in ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.24.11.1878
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardio...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.12.2890
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1518
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Large prospective studies have demonstrated that optimum glycemic control is not routinely achieved in clinical practice. Barriers to optimal insulin therapy include hypoglycemia, weight gain, and suboptimal initiation and dose titration. This study compared two treatment algorithms for insulin glargine initi...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.28.6.1282
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of two doses of once-weekly dulaglutide, a glucagon-like peptide 1 receptor agonist, to sitagliptin in uncontrolled, metformin-treated patients with type 2 diabetes. The primary objective was to compare (for noninferiority and then superiority) dulaglutide 1.5 mg versus sita...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-2761
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0827
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA) are more prone to need insulin treatment than those with type 2 diabetes. However, not all patients with LADA develop the need for insulin treatment, indicating the heterogeneity of LADA. We investigated this heterogeneity by comparing...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1468
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To describe the methods used to implement intensive and conventional therapies in the Diabetes Control and Complications Trial (DCCT) and the metabolic results that occurred with the different treatment regimens. RESEARCH DESIGN AND METHODS:The DCCT was a controlled clinical trial that demonstrated the benef...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.18.3.361
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine medication adherence and other self-management practices as potential determinants of higher glycemic risk among black relative to white patients. RESEARCH DESIGN AND METHODS:We used a retrospective, longitudinal repeated-measures design to model the contribution of m...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-1924
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To determine 1) whether participants in the Spanish Diabetes Self-Management Program (SDSMP), when compared at 6 months to randomized control subjects, would demonstrate improvements in health status, health behaviors, and self-efficacy; and 2) whether SDSMP participants receiving monthly automated telephone ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc07-1313
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc18-0289
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To determine whether perceived risk and other health beliefs held by individuals at high risk for developing NIDDM predict weight loss and behavior change during a behavioral weight loss program to reduce the risk of NIDDM. RESEARCH DESIGN AND METHODS:Health beliefs and objective risk factors for diabetes we...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.10.1533
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the short-term impact of a 7-h type 2 diabetes continuing medical education (CME) program. Outcomes included a measure of health care providers' diabetes knowledge and the Diabetes Attitude Scale (DAS), a validated measure of attitudes toward diabetes. RESEARCH DES...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.12.1929
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Left ventricular remodeling occurs immediately after MI, involving structural changes in noninfarcted segment. However, the residual left ventricular pump function in NIDDM patients after acute MI has not been clarified. The purpose of this study was to evaluate the difference in the process of left ventricul...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.11.1522
更新日期:1992-11-01 00:00:00
abstract::OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc09-0455
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METH...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1654
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of a combination weight loss program using intermittent low-calorie diets, energy-controlled meal replacement products, and sibutramine on weight loss, diabetes control, and cardiovascular risk factors in overweight or obese subjects with type 2 diabetes. ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.9.2505
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. R...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0746
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess racial/ethnic variation in access to health care, use of particular health care services, presence of cardiovascular risk factors, and perceptions of health and impairment among women at risk for type 2 diabetes because of their histories of gestational diabetes mellitu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2523
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To determine, after 1 yr of follow-up in type II diabetes patients, whether a statistically and clinically significant difference can be achieved in HbA1c between a standard therapy group and an intensively treated group, while maintaining HbA1c levels in both groups within ranges acceptable in regular commun...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.15.11.1560
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1520
更新日期:2021-01-01 00:00:00
abstract::The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is compl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-0880
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The ability of the Adult Treatment Panel III (ATP III) criteria of metabolic syndrome to identify insulin-resistant subjects at increased cardiovascular risk is suboptimal, especially in the absence of obesity and diabetes. Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and is ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-1526
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of type 2 diabetes and impaired fasting glycemia (IFG) in a tribal population of Bangladesh. RESEARCH DESIGN AND METHODS:A cluster sampling of 1,287 tribal subjects of age > or =20 years was investigated. They live in a hilly area of Khagrachari in the far northeast of Bangladesh....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.5.1054
更新日期:2004-05-01 00:00:00
abstract::Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.4.313
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVE:Physical activity is a cornerstone of treatment for diabetes, yet people with diabetes perform less moderate and vigorous physical activity (MVPA) than people without diabetes. In contrast, whether differences in walking activity exist has been understudied. Diabetes-specific barriers to physical activity are...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1801
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To characterize renal impairment associated with diabetes in older adults by serum markers of glomerular filtration rate and microalbuminuria tests. RESEARCH DESIGN AND METHODS:The study population consisted of 187 diabetic and 1,073 nondiabetic subjects (age range 64-100 years) participating in a cross-sect...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.11.2648
更新日期:2004-11-01 00:00:00