Heterogeneity of patients with latent autoimmune diabetes in adults: linkage to autoimmunity is apparent only in those with perceived need for insulin treatment: results from the Nord-Trøndelag Health (HUNT) study.


OBJECTIVE:Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA) are more prone to need insulin treatment than those with type 2 diabetes. However, not all patients with LADA develop the need for insulin treatment, indicating the heterogeneity of LADA. We investigated this heterogeneity by comparing phenotypes of LADA with and without perceived need for insulin treatment (data obtained at times when diagnosis of LADA was not investigated) and also compared LADA and type 2 diabetes phenotypes. RESEARCH DESIGN AND METHODS:We used data from the all population-based Nord-Trøndelag Health study (n = 64,931), performed in 1995-1997. Data were assembled for individuals with LADA (n = 106) and type 2 diabetes (n = 943). RESULTS:In the comparison of individuals with LADA both with and without the need for insulin, insulin-treated subjects had higher titers of GAD antibodies (P < 0.001) and lower fasting C-peptide levels (P < 0.001). GAD antibodies and C-peptide correlated negatively (r = -0.40; P = 0.009). In the comparison of individuals with LADA and type 2 diabetes, all without the need for insulin, markers of metabolic syndrome were equally prevalent and pronounced. Age, C-peptide, and glucose levels were also similar. In the comparison of insulin-treated individuals with LADA and type 2 diabetes, more patients with LADA received insulin (40 vs. 22%, P < 0.001) and C-peptide levels were lower (P < 0.001). Patients with LADA were leaner but were still overweight (mean BMI 28.7 vs. 30.9 kg/m2 in type 2 diabetes, P < 0.001). In the comparison of type 2 diabetic patients with and without insulin, insulin-treated subjects were more obese and had higher A1C and lower C-peptide levels (P < 0.001). CONCLUSIONS:Our conclusions are that 1) the need for insulin treatment in LADA is linked to the degree of autoimmunity and beta-cell failure, 2) subjects with LADA and type 2 diabetes without the need for insulin treatment are phenotypically similar, and 3) insulin treatment in type 2 diabetic patients is associated with both insulin resistance and beta-cell insufficiency.


Diabetes Care


Diabetes care


Radtke MA,Midthjell K,Nilsen TI,Grill V




Has Abstract


2009-02-01 00:00:00














  • Type 2 Diabetes in Relation to the Risk of Renal Cell Carcinoma Among Men and Women in Two Large Prospective Cohort Studies.

    abstract:OBJECTIVE:We assessed whether type 2 diabetes is associated with renal cell carcinoma (RCC), independent of key potential confounders, in two large prospective cohorts with biennially updated covariate data. RESEARCH DESIGN AND METHODS:A total of 117,570 women from the Nurses' Health Study (NHS) and 48,866 men from th...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Graff RE,Sanchez A,Tobias DK,Rodríguez D,Barrisford GW,Blute ML,Li Y,Sun Q,Preston MA,Wilson KM,Cho E

    更新日期:2018-07-01 00:00:00

  • Beneficial effect of low-glycemic index diet in overweight NIDDM subjects.

    abstract:OBJECTIVE:To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossov...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolever TM,Jenkins DJ,Vuksan V,Jenkins AL,Wong GS,Josse RG

    更新日期:1992-04-01 00:00:00

  • Impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes.

    abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ly TT,Gallego PH,Davis EA,Jones TW

    更新日期:2009-10-01 00:00:00

  • Accelerated insulin degradation: an alternate mechanism for insulin resistance.

    abstract::We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kitabchi AE,Stentz FB,Cole C,Duckworth WC

    更新日期:1979-09-01 00:00:00

  • Racial and ethnic variation in access to health care, provision of health care services, and ratings of health among women with histories of gestational diabetes mellitus.

    abstract:OBJECTIVE:The purpose of this study was to assess racial/ethnic variation in access to health care, use of particular health care services, presence of cardiovascular risk factors, and perceptions of health and impairment among women at risk for type 2 diabetes because of their histories of gestational diabetes mellitu...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kim C,Sinco B,Kieffer EA

    更新日期:2007-06-01 00:00:00

  • Combination insulin-sulfonylurea therapy.

    abstract::Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审


    authors: Lebovitz HE,Pasmantier R

    更新日期:1990-06-01 00:00:00

  • A cohort study of mortality in two clinic populations of patients with diabetes mellitus.

    abstract::Mortality rates of two cohorts of patients with diabetes mellitus are estimated and compared. The Atlanta cohort is defined as all black patients receiving care at the diabetes clinic of Grady Memorial Hospital for the first time during calendar year 1971. The Memphis cohort is defined as all black patients referred f...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Vander Zwaag R,Runyan JW Jr,Davidson JK,Delcher HK,Mainzer I,Baggett HW

    更新日期:1983-07-01 00:00:00

  • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy.

    abstract:OBJECTIVE:To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone. RESEARCH DESIGN AND METHODS:Treatment-naive patients or those receiving metformin, sulfonylurea, or thiazolidinedione entered a...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rosenstock J,Vico M,Wei L,Salsali A,List JF

    更新日期:2012-07-01 00:00:00

  • Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood.

    abstract:OBJECTIVE:Gestational diabetes mellitus has been associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models. We assessed the associations of maternal random glucose concentrations across the full ran...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Wahab RJ,Jaddoe VWV,Roest AAW,Toemen L,Gaillard R

    更新日期:2020-09-01 00:00:00

  • Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to a...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Potter JM,Hickman PE,Oakman C,Woods C,Nolan CJ

    更新日期:2020-07-01 00:00:00

  • Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.

    abstract:OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

    更新日期:2009-01-01 00:00:00

  • Incidence of type 2 diabetes using proposed HbA1c diagnostic criteria in the european prospective investigation of cancer-norfolk cohort: implications for preventive strategies.

    abstract:OBJECTIVE:To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA(1c) diagnostic criteria in groups categorized by different baseline HbA(1c) levels. RESEARCH DESIGN AND METHODS:Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat H...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Chamnan P,Simmons RK,Forouhi NG,Luben RN,Khaw KT,Wareham NJ,Griffin SJ

    更新日期:2011-04-01 00:00:00

  • Effect of rosiglitazone versus insulin on the pancreatic beta-cell function of subjects with type 2 diabetes.

    abstract:OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ovalle F,Bell DS

    更新日期:2004-11-01 00:00:00

  • Psychosocial crisis in diabetic renal failure.

    abstract::Twenty-nine diabetic renal failure patients suffered a psychosocial crisis at the time when chronic dialysis or renal transplantation was required. These patients could be classified into groups as to the impact of the crisis in terms of participation in life-support therapy. Group 1 consisted of potentially lethal me...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: D'Elia JA,Piening S,Kaldany A,Malarick C,Unger K,Ice S,Anderson RB,Miller DG,Lundin AP

    更新日期:1981-01-01 00:00:00

  • Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians.

    abstract:OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

    更新日期:1991-04-01 00:00:00

  • Association Between Inflammatory Markers and Progression to Kidney Dysfunction: Examining Different Assessment Windows in Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:To determine whether biomarkers of inflammation and endothelial dysfunction are associated with the development of kidney dysfunction and the time frame of their association. RESEARCH DESIGN AND METHODS:Biomarkers were measured at four time points during 28 years of treatment and follow-up in patients with t...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Baker NL,Hunt KJ,Stevens DR,Jarai G,Rosen GD,Klein RL,Virella G,Lopes-Virella MF,DCCT\/EDIC Research Group.

    更新日期:2018-01-01 00:00:00

  • A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos.

    abstract:OBJECTIVE:We aimed to identify hemoglobin A1c (HbA1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA1c in U.S. Hispanics/Latinos with diverse genetic ancestries. RESEARCH DESIGN AND METHODS:We conducted a genome-wide association study (GWAS) of HbA1c in 9,636 U.S. Hispa...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Moon JY,Louie TL,Jain D,Sofer T,Schurmann C,Below JE,Lai CQ,Aviles-Santa ML,Talavera GA,Smith CE,Petty LE,Bottinger EP,Chen YI,Taylor KD,Daviglus ML,Cai J,Wang T,Tucker KL,Ordovás JM,Hanis CL,Loos RJF,Schneiderm

    更新日期:2019-09-01 00:00:00

  • Improvement of the plasma lipoprotein pattern after institution of insulin treatment in diabetes mellitus.

    abstract::Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Agardh CD,Nilsson-Ehle P,Scherstén B

    更新日期:1982-05-01 00:00:00

  • High systolic blood pressure increases prevalence and severity of retinopathy in NIDDM patients.

    abstract:OBJECTIVE:To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS:Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP abov...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Cignarelli M,De Cicco ML,Damato A,Paternostro A,Pagliarini S,Santoro S,Cardia L,De Pergola G,Giorgino R

    更新日期:1992-08-01 00:00:00

  • Distinct diagnostic criteria of fulminant type 1 diabetes based on serum C-peptide response and HbA1c levels at onset.

    abstract:OBJECTIVE:Diagnostic criteria in fulminant type 1 diabetes, a novel subtype of type 1 diabetes, remain unclear. RESEARCH DESIGN AND METHODS:We analyzed basal and longitudinal changes of serum C-peptide levels during a 75-g oral glucose tolerance test (OGTT) in 125 consecutively recruited patients with type 1 diabetes ...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Tanaka S,Endo T,Aida K,Shimura H,Yokomori N,Kaneshige M,Furuya F,Amemiya S,Mochizuki M,Nakanishi K,Kobayashi T

    更新日期:2004-08-01 00:00:00

  • Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better?

    abstract:OBJECTIVE:Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS:In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验


    authors: Lingvay I,Legendre JL,Kaloyanova PF,Zhang S,Adams-Huet B,Raskin P

    更新日期:2009-10-01 00:00:00

  • Impact of diabetes among revascularized patients in Japan and the U.S.

    abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Kohsaka S,Goto M,Nagai T,Lee VV,Elayda M,Furukawa Y,Fukushima M,Komeda M,Sakata R,Ohsugi M,Fukuda K,Wilson JM,Kita T,Kimura T

    更新日期:2012-03-01 00:00:00

  • Clinical correlates of plantar pressure among diabetic veterans.

    abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ahroni JH,Boyko EJ,Forsberg RC

    更新日期:1999-06-01 00:00:00

  • Na/Li countertransport abnormalities in type 1 diabetes with and without nephropathy are familial.

    abstract:OBJECTIVE:To determine whether there is a familial abnormality in erythrocyte Na/Li countertransport (CT) kinetics in the approximate one-third of type 1 diabetic patients that succumb to a familial predisposition to nephropathy. RESEARCH DESIGN AND METHODS:Erythrocyte Na/Li CT kinetics were measured in nondiabetic fi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Mead PA,Wilkinson R,Thomas TH

    更新日期:2001-03-01 00:00:00

  • Predictors of Quality of Life and Other Patient-Reported Outcomes in the PANORAMA Multinational Study of People With Type 2 Diabetes.

    abstract:OBJECTIVE:PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS:Patients were randomly or consecutively selected from primary/secondary care. PROMs inclu...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究


    authors: Bradley C,Eschwège E,de Pablos-Velasco P,Parhofer KG,Simon D,Vandenberghe H,Gönder-Frederick L

    更新日期:2018-02-01 00:00:00

  • Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

    abstract:OBJECTIVE:We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS:We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI abov...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Ferrara CT,Geyer SM,Liu YF,Evans-Molina C,Libman IM,Besser R,Becker DJ,Rodriguez H,Moran A,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.

    更新日期:2017-05-01 00:00:00

  • Effectiveness of a behavioral weight control program for blacks and whites with NIDDM.

    abstract:OBJECTIVE:To compare the weight losses of black and white patients with NIDDM treated in a year-long behavioral weight loss program. RESEARCH DESIGN AND METHODS:Subjects were randomly assigned to a behavioral program that either used a low-calorie diet throughout or included two 12-week periods of a very-low calorie d...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wing RR,Anglin K

    更新日期:1996-05-01 00:00:00

  • Waist circumference and waist-to-hip ratio are related to gestational glucose tolerance.

    abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Branchtein L,Schmidt MI,Mengue SS,Reichelt AJ,Matos MC,Duncan BB

    更新日期:1997-04-01 00:00:00

  • Apolipoprotein E polymorphism as a risk factor for vascular disease in diabetic patients.

    abstract:OBJECTIVE:To examine the prevalence of cardiovascular disease in diabetic patients as a function of apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:The apo E phenotypes and plasma lipid, lipoprotein, and apo levels were determined for 517 Italian diabetic patients. The prevalence of cardiovascular dis...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Boemi M,Sirolla C,Amadio L,Fumelli P,Pometta D,James RW

    更新日期:1995-04-01 00:00:00

  • A model to determine workforce needs for endocrinologists in the United States until 2020.

    abstract::The objective of this study was to define the workforce needs for the specialty of Endocrinology, Diabetes, and Metabolism in the United States between 1999 and 2020. An interactive model of factors likely to influence the balance between the supply and demand of endocrinologists during the next 20 years was construct...

    journal_title:Diabetes care

    pub_type: 杂志文章


    authors: Rizza RA,Vigersky RA,Rodbard HW,Ladenson PW,Young WF Jr,Surks MI,Kahn R,Hogan PF

    更新日期:2003-05-01 00:00:00