Nonfasting plasma glucose is a better marker of diabetic control than fasting plasma glucose in type 2 diabetes.

Abstract:

OBJECTIVE:To evaluate the relative value of plasma glucose (PG) at different time points in assessing glucose control of type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Glycemic profiles, i.e., PG at prebreakfast (8:00 A.M.), prelunch (11:00 A.M.), postlunch (2:00 P.M.), and extended postlunch (5:00 P.M.) times over the same day, were obtained in 66 type 2 diabetic patients on an ambulatory basis. The different time points of PG were compared with a measurement of HbA1c made in a reference laboratory. RESULTS:Extended postlunch PG was lower than prebreakfast PG (104 +/- 21 vs. 133 +/- 35 mg/dl, P < 0.02) in patients demonstrating good diabetic control (HbA1c < or = 7.0%), was not different from prebreakfast PG (149 +/- 47 vs. 166 +/- 26 mg/dl, NS) in patients demonstrating fair diabetic control (7.0% < HbA1c < or = 8.5%), and was higher than prebreakfast PG (221 +/- 62 vs. 199 +/- 49 mg/dl, P < or = 0.01) in those demonstrating poor diabetic control (HbA1c < or = 8.5%). Prebreakfast, prelunch, postlunch, and extended postlunch PG values were all significantly correlated with HbA1c. Multiple linear regression analysis demonstrated that postlunch PG and extended postlunch PG correlated significantly and independently with HbA1c, but that prebreakfast PG and prelunch PG did not. Moreover, postlunch PG and extended postlunch PG demonstrated better sensitivity, specificity, and positive predictive value in predicting poor glycemic control than did prebreakfast PG or prelunch PG. CONCLUSIONS:In type 2 diabetes, postlunch PG and extended postlunch PG are better predictors of glycemic control than fasting plasma glucose (FPG). We therefore suggest that they be more widely used to supplement, or substitute for, FPG in evaluating the metabolic control of type 2 diabetic patients.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Avignon A,Radauceanu A,Monnier L

doi

10.2337/diacare.20.12.1822

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

1822-6

issue

12

eissn

0149-5992

issn

1935-5548

journal_volume

20

pub_type

杂志文章
  • Personality and family profiles of chronic insulin-dependent diabetic patients using portable insulin infusion pump therapy: a preliminary investigation.

    abstract::Thirty patients were studied before and after introduction of portable insulin infusion pump therapy to determine the psychological and family impact of this new technological intervention. No negative psychological impact or dysfunction appeared to be associated with introduction of the pump. On the contrary, the pos...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.2.137

    authors: Shapiro J,Wigg D,Charles MA,Perley M

    更新日期:1984-03-01 00:00:00

  • Plasma glucose within the normal range is not associated with carotid atherosclerosis: prospective results in subjects with normal glucose tolerance from the Bruneck Study.

    abstract:OBJECTIVE:There is substantial evidence that glucose intolerance is associated with an increased risk of cardiovascular disease. However, it is not well established whether plasma glucose is independently related to atherosclerosis when glucose tolerance is normal and, if so, to which stage of the complex atherosclerot...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.8.1339

    authors: Bonora E,Kiechl S,Willeit J,Oberhollenzer F,Egger G,Bonadonna R,Muggeo M

    更新日期:1999-08-01 00:00:00

  • Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study.

    abstract:OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0286

    authors: van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

    更新日期:2010-09-01 00:00:00

  • Evaluation of postural stability in elderly with diabetic neuropathy.

    abstract:OBJECTIVE:The objective of this study was to compare clinical and biomechanical characteristics of balance in diabetic polyneuropathic elderly patients and normal age-matched subjects. RESEARCH DESIGN AND METHODS:Fifteen elderly with distal neuropathy (DNP) and 15 healthy age-matched subjects were evaluated with the b...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.8.1187

    authors: Corriveau H,Prince F,Hébert R,Raîche M,Tessier D,Maheux P,Ardilouze JL

    更新日期:2000-08-01 00:00:00

  • The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes.

    abstract:OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1669

    authors: Lee AK,Warren B,Lee CJ,McEvoy JW,Matsushita K,Huang ES,Sharrett AR,Coresh J,Selvin E

    更新日期:2018-01-01 00:00:00

  • Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.

    abstract:OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-2101

    authors: Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D

    更新日期:2015-06-01 00:00:00

  • Diabeloop DBLG1 Closed-Loop System Enables Patients With Type 1 Diabetes to Significantly Improve Their Glycemic Control in Real-Life Situations Without Serious Adverse Events: 6-Month Follow-up.

    abstract:OBJECTIVE:To analyze safety and efficacy of the Diabeloop Generation 1 (DBLG1) hybrid closed-loop artificial pancreas system in patients with type 1 diabetes in real-world conditions. RESEARCH DESIGN AND METHODS:After a 1-week run-in period with their usual pump, 25 patients were provided the commercial DBLG1 system. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1809

    authors: Amadou C,Franc S,Benhamou PY,Lablanche S,Huneker E,Charpentier G,Penfornis A,Diabeloop Consortium.

    更新日期:2021-01-11 00:00:00

  • The impact of patient preferences on the cost-effectiveness of intensive glucose control in older patients with new-onset diabetes.

    abstract:OBJECTIVE:Cost-effectiveness analyses have reported that intensive glucose control is not cost-effective in older patients with new-onset diabetes. However, these analyses have had limited data on patient preferences concerning diabetic health states. We examined how the cost- effectiveness of intensive glucose control...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.29.02.06.dc05-1443

    authors: Huang ES,Shook M,Jin L,Chin MH,Meltzer DO

    更新日期:2006-02-01 00:00:00

  • Long-acting insulin analogs.

    abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Rosskamp RH,Park G

    更新日期:1999-03-01 00:00:00

  • Comparative Effectiveness of the Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Versus Other Antihyperglycemics on Risk of Major Adverse Kidney Events.

    abstract:OBJECTIVE:To examine the comparative effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin and other non-SGLT2i antihyperglycemics on the risk of major adverse kidney events (MAKE) of estimated glomerular filtration rate (eGFR) decline >50%, end-stage kidney disease, or all-cause mortalit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1231

    authors: Xie Y,Bowe B,Gibson AK,McGill JB,Yan Y,Maddukuri G,Al-Aly Z

    更新日期:2020-11-01 00:00:00

  • The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue.

    abstract:OBJECTIVE:The sympathetic nervous system and thiazolidinediones control lipid metabolism and have been implicated in body weight regulation. This study was conducted to determine whether the simultaneous activation of these two signaling systems might synergize to exert beneficial effects on the expression of key genes...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1962

    authors: Bogacka I,Gettys TW,de Jonge L,Nguyen T,Smith JM,Xie H,Greenway F,Smith SR

    更新日期:2007-05-01 00:00:00

  • The diagnosis of gestational diabetes.

    abstract::The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Coustan DR,Carpenter MW

    更新日期:1998-08-01 00:00:00

  • The dynamics of diabetes among birth cohorts in the U.S.

    abstract::OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated trends in diabetes prevalence across cohorts born 1910-1989 and provide the first estimates of age-specific diabetes incidence using nationally representative, measured data. RESEARCH DESIGN AND METHOD...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1982

    authors: Fishman EI,Stokes A,Preston SH

    更新日期:2014-04-01 00:00:00

  • Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study.

    abstract:OBJECTIVE:To assess the efficacy and safety of topical human recombinant basic fibroblast growth factor (bFGF) on the healing of diabetic neurotrophic foot ulcers. RESEARCH DESIGN AND METHODS:Seventeen diabetic patients suffering from chronic neuropathic ulcer of the plantar surface of the foot entered a pilot, random...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.18.1.64

    authors: Richard JL,Parer-Richard C,Daures JP,Clouet S,Vannereau D,Bringer J,Rodier M,Jacob C,Comte-Bardonnet M

    更新日期:1995-01-01 00:00:00

  • Variations of ambulatory blood pressure with position in patients with type 1 diabetes: influence of disease duration and microangiopathy in a pilot study.

    abstract:OBJECTIVE:To study the influence of position changes on 24-h ambulatory blood pressure (ABP) in normotensive or mildly hypertensive normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional evaluation of patients was staged according to the duration of diabetes (DD) and the presence...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.9.1624

    authors: Benhamou PY,Mouret S,Quesada JL,Boizel R,Baguet JP,Halimi S,Mallion JM

    更新日期:2001-09-01 00:00:00

  • Differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people with metabolic syndrome.

    abstract:OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1373

    authors: Bakris G,Molitch M,Hewkin A,Kipnes M,Sarafidis P,Fakouhi K,Bacher P,Sowers J,STAR Investigators.

    更新日期:2006-12-01 00:00:00

  • Exercise training improves vascular endothelial function in patients with type 1 diabetes.

    abstract::OBJECTIVE-Impaired endothelial function of resistance and conduit arteries can be detected in patients with type 1 diabetes. We studied whether a persistent improvement of endothelial function can be achieved by regular physical training. RESEARCH DESIGN AND METHODS-The study included 26 patients with type 1 diabetes ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.25.10.1795

    authors: Fuchsjäger-Mayrl G,Pleiner J,Wiesinger GF,Sieder AE,Quittan M,Nuhr MJ,Francesconi C,Seit HP,Francesconi M,Schmetterer L,Wolzt M

    更新日期:2002-10-01 00:00:00

  • Impaired endothelial function in preadolescent children with type 1 diabetes.

    abstract:OBJECTIVE:We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS:We studied 21 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2134

    authors: Babar GS,Zidan H,Widlansky ME,Das E,Hoffmann RG,Daoud M,Alemzadeh R

    更新日期:2011-03-01 00:00:00

  • Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

    abstract:OBJECTIVE:We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS:We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI abov...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2331

    authors: Ferrara CT,Geyer SM,Liu YF,Evans-Molina C,Libman IM,Besser R,Becker DJ,Rodriguez H,Moran A,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.

    更新日期:2017-05-01 00:00:00

  • Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project.

    abstract:OBJECTIVE:Thiazolidinediones (TZDs) and metformin are insulin-sensitizing antihyperglycemic agents with reported benefits on atherosclerosis. Despite extensive use in patients with diabetes and cardiovascular disease, there is a paucity of outcomes data with metformin and none yet with TZDs. We sought to determine the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.28.7.1680

    authors: Inzucchi SE,Masoudi FA,Wang Y,Kosiborod M,Foody JM,Setaro JF,Havranek EP,Krumholz HM

    更新日期:2005-07-01 00:00:00

  • Effects of Vildagliptin and Metformin on Blood Pressure and Heart Rate Responses to Small Intestinal Glucose in Type 2 Diabetes.

    abstract:OBJECTIVE:To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 k...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2391

    authors: Wu T,Trahair LG,Little TJ,Bound MJ,Zhang X,Wu H,Sun Z,Horowitz M,Rayner CK,Jones KL

    更新日期:2017-05-01 00:00:00

  • Severe hypoglycemia in type I diabetic patients with impaired kidney function.

    abstract:OBJECTIVE:To assess the frequency and possible risk indicators of severe hypoglycemia in insulin-dependent (type I) diabetic patients with impaired kidney function. RESEARCH DESIGN AND METHODS:Retrospective follow-up examination of case subjects and control subjects with mean follow-up periods of 2.9 and 1.3 yr, respe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.4.344

    authors: Mühlhauser I,Toth G,Sawicki PT,Berger M

    更新日期:1991-04-01 00:00:00

  • Glycemic control and prevention of retinopathy in Japanese NIDDM patients. A 10-year follow-up study.

    abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.621

    authors: Nakagami T,Kawahara R,Hori S,Omori Y

    更新日期:1997-04-01 00:00:00

  • Core Outcome Sets for Studies of Diabetes in Pregnancy: A Review.

    abstract::Core Outcome Sets (COS) contain an agreed minimum set of outcomes to be measured and reported in all studies in a specific area, with the objective of standardizing outcome reporting. COS may minimize research waste by identifying outcomes important to key stakeholders, allowing for improved evidence synthesis, and fa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc20-1621

    authors: Egan AM,Bogdanet D,Biesty L,Kgosidialwa O,McDonagh C,O'Shea C,O'Shea PM,Devane D,Dunne FP,INSPIRED research group.

    更新日期:2020-12-01 00:00:00

  • Accelerated insulin degradation: an alternate mechanism for insulin resistance.

    abstract::We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.5.414

    authors: Kitabchi AE,Stentz FB,Cole C,Duckworth WC

    更新日期:1979-09-01 00:00:00

  • Effect of pregnancy on autonomic nervous function and heart rate in diabetic and nondiabetic women.

    abstract::Supine and standing heart rate and heart rate responses to deep breathing and standing up (the 30-to-15 ratio), indices of autonomic nervous function, were measured during each trimester and postpartum in 25 women with insulin-dependent diabetes and 10 nondiabetic women. The groups did not differ with respect to auton...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.748

    authors: Airaksinen KE,Salmela PI,Ikäheimo MJ,Kirkinen P,Linnaluoto MK,Takkunen JT

    更新日期:1987-11-01 00:00:00

  • Effect of moderate improvement in metabolic control on magnesium and lipid concentrations in patients with type 1 diabetes.

    abstract:OBJECTIVE:To evaluate the effect of clinically obtainable improvements in metabolic control in patients with type 1 diabetes on biochemical cardiovascular risk factors. RESEARCH DESIGN AND METHODS:Blood and 24-h urinary samples were obtained from 49 patients with type 1 diabetes before and after a run-in period and af...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.22.4.546

    authors: Djurhuus MS,Henriksen JE,Klitgaard NA,Blaabjerg O,Thye-Rønn P,Altura BM,Altura BT,Beck-Nielsen H

    更新日期:1999-04-01 00:00:00

  • Pioglitazone treatment improves nitrosative stress in type 2 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/diacare.29.04.06.dc05-0517

    authors: Vinik AI,Ullal J,Parson HK,Barlow PM,Casellini CM

    更新日期:2006-04-01 00:00:00

  • Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study).

    abstract:OBJECTIVE:Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregest...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0571

    authors: Knorr S,Bytoft B,Lohse Z,Boisen AB,Clausen TD,Jensen RB,Damm P,Beck-Nielsen H,Holst JJ,Hartmann B,Møller HJ,Højlund K,Gravholt CH,Jensen DM

    更新日期:2019-08-01 00:00:00

  • Psychosocial correlates of survival in diabetes.

    abstract::The goal of this research was to quantify the relationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.7.538

    authors: Davis WK,Hess GE,Hiss RG

    更新日期:1988-07-01 00:00:00