Metformin for obesity in children and adolescents: a systematic review.

Abstract:

OBJECTIVE:To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes. RESEARCH DESIGN AND METHODS:We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subjects age < or =19 years without diabetes were included. Our primary outcomes of interest include changes in BMI and measures of insulin sensitivity. RESULTS:Five trials met inclusion criteria (n = 320 individuals). Compared with placebo, metformin reduced BMI by 1.42 kg/m(2) (95% CI 0.83-2.02) and homeostasis model assessment insulin of resistance (HOMA-IR) score by 2.01 (95% CI 0.75-3.26). CONCLUSIONS:Metformin appears to be moderately efficacious in reducing BMI and insulin resistance in hyperinsulinemic obese children and adolescents in the short term. Larger, longer-term studies in different populations are needed to establish its role in the treatment of overweight children.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Park MH,Kinra S,Ward KJ,White B,Viner RM

doi

10.2337/dc09-0258

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

1743-5

issue

9

eissn

0149-5992

issn

1935-5548

pii

dc09-0258

journal_volume

32

pub_type

杂志文章,评审
  • Alcohol and the NIDDM patient.

    abstract::Historically, alcohol use by the diabetic patient has been controversial. Recent studies in the general population have shown an improvement in mortality with moderate alcohol intake (one to three drinks per day). This improved mortality is greatest in those individuals who have a higher risk of ischemic heart disease...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.19.5.509

    authors: Bell DS

    更新日期:1996-05-01 00:00:00

  • Glycemic control and prevention of retinopathy in Japanese NIDDM patients. A 10-year follow-up study.

    abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.4.621

    authors: Nakagami T,Kawahara R,Hori S,Omori Y

    更新日期:1997-04-01 00:00:00

  • Epidemiology and treatment of diabetic ketoacidosis in a community population.

    abstract::We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing inc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.6.528

    authors: Ellemann K,Soerensen JN,Pedersen L,Edsberg B,Andersen OO

    更新日期:1984-11-01 00:00:00

  • Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.

    abstract:OBJECTIVE:Visfatin is a novel adipokine that is predominantly secreted by visceral adipose tissue. Accumulation of visceral adipose tissue is also associated with iron metabolism. Despite the coincidence of visfatin expression in iron-rich tissues, no study has investigated the possible interaction of visfatin with par...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1581

    authors: Fernández-Real JM,Moreno JM,Chico B,López-Bermejo A,Ricart W

    更新日期:2007-03-01 00:00:00

  • Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial.

    abstract:OBJECTIVE:Progressive nephropathy represents a substantial source of morbidity and mortality in type 1 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0277

    authors: Lin J,Glynn RJ,Rifai N,Manson JE,Ridker PM,Nathan DM,Schaumberg DA

    更新日期:2008-12-01 00:00:00

  • Reduced testing frequency for glycated hemoglobin, HbA1c, is associated with deteriorating diabetes control.

    abstract:OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-0297

    authors: Driskell OJ,Holland D,Waldron JL,Ford C,Scargill JJ,Heald A,Tran M,Hanna FW,Jones PW,Pemberton RJ,Fryer AA

    更新日期:2014-10-01 00:00:00

  • Specific relation between abdominal obesity and early-phase hyperglycemia is modulated by hepatic insulin resistance in healthy older women.

    abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1365

    authors: DiPietro L,Dziura J,Yeckel CW

    更新日期:2010-01-01 00:00:00

  • Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

    abstract:OBJECTIVE:We assessed the extent to which both standard and alternative indexes from 2-h oral glucose tolerance testing predict type 1 diabetes and whether oral glucose tolerance tests (OGTTs) predict type 1 diabetes in individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:The prediction of type 1 dia...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc06-1615

    authors: Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS,Diabetes Prevention Trial-Type 1 Study Group.

    更新日期:2007-01-01 00:00:00

  • Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:OBJECTIVE:To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy. RESEARCH DESIGN AND METHODS:Population-based study using data from the Multi-Ethnic Study of Atherosclerosis (MESA), comprising 5,976 individuals (whites, blacks, Hispanics, and Chinese) residing in six...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1528

    authors: Nguyen TT,Wang JJ,Sharrett AR,Islam FM,Klein R,Klein BE,Cotch MF,Wong TY

    更新日期:2008-03-01 00:00:00

  • Long-acting insulin analogs.

    abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Rosskamp RH,Park G

    更新日期:1999-03-01 00:00:00

  • Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients.

    abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.3.272

    authors: Martinenghi S,Dell'Antonio G,Secchi A,Di Carlo V,Pozza G

    更新日期:1997-03-01 00:00:00

  • Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.

    abstract:OBJECTIVE:β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk. RESEARCH DESIGN AND METHODS:Children were up to 10 years of age and scre...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0181

    authors: Vehik K,Lynch KF,Schatz DA,Akolkar B,Hagopian W,Rewers M,She JX,Simell O,Toppari J,Ziegler AG,Lernmark Å,Bonifacio E,Krischer JP,TEDDY Study Group.

    更新日期:2016-09-01 00:00:00

  • Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study.

    abstract:OBJECTIVE:We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk. RESEARCH DESIGN AND METHODS:A total of 1,741 men and women randomly selected from Central Pennsylvania were studied in the sleep laboratory. Insomnia w...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0284

    authors: Vgontzas AN,Liao D,Pejovic S,Calhoun S,Karataraki M,Bixler EO

    更新日期:2009-11-01 00:00:00

  • Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.

    abstract:OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1342

    authors: Bardini G,Dicembrini I,Cresci B,Rotella CM

    更新日期:2010-02-01 00:00:00

  • Closing the gap: the problem of diabetes mellitus in the United States. The Carter Center of Emory University.

    abstract::Diabetes mellitus is a major public health problem and a leading cause of death, disability, and cost in the United States. We review the epidemiology of diabetes and its complications, the costs of diabetes, and discuss intervention strategies to reduce the burden of diabetes in the United States. ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.8.4.391

    authors:

    更新日期:1985-07-01 00:00:00

  • Effect of troglitazone on body fat distribution in type 2 diabetic patients.

    abstract:OBJECTIVE:Troglitazone was recently reported to specifically promote the differentiation of pre-adipocytes into adipocytes in vitro in subcutaneous fat only, indicating a relation to insulin-resistance-improving action of troglitazone. To expand on this finding, we investigated at the clinical level how long-term admin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.22.6.908

    authors: Mori Y,Murakawa Y,Okada K,Horikoshi H,Yokoyama J,Tajima N,Ikeda Y

    更新日期:1999-06-01 00:00:00

  • Cholesterol absorption and synthesis in children with type 1 diabetes.

    abstract:OBJECTIVE:The levels of the surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholesterol precursors) in serum have suggested that in adult type 1 diabetes, cholesterol absorption is high and synthesis is low compared with type 2 diabetic or control subjects. Accordingly, these ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2235

    authors: Järvisalo M,Raitakari O,Gylling H,Miettinen TA

    更新日期:2006-10-01 00:00:00

  • Nonremovable, windowed, fiberglass cast boot in the treatment of diabetic plantar ulcers: efficacy, safety, and compliance.

    abstract:OBJECTIVE:To compare the efficacy, safety, and compliance of a nonremovable fiberglass cast boot and off-loading shoes in the treatment of diabetic plantar ulcers. RESEARCH DESIGN AND METHODS:Patients (n = 93) with noninfected, nonischemic plantar ulcers were included in this prospective nonrandomized study. Treatment...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.26.10.2848

    authors: Ha Van G,Siney H,Hartmann-Heurtier A,Jacqueminet S,Greau F,Grimaldi A

    更新日期:2003-10-01 00:00:00

  • Hyperinsulinism complicating control of diabetes mellitus by an artificial beta-cell.

    abstract::Serum free insulin concentrations were measured in diabetic subjects given insulin intravenously by a glucose-controlled insulin infusion system ("closed-loop" artificial beta-cell) in two experimental situations: hourly during the day while given their usual diet and at short intervals after administration of a stand...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.2.274

    authors: Horwitz DL,Zeidler A,Gonen B,Jaspan JB

    更新日期:1980-03-01 00:00:00

  • The diagnosis of gestational diabetes.

    abstract::The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Coustan DR,Carpenter MW

    更新日期:1998-08-01 00:00:00

  • Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load.

    abstract::Type II diabetic subjects were given 50 g protein, 50 g glucose, or 50 g glucose with 50 g protein as a single meal in random sequence. The plasma glucose and insulin response was determined over the subsequent 5 h. The plasma glucose area above the baseline following a glucose meal was reduced 34% when protein was gi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.7.5.465

    authors: Nuttall FQ,Mooradian AD,Gannon MC,Billington C,Krezowski P

    更新日期:1984-09-01 00:00:00

  • Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes.

    abstract:OBJECTIVE:The aim of this study was to investigate the presence and correlates of clinically relevant cognitive impairment in middle-aged adults with childhood-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:During 2010-2013, 97 adults diagnosed with T1D and aged <18 years (age and duration 49 ± 7 and 41 ± 6 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-0041

    authors: Nunley KA,Rosano C,Ryan CM,Jennings JR,Aizenstein HJ,Zgibor JC,Costacou T,Boudreau RM,Miller R,Orchard TJ,Saxton JA

    更新日期:2015-09-01 00:00:00

  • Distinct Patterns of Daily Glucose Variability by Pubertal Status in Youth With Type 1 Diabetes.

    abstract:OBJECTIVE:To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status. RESEARCH DESIGN AND METHODS:Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous gluco...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0083

    authors: Zhu J,Volkening LK,Laffel LM

    更新日期:2020-01-01 00:00:00

  • Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes.

    abstract:OBJECTIVE:We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS:Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0811

    authors: Pavkov ME,Hanson RL,Knowler WC,Sievers ML,Bennett PH,Nelson RG

    更新日期:2010-11-01 00:00:00

  • Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study.

    abstract:OBJECTIVE:Reports of amputations associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors have been inconsistent. We aimed to compare the risk of below-knee amputation with SGLT2 inhibitors versus dipeptidyl peptidase 4 (DPP-4) inhibitors among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This m...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-0267

    authors: Yu OHY,Dell'Aniello S,Shah BR,Brunetti VC,Daigle JM,Fralick M,Douros A,Hu N,Alessi-Severini S,Fisher A,Bugden SC,Ronksley PE,Filion KB,Ernst P,Lix LM,Canadian Network for Observational Drug Effect Studies (CNODES) Investiga

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  • Is "sugar" the same as diabetes? A community-based study among rural African-Americans.

    abstract:OBJECTIVE:To determine if differing beliefs about high blood glucose exist and are associated with blood glucose control among rural African-Americans. RESEARCH DESIGN AND METHODS:A community-based sample of rural African-Americans completed a survey, and a subsample underwent a subsequent screening that included gluc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.3.330

    authors: Schorling JB,Saunders JT

    更新日期:2000-03-01 00:00:00

  • Hemoglobin A1c versus oral glucose tolerance test in postpartum diabetes screening.

    abstract:OBJECTIVE:To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with the fasting glucose test, compared with the oral glucose tolerance test (OGTT) for the reassessment of the carbohydrate metabolism status in postpartum women with a history of gestational diabetes mellitus (GDM). RESEARCH...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2111

    authors: Picón MJ,Murri M,Muñoz A,Fernández-García JC,Gomez-Huelgas R,Tinahones FJ

    更新日期:2012-08-01 00:00:00

  • A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.

    abstract:OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.23.11.1666

    authors: Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

    更新日期:2000-11-01 00:00:00

  • Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women.

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    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc13-2513

    authors: Sun Q,Wedick NM,Pan A,Townsend MK,Cassidy A,Franke AA,Rimm EB,Hu FB,van Dam RM

    更新日期:2014-01-01 00:00:00

  • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes.

    abstract:OBJECTIVE:To assess the 12- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 versus placebo in patients with type 2 diabetes continuing metformin treatment. RESEARCH DESIGN AND METHODS:We conducted a 12-week, randomized, double-blind, placebo-controlled trial in 107 patients with type 2 diabetes wi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.27.12.2874

    authors: Ahrén B,Gomis R,Standl E,Mills D,Schweizer A

    更新日期:2004-12-01 00:00:00