Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

abstract：OBJECTIVE:To assess the frequency and possible risk indicators of severe hypoglycemia in insulin-dependent (type I) diabetic patients with impaired kidney function. RESEARCH DESIGN AND METHODS:Retrospective follow-up examination of case subjects and control subjects with mean follow-up periods of 2.9 and 1.3 yr, respe...

journal_title：Diabetes care

authors： Mühlhauser I,Toth G,Sawicki PT,Berger M

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on the presence of impaired fasting glucose. RESEARCH DESIGN AND METHODS:A total of 7,849 individuals (5,409 men and 2,440 women) without diabetes, who underwent comprehen...

journal_title：Diabetes care

authors： Bae JC,Rhee EJ,Lee WY,Park SE,Park CY,Oh KW,Park SW,Kim SW

更新日期：2011-03-01 00:00:00

abstract：:A case-control study examining the 1-yr motor vehicle accident experiences of 158 insulin-dependent diabetes mellitus (IDDM) cases and 158 nondiabetic siblings was undertaken to evaluate the risk of motor vehicle accidents among drivers with IDDM. In multivariate analyses the overall accident risk of the cases and con...

journal_title：Diabetes care

authors： Songer TJ,LaPorte RE,Dorman JS,Orchard TJ,Cruickshanks KJ,Becker DJ,Drash AL

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:Physical activity is integral to the management of type 2 diabetes. Unfortunately, the majority of adults with type 2 diabetes do not regularly engage in physical activity. The purpose of this study was to assess physical activity behavior and its correlates (i.e., physical activity knowledge, barriers, and p...

journal_title：Diabetes care

authors： Hays LM,Clark DO

更新日期：1999-05-01 00:00:00

abstract：:In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...

journal_title：Diabetes care

authors： Nijs HG,Radder JK,Frölich M,Krans HM

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes. RESEARCH DESIGN AND METHODS:We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subj...

journal_title：Diabetes care

authors： Park MH,Kinra S,Ward KJ,White B,Viner RM

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...

journal_title：Diabetes care

authors： Ferrannini E,Veltkamp SA,Smulders RA,Kadokura T

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Assessing updated incidence of type 1 diabetes in 0- to 14-year-old children in Liguria, a Northwest region of Italy. RESEARCH DESIGN AND METHODS:Incident cases were recorded prospectively from 1989 to 1998. Incidence rates (IRs) were standardized to the 1999 world population using the direct method. The ind...

journal_title：Diabetes care

authors： Cotellessa M,Barbieri P,Mazzella M,Bonassi S,Minicucci L,Lorini R

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor (TGF)-beta1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. We sought to examine the role of both urinary and circulating T...

journal_title：Diabetes care

authors： Chaturvedi N,Schalkwijk CG,Abrahamian H,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and incidence of diabetes in Alaska Natives and the incidence of cerebrovascular accidents (stroke), myocardial infarction (MI), end-stage renal disease (ESRD), lower-extremity amputations (LEA), and mortality over a 6- to 8-year period. RESEARCH DESIGN AND METHODS:The data derive...

journal_title：Diabetes care

authors： Schraer CD,Adler AI,Mayer AM,Halderson KR,Trimble BA

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. ...

journal_title：Diabetes care

authors： Kashiwazaki K,Hirano T,Yoshino G,Kurokawa M,Tajima H,Adachi M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS:Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed...

journal_title：Diabetes care

authors： Ouellet V,Marois J,Weisnagel SJ,Jacques H

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we describ...

journal_title：Diabetes care

authors： Dubois-Laforgue D,Cornu E,Saint-Martin C,Coste J,Bellanné-Chantelot C,Timsit J,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

journal_title：Diabetes care

authors： Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...

journal_title：Diabetes care

authors： Perassolo MS,Almeida JC,Prá RL,Mello VD,Maia AL,Moulin CC,Camargo JL,Zelmanovitz T,Azevedo MJ,Gross JL

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes. RESEARCH DESIGN AND METHODS:We conducted an observational cohort study in male workers > or = 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake > or = 20...

journal_title：Diabetes care

authors： Shibata M,Kihara Y,Taguchi M,Tashiro M,Otsuki M

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN...

journal_title：Diabetes care

authors： Power C,Thomas C

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS:There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurem...

journal_title：Diabetes care

authors： Freccero C,Svensson H,Bornmyr S,Wollmer P,Sundkvist G

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Women exhibit exaggerated renal hemodynamic responses to hyperglycemia, which may promote kidney disease progression. Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus. R...

journal_title：Diabetes care

authors： Cherney DZ,Scholey JW,Sochett EB

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 k...

journal_title：Diabetes care

authors： Wu T,Trahair LG,Little TJ,Bound MJ,Zhang X,Wu H,Sun Z,Horowitz M,Rayner CK,Jones KL

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Raskin P,Jovanovic L,Berger S,Schwartz S,Woo V,Ratner R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To assess the relevance of pulse pressure as a predictor of foot ulcers in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:A cohort study was performed on a consecutive series of 1,945 type 2 diabetic outpatients without a foot ulcer at baseline. Incident foot ulcers were identified through the regiona...

journal_title：Diabetes care

authors： Monami M,Vivarelli M,Desideri CM,Colombi C,Marchionni N,Mannucci E

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The symptoms of 430 type 2 diabetic patients were determined by a self-administered questionnaire before entry into the U.K. Prospective Diabetes Study. RESEARCH DESIGN AND METHODS:Entry into the trial followed 2 months of dietary treatment for newly diagnosed patients with type 2 diabetes. Forty symptoms wi...

journal_title：Diabetes care

authors： Bulpitt CJ,Palmer AJ,Battersby C,Fletcher AE

更新日期：1998-01-01 00:00:00

abstract：:The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). The study included 37 NIDDM patients with HbA1 concentrations greater than 8.5% and normal kidney and liver function who were being treated with diet alone or diet...

journal_title：Diabetes care

authors： Jones IR,Swai A,Taylor R,Miller M,Laker MF,Alberti KG

更新日期：1990-08-01 00:00:00

abstract：:Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

journal_title：Diabetes care

authors： Sönksen PH,Lowy C,Perkins JR,Lim HS

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the prevalence of both impaired fasting glucose (IFG) and diabetes between hepatitis C virus (HCV)-infected patients and patients with other liver diseases but anti-HCV-, taking into account the degree of liver damage. RESEARCH DESIGN AND METHODS:A total of 642 consecutiv...

journal_title：Diabetes care

authors： Lecube A,Hernández C,Genescà J,Esteban JI,Jardí R,Simó R

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To determine whether overweight Latino children with impaired fasting glucose (IFG) (> or = 100 mg/dl) have increased insulin resistance or decreased beta-cell function compared with those with normal fasting glucose (NFG). RESEARCH DESIGN AND METHODS:We studied 207 healthy overweight Latino children, aged 8...

journal_title：Diabetes care

authors： Weigensberg MJ,Ball GD,Shaibi GQ,Cruz ML,Goran MI

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:The current standard for hospital glucose management is point-of-care (POC) testing. We conducted a randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) compared with POC in a non-intensive care unit (ICU) hospital setting. RESEARCH DESIGN AND METHODS:A total of 110 adults with typ...

journal_title：Diabetes care

authors： Fortmann AL,Spierling Bagsic SR,Talavera L,Garcia IM,Sandoval H,Hottinger A,Philis-Tsimikas A

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...

journal_title：Diabetes care

authors： Bardini G,Dicembrini I,Cresci B,Rotella CM

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:There is a well-documented gap between diabetes care guidelines and the services received by patients in most health care settings. This report presents 12-month follow-up results from a computer-assisted, patient-centered intervention to improve the level of recommended services patients received from a vari...

journal_title：Diabetes care

authors： Glasgow RE,Nutting PA,King DK,Nelson CC,Cutter G,Gaglio B,Rahm AK,Whitesides H

更新日期：2005-01-01 00:00:00